{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:17:33Z","timestamp":1791983853569,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":3310,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s12192-014-0513-8","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T03:42:27Z","timestamp":1399261347000},"page":"887-894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes"],"prefix":"10.1016","volume":"19","author":[{"given":"Stefan","family":"Tukaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Gr\u00fcner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kasperkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-014-0513-8_bb0010","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/hep.24802","article-title":"Inhibition of heat shock protein (molecular weight 90\u00a0kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice","volume":"55","author":"Ambade","year":"2012","journal-title":"Hepatology"},{"key":"10.1007\/s12192-014-0513-8_bb0015","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1172\/JCI11494","article-title":"Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid","volume":"108","author":"Chen","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1007\/s12192-014-0513-8_bb0020","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mi.2012.134","article-title":"Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function","volume":"6","author":"Collins","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/13547500903261347","article-title":"An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors","volume":"5","author":"Dakappagari","year":"2010","journal-title":"Biomarkers"},{"key":"10.1007\/s12192-014-0513-8_bb0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12192-008-0066-9","article-title":"Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects","volume":"14","author":"de Jong","year":"2009","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-014-0513-8_bb0035","first-page":"687","article-title":"Extracellular Hsp90 serves as a co-factor for NF-\u03baB activation and cellular pathogenesis induced by an oncogenic herpes virus","volume":"1","author":"Defee","year":"2011","journal-title":"Am J Cancer Res"},{"key":"10.1007\/s12192-014-0513-8_bb0040","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1471-4159.2006.04221.x","article-title":"The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis","volume":"99","author":"Dello Russo","year":"2006","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-014-0513-8_bb0045","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2011.09.015","article-title":"Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity","volume":"35","author":"Feyerabend","year":"2011","journal-title":"Immunity"},{"key":"10.1007\/s12192-014-0513-8_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2165\/11310740-000000000-00000","article-title":"Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of current data","volume":"10","author":"G\u00fcrcan","year":"2009","journal-title":"Am J Clin Dermatol"},{"key":"10.1007\/s12192-014-0513-8_bb0055","doi-asserted-by":"crossref","first-page":"e9792","DOI":"10.1371\/journal.pone.0009792","article-title":"Identification of gp96 as a novel target for treatment of autoimmune disease in mice","volume":"5","author":"Han","year":"2010","journal-title":"PLoS One"},{"key":"10.1007\/s12192-014-0513-8_bb0060","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12192-013-0444-9","article-title":"Do reciprocal interactions between cell stress proteins and cytokines create a new intra-\/extra-cellular signalling nexus?","volume":"18","author":"Henderson","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-014-0513-8_bb0065","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"Hoffmann","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1007\/s12192-014-0513-8_bb0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0923-1811(97)00044-3","article-title":"Increased serum levels of interleukin (IL)-5, IL-6 and IL-8 in bullous pemphigoid","volume":"16","author":"Inaoki","year":"1998","journal-title":"J Dermatol Sci"},{"key":"10.1007\/s12192-014-0513-8_bb0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12016-007-0030-y","article-title":"The pathophysiology of bullous pemphigoid","volume":"33","author":"Kasperkiewicz","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0080","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1182\/blood-2010-10-314609","article-title":"Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets","volume":"117","author":"Kasperkiewicz","year":"2011","journal-title":"Blood"},{"key":"10.1007\/s12192-014-0513-8_bb0085","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2249.2008.03849.x","article-title":"5,7-Dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture","volume":"155","author":"Kim","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0090","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2741\/2853","article-title":"The role of chemokines in neutrophil biology","volume":"13","author":"Kobayashi","year":"2008","journal-title":"Front Biosci"},{"key":"10.1007\/s12192-014-0513-8_bb0095","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1158\/1078-0432.CCR-07-1104","volume":"13","author":"Lang","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1007\/s12192-014-0513-8_bb0100","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1007\/s12192-014-0513-8_bb0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4049\/jimmunol.1001753","article-title":"FcR-independent effects of IgE and IgG autoantibodies in bullous pemphigoid","volume":"187","author":"Messingham","year":"2011","journal-title":"J Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0110","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1182\/blood-2005-03-1158","article-title":"Antimyeloma activity of heat shock protein-90 inhibition","volume":"107","author":"Mitsiades","year":"2006","journal-title":"Blood"},{"key":"10.1007\/s12192-014-0513-8_bb0115","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1172\/JCI17891","article-title":"Role of different pathways of the complement cascade in experimental bullous pemphigoid","volume":"116","author":"Nelson","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1007\/s12192-014-0513-8_bb0120","doi-asserted-by":"crossref","first-page":"e49496","DOI":"10.1371\/journal.pone.0049496","article-title":"17-AAG kills intracellular Leishmania amazonensis while reducing inflammatory responses in infected macrophages","volume":"7","author":"Petersen","year":"2012","journal-title":"PLoS One"},{"key":"10.1007\/s12192-014-0513-8_bb0125","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1002\/art.24047","article-title":"Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis","volume":"58","author":"Rice","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1007\/s12192-014-0513-8_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2007.12.017","article-title":"Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90","volume":"117","author":"Salminen","year":"2008","journal-title":"Immunol Lett"},{"key":"10.1007\/s12192-014-0513-8_bb0135","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0006-291X(02)02941-8","article-title":"Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3","volume":"300","author":"Sato","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12192-014-0513-8_bb0140","doi-asserted-by":"crossref","unstructured":"Schmidt E, Zillikens D (2013) Pemphigoid diseases. Lancet 381:320\u2013332","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"10.1007\/s12192-014-0513-8_bb0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0190-9622(96)80146-0","article-title":"Elevated levels of interleukin-8 in blister fluid of bullous pemphigoid compared with suction blisters of healthy control subjects","volume":"34","author":"Schmidt","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1007\/s12192-014-0513-8_bb0150","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF02507102","article-title":"Detection of elevated levels of IL-4, IL-6, and IL-10 in blister fluid of bullous pemphigoid","volume":"288","author":"Schmidt","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.1007\/s12192-014-0513-8_bb0155","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1523-1747.2000.00141.x","article-title":"Autoantibodies to BP180 associated with bullous pemphigoid release interleukin-6 and interleukin-8 from cultured human keratinocytes","volume":"115","author":"Schmidt","year":"2000","journal-title":"J Investig Dermatol"},{"key":"10.1007\/s12192-014-0513-8_bb0160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2249.2001.01503.x","article-title":"The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsone","volume":"124","author":"Schmidt","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0165","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/cmi.2012.5","article-title":"Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL\/lpr mouse model of systemic lupus erythematosus","volume":"9","author":"Shimp","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"10.1007\/s12192-014-0513-8_bb0170","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00011-012-0442-x","article-title":"HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-\u03baB pathways","volume":"61","author":"Shimp","year":"2012","journal-title":"Inflamm Res"},{"key":"10.1007\/s12192-014-0513-8_bb0175","doi-asserted-by":"crossref","first-page":"R1152","DOI":"10.1152\/ajpregu.00376.2010","article-title":"MAPKs and NF-\u03baB differentially regulate cytokine expression in the diaphragm in response to resistive breathing: the role of oxidative stress","volume":"300","author":"Sigala","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1007\/s12192-014-0513-8_bb0180","first-page":"617213","article-title":"The immunosuppressive activity of heat shock protein 70","volume":"2012","author":"Stocki","year":"2012","journal-title":"Autoimmune Dis"},{"key":"10.1007\/s12192-014-0513-8_bb0185","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrm2918","article-title":"HSP90 at the hub of protein homeostasis: emerging mechanistic insights","volume":"11","author":"Taipale","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1007\/s12192-014-0513-8_bb0190","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2180-7-102","article-title":"Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells","volume":"7","author":"Teruya","year":"2007","journal-title":"BMC Microbiol"},{"key":"10.1007\/s12192-014-0513-8_bb0195","doi-asserted-by":"crossref","first-page":"e70496","DOI":"10.1371\/journal.pone.0070496","article-title":"Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid","volume":"8","author":"Tukaj","year":"2013","journal-title":"PLoS One"},{"key":"10.1007\/s12192-014-0513-8_bb0200","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1600-0625.2012.01529.x","article-title":"Collagen XVII (BP180) modulates keratinocyte expression of the proinflammatory chemokine, IL-8","volume":"21","author":"Van den Bergh","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1007\/s12192-014-0513-8_bb0205","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/art.10780","article-title":"Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts","volume":"48","author":"Wax","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1007\/s12192-014-0513-8_bb0210","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.bbrc.2004.05.214","article-title":"Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB","volume":"320","author":"Yeo","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12192-014-0513-8_bb0215","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4049\/jimmunol.1000222","article-title":"EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity","volume":"186","author":"Yun","year":"2011","journal-title":"J Immunol"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-014-0513-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-014-0513-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523022204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523022204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-014-0513-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:06:56Z","timestamp":1761181616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523022204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1355814523022204"],"URL":"https:\/\/doi.org\/10.1007\/s12192-014-0513-8","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-014-0513-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}