{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:45:59Z","timestamp":1771256759106,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T00:00:00Z","timestamp":1573862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12192-019-01048-1","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T12:01:32Z","timestamp":1573905692000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme"],"prefix":"10.1016","volume":"25","author":[{"given":"Rebecca V","family":"Vince","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myint M","family":"Aye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh A","family":"Madden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-019-01048-1_bb0010","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1007\/s12192-019-01048-1_bb0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1379\/1466-1268(1998)003<0168:FCIARA>2.3.CO;2","article-title":"Flow cytometry is a rapid and reliable method for evaluating heat shock protein 70 expression in human monocytes","volume":"3","author":"Bachelet","year":"1998","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-019-01048-1_bb0020","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1007\/s12192-019-01048-1_bb0025","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.2337\/diabetes.52.9.2338","article-title":"Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes - Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism","volume":"52","author":"Bruce","year":"2003","journal-title":"Diabetes"},{"key":"10.1007\/s12192-019-01048-1_bb0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0092-8674(00)80928-9","article-title":"The Hsp70 and Hsp60 chaperone machines","volume":"92","author":"Bukau","year":"1998","journal-title":"Cell"},{"key":"10.1007\/s12192-019-01048-1_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Chang","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1007\/s12192-019-01048-1_bb0040","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1073\/pnas.0705799105","article-title":"HSP72 protects against obesity-induced insulin resistance","volume":"105","author":"Chung","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1007\/s12192-019-01048-1_bb0045","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.fertnstert.2004.11.070","article-title":"Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment","volume":"83","author":"DeUgarte","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1007\/s12192-019-01048-1_bb0050","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Medical progress: polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1007\/s12192-019-01048-1_bb0055","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1055\/s-2004-830334","article-title":"Exercise intensity and duration affect blood soluble HSP72","volume":"26","author":"Fehrenbach","year":"2005","journal-title":"Int J Sports Med"},{"key":"10.1007\/s12192-019-01048-1_bb0060","first-page":"6","article-title":"Can exercise stress facilitate innate immunity? A functional role for stress-induced extracellular Hsp72","volume":"9","author":"Fleshner","year":"2003","journal-title":"Exerc Immunol Rev"},{"key":"10.1007\/s12192-019-01048-1_bb0065","first-page":"109","article-title":"A new approach to monitoring exercise training","volume":"15","author":"Foster","year":"2001","journal-title":"J Strength Cond Res"},{"issue":"6","key":"10.1007\/s12192-019-01048-1_bb0070","doi-asserted-by":"crossref","first-page":"e67727","DOI":"10.1371\/journal.pone.0067727","article-title":"Serum Heat Shock Protein 70 Concentration in Relation to Polycystic Ovary Syndrome in a Non-Obese Chinese Population","volume":"8","author":"Gao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1007\/s12192-019-01048-1_bb0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/humupd\/dmq045","article-title":"Exercise therapy in polycystic ovary syndrome: a systematic review","volume":"17","author":"Harrison","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1007\/s12192-019-01048-1_bb0080","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/met.2007.0005","article-title":"Insulin signaling, GSK-3, heat shock proteins and the natural history of type 2 diabetes mellitus: a hypothesis","volume":"5","author":"Hooper","year":"2007","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1007\/s12192-019-01048-1_bb0085","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.addr.2009.02.003","article-title":"Induction of heat shock proteins for protection against oxidative stress","volume":"61","author":"Kalmar","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1007\/s12192-019-01048-1_bb0090","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1152\/japplphysiol.01267.2001","article-title":"Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance","volume":"92","author":"Kregel","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1007\/s12192-019-01048-1_bb0095","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2337\/diabetes.51.4.1102","article-title":"Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance","volume":"51","author":"Kurucz","year":"2002","journal-title":"Diabetes"},{"key":"10.1007\/s12192-019-01048-1_bb0100","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1007\/s12192-019-01048-1_bb0105","doi-asserted-by":"crossref","first-page":"e0152837","DOI":"10.1371\/journal.pone.0152837","article-title":"The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome","volume":"11","author":"Li","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1007\/s12192-019-01048-1_bb0110","first-page":"D12","article-title":"Changes in skeletal muscle heat shock proteins: Pathological significance","volume":"6","author":"Liu","year":"2001","journal-title":"Front Biosci"},{"key":"10.1007\/s12192-019-01048-1_bb0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00726-006-0400-4","article-title":"The time-profile of the PBMC HSP70 response to in vitro heat shock appears temperature-dependent","volume":"33","author":"Lovell","year":"2007","journal-title":"Amino Acids"},{"key":"10.1007\/s12192-019-01048-1_bb0120","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00726-007-0004-7","article-title":"Inducible heat shock protein 70 and its role in preconditioning and exercise","volume":"34","author":"Madden","year":"2008","journal-title":"Amino Acids"},{"key":"10.1007\/s12192-019-01048-1_bb0125","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1007\/s12192-019-01048-1_bb0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-2840-10-42","article-title":"The interleukin-6 and noradrenaline mediated inflammation-stress feedback mechanism is dysregulated in metabolic syndrome: Effect of exercise","volume":"10","author":"Mart\u00edn-Cordero","year":"2011","journal-title":"Cardiovascular Diabetology"},{"key":"10.1007\/s12192-019-01048-1_bb0135","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.mehy.2004.08.033","article-title":"Induction of heat shock proteins may combat insulin resistance","volume":"66","author":"McCarty","year":"2006","journal-title":"Med Hypotheses"},{"key":"10.1007\/s12192-019-01048-1_bb0140","first-page":"R185","article-title":"Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells","volume":"294","author":"McClung","year":"2008","journal-title":"Am J Phys Regul Integr Comp Phys"},{"key":"10.1007\/s12192-019-01048-1_bb0145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1139\/H08-146","article-title":"Evaluation of true maximal oxygen uptake based on a novel set of standardized criteria","volume":"34","author":"Midgley","year":"2009","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1007\/s12192-019-01048-1_bb0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/humupd\/dmp008","article-title":"Metabolic features of the reproductive phenotypes of polycystic ovary syndrome","volume":"15","author":"Moran","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1007\/s12192-019-01048-1_bb0155","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1128\/MCB.17.9.5317","article-title":"Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis","volume":"17","author":"Mosser","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1007\/s12192-019-01048-1_bb0160","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/humrep\/deq254","article-title":"Six weeks of structured exercise training and hypocaloric diet increases the probability of ovulation after clomiphene citrate in overweight and obese patients with polycystic ovary syndrome: a randomized controlled trial","volume":"25","author":"Palomba","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1007\/s12192-019-01048-1_bb0165","first-page":"907","article-title":"Hypoxia induces HSP 70 gene expression in human hepatoma (HEP G2) cells","volume":"36","author":"Patel","year":"1995","journal-title":"Biochem Mol Biol Int"},{"key":"10.1007\/s12192-019-01048-1_bb0170","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jsams.2011.03.006","article-title":"Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise","volume":"14","author":"Peart","year":"2011","journal-title":"J Sci Med Sport"},{"key":"10.1007\/s12192-019-01048-1_bb0175","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/aogs.12064","article-title":"Effects of exercise and group counselling on body composition and VO2max in overweight women with polycystic ovary syndrome","volume":"92","author":"Roessler","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1007\/s12192-019-01048-1_bb0180","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12192-008-0022-8","article-title":"The effect of 15 consecutive days of heat-exercise acclimation on heat shock protein 70","volume":"13","author":"Sandstrom","year":"2008","journal-title":"Cell Stress Chaperones"},{"key":"10.1007\/s12192-019-01048-1_bb0185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00726-008-0144-4","article-title":"Variation in basal heat shock protein 70 is correlated to core temperature in human subjects","volume":"37","author":"Sandstrom","year":"2009","journal-title":"Amino Acids"},{"key":"10.1007\/s12192-019-01048-1_bb0190","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/EJE-11-0755","article-title":"Recent advances in cardiovascular aspects of polycystic ovary syndrome","volume":"166","author":"Sathyapalan","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1007\/s12192-019-01048-1_bb0195","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/sj.bjp.0706396","article-title":"Heat shock proteins as emerging therapeutic targets","volume":"146","author":"Soti","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1007\/s12192-019-01048-1_bb0200","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00421-010-1430-x","article-title":"The effect of acute hypoxia on heat shock protein 72 expression and oxidative stress in vivo","volume":"109","author":"Taylor","year":"2010","journal-title":"Eur J Appl Physiol"},{"key":"10.1007\/s12192-019-01048-1_bb0205","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/humrep\/des138","article-title":"The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome","volume":"27","author":"Thomson","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1007\/s12192-019-01048-1_bb0210","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/humupd\/dmr025","article-title":"Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome","volume":"17","author":"Toulis","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1007\/s12192-019-01048-1_bb0215","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00726-009-0354-4","article-title":"In vitro heat shock of human monocytes results in a proportional increase of inducible Hsp70 expression according to the basal content","volume":"38","author":"Vince","year":"2010","journal-title":"Amino Acids"},{"key":"10.1007\/s12192-019-01048-1_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-019-0548-7","article-title":"Abnormal expression of HSP70 may contribute to PCOS pathology","volume":"12","author":"Wu","year":"2019","journal-title":"J Ovarian Res"},{"key":"10.1007\/s12192-019-01048-1_bb0225","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1161\/01.ATV.0000029720.59649.50","article-title":"Role of heat shock proteins in atherosclerosis","volume":"22","author":"Xu","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-019-01048-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12192-019-01048-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523011641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523011641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-019-01048-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:14:43Z","timestamp":1761182083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523011641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1355814523011641"],"URL":"https:\/\/doi.org\/10.1007\/s12192-019-01048-1","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-019-01048-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}