{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:58:19Z","timestamp":1786982299917,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":2640,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81401041"],"award-info":[{"award-number":["No. 81401041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81302602"],"award-info":[{"award-number":["No. 81302602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31571173"],"award-info":[{"award-number":["No. 31571173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31400948"],"award-info":[{"award-number":["No. 31400948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81500454"],"award-info":[{"award-number":["No. 81500454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s12192-016-0718-0","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T08:21:19Z","timestamp":1468916479000},"page":"915-926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The involvement of homocysteine in stress-induced A\u03b2 precursor protein misprocessing and related cognitive decline in rats"],"prefix":"10.1016","volume":"21","author":[{"given":"Fang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Bo","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Jia","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-016-0718-0_bb0010","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1476-5381.2011.01602.x","article-title":"Stress-induced anhedonia is associated with an increase in Alzheimer\u2019s disease-related markers","volume":"165","author":"Briones","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1007\/s12192-016-0718-0_bb0015","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s11239-012-0856-x","article-title":"Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer\u2019s disease","volume":"36","author":"Cacciapuoti","year":"2013","journal-title":"J Thromb Thrombolysis"},{"key":"10.1007\/s12192-016-0718-0_bb0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.mp.4002101","article-title":"The amyloidogenic potential and behavioral correlates of stress","volume":"14","author":"Catania","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1007\/s12192-016-0718-0_bb0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jnc.12094","article-title":"Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine","volume":"124","author":"Chai","year":"2013","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-016-0718-0_bb0030","doi-asserted-by":"crossref","first-page":"e106625","DOI":"10.1371\/journal.pone.0106625","article-title":"Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress","volume":"9","author":"Chengfeng","year":"2014","journal-title":"PLoS One"},{"issue":"Suppl 2","key":"10.1007\/s12192-016-0718-0_bb0035","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.neurobiolaging.2014.03.040","article-title":"Critical levels of brain atrophy associated with homocysteine and cognitive decline","volume":"35","author":"de Jager","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-016-0718-0_bb0040","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav Brain Res"},{"key":"10.1007\/s12192-016-0718-0_bb0050","doi-asserted-by":"crossref","first-page":"e112683","DOI":"10.1371\/journal.pone.0112683","article-title":"Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal autophagic flux","volume":"9","author":"Gu","year":"2014","journal-title":"PLoS One"},{"key":"10.1007\/s12192-016-0718-0_bb0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1007\/s12192-016-0718-0_bb0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-2012-120022","article-title":"Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer\u2019s disease patients","volume":"31","author":"Hasegawa","year":"2012","journal-title":"J Alzheimers Disease JAD"},{"key":"10.1007\/s12192-016-0718-0_bb0065","doi-asserted-by":"crossref","first-page":"e8593","DOI":"10.1371\/journal.pone.0008593","article-title":"Treatment of Alzheimer\u2019s disease with anti-homocysteic acid antibody in 3xTg-AD male mice","volume":"5","author":"Hasegawa","year":"2010","journal-title":"PLoS One"},{"key":"10.1007\/s12192-016-0718-0_bb0070","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/brain\/awq116","article-title":"Midlife psychological stress and risk of dementia: a 35-year longitudinal population study","volume":"133","author":"Johansson","year":"2010","journal-title":"Brain J Neurol"},{"key":"10.1007\/s12192-016-0718-0_bb0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1182\/blood-2005-06-2506","article-title":"Elevated levels of homocysteine compromise blood-brain barrier integrity in mice","volume":"107","author":"Kamath","year":"2006","journal-title":"Blood"},{"key":"10.1007\/s12192-016-0718-0_bb0080","first-page":"85","article-title":"Alzheimer\u2019s disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention","volume":"13","author":"Kidd","year":"2008","journal-title":"Altern Med Rev J Clin Ther"},{"key":"10.1007\/s12192-016-0718-0_bb0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer\u2019s disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0095","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ana.24145","article-title":"Homocysteine exacerbates beta-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles","volume":"75","author":"Li","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1007\/s12192-016-0718-0_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pnpbp.2013.10.017","article-title":"Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats","volume":"49","author":"Liu","year":"2014","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1007\/s12192-016-0718-0_bb0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbapap.2008.10.001","article-title":"Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells","volume":"1794","author":"Liu","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1007\/s12192-016-0718-0_bb0110","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0115","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1515\/revneuro-2014-0035","article-title":"Chronic stress as a risk factor for Alzheimer\u2019s disease","volume":"25","author":"Machado","year":"2014","journal-title":"Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.nlm.2011.02.016","article-title":"Chronic stress, cognitive functioning and mental health","volume":"96","author":"Marin","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1007\/s12192-016-0718-0_bb0125","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2174\/156720512802455368","article-title":"Mechanisms involved in BACE upregulation associated to stress","volume":"9","author":"Martisova","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"10.1007\/s12192-016-0718-0_bb0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1749-6632.2009.05331.x","article-title":"Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease","volume":"1186","author":"McEwen","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1007\/s12192-016-0718-0_bb0135","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/an.112.002535","article-title":"The role of B vitamins in preventing and treating cognitive impairment and decline","volume":"3","author":"Morris","year":"2012","journal-title":"Adv Nutr"},{"key":"10.1007\/s12192-016-0718-0_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"key":"10.1007\/s12192-016-0718-0_bb0145","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","article-title":"Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia","volume":"580","author":"Obeid","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1007\/s12192-016-0718-0_bb0150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1007\/s12192-016-0718-0_bb0155","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ajcn\/82.3.636","article-title":"Homocysteine and folate as risk factors for dementia and Alzheimer disease","volume":"82","author":"Ravaglia","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1007\/s12192-016-0718-0_bb0160","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.neurobiolaging.2011.07.005","article-title":"3xTgAD mice exhibit altered behavior and elevated Abeta after chronic mild social stress","volume":"33","author":"Rothman","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-016-0718-0_bb0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12017-009-8107-9","article-title":"Adverse stress, hippocampal networks, and Alzheimer\u2019s disease","volume":"12","author":"Rothman","year":"2010","journal-title":"Neruomol Med"},{"key":"10.1007\/s12192-016-0718-0_bb0170","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrn1555","article-title":"Stress, cognitive impairment and cell adhesion molecules","volume":"5","author":"Sandi","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1007\/s12192-016-0718-0_bb0175","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.freeradbiomed.2011.02.035","article-title":"Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease","volume":"50","author":"Seo","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1007\/s12192-016-0718-0_bb0180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2006-9404","article-title":"Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer\u2019s disease?","volume":"9","author":"Seshadri","year":"2006","journal-title":"J Alzheimers Dis JAD"},{"key":"10.1007\/s12192-016-0718-0_bb0185","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jalz.2011.03.001","article-title":"Psychosocial stress at work is associated with increased dementia risk in late life","volume":"8","author":"Wang","year":"2012","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.1007\/s12192-016-0718-0_bb0190","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1210\/en.2011-0145","article-title":"Glucocorticoids facilitate astrocytic amyloid-beta peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-beta-degrading proteases","volume":"152","author":"Wang","year":"2011","journal-title":"Endocrinology"},{"key":"10.1007\/s12192-016-0718-0_bb0195","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ageing\/31.6.440","article-title":"Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people","volume":"31","author":"Williams","year":"2002","journal-title":"Age Ageing"},{"key":"10.1007\/s12192-016-0718-0_bb0200","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3892\/ijmm.2013.1486","article-title":"Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS","volume":"32","author":"Xie","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1007\/s12192-016-0718-0_bb0205","doi-asserted-by":"crossref","first-page":"e88427","DOI":"10.1371\/journal.pone.0088427","article-title":"A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats","volume":"9","author":"Xinxing","year":"2014","journal-title":"PLoS One"},{"key":"10.1007\/s12192-016-0718-0_bb0210","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2353\/ajpath.2009.081036","article-title":"Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain","volume":"174","author":"Zhang","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1007\/s12192-016-0718-0_bb0215","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3892\/mmr.2012.1009","article-title":"Correlations between cognitive impairment and brainderived neurotrophic factor expression in the hippocampus of post-stroke depression rats","volume":"6","author":"Zhang","year":"2012","journal-title":"Mol Med Rep"},{"key":"10.1007\/s12192-016-0718-0_bb0220","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/abbs\/gmu076","article-title":"Homocysteine-mediated intestinal epithelial barrier dysfunction in the rat model of irritable bowel syndrome caused by maternal separation","volume":"46","author":"Zhao","year":"2014","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1007\/s12192-016-0718-0_bb0225","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12192-013-0416-0","article-title":"Inhibition of cystathionine beta-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver","volume":"18","author":"Zhao","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-016-0718-0_bb0230","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exger.2009.12.005","article-title":"Acceleration of brain amyloidosis in an Alzheimer\u2019s disease mouse model by a folate, vitamin B6 and B12-deficient diet","volume":"45","author":"Zhuo","year":"2010","journal-title":"Exp Gerontol"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0718-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-016-0718-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523004911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523004911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0718-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:10:26Z","timestamp":1761181826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523004911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1355814523004911"],"URL":"https:\/\/doi.org\/10.1007\/s12192-016-0718-0","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The involvement of homocysteine in stress-induced A\u03b2 precursor protein misprocessing and related cognitive decline in rats","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-016-0718-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}