{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:40:38Z","timestamp":1778366438996,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":3068,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s12192-015-0585-0","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T16:06:15Z","timestamp":1430755575000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway"],"prefix":"10.1016","volume":"20","author":[{"given":"Shuai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-015-0585-0_bb0010","first-page":"1","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1007\/s12192-015-0585-0_bb0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/15216540601156188","article-title":"Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells","volume":"59","author":"Arai","year":"2007","journal-title":"IUBMB Life"},{"key":"10.1007\/s12192-015-0585-0_bb0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12192-015-0585-0_bb0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1515\/JBCPP.2007.18.2.115","article-title":"Glucocorticoids and oxidative stress","volume":"18","author":"Bjelakovic","year":"2007","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10.1007\/s12192-015-0585-0_bb0030","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1210\/endo-112-3-931","article-title":"Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae","volume":"112","author":"Canalis","year":"1983","journal-title":"Endocrinology"},{"key":"10.1007\/s12192-015-0585-0_bb0035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF02405312","article-title":"Effect of cortisol on periosteal and nonperiosteal collagen and DNA synthesis in cultured rat calvariae","volume":"36","author":"Canalis","year":"1984","journal-title":"Calcif Tissue Int"},{"key":"10.1007\/s12192-015-0585-0_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11914-005-0017-7","article-title":"Mechanisms of glucocorticoid action in bone","volume":"3","author":"Canalis","year":"2005","journal-title":"Curr Osteoporos Rep"},{"key":"10.1007\/s12192-015-0585-0_bb0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02702627","article-title":"Metabolism of echitamine and plumbagin in rats","volume":"3","author":"Chandrasekaran","year":"1981","journal-title":"J Biosci"},{"key":"10.1007\/s12192-015-0585-0_bb0050","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s10753-013-9768-y","article-title":"Plumbagin, a vitamin K3 analogue, abrogates lipopolysaccharide-induced oxidative stress, inflammation and endotoxic shock via NF-\u03baB suppression","volume":"37","author":"Checker","year":"2014","journal-title":"Inflammation"},{"key":"10.1007\/s12192-015-0585-0_bb0055","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1039\/b910133k","article-title":"Cytotoxicity of the traditional Chinese medicine (TCM) plumbagin in its copper chemistry","volume":"48","author":"Chen","year":"2009","journal-title":"Dalton Trans"},{"key":"10.1007\/s12192-015-0585-0_bb0060","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcb.240570314","article-title":"Cortisol down regulates osteoblast 1(I) procollagen mRNA by transcriptional and post-transcriptional mechanisms","volume":"57","author":"Delany","year":"1995","journal-title":"J Cell Biochem"},{"key":"10.1007\/s12192-015-0585-0_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11926-011-0173-y","article-title":"Advances in glucocorticoid-induced osteoporosis","volume":"13","author":"den Uyl","year":"2011","journal-title":"Curr Rheumatol Rep"},{"key":"10.1007\/s12192-015-0585-0_bb0070","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/ Runx2: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"10.1007\/s12192-015-0585-0_bb0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbi.2013.11.004","article-title":"Effect of glucocorticoid-induced oxidative stress on the expression of Cbfa1","volume":"207","author":"Feng","year":"2014","journal-title":"Chem Biol Interact"},{"key":"10.1007\/s12192-015-0585-0_bb0080","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jcb.10369","article-title":"Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways","volume":"88","author":"Franceschi","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1007\/s12192-015-0585-0_bb0085","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1210\/endo.140.11.7135","article-title":"Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro","volume":"140","author":"Gohel","year":"1999","journal-title":"Endocrinology"},{"key":"10.1007\/s12192-015-0585-0_bb0090","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"GlutathioneS-transferases the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-015-0585-0_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2006.06.024","article-title":"Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography\/tandem mass spectrometry","volume":"844","author":"Hsieh","year":"2006","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"10.1007\/s12192-015-0585-0_bb0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10565-006-0018-z","article-title":"Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines","volume":"22","author":"Lee","year":"2006","journal-title":"Cell Biol Toxicol"},{"key":"10.1007\/s12192-015-0585-0_bb0105","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2147\/DDDT.S65410","article-title":"Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway","volume":"8","author":"Lin","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"10.1007\/s12192-015-0585-0_bb0110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1359\/JBMR.0301242","article-title":"Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k","volume":"19","author":"Liu","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1007\/s12192-015-0585-0_bb0115","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1124\/jpet.110.170852","article-title":"Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-\u03baB activation","volume":"335","author":"Luo","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1007\/s12192-015-0585-0_bb0120","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tem.2006.03.009","article-title":"Glucocorticoid-induced osteoporosis: an update","volume":"17","author":"Mazziotti","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"10.1007\/s12192-015-0585-0_bb0125","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0891-5849(01)00610-4","article-title":"Oxidative stress modulates osteoblastic differentiation of vascular and bone cells","volume":"31","author":"Mody","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1007\/s12192-015-0585-0_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1007\/s12192-015-0585-0_bb0135","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2003-0990","article-title":"Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength","volume":"145","author":"O'Brien","year":"2004","journal-title":"Endocrinology"},{"key":"10.1007\/s12192-015-0585-0_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbitturic acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1007\/s12192-015-0585-0_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/odi.12310","article-title":"Plumbagin suppresses tumor cell growth in oral squamous cell carcinoma cell lines","author":"Ono","year":"2015","journal-title":"Oral Dis"},{"key":"10.1007\/s12192-015-0585-0_bb0150","first-page":"158","article-title":"Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1007\/s12192-015-0585-0_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2005.07.003","article-title":"Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells","volume":"215","author":"Park","year":"2005","journal-title":"Toxicology"},{"key":"10.1007\/s12192-015-0585-0_bb0160","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/abbi.1993.1222","article-title":"Evaluation of 2,7-dichlorofluorescein and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells","volume":"302","author":"Royall","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"10.1007\/s12192-015-0585-0_bb0165","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3390\/cancers3021605","article-title":"The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells","volume":"3","author":"Rushworth","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1007\/s12192-015-0585-0_bb0170","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3164\/jcbn.10-58","article-title":"Glucocorticoid generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats","volume":"47","author":"Sato","year":"2010","journal-title":"J Clin Biochem Nutr"},{"key":"10.1007\/s12192-015-0585-0_bb0175","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/13880200903156424","article-title":"Bioassay-guided isolation of anti-inflammatory and antinociceptive compound from Plumbago zeylanica leaf","volume":"48","author":"Sheeja","year":"2010","journal-title":"Pharm Biol"},{"key":"10.1007\/s12192-015-0585-0_bb0180","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1471-4159.2009.06552.x","article-title":"Plumbagin, a novel Nrf2\/ARE activator, protects against cerebral ischemia","volume":"112","author":"Son","year":"2010","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-015-0585-0_bb0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejim.2007.08.005","volume":"19","author":"Sosa","year":"2008","journal-title":"Eur J Intern Med"},{"key":"10.1007\/s12192-015-0585-0_bb0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3835(98)00035-4","article-title":"Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats","volume":"127","author":"Sugie","year":"1998","journal-title":"Cancer Lett"},{"issue":"3","key":"10.1007\/s12192-015-0585-0_bb0195","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin Chem"},{"key":"10.1007\/s12192-015-0585-0_bb0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fct.2013.11.027","article-title":"Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells","volume":"64","author":"Wang","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1007\/s12192-015-0585-0_bb0205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMcp1012926","article-title":"Clinical practice. Glucocorticoid-induced bone disease","volume":"365","author":"Weinstein","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1007\/s12192-015-0585-0_bb0210","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1139\/Y09-027","article-title":"Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures","volume":"87","author":"You","year":"2009","journal-title":"Can J Physiol Pharmacol"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-015-0585-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-015-0585-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523016371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523016371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-015-0585-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:06:58Z","timestamp":1761181618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523016371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1355814523016371"],"URL":"https:\/\/doi.org\/10.1007\/s12192-015-0585-0","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-015-0585-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}