{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:35:18Z","timestamp":1780108518705,"version":"3.54.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":5136,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1007\/s12192-009-0107-z","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T20:19:48Z","timestamp":1236802788000},"page":"555-567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders"],"prefix":"10.1016","volume":"14","author":[{"given":"Joseph","family":"Gabriele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe F.","family":"Pontoriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy A.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Skoblenick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek B.","family":"Pristupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-009-0107-z_bb0010","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/1097-4644(20010301)80:3<382::AID-JCB120>3.0.CO;2-D","article-title":"A heat shock transcription factor like protein in the nuclear matrix compartment of the tissue cultured mammalian lens epithelial cell","volume":"80","author":"Bagchi","year":"2001","journal-title":"J Cell Biochem"},{"key":"10.1007\/s12192-009-0107-z_bb0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1007\/s12192-009-0107-z_bb0020","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.semcdb.2007.09.001","article-title":"The activities and function of molecular chaperones in the endoplasmic reticulum","volume":"18","author":"Buck","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"10.1007\/s12192-009-0107-z_bb0025","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1016\/j.febslet.2007.04.044","article-title":"Extracellular heat shock proteins in cell signaling","volume":"581","author":"Calderwood","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1007\/s12192-009-0107-z_bb0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-8628(19990618)88:3<229::AID-AJMG4>3.0.CO;2-B","article-title":"Report of the Chromosome 5 Workshop of the Sixth World Congress on Psychiatric Genetics","volume":"88","author":"Crowe","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1007\/s12192-009-0107-z_bb0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0003-2697(87)90568-9","article-title":"A method for the production of highly specific polyclonal antibodies","volume":"166","author":"Diano","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1007\/s12192-009-0107-z_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2003.12.008","article-title":"Principles of protein folding, misfolding and aggregation","volume":"15","author":"Dobson","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"10.1007\/s12192-009-0107-z_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-2999(02)02366-X","article-title":"Modulation of a 40-kDa catecholamine-regulated protein following d-amphetamine treatment in discrete brain regions","volume":"453","author":"Gabriele","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1007\/s12192-009-0107-z_bb0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/syn.10224","article-title":"Asymmetric modulation of a catecholamine-regulated protein in the rat brain, following quinpirole administration","volume":"49","author":"Gabriele","year":"2003","journal-title":"Synapse"},{"key":"10.1007\/s12192-009-0107-z_bb0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.schres.2004.03.025","article-title":"Decreased expression of a 40-kDa catecholamine-regulated protein in the ventral striatum of schizophrenic brain specimens from the Stanley Foundation Neuropathology Consortium","volume":"74","author":"Gabriele","year":"2005","journal-title":"Schizophr Res"},{"key":"10.1007\/s12192-009-0107-z_bb0060","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/syn.20435","article-title":"Differential modulation of a 40\u00a0kDa catecholamine regulated protein in the core and shell subcompartments of the nucleus accumbens following chronic quinpirole and haloperidol administration in the rat","volume":"61","author":"Gabriele","year":"2007","journal-title":"Synapse"},{"key":"10.1007\/s12192-009-0107-z_bb0065","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1242\/jeb.01034","article-title":"Chaperones, protein aggregation, and brain protection from hypoxic\/ischemic injury","volume":"207","author":"Giffard","year":"2004","journal-title":"J Exp Biol"},{"key":"10.1007\/s12192-009-0107-z_bb0070","doi-asserted-by":"crossref","first-page":"18091","DOI":"10.1074\/jbc.M107731200","article-title":"Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors","volume":"277","author":"Hillion","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-009-0107-z_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ajmg.b.20091","article-title":"Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31\u201333","volume":"125B","author":"Hong","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1007\/s12192-009-0107-z_bb0080","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2119\/2007-00100.Irvine","article-title":"Protein aggregation in the brain: the molecular basis for Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"14","author":"Irvine","year":"2008","journal-title":"Mol Med"},{"key":"10.1007\/s12192-009-0107-z_bb0085","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molbrainres.2004.10.003","article-title":"Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson\u2019s disease","volume":"134","author":"Jin","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1007\/s12192-009-0107-z_bb0090","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1074\/mcp.M500382-MCP200","article-title":"Proteomic identification of a stress protein, mortalin\/mthsp70\/GRP75: relevance to Parkinson disease","volume":"5","author":"Jin","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"10.1007\/s12192-009-0107-z_bb0095","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/sj.neo.7900139","article-title":"An N-terminal region of mot-2 binds to p53 in vitro","volume":"3","author":"Kaul","year":"2001","journal-title":"Neoplasia"},{"key":"10.1007\/s12192-009-0107-z_bb0100","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0531-5565(02)00135-3","article-title":"Mortalin: present and prospective","volume":"37","author":"Kaul","year":"2002","journal-title":"Exp Gerontol"},{"key":"10.1007\/s12192-009-0107-z_bb0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.exger.2006.10.020","article-title":"Three faces of mortalin: a housekeeper, guardian and killer","volume":"42","author":"Kaul","year":"2007","journal-title":"Exp Gerontol"},{"key":"10.1007\/s12192-009-0107-z_bb0110","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1582-4934.2008.00273.x","article-title":"Heat shock proteins: essential proteins for apoptosis regulation","volume":"12","author":"Lanneau","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1007\/s12192-009-0107-z_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1086\/376549","article-title":"Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia","volume":"73","author":"Lewis","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1007\/s12192-009-0107-z_bb0120","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/sj.emboj.7601970","article-title":"Chaperones in control of protein disaggregation","volume":"27","author":"Liberek","year":"2008","journal-title":"EMBO J"},{"key":"10.1007\/s12192-009-0107-z_bb0125","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1128\/MCB.00296-08","article-title":"CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control","volume":"28","author":"Min","year":"2008","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s12192-009-0107-z_bb0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-2999(95)00849-7","article-title":"Modulation of brain catecholamine absorbing proteins by dopaminergic agents","volume":"299","author":"Modi","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1007\/s12192-009-0107-z_bb0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrn1587","article-title":"Modulation of neurodegeneration by molecular chaperones","volume":"6","author":"Muchowski","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-009-0107-z_bb0140","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1046\/j.1471-4159.2001.00117.x","article-title":"Molecular cloning, localization and characterization of a 40-kDa catecholamine-regulated protein","volume":"76","author":"Nair","year":"2001","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-009-0107-z_bb0145","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1046\/j.1471-4159.1996.66062390.x","article-title":"Interaction of NMDA and dopamine D2L receptors in human neuroblastoma SH-SY5Y cells","volume":"66","author":"Nair","year":"1996","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-009-0107-z_bb0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0361-9230(00)00325-7","article-title":"Roles of molecular chaperones in the nervous system","volume":"53","author":"Ohtsuka","year":"2000","journal-title":"Brain Res Bull"},{"key":"10.1007\/s12192-009-0107-z_bb0155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02782497","article-title":"Identification of novel catecholamine absorbing proteins in the central nervous system","volume":"4","author":"Ross","year":"1993","journal-title":"J Mol Neurosci"},{"key":"10.1007\/s12192-009-0107-z_bb0160","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1046\/j.1471-4159.1995.65062783.x","article-title":"Covalent affinity labeling of brain catecholamine-absorbing proteins using a high-specific-activity substituted tetrahydronaphthalene","volume":"65","author":"Ross","year":"1995","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-009-0107-z_bb0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-2999(01)00736-1","article-title":"Modulation of a 40-kDa catecholamine regulated protein by dopamine receptor antagonists","volume":"413","author":"Sharan","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1007\/s12192-009-0107-z_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/syn.10140","article-title":"Cocaine treatment increases expression of a 40\u00a0kDa catecholamine-regulated protein in discrete brain regions","volume":"47","author":"Sharan","year":"2003","journal-title":"Synapse"},{"key":"10.1007\/s12192-009-0107-z_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(01)00177-5","article-title":"Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases","volume":"29","author":"Sherman","year":"2001","journal-title":"Neuron"},{"key":"10.1007\/s12192-009-0107-z_bb0180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/nen.0b013e318163354a","article-title":"Mortalin: a protein associated with progression of Parkinson disease?","volume":"67","author":"Shi","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1007\/s12192-009-0107-z_bb0185","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.mp.4001418","article-title":"Genome-wide scan in Portuguese Island families identifies 5q31\u20135q35 as a susceptibility locus for schizophrenia and psychosis","volume":"9","author":"Sklar","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1007\/s12192-009-0107-z_bb0190","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-0186(02)00043-8","article-title":"Chaperones and aging: role in neurodegeneration and in other civilizational diseases","volume":"41","author":"Soti","year":"2002","journal-title":"Neurochem Int"},{"key":"10.1007\/s12192-009-0107-z_bb0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1379\/1466-1268(2002)007<0186:CCOA>2.0.CO;2","article-title":"Chaperones come of age","volume":"7","author":"Soti","year":"2002","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-009-0107-z_bb0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1745-6150-3-5","article-title":"Molecular chaperones and selection against mutations","volume":"3","author":"Tomala","year":"2008","journal-title":"Biol Direct"},{"key":"10.1007\/s12192-009-0107-z_bb0205","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/path.2273","article-title":"Stress proteins in CNS inflammation","volume":"214","author":"van Noort","year":"2008","journal-title":"J Pathol"},{"key":"10.1007\/s12192-009-0107-z_bb0210","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1124\/jpet.105.091256","article-title":"Modulation of agonist binding to human dopamine receptor subtypes by l-prolyl-l-leucyl-glycinamide and a peptidomimetic analog","volume":"315","author":"Verma","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1007\/s12192-009-0107-z_bb0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0921-8734(91)90015-4","article-title":"Protein markers for cellular mortality and immortality","volume":"256","author":"Wadhwa","year":"1991","journal-title":"Mutat Res"},{"key":"10.1007\/s12192-009-0107-z_bb0220","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1016\/S0021-9258(18)53295-6","article-title":"Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype","volume":"268","author":"Wadhwa","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-009-0107-z_bb0225","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/bbrc.1993.2461","article-title":"Spontaneous immortalization of mouse fibroblasts involves structural changes in senescence inducing protein, mortalin","volume":"197","author":"Wadhwa","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12192-009-0107-z_bb0230","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/excr.2002.5468","article-title":"Hsp70 family member, mot-2\/mthsp70\/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein","volume":"274","author":"Wadhwa","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1007\/s12192-009-0107-z_bb0235","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.leu.2401935","article-title":"Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31","volume":"14","author":"Xie","year":"2000","journal-title":"Leukemia"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-009-0107-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-009-0107-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523017844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523017844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-009-0107-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:00:43Z","timestamp":1761181243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523017844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1355814523017844"],"URL":"https:\/\/doi.org\/10.1007\/s12192-009-0107-z","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-009-0107-z","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}