{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:39:38Z","timestamp":1793381978650,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["EU H2020 MSCA ITN-675448 (TRAINERS)."],"award-info":[{"award-number":["EU H2020 MSCA ITN-675448 (TRAINERS)."]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s12192-018-0897-y","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T20:56:58Z","timestamp":1525381018000},"page":"897-912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Amyotrophic lateral sclerosis (ALS) and Alzheimer\u2019s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes"],"prefix":"10.1016","volume":"23","author":[{"given":"L.","family":"Montibeller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-9577","authenticated-orcid":false,"given":"J.","family":"de Belleroche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-018-0897-y_bb0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molcel.2007.06.011","article-title":"XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks","volume":"27","author":"Acosta-Alvear","year":"2007","journal-title":"Mol Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1247\/csf.07044","article-title":"ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum","volume":"33","author":"Adachi","year":"2008","journal-title":"Cell Struct Funct"},{"key":"10.1007\/s12192-018-0897-y_bb0020","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neurobiolaging.2008.07.005","article-title":"Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord","volume":"31","author":"Anagnostou","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-018-0897-y_bb0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.febslet.2005.11.072","article-title":"Transformation-associated gene regulation by ATF6\u03b1 during hepatocarcinogenesis","volume":"580","author":"Arai","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1007\/s12192-018-0897-y_bb0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2013.01.027","article-title":"Differential molecular chaperone response associated with various mouse adapted scrapie strains","volume":"538","author":"Asuni","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1007\/s12192-018-0897-y_bb0035","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.nbd.2008.02.009","article-title":"Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis","volume":"30","author":"Atkin","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1007\/s12192-018-0897-y_bb0040","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.jmb.2015.02.011","article-title":"BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions","volume":"427","author":"Behnke","year":"2015","journal-title":"J Mol Biol"},{"key":"10.1007\/s12192-018-0897-y_bb0045","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2011.4439","article-title":"The protein disulfide isomerase family: key players in health and disease","volume":"16","author":"Benham","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1007\/s12192-018-0897-y_bb0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ncl.2015.07.001","article-title":"Familial amyotrophic lateral sclerosis","volume":"33","author":"Boylan","year":"2015","journal-title":"Neurol Clin"},{"key":"10.1007\/s12192-018-0897-y_bb0055","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/MCB.00013-15","article-title":"Cleavage of BLOC1S1 mRNA by IRE1 is sequence specific, temporally separate from XBP1 splicing, and dispensable for cell viability under acute endoplasmic reticulum stress","volume":"35","author":"Bright","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s12192-018-0897-y_bb0060","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1093\/hmg\/ddr100","article-title":"The ER stress factor XBP1s prevents amyloid- neurotoxicity","volume":"20","author":"Casas-Tinto","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1007\/s12192-018-0897-y_bb0065","doi-asserted-by":"crossref","first-page":"40266","DOI":"10.1074\/jbc.M110.161398","article-title":"Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis","volume":"285","author":"Chen","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-018-0897-y_bb0070","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/MCB.23.20.7198-7209.2003","article-title":"Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival","volume":"23","author":"Cullinan","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s12192-018-0897-y_bb0075","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ajhg.2010.03.017","article-title":"Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells","volume":"86","author":"Dombroski","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1007\/s12192-018-0897-y_bb0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"10.1007\/s12192-018-0897-y_bb0085","first-page":"247","article-title":"ER-stress in Alzheimer\u2019s disease: turning the scale?","volume":"2","author":"Endres","year":"2013","journal-title":"Am J Neurodegener Dis"},{"key":"10.1007\/s12192-018-0897-y_bb0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4161\/cbt.5.7.2967","article-title":"The PERK\/eIF2alpha\/ATF4 module of the UPR in hypoxia resistance and tumor growth","volume":"5","author":"Fels","year":"2006","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"10.1007\/s12192-018-0897-y_bb0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nn.3903","article-title":"Marinesco-Sj\u00f6gren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS","volume":"18","author":"Fil\u00e9zac de L\u2019etang","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1007\/s12192-018-0897-y_bb0100","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0105","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1007\/s12192-018-0897-y_bb0110","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1101\/gad.1830709","article-title":"XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy","volume":"23","author":"Hetz","year":"2009","journal-title":"Genes Dev"},{"key":"10.1007\/s12192-018-0897-y_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00401-005-1038-0","article-title":"The unfolded protein response is activated in Alzheimer\u2019s disease","volume":"110","author":"Hoozemans","year":"2005","journal-title":"Acta Neuropathol"},{"key":"10.1007\/s12192-018-0897-y_bb0120","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The unfolded protein response is activated in pretangle neurons in Alzheimer\u2019s disease hippocampus","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1007\/s12192-018-0897-y_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004335","article-title":"Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish","volume":"10","author":"Howarth","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1007\/s12192-018-0897-y_bb0130","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"key":"10.1007\/s12192-018-0897-y_bb0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dmm.012146","article-title":"Selective vulnerability to neurodegenerative disease: the curious case of prion protein","volume":"7","author":"Jackson","year":"2014","journal-title":"Dis Model Mech"},{"key":"10.1007\/s12192-018-0897-y_bb0140","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S1474-4422(16)00099-5","article-title":"Heat shock proteins as potential targets for protective strategies in neurodegeneration","volume":"15","author":"Kampinga","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1007\/s12192-018-0897-y_bb0145","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1016\/j.febslet.2007.10.033","article-title":"A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes","volume":"581","author":"Kaneko","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1007\/s12192-018-0897-y_bb0150","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbrc.2005.04.039","article-title":"XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress","volume":"331","author":"Kanemoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12192-018-0897-y_bb0155","doi-asserted-by":"crossref","first-page":"43446","DOI":"10.1074\/jbc.M104096200","article-title":"Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer\u2019s disease-linked presenilin-1 mutations","volume":"276","author":"Katayama","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-018-0897-y_bb0160","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2443.2003.00625.x","article-title":"MDG1\/ERdj4, an ER-resident DnaJ family member, suppresses cell death induced by ER stress","volume":"8","author":"Kurisu","year":"2003","journal-title":"Genes Cells"},{"key":"10.1007\/s12192-018-0897-y_bb0165","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3858\/emm.2010.42.5.040","article-title":"Induction of the unfolded protein response and cell death pathway in Alzheimer\u2019s disease, but not in aged Tg2576 mice","volume":"42","author":"Lee","year":"2010","journal-title":"Exp Mol Med"},{"key":"10.1007\/s12192-018-0897-y_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2012.00032","article-title":"Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer\u2019s disease and frontotemporal lobar degeneration?","volume":"4","author":"Lindberg","year":"2012","journal-title":"Front Aging Neurosci"},{"key":"10.1007\/s12192-018-0897-y_bb0175","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0022-2836(02)00234-6","article-title":"Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response","volume":"318","author":"Ma","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1007\/s12192-018-0897-y_bb0180","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2014.02.008","article-title":"Getting RIDD of RNA: IRE1 in cell fate regulation","volume":"39","author":"Maurel","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"10.1007\/s12192-018-0897-y_bb0185","doi-asserted-by":"crossref","first-page":"20378","DOI":"10.1074\/jbc.M113.457242","article-title":"Identification of a novel endoplasmic reticulum stress response element regulated by XBP1","volume":"288","author":"Misiewicz","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-018-0897-y_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neurobiolaging.2015.10.020","article-title":"Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer\u2019s disease","volume":"38","author":"M\u00f6ller","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-018-0897-y_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025545","article-title":"Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells","volume":"6","author":"Nardo","year":"2011","journal-title":"PLoS One"},{"key":"10.1007\/s12192-018-0897-y_bb0200","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1084648","article-title":"Comprehensive identification of human bZIP interactions with coiled-coil arrays","volume":"300","author":"Newman","year":"2003","journal-title":"Science"},{"key":"10.1007\/s12192-018-0897-y_bb0205","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1640108","article-title":"ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1","volume":"22","author":"Nishitoh","year":"2008","journal-title":"Genes Dev"},{"key":"10.1007\/s12192-018-0897-y_bb0210","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.neurobiolaging.2013.09.005","article-title":"Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine","volume":"35","author":"Paul","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-018-0897-y_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000415","article-title":"BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response","volume":"8","author":"Pincus","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1007\/s12192-018-0897-y_bb0220","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1460-9568.2012.08008.x","article-title":"The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis","volume":"35","author":"Prell","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1007\/s12192-018-0897-y_bb0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.devcel.2015.02.011","article-title":"BORC, a multisubunit complex that regulates lysosome positioning","volume":"33","author":"Pu","year":"2015","journal-title":"Dev Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0230","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/B978-0-12-385883-2.00002-3","article-title":"The complex molecular biology of amyotrophic lateral sclerosis (ALS)","volume":"107","author":"Redler","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1007\/s12192-018-0897-y_bb0235","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.2174\/0929867322666150818104254","article-title":"Unfolded protein response and PERK kinase as a new therapeutic target in the pathogenesis of Alzheimer\u2019s disease","volume":"22","author":"Rozpedek","year":"2015","journal-title":"Curr Med Chem"},{"key":"10.1007\/s12192-018-0897-y_bb0240","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.celrep.2013.03.024","article-title":"Stress-independent activation of XBP1s and\/or ATF6 reveals three functionally diverse ER proteostasis environments","volume":"3","author":"Shoulders","year":"2013","journal-title":"Cell Rep"},{"key":"10.1007\/s12192-018-0897-y_bb0245","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nn.4019","article-title":"Regulation of axon regeneration by the RNA repair and splicing pathway","volume":"18","author":"Song","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1007\/s12192-018-0897-y_bb0250","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1074\/jbc.M609490200","article-title":"Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis","volume":"282","author":"Sriburi","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1007\/s12192-018-0897-y_bb0255","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.celrep.2014.09.016","article-title":"Ire1 has distinct catalytic mechanisms for XBP1\/HAC1 splicing and RIDD","volume":"9","author":"Tam","year":"2014","journal-title":"Cell Rep"},{"key":"10.1007\/s12192-018-0897-y_bb0260","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0092-8674(00)80835-1","article-title":"Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation","volume":"101","author":"Travers","year":"2000","journal-title":"Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10495-016-1296-4","article-title":"The role of endoplasmic reticulum stress in neurodegenerative disease","volume":"22","author":"Xiang","year":"2017","journal-title":"Apoptosis"},{"key":"10.1007\/s12192-018-0897-y_bb0270","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jb\/mvh122","article-title":"Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II","volume":"136","author":"Yamamoto","year":"2004","journal-title":"J Biochem"},{"key":"10.1007\/s12192-018-0897-y_bb0275","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6\u03b1 and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neurobiolaging.2016.02.005","article-title":"Repression of the eIF2\u03b1 kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer\u2019s disease","volume":"41","author":"Yang","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12192-018-0897-y_bb0285","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"Ye","year":"2000","journal-title":"Mol Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0290","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1007\/s12192-018-0897-y_bb0295","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1534-5807(03)00022-4","article-title":"A time-dependent phase shift in the mammalian unfolded protein response","volume":"4","author":"Yoshida","year":"2003","journal-title":"Dev Cell"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-018-0897-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-018-0897-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523003449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523003449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-018-0897-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:15:00Z","timestamp":1761182100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523003449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1355814523003449"],"URL":"https:\/\/doi.org\/10.1007\/s12192-018-0897-y","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyotrophic lateral sclerosis (ALS) and Alzheimer\u2019s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-018-0897-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}