{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:17:35Z","timestamp":1778624255952,"version":"3.51.4"},"reference-count":124,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"n\/a"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s12192-016-0719-z","type":"journal-article","created":{"date-parts":[[2016,8,14]],"date-time":"2016-08-14T19:26:26Z","timestamp":1471202786000},"page":"943-958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endoplasmic reticulum stress in chondrodysplasias caused by mutations in collagen types II and X"],"prefix":"10.1016","volume":"21","author":[{"given":"Katarzyna","family":"Gawron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1007\/s12192-016-0719-z_bb0010","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1164\/rccm.201308-1458OC","article-title":"Z \u03b11-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease","volume":"189","author":"Alam","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0015","first-page":"896","article-title":"Spondyloepiphyseal dysplasia congenita: genetic linkage to type II collagen (COL2A1)","volume":"46","author":"Anderson","year":"1990","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7601974","article-title":"Protein quality control in the early secretory pathway","volume":"27","author":"Anelli","year":"2008","journal-title":"EMBO J"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0025","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ajmg.a.31527","article-title":"Vitreous phenotype: a key diagnostic sign in Stickler syndrome types 1 and 2 complicated by double heterozygosity","volume":"143A","author":"Ang","year":"2007","journal-title":"Am J Med Genet A"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ajpath.2014.09.003","article-title":"Mechanisms of aberrant organization of growth plates in conditional transgenic mouse model of spondyloepiphyseal dysplasia associated with the R992C substitution in collagen II","volume":"185","author":"Arita","year":"2015","journal-title":"Am J Pathol"},{"issue":"8","key":"10.1007\/s12192-016-0719-z_bb0035","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.biocel.2013.05.017","article-title":"Skeletal diseases caused by mutations that affect collagen structure and function","volume":"45","author":"Arnold","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcdb.2003.12.010","article-title":"Roles of molecular chaperones in protein misfolding diseases","volume":"15","author":"Barral","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"10.1007\/s12192-016-0719-z_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-385928-0.00001-8","article-title":"CFTR expression regulation by the unfolded protein response","volume":"491","author":"Bartoszewski","year":"2011","journal-title":"Methods Enzymol"},{"key":"10.1007\/s12192-016-0719-z_bb0050","doi-asserted-by":"crossref","first-page":"481840","DOI":"10.1155\/2012\/481840","article-title":"Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress?","volume":"2012","author":"Basha","year":"2012","journal-title":"Exp Diabetes Res"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrg2520","article-title":"Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations","volume":"10","author":"Bateman","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0060","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/hmg\/ddg054","article-title":"Tissue-specific RNA surveillance? Nonsense-mediated mRNA decay causes collagen X haploinsufficiency in Schmid metaphyseal chondrodysplasia cartilage","volume":"12","author":"Bateman","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0065","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/humu.20183","article-title":"Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia","volume":"25","author":"Bateman","year":"2005","journal-title":"Hum Mutat"},{"key":"10.1007\/s12192-016-0719-z_bb0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-1172-6-7","article-title":"Prenatal manifestation and management of a mother and child affected by spondyloperipheral dysplasia with a C-propeptide mutation in COL2A1: case report","volume":"6","author":"Bedeschi","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"10.1007\/s12192-016-0719-z_bb0075","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.21.122303.120200","article-title":"Intracellular signaling by the unfolded protein response","volume":"22","author":"Bernales","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/hmg\/ddn374","article-title":"Mutation and polymorphism spectrum in osteogenesis imperfecta type II: implications for genotype-phenotype relationships","volume":"18","author":"Bodian","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00441-009-0877-8","article-title":"The unfolded protein response and its relevance to connective tissue diseases","volume":"339","author":"Boot-Handford","year":"2010","journal-title":"Cell Tissue Res"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0090","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1517\/21678707.2015.1083853","article-title":"New therapeutic targets in rare genetic skeletal diseases","volume":"3","author":"Briggs","year":"2015","journal-title":"Expert Opin Orphan Drugs"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80675-3","article-title":"Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans","volume":"100","author":"Brown","year":"2000","journal-title":"Cell"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0100","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1172\/JCI1976","article-title":"A nonsense mutation in the carboxyl-terminal domain of type X collagen causes haploinsufficiency in Schmid metaphyseal chondrodysplasia","volume":"101","author":"Chan","year":"1998","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0105","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1742-4658.2006.05181.x","article-title":"Protein-misfolding diseases and chaperone-based therapeutic approaches","volume":"273","author":"Chaudhuri","year":"2006","journal-title":"FEBS J"},{"key":"10.1007\/s12192-016-0719-z_bb0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13045-015-0177-6","article-title":"High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma","volume":"8","author":"Chhabra","year":"2015","journal-title":"J Hematol Oncol"},{"issue":"14","key":"10.1007\/s12192-016-0719-z_bb0115","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/MCB.01507-09","article-title":"Molecular symbiosis of CHOP and C\/EBP beta isoform LIP contributes to endoplasmic reticulum stress-induced apoptosis","volume":"30","author":"Chiribau","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0120","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jmb.2009.05.004","article-title":"R992C (p.R1192C) substitution in collagen II alters the structure of mutant molecules and induces the unfolded protein response","volume":"390","author":"Chung","year":"2009","journal-title":"J Mol Biol"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0125","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/ajmg.a.33463","article-title":"Recurrence of achondrogenesis type 2 in sibs: additional evidence for germline mosaicism","volume":"152A","author":"Comstock","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0130","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/ajmg.a.33016","article-title":"Severe neonatal spondylometaphyseal dysplasia in two siblings","volume":"149A","author":"Czarny-Ratajczak","year":"2009","journal-title":"Am J Med Genet A"},{"issue":"11","key":"10.1007\/s12192-016-0719-z_bb0135","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1021\/pr500675e","article-title":"Muscle proteomics reveals novel insights into the pathophysiological mechanisms of collagen VI myopathies","volume":"13","author":"De Palma","year":"2014","journal-title":"J Proteome Res"},{"issue":"9","key":"10.1007\/s12192-016-0719-z_bb0140","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1359\/jbmr.2003.18.9.1612","article-title":"A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis","volume":"18","author":"Donahue","year":"2003","journal-title":"J Bone Miner Res"},{"issue":"Suppl 2","key":"10.1007\/s12192-016-0719-z_bb0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1463-1326.2010.01282.x","article-title":"Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases","volume":"12","author":"Engin","year":"2010","journal-title":"Diabetes Obes Metab"},{"issue":"Pt 1","key":"10.1007\/s12192-016-0719-z_bb0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj3390135","article-title":"Complexes containing activating transcription factor (ATF)\/cAMP-responsive element-binding protein (CREB) interact with the CCAAT\/enhancer-binding protein (C\/EBP)-ATF composite site to regulate Gadd153 expression during the stress response","volume":"339","author":"Fawcett","year":"1999","journal-title":"Biochem J"},{"issue":"51","key":"10.1007\/s12192-016-0719-z_bb0155","doi-asserted-by":"crossref","first-page":"35872","DOI":"10.1074\/jbc.M109.060384","article-title":"Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract","volume":"284","author":"Firtina","year":"2009","journal-title":"J Biol Chem"},{"issue":"23","key":"10.1007\/s12192-016-0719-z_bb0160","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/ajmg.a.32047","article-title":"A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and \u2018patchy\u2019 expression in the mosaic father","volume":"143A","author":"Forzano","year":"2007","journal-title":"Am J Med Genet A"},{"issue":"5\u20136","key":"10.1007\/s12192-016-0719-z_bb0165","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00335-011-9329-3","article-title":"ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type","volume":"22","author":"Furuichi","year":"2011","journal-title":"Mamm Genome"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0170","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbrc.2010.04.056","article-title":"Reducing the effects of intracellular accumulation of thermolabile collagen II mutants by increasing their thermostability in cell culture conditions","volume":"396","author":"Gawron","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/(SICI)1096-8628(19960503)63:1<34::AID-AJMG9>3.0.CO;2-S","article-title":"Kniest dysplasia: radiologic, histopathological, and scanning electronmicroscopic findings","volume":"63","author":"Gilbert-Barnes","year":"1996","journal-title":"Am J Med Genet"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0180","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/hmg\/ddm024","article-title":"Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis","volume":"16","author":"Gould","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0719-z_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.281","article-title":"Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma","volume":"6","author":"Ha","year":"2015","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0190","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0195","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/humu.20736","article-title":"Cells expressing partially unfolded R789C\/p.R989C type II procollagen mutant associated with spondyloepiphyseal dysplasia undergo apoptosis","volume":"29","author":"Hintze","year":"2008","journal-title":"Hum Mutat"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0200","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/hmg\/ddm067","article-title":"COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid","volume":"16","author":"Ho","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0205","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/jmg.2005.035717","article-title":"The phenotypic spectrum in patients with arginine to cysteine mutations in the COL2A1 gene","volume":"43","author":"Hoornaert","year":"2006","journal-title":"J Med Genet"},{"issue":"12","key":"10.1007\/s12192-016-0719-z_bb0210","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/sj.ejhg.5201913","article-title":"Czech dysplasia metatarsal type: another type II collagen disorder","volume":"15","author":"Hoornaert","year":"2007","journal-title":"Eur J Hum Genet"},{"issue":"8","key":"10.1007\/s12192-016-0719-z_bb0215","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ejhg.2010.23","article-title":"Stickler syndrome caused by COL2A1 mutations: genotype-phenotype correlation in a series of 100 patients","volume":"18","author":"Hoornaert","year":"2010","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0220","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2007.01.043","article-title":"Activation of the unfolded protein response in Parkinson\u2019s disease","volume":"354","author":"Hoozemans","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"7008","key":"10.1007\/s12192-016-0719-z_bb0225","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/431520a","article-title":"Cell biology: sight at the end of the tunnel","volume":"431","author":"Horwich","year":"2004","journal-title":"Nature"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0230","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/CS20080680","article-title":"Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities","volume":"118","author":"Hosoi","year":"2009","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0235","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1124\/mol.108.050070","article-title":"Endoplasmic reticulum stress induces leptin resistance","volume":"74","author":"Hosoi","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0240","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0245","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajhg.2011.11.022","article-title":"COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke","volume":"90","author":"Jeanne","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0250","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/humu.21506","article-title":"Persistence of intracellular and extracellular changes after incompletely suppressing expression of the R789C (p.R989C) and R992C (p.R1192C) collagen II mutants","volume":"32","author":"Jensen","year":"2011","journal-title":"Hum Mutat"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0255","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/MCB.24.3.1365-1377.2004","article-title":"Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response","volume":"24","author":"Jiang","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"11","key":"10.1007\/s12192-016-0719-z_bb0260","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.biochi.2013.07.030","article-title":"Small molecule modulators of eukaryotic initiation factor 2\u03b1 kinases, the key regulators of protein synthesis","volume":"95","author":"Joshi","year":"2013","journal-title":"Biochimie"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0265","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/ajmg.a.34056","article-title":"Avascular necrosis of the femoral head due to a novel C propeptide mutation in COL2A1","volume":"155A","author":"Kannu","year":"2011","journal-title":"Am J Med Genet A"},{"key":"10.1007\/s12192-016-0719-z_bb0270","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.genom.9.081307.164437","article-title":"Transcriptional control of skeletogenesis","volume":"9","author":"Karsenty","year":"2008","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1007\/s12192-016-0719-z_bb0275","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"Karsenty","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0280","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0285","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jbmr.250","article-title":"Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome","volume":"26","author":"Kelley","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"12","key":"10.1007\/s12192-016-0719-z_bb0290","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0295","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ncb1213","article-title":"OASIS, a CREB\/ATF-family member, modulates UPR signalling in astrocytes","volume":"7","author":"Kondo","year":"2005","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0300","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/(SICI)1098-1004(1997)9:4<300::AID-HUMU2>3.0.CO;2-9","article-title":"Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels","volume":"9","author":"Kuivaniemi","year":"1997","journal-title":"Hum Mutat"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0305","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/hmg\/ddt560","article-title":"Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations","volume":"23","author":"Kuo","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100505","article-title":"A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg-Calv\u00e9-Perthes disease or avascular necrosis of the femoral head","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0315","doi-asserted-by":"crossref","first-page":"e86894","DOI":"10.1371\/journal.pone.0086894","article-title":"Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"key":"10.1007\/s12192-016-0719-z_bb0320","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434","article-title":"Endoplasmic reticulum stress in disease pathogenesis","volume":"3","author":"Lin","year":"2008","journal-title":"Annu Rev Pathol"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0040007","article-title":"ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta","volume":"4","author":"Lisse","year":"2008","journal-title":"PLoS Genet"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0330","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/aps.2015.145","article-title":"Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases","volume":"37","author":"Liu","year":"2016","journal-title":"Acta Pharmacol Sin"},{"issue":"22","key":"10.1007\/s12192-016-0719-z_bb0335","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMoa042480","article-title":"Type II collagen gene variants and inherited osteonecrosis of the femoral head","volume":"352","author":"Liu","year":"2005","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0340","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/JOE-11-0048","article-title":"The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification","volume":"211","author":"Mackie","year":"2011","journal-title":"J Endocrinol"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0345","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12291-015-0502-4","article-title":"Role of endoplasmic reticulum stress and unfolded protein responses in health and diseases","volume":"31","author":"Mahdi","year":"2016","journal-title":"Indian J Clin Biochem"},{"key":"10.1007\/s12192-016-0719-z_bb0350","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1750-1172-8-140","article-title":"Unfolded protein response in Gaucher disease: from human to Drosophila","volume":"8","author":"Maor","year":"2013","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0355","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00441-009-0872-0","article-title":"Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta","volume":"339","author":"Marini","year":"2010","journal-title":"Cell Tissue Res"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0360","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/ajmg.a.33010","article-title":"Czech dysplasia occurring in a Japanese family","volume":"149A","author":"Matsui","year":"2009","journal-title":"Am J Med Genet A"},{"issue":"11","key":"10.1007\/s12192-016-0719-z_bb0365","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/jor.21161","article-title":"Early-onset metaphyseal chondrodysplasia type Schmid associated with a COL10A1 frame-shift mutation and impaired trimerization of wild-type \u03b11(X) protein chains","volume":"28","author":"M\u00e4kitie","year":"2010","journal-title":"J Orthop Res"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0370","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ajmg.a.30855","article-title":"Schmid type of metaphyseal chondrodysplasia and COL10A1 mutations-findings in 10 patients","volume":"137A","author":"M\u00e4kitie","year":"2005","journal-title":"Am J Med Genet A"},{"issue":"9","key":"10.1007\/s12192-016-0719-z_bb0375","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCRESAHA.110.227819","article-title":"Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease","volume":"107","author":"Minamino","year":"2010","journal-title":"Circ Res"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0380","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00439-007-0354-y","article-title":"A recurrent mutation in type II collagen gene causes Legg-Calv\u00e9-Perthes disease in a Japanese family","volume":"121","author":"Miyamoto","year":"2007","journal-title":"Hum Genet"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0385","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00439-005-0058-0","article-title":"A type II collagen mutation also results in oto-spondylo-megaepiphyseal dysplasia","volume":"118","author":"Miyamoto","year":"2005","journal-title":"Hum Genet"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0390","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1247\/csf.06015","article-title":"Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells","volume":"31","author":"Nadanaka","year":"2006","journal-title":"Cell Struct Funct"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0395","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/humu.20179","article-title":"The phenotypic spectrum of COL2A1 mutations","volume":"26","author":"Nishimura","year":"2005","journal-title":"Hum Mutat"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0400","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/jmg.2003.013722","article-title":"Identification of COL2A1 mutations in platyspondylic skeletal dysplasia, Torrance type","volume":"41","author":"Nishimura","year":"2004","journal-title":"J Med Genet"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0405","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1369\/jhc.2009.953893","article-title":"Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1","volume":"57","author":"Nugent","year":"2009","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0410","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/hmg\/ddu444","article-title":"Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells","volume":"24","author":"Okada","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0415","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1399-0004.2007.00947.x","article-title":"Stickler and branchio-oto-renal syndromes in a patient with mutations in EYA1 and COL2A1 genes","volume":"73","author":"Olavarrieta","year":"2008","journal-title":"Clin Genet"},{"issue":"9","key":"10.1007\/s12192-016-0719-z_bb0420","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1074\/jbc.M111.280248","article-title":"Direct in vitro and in vivo evidence for interaction between Hsp47 protein and collagen triple helix","volume":"287","author":"Ono","year":"2012","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0425","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/dvdy.24131","article-title":"Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia","volume":"243","author":"Patterson","year":"2014","journal-title":"Dev Dyn"},{"key":"10.1007\/s12192-016-0719-z_bb0430","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcell.2015.00080","article-title":"The unfolded protein response and the role of protein disulfide isomerase in neurodegeneration","volume":"3","author":"Perri","year":"2016","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0435","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1681\/ASN.2012121217","article-title":"Evidence for activation of the unfolded protein response in collagen IV nephropathies","volume":"25","author":"Pieri","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"10.1007\/s12192-016-0719-z_bb0440","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000691","article-title":"Targeted induction of endoplasmic reticulum stress induces cartilage pathology","volume":"5","author":"Rajpar","year":"2009","journal-title":"PLoS Genet"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0445","first-page":"1083","article-title":"Variation in the vitreous phenotype of Stickler syndrome can be caused by different amino acid substitutions in the X position of the type II collagen Gly-X-Y triple helix","volume":"67","author":"Richards","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"19","key":"10.1007\/s12192-016-0719-z_bb0450","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1093\/hmg\/ddq292","article-title":"Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease","volume":"19","author":"Ron","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"7","key":"10.1007\/s12192-016-0719-z_bb0455","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0460","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol"},{"issue":"12","key":"10.1007\/s12192-016-0719-z_bb0465","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","article-title":"ER stress-induced cell death mechanisms","volume":"1833","author":"Sano","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0470","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00018-007-7383-5","article-title":"Endoplasmic reticulum stress responses","volume":"65","author":"Schr\u00f6der","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1007\/s12192-016-0719-z_bb0475","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schr\u00f6der","year":"2005","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0480","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/01913120600967004","article-title":"Rough endoplasmic reticulum abnormalities in a patient with spondyloepimetaphyseal dysplasia with scoliosis, joint laxity, and finger deformities","volume":"30","author":"Shapiro","year":"2006","journal-title":"Ultrastruct Pathol"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0485","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of Golgi localization signals","volume":"3","author":"Shen","year":"2002","journal-title":"Dev Cell"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0490","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0495","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/gm13","article-title":"The Human Gene Mutation Database: 2008 update","volume":"1","author":"Stenson","year":"2009","journal-title":"Genome Med"},{"issue":"6","key":"10.1007\/s12192-016-0719-z_bb0500","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/art.23491","article-title":"Age at onset-dependent presentations of premature hip osteoarthritis, avascular necrosis of the femoral head, or Legg-Calve-Perthes disease in a single family, consequent upon a p.Gly1170Ser mutation of COL2A1","volume":"58","author":"Su","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1007\/s12192-016-0719-z_bb0505","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1749-6632.2012.06739.x","article-title":"Unfolded protein response to autophagy as a promising druggable target for anticancer therapy","volume":"1271","author":"Suh","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0510","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ajmg.a.30881","article-title":"Novel amino acid substitution in the Y-position of collagen type II causes spondyloepimetaphyseal dysplasia congenita","volume":"137A","author":"Sulko","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1007\/s12192-016-0719-z_bb0515","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1750-1172-8-154","article-title":"Deficiency for the ER-stress transducer OASIS causes severe recessive osteogenesis imperfecta in humans","volume":"8","author":"Symoens","year":"2013","journal-title":"Orphanet J Rare Dis"},{"issue":"9","key":"10.1007\/s12192-016-0719-z_bb0520","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0525","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2010.00758.x","article-title":"Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage","volume":"92","author":"Takada","year":"2011","journal-title":"Int J Exp Pathol"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0530","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050044","article-title":"Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function","volume":"5","author":"Tsang","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1007\/s12192-016-0719-z_bb0535","doi-asserted-by":"crossref","first-page":"24217","DOI":"10.1038\/srep24217","article-title":"Novel mechanism of enhancing IRE1\u03b1-XBP1 signalling via the PERK-ATF4 pathway","volume":"6","author":"Tsuru","year":"2016","journal-title":"Sci Rep"},{"issue":"14","key":"10.1007\/s12192-016-0719-z_bb0540","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/ajmg.a.32389","article-title":"Czech dysplasia: report of a large family and further delineation of the phenotype","volume":"146A","author":"Tzschach","year":"2008","journal-title":"Am J Med Genet A"},{"issue":"7092","key":"10.1007\/s12192-016-0719-z_bb0545","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature04782","article-title":"S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration","volume":"441","author":"Uehara","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0550","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/sj.cdd.4402234","article-title":"Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress","volume":"15","author":"Ullman","year":"2008","journal-title":"Cell Death Differ"},{"issue":"12","key":"10.1007\/s12192-016-0719-z_bb0555","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nrm2546","article-title":"One step at a time: endoplasmic reticulum-associated degradation","volume":"9","author":"Vembar","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"10.1007\/s12192-016-0719-z_bb0560","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ejhg.2012.20","article-title":"COL4A2 mutation associated with familial porencephaly and small-vessel disease","volume":"20","author":"Verbeek","year":"2012","journal-title":"Eur J Hum Genet"},{"issue":"13","key":"10.1007\/s12192-016-0719-z_bb0565","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2174\/092986710790936293","article-title":"Role of COL4A1 in basement-membrane integrity and cerebral small-vessel disease. The COL4A1 stroke syndrome","volume":"17","author":"Volonghi","year":"2010","journal-title":"Curr Med Chem"},{"issue":"6059","key":"10.1007\/s12192-016-0719-z_bb0570","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"issue":"5","key":"10.1007\/s12192-016-0719-z_bb0575","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/ajmg.a.33909","article-title":"Nosology and classification of genetic skeletal disorders: 2010 revision","volume":"155A","author":"Warman","year":"2011","journal-title":"Am J Med Genet A"},{"issue":"15","key":"10.1007\/s12192-016-0719-z_bb0580","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1074\/jbc.M112044200","article-title":"Collagen X chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells","volume":"277","author":"Wilson","year":"2002","journal-title":"J Biol Chem"},{"issue":"16","key":"10.1007\/s12192-016-0719-z_bb0585","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1074\/jbc.M410758200","article-title":"Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response","volume":"280","author":"Wilson","year":"2005","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0590","doi-asserted-by":"crossref","first-page":"C1076","DOI":"10.1152\/ajpcell.00426.2005","article-title":"Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants","volume":"290","author":"Yam","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"35","key":"10.1007\/s12192-016-0719-z_bb0595","doi-asserted-by":"crossref","first-page":"31156","DOI":"10.1074\/jbc.M501069200","article-title":"Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis","volume":"280","author":"Yang","year":"2005","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0600","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1742-4658.2007.05639.x","article-title":"ER stress and diseases","volume":"274","author":"Yoshida","year":"2007","journal-title":"FEBS J"},{"issue":"12","key":"10.1007\/s12192-016-0719-z_bb0605","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1089\/ars.2007.1800","article-title":"Unconventional splicing of XBP-1 mRNA in the unfolded protein response","volume":"9","author":"Yoshida","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1007\/s12192-016-0719-z_bb0610","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajmg.a.30531","article-title":"Dominant negative mutations in the C-propeptide of COL2A1 cause platyspondylic lethal skeletal dysplasia, Torrance type, and define a novel subfamily within the type 2 collagenopathies","volume":"133A","author":"Zankl","year":"2005","journal-title":"Am J Med Genet A"},{"issue":"2","key":"10.1007\/s12192-016-0719-z_bb0615","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ajmg.a.30222","article-title":"Spondyloperipheral dysplasia is caused by truncating mutations in the C-propeptide of COL2A1","volume":"129A","author":"Zankl","year":"2004","journal-title":"Am J Med Genet A"},{"issue":"4","key":"10.1007\/s12192-016-0719-z_bb0620","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/bph.12306","article-title":"Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues","volume":"170","author":"Zhang","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1007\/s12192-016-0719-z_bb0625","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0719-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-016-0719-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523004959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523004959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0719-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:09:51Z","timestamp":1761181791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523004959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":124,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1355814523004959"],"URL":"https:\/\/doi.org\/10.1007\/s12192-016-0719-z","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress in chondrodysplasias caused by mutations in collagen types II and X","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-016-0719-z","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}