{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:48:44Z","timestamp":1773344924611,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":2459,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Atomic Enegery, Government of India","award":["2010\/21\/02-BRNS\/2115"],"award-info":[{"award-number":["2010\/21\/02-BRNS\/2115"]}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["(Fellowship)"],"award-info":[{"award-number":["(Fellowship)"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s12192-016-0754-9","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T23:56:59Z","timestamp":1481673419000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock"],"prefix":"10.1016","volume":"22","author":[{"given":"Navodita","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-9177","authenticated-orcid":false,"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-016-0754-9_bb0010","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/hmg\/ddq190","article-title":"Laforin, the most common protein mutated in Lafora disease, regulates autophagy","volume":"19","author":"Aguado","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0015","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1146\/annurev-biochem-060809-095203","article-title":"Regulation of HSF1 function in the heat stress response: implications in aging and disease","volume":"80","author":"Anckar","year":"2011","journal-title":"Annu Rev Biochem"},{"key":"10.1007\/s12192-016-0754-9_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/exnr.1998.6900","article-title":"The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo","volume":"153","author":"Arias","year":"1998","journal-title":"Exp Neurol"},{"key":"10.1007\/s12192-016-0754-9_bb0025","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1128\/MCB.00909-09","article-title":"The ubiquitin ligase Hul5 promotes proteasomal processivity","volume":"30","author":"Aviram","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s12192-016-0754-9_bb0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","article-title":"p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death","volume":"171","author":"Bjorkoy","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1007\/s12192-016-0754-9_bb0035","first-page":"105","article-title":"Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors","volume":"64","author":"Cotto","year":"1999","journal-title":"Biochem Soc Symp"},{"key":"10.1007\/s12192-016-0754-9_bb0040","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/hmg\/ddr590","article-title":"Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy","volume":"21","author":"Criado","year":"2012","journal-title":"Hum Mole Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0045","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/hmg\/ddq257","article-title":"The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)","volume":"19","author":"Crippa","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajmg.1575","article-title":"Advances in the genetics of progressive myoclonus epilepsy","volume":"106","author":"Delgado-Escueta","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0055","doi-asserted-by":"crossref","first-page":"9165","DOI":"10.1074\/jbc.M112.422071","article-title":"Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7)","volume":"288","author":"Desai","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-016-0754-9_bb0060","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/15548627.2015.1009776","article-title":"Heat shock response and autophagy\u2014cooperation and control","volume":"11","author":"Dokladny","year":"2015","journal-title":"Autophagy"},{"key":"10.1007\/s12192-016-0754-9_bb0065","doi-asserted-by":"crossref","first-page":"14959","DOI":"10.1074\/jbc.M113.462408","article-title":"Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy","volume":"288","author":"Dokladny","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-016-0754-9_bb0070","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/hmg\/11.11.1251","article-title":"Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice","volume":"11","author":"Ganesh","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10038-005-0321-1","article-title":"Recent advances in the molecularbasis of Lafora\u2019s progressive myoclonus epilepsy","volume":"51","author":"Ganesh","year":"2006","journal-title":"J Hum Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0080","doi-asserted-by":"crossref","first-page":"20606","DOI":"10.1074\/jbc.M114.580167","article-title":"Protein degradation and quality control in cells from laforin and malin knockout mice","volume":"289","author":"Garyali","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-016-0754-9_bb0085","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/hmg\/ddn398","article-title":"The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system","volume":"18","author":"Garyali","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0090","doi-asserted-by":"crossref","first-page":"18649","DOI":"10.1073\/pnas.1113170108","article-title":"UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity","volume":"108","author":"Guo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1007\/s12192-016-0754-9_bb0095","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bbrc.2016.04.094","article-title":"FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy","volume":"474","author":"Jain","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1007\/s12192-016-0754-9_bb0100","first-page":"17","article-title":"Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates","volume":"33","author":"Korolchuk","year":"2009","journal-title":"Mol Cell"},{"key":"10.1007\/s12192-016-0754-9_bb0105","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s00018-008-8090-6","article-title":"Polyubiquitin chains: functions, structures, and mechanisms","volume":"65","author":"Li","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1007\/s12192-016-0754-9_bb0110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/SHK.0b013e3181e761c1","article-title":"Heat stroke induces autophagy as a protection mechanism against neurodegeneration in the brain","volume":"34","author":"Liu","year":"2010","journal-title":"Shock"},{"key":"10.1007\/s12192-016-0754-9_bb0115","doi-asserted-by":"crossref","first-page":"e0126229","DOI":"10.1371\/journal.pone.0126229","article-title":"Small heat shock protein beta-1 (HSPB1) is upregulated and regulates autophagy and apoptosis of renal tubular cells in acute kidney injury","volume":"10","author":"Matsumoto","year":"2015","journal-title":"PLoS One"},{"key":"10.1007\/s12192-016-0754-9_bb0120","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1379\/1466-1268(2003)008<0303:CALBTC>2.0.CO;2","article-title":"CHIP: a link between the chaperone and proteasome systems","volume":"8","author":"McDonough","year":"2003","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-016-0754-9_bb0125","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/hmg\/ddm006","article-title":"Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment","volume":"16","author":"Mittal","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0130","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1101\/gad.1657108","article-title":"Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging","volume":"22","author":"Morimoto","year":"2008","journal-title":"Genes Dev"},{"key":"10.1007\/s12192-016-0754-9_bb0135","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1242\/jcs.091041","article-title":"NF-kappaB regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex","volume":"125","author":"Nivon","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1007\/s12192-016-0754-9_bb0140","doi-asserted-by":"crossref","first-page":"766","DOI":"10.4161\/auto.8788","article-title":"Autophagy activation by NFkappaB is essential for cell survival after heat shock","volume":"5","author":"Nivon","year":"2009","journal-title":"Autophagy"},{"key":"10.1007\/s12192-016-0754-9_bb0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4161\/auto.5172","article-title":"Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway","volume":"4","author":"Olzmann","year":"2008","journal-title":"Autophagy"},{"key":"10.1007\/s12192-016-0754-9_bb0150","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/jnc.12080","article-title":"Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer\u2019s-like deficits in mice modeling the disease","volume":"124","author":"Pierce","year":"2013","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-016-0754-9_bb0155","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/hmg\/ddr452","article-title":"Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease","volume":"21","author":"Puri","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-016-0754-9_bb0160","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00030.2009","article-title":"Regulation of mammalian autophagy in physiology and pathophysiology","volume":"90","author":"Ravikumar","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1007\/s12192-016-0754-9_bb0165","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1242\/jcs.082800","article-title":"Malin and laforin are essential components of a protein complex that protects cells from thermal stress","volume":"124","author":"Sengupta","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1007\/s12192-016-0754-9_bb0170","doi-asserted-by":"crossref","unstructured":"Serratosa JM, Minassian BA, Ganesh S (2012) Progressive myoclonus epilepsy of Lafora. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV (eds). Jasper\u2019s basic mechanisms of the epilepsies. National Center for Biotechnology Information (US)","DOI":"10.1093\/med\/9780199746545.003.0068"},{"key":"10.1007\/s12192-016-0754-9_bb0175","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1091\/mbc.e13-05-0261","article-title":"Activation of serum\/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease","volume":"24","author":"Singh","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1007\/s12192-016-0754-9_bb0180","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/humu.20954","article-title":"Lafora progressive myoclonus epilepsy: a meta-analysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes","volume":"30","author":"Singh","year":"2009","journal-title":"Hum Mut"},{"key":"10.1007\/s12192-016-0754-9_bb0185","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s12192-015-0609-9","article-title":"Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy","volume":"20","author":"Sisti","year":"2015","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-016-0754-9_bb0190","doi-asserted-by":"crossref","first-page":"e1625","DOI":"10.1038\/cddis.2014.572","article-title":"Angelman syndrome-associated ubiquitin ligase UBE3A\/E6AP mutants interfere with the proteolytic activity of the proteasome","volume":"6","author":"Tomaic","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1007\/s12192-016-0754-9_bb0195","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/jnr.21760","article-title":"Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer\u2019s disease","volume":"86","author":"Yoon","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1007\/s12192-016-0754-9_bb0200","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s11033-009-9451-4","article-title":"Induction of macroautophagy by heat","volume":"36","author":"Zhao","year":"2009","journal-title":"Mol Biol Rep"},{"key":"10.1007\/s12192-016-0754-9_bb0205","doi-asserted-by":"crossref","first-page":"e1003196","DOI":"10.1371\/journal.pgen.1003196","article-title":"NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses","volume":"9","author":"Zhou","year":"2013","journal-title":"PLoS Genet"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0754-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-016-0754-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523001633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523001633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-016-0754-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:09:16Z","timestamp":1761181756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523001633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1355814523001633"],"URL":"https:\/\/doi.org\/10.1007\/s12192-016-0754-9","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-016-0754-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}