{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:11:13Z","timestamp":1780539073306,"version":"3.54.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":2032,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s12192-017-0852-3","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T19:46:55Z","timestamp":1508788015000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lactic acid alleviates stress: good for female genital tract homeostasis, bad for protection against malignancy"],"prefix":"10.1016","volume":"23","author":[{"given":"Steven S.","family":"Witkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-017-0852-3_bb0010","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/AEM.66.5.2001-2005.2000","article-title":"Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane","volume":"66","author":"Alakomi","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"10.1007\/s12192-017-0852-3_bb0015","doi-asserted-by":"crossref","unstructured":"Aldunate M, Tyssen D, Johnson A, Zakir T, Sonza S, Moench T, Cone R, Tachedijan G (2013) Vaginal concentrations of lactic acid potently inactivate HIV. J Antimicrob Chemother 68:2015\u20132025","DOI":"10.1093\/jac\/dkt156"},{"key":"10.1007\/s12192-017-0852-3_bb0020","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fphys.2015.00164","article-title":"Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis","volume":"6","author":"Aldunate","year":"2015","journal-title":"Front Physiol"},{"key":"10.1007\/s12192-017-0852-3_bb0025","doi-asserted-by":"crossref","unstructured":"Ayre WB (1951) The glycogen-estrogen relationship in the vaginal tract. J Clin Endocrinol Metab 11:103\u2013110","DOI":"10.1210\/jcem-11-1-103"},{"key":"10.1007\/s12192-017-0852-3_bb0030","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1080\/15384101.2015.1042634","article-title":"Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers","volume":"14","author":"Bhaskara","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1007\/s12192-017-0852-3_bb0035","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0002-9378(16)33936-9","article-title":"The effect of progesterone and progesterone-estrogen on the glycogen deposition in the vagina of the squirrel monkey","volume":"107","author":"Bo","year":"1970","journal-title":"Am J Obstet Gynecol"},{"key":"10.1007\/s12192-017-0852-3_bb0040","doi-asserted-by":"crossref","unstructured":"Boskey ER, Cone RA, Whaley KJ, Moench TR (2001) Origins of vaginal acidity: high D\/L lactate ratio is consistent with bacteria being the primary source. Hum Reprod 16:1809\u20131813","DOI":"10.1093\/humrep\/16.9.1809"},{"key":"10.1007\/s12192-017-0852-3_bb0045","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2016.08.011","article-title":"LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab"},{"key":"10.1007\/s12192-017-0852-3_bb0050","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/icb.2014.67","article-title":"Tumor cells hijack macrophages via lactic acid","volume":"92","author":"Bronte","year":"2014","journal-title":"Immunol Cell Biol"},{"key":"10.1007\/s12192-017-0852-3_bb0055","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"10.1007\/s12192-017-0852-3_bb0060","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.anndiagpath.2012.12.002","article-title":"How does hypoxia inducible factor-1\u03b1 participate in enhancing the glycolysis activity in cervical cancer?","volume":"17","author":"Cheng","year":"2013","journal-title":"Ann Diagn Pathol"},{"key":"10.1007\/s12192-017-0852-3_bb0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/path.4218","article-title":"Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?","volume":"230","author":"Choi","year":"2013","journal-title":"J Pathol"},{"key":"10.1007\/s12192-017-0852-3_bb0070","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fertnstert.2007.11.045","article-title":"Etiology of sperm immunity in women","volume":"91","author":"Clark","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1007\/s12192-017-0852-3_bb0075","doi-asserted-by":"crossref","first-page":"e1014774","DOI":"10.1080\/2162402X.2015.1014774","article-title":"Lactic acid polarizes macrophages to a tumor-promoting state","volume":"5","author":"Colegio","year":"2015","journal-title":"Oncoimmunology"},{"key":"10.1007\/s12192-017-0852-3_bb0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature13490","article-title":"Functional polarization of tumour-associated macrophages by tumour-derived lactic acid","volume":"513","author":"Colegio","year":"2014","journal-title":"Nature"},{"issue":"Suppl 6","key":"10.1007\/s12192-017-0852-3_bb0085","first-page":"19","article-title":"Inhibition of herpes simplex virus type 2 by vaginal lactobacilli","volume":"60","author":"Conti","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1007\/s12192-017-0852-3_bb0090","doi-asserted-by":"crossref","unstructured":"Dietl K, Renner K, Dettmer K, Timischi B, Eberhart K, Dorn C, Hellerbrand C et al (2010) Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol 184:1200\u20131209","DOI":"10.4049\/jimmunol.0902584"},{"key":"10.1007\/s12192-017-0852-3_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/S1064744903000024","article-title":"Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization","volume":"11","author":"Eckert","year":"2003","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.1007\/s12192-017-0852-3_bb0100","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin","year":"2006","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1007\/s12192-017-0852-3_bb0105","doi-asserted-by":"crossref","first-page":"e80657","DOI":"10.1371\/journal.pone.0080657","article-title":"Targeting of histone deacetylases to reactivate tumour suppressor genes and its therapeutic potential in a human cervical cancer xenograft model","volume":"8","author":"Feng","year":"2013","journal-title":"PLoS One"},{"key":"10.1007\/s12192-017-0852-3_bb0110","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1007\/s12192-017-0852-3_bb0115","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.intimp.2010.03.014","volume":"10","author":"Ghadimi","year":"2010","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"10.1007\/s12192-017-0852-3_bb0120","doi-asserted-by":"crossref","first-page":"e107758","DOI":"10.1371\/journal.pone.0107758","article-title":"Lactobacilli inactivate Chlamydia trachomatis through lactic acid but not H2O2","volume":"9","author":"Gong","year":"2014","journal-title":"PLoS One"},{"key":"10.1007\/s12192-017-0852-3_bb0125","doi-asserted-by":"crossref","unstructured":"Graver MA, Wade JJ (2011) The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth. Ann Clin Microbiol Antimicrob 10:8","DOI":"10.1186\/1476-0711-10-8"},{"key":"10.1007\/s12192-017-0852-3_bb0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0015-0282(16)61172-X","article-title":"Biochemical changes in the reproductive cycle","volume":"12","author":"Gross","year":"1961","journal-title":"Fertil Steril"},{"issue":"7","key":"10.1007\/s12192-017-0852-3_bb0135","doi-asserted-by":"crossref","first-page":"e1002202","DOI":"10.1371\/journal.pbio.1002202","article-title":"Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions","volume":"13","author":"Haas","year":"2015","journal-title":"PLoS Biol"},{"key":"10.1007\/s12192-017-0852-3_bb0140","doi-asserted-by":"crossref","unstructured":"Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA et al (2017) Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition. Mucosal Immunol. https:\/\/doi.org\/10.1038\/mi2017\/27","DOI":"10.1038\/mi.2017.27"},{"key":"10.1007\/s12192-017-0852-3_bb0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Hsu","year":"2008","journal-title":"Cell"},{"key":"10.1007\/s12192-017-0852-3_bb0150","doi-asserted-by":"crossref","unstructured":"Huggins GR, Preti G (1976) Volatile constituents of human vaginal secretions. Am J Obstet Gynecol 126:129\u2013136","DOI":"10.1016\/0002-9378(76)90477-4"},{"key":"10.1007\/s12192-017-0852-3_bb0155","doi-asserted-by":"crossref","unstructured":"Jang SE, Hyam SR, Han MJ, Kim SY, Lee BG, Kim DH (2013) Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-kappaB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages. J Appl Microbiol 115:888\u2013896","DOI":"10.1111\/jam.12273"},{"key":"10.1007\/s12192-017-0852-3_bb0160","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/BST20130010","article-title":"The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts","volume":"41","author":"Kelly","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"10.1007\/s12192-017-0852-3_bb0165","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1189\/jlb.69.4.522","article-title":"The effect of extracellular pH on immune function","volume":"69","author":"Lardner","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1007\/s12192-017-0852-3_bb0170","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1093\/nar\/gks066","article-title":"Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression","volume":"40","author":"Latham","year":"2012","journal-title":"Nucleic Acid Res"},{"key":"10.1007\/s12192-017-0852-3_bb0175","doi-asserted-by":"crossref","unstructured":"Leizer J, Nasioudis D, Forney LJ, Schneider GM, Gliniewicz K, Boester A, Witkin SS (2017) Properties of epithelial cells and vaginal secretions in pregnant women when Lactobacillus crispatus or Lactobacillus iners dominate the vaginal microbiome. Reprod Sci. https:\/\/doi.org\/10.1177\/1933719117698583","DOI":"10.1177\/1933719117698583"},{"issue":"4","key":"10.1007\/s12192-017-0852-3_bb0180","doi-asserted-by":"crossref","first-page":"e1004818","DOI":"10.1371\/journal.ppat.1004818","article-title":"Role of hypoxia inducible factor-1\u03b1 (HIF-1\u03b1) in innate defense against uropathogenic Escherichia coli infection","volume":"11","author":"Lin","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1007\/s12192-017-0852-3_bb0185","doi-asserted-by":"crossref","first-page":"120.e1","DOI":"10.1016\/j.ajog.2010.07.010","article-title":"Contemporary perspectives on vaginal pH and lactobacilli","volume":"204","author":"Linhares","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1007\/s12192-017-0852-3_bb0190","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1007\/s12192-017-0852-3_bb0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ydbio.2008.04.011","article-title":"Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos","volume":"319","author":"Ma","year":"2008","journal-title":"Dev Biol"},{"key":"10.1007\/s12192-017-0852-3_bb0200","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/imm.12527","article-title":"Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells","volume":"146","author":"Masson","year":"2015","journal-title":"Immunology"},{"key":"10.1007\/s12192-017-0852-3_bb0205","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2012-01-405993","article-title":"Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1\u03b1","volume":"120","author":"McInturff","year":"2012","journal-title":"Blood"},{"key":"10.1007\/s12192-017-0852-3_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1615\/CritRevOncog.2014012554","article-title":"Altered expression of histone deacetylases in cancer","volume":"20","author":"Montezuma","year":"2015","journal-title":"Crit Rev Oncog"},{"key":"10.1007\/s12192-017-0852-3_bb0215","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/1933719115581000","article-title":"\u03b1 amylase in vaginal fluid: association with conditions favorable to dominance of lactobacillus","volume":"22","author":"Nasioudis","year":"2015","journal-title":"Reprod Sci"},{"key":"10.1007\/s12192-017-0852-3_bb0220","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1471-2334-11-200","article-title":"In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide","volume":"11","author":"O\u2019Hanlon","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1007\/s12192-017-0852-3_bb0225","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ijc.28524","article-title":"Involvement of autophagy in cervical, endometrial and ovarian cancer","volume":"135","author":"Orfanelli","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1007\/s12192-017-0852-3_bb0230","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00988838","article-title":"Cyclic changes in volatile acidic metabolites of human vaginal secretions and their relation to ovulation","volume":"1","author":"Preti","year":"1975","journal-title":"J Chem Ecol"},{"key":"10.1007\/s12192-017-0852-3_bb0235","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s12192-016-0715-3","article-title":"The influence of oxidative stress and autophagy cross regulation on pregnancy outcome","volume":"21","author":"Ramos","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-017-0852-3_bb0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2049-2618-2-4","article-title":"The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women","volume":"2","author":"Romero","year":"2014","journal-title":"Microbiome"},{"key":"10.1007\/s12192-017-0852-3_bb0245","doi-asserted-by":"crossref","unstructured":"Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N (2008) Tumor-secreted lactic acid promotes IL-23\/IL-17 proinflammatory pathway. J Immunol 180:7175\u20137183","DOI":"10.4049\/jimmunol.180.11.7175"},{"key":"10.1007\/s12192-017-0852-3_bb0250","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/infdis\/jiu231","article-title":"Human \u03b1-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by lactobacillus","volume":"210","author":"Spear","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1007\/s12192-017-0852-3_bb0255","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/excr.2002.5508","article-title":"Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited","volume":"276","author":"Stern","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1007\/s12192-017-0852-3_bb0260","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ajpa.22395","article-title":"The primate vaginal microbiome: comparative context and implications for human health and disease","volume":"57","author":"Stumpf","year":"2013","journal-title":"Am J Phys Anthropol"},{"key":"10.1007\/s12192-017-0852-3_bb0265","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12964-015-0114-x","article-title":"L- and D- lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation","volume":"13","author":"Wagner","year":"2015","journal-title":"Cell Commun Signal"},{"key":"10.1007\/s12192-017-0852-3_bb0270","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03402040","article-title":"The molecular mechanism of autophagy","volume":"9","author":"Wang","year":"2003","journal-title":"Mol Med"},{"key":"10.1007\/s12192-017-0852-3_bb0275","first-page":"1029","article-title":"On the origin of cancer cells","volume":"324","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1007\/s12192-017-0852-3_bb0280","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3110","article-title":"Disregulated pH: a perfect storm for cancer progression","volume":"11","author":"Webb","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1007\/s12192-017-0852-3_bb0285","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1471-0528.13115","article-title":"The vaginal microbiome, vaginal anti-microbial defence mechanisms and the clinical challenge of reducing infection-related preterm birth","volume":"122","author":"Witkin","year":"2015","journal-title":"BJOG"},{"key":"10.1007\/s12192-017-0852-3_bb0290","doi-asserted-by":"crossref","unstructured":"Witkin SS, Ledger WJ (2012) Complexities of the uniquely human vagina. Sci Transl Med 4:132fs11","DOI":"10.1126\/scitranslmed.3003944"},{"key":"10.1007\/s12192-017-0852-3_bb0295","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/1471-0528.14390","article-title":"Why do lactobacilli dominate the human vaginal microbiota?","volume":"124","author":"Witkin","year":"2017","journal-title":"BJOG"},{"key":"10.1007\/s12192-017-0852-3_bb0300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1574-695X.2010.00757.x","article-title":"Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial liposaccharide","volume":"61","author":"Witkin","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1007\/s12192-017-0852-3_bb0305","doi-asserted-by":"crossref","unstructured":"Witkin SS, Mendes-Soares H, Linhares IM, Jayaram A, Ledger WJ, Forney LJ (2013) Influence of vaginal bacteria and D- and L- lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections. MBio 4:e00460\u2013e00413","DOI":"10.1128\/mBio.00460-13"},{"key":"10.1007\/s12192-017-0852-3_bb0310","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1007\/s13277-015-4737-8","article-title":"Neferine induces autophagy of human ovarian cancer cells via p38 MAPK\/JNK activation","volume":"37","author":"Xu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1007\/s12192-017-0852-3_bb0315","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/intimm\/dxq455","article-title":"IL-12-dependent and -independent enhancement pathways of IL-17A production by lactic acid","volume":"23","author":"Yabu","year":"2011","journal-title":"Int Immunol"},{"key":"10.1007\/s12192-017-0852-3_bb0320","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1038\/ismej.2014.90","article-title":"Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance","volume":"8","author":"Yildirim","year":"2014","journal-title":"ISME J"},{"key":"10.1007\/s12192-017-0852-3_bb0325","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1099\/mic.0.26905-0","article-title":"Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods","volume":"150","author":"Zhou","year":"2004","journal-title":"Microbiology"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-017-0852-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-017-0852-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523003000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523003000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-017-0852-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:11:36Z","timestamp":1761181896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523003000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S1355814523003000"],"URL":"https:\/\/doi.org\/10.1007\/s12192-017-0852-3","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactic acid alleviates stress: good for female genital tract homeostasis, bad for protection against malignancy","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-017-0852-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}