{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:26:14Z","timestamp":1784647574679,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":691,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s12192-021-01248-8","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T16:34:01Z","timestamp":1638981241000},"page":"55-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NF\u03baB\/iNOS, and HIF-1\u03b1 signaling pathways"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-7944","authenticated-orcid":false,"given":"Fatma F.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa Hassanein","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa M.","family":"Elroby Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-021-01248-8_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116840","article-title":"Underlying mechanisms behind the protective effect of angiotensin (1\u20137) in experimental rat model of ovarian ischemia reperfusion injury","volume":"235","author":"Ali","year":"2019","journal-title":"Life Sci"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12192-019-01055-2","article-title":"Hydrogen sulfide renal protective effects: possible link between hydrogen sulfide and endogenous carbon monoxide in a rat model of renal injury","volume":"25","author":"Aziz","year":"2020","journal-title":"Cell Stress Chaperones"},{"issue":"4","key":"10.1007\/s12192-021-01248-8_bb0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1165\/rcmb.2017-0114TR","article-title":"Hydrogen sulfide: a novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses","volume":"57","author":"Bazhanov","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1007\/s12192-021-01248-8_bb0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fcell.2018.00132","article-title":"Reactive oxygen species formation in the brain at different oxygen levels: the role of hypoxia inducible factors","volume":"6","author":"Chen","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"10.1007\/s12192-021-01248-8_bb0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2015.01.010","article-title":"Alterations in the Nrf2-Keap1 signaling pathway and its downstream target genes in rat brain under stress","volume":"1602","author":"Djordjevic","year":"2015","journal-title":"Brain Res"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4149\/gpb_2017029","article-title":"Novel neuroprotective role of hydrogen sulfide in a rat model of stress brain injury","volume":"37","author":"Elbassuoni","year":"2018","journal-title":"Gen Physiol Biophys"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0040","first-page":"16","article-title":"Neuroprotective effects of melatonin administration against chronic immobilization stress in rats","volume":"9","author":"Gomaa","year":"2017","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"10.1007\/s12192-021-01248-8_bb0045","doi-asserted-by":"crossref","first-page":"2518676","DOI":"10.1155\/2018\/2518676","article-title":"C(60) Fullerene prevents restraint stress-induced oxidative disorders in rat tissues: possible involvement of the Nrf2\/ARE-antioxidant pathway","volume":"2018","author":"Gonchar","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1007\/s12192-021-01248-8_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105979","article-title":"Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2\/HIF-1\u03b1\/MAPK signaling pathway","volume":"81","author":"Guan","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1007\/s12192-021-01248-8_bb0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fphar.2018.00263","article-title":"Sodium tanshinone IIA sulfonate decreases cigarette smoke-induced inflammation and oxidative stress via blocking the activation of MAPK\/HIF-1\u03b1 signaling pathway","volume":"9","author":"Guan","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1007\/s12192-021-01248-8_bb0060","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1038\/s41598-017-09943-2","article-title":"Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-\u03baB\/iNOS and Nrf2\/ HO-1 signaling pathway","volume":"7","author":"Guo","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1007\/s12192-021-01248-8_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.951","article-title":"Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis","volume":"9","author":"Han","year":"2020","journal-title":"MicrobiologyOpen"},{"issue":"1","key":"10.1007\/s12192-021-01248-8_bb0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3892\/etm.2015.2482","article-title":"Protective effects of hydrogen sulfide inhalation on oxidative stress in rats with cotton smoke inhalation-induced lung injury","volume":"10","author":"Han","year":"2015","journal-title":"Exp Ther Med"},{"key":"10.1007\/s12192-021-01248-8_bb0075","unstructured":"Health NIo (1985) Guide for the care and use of laboratory animals. National Academies,"},{"issue":"6","key":"10.1007\/s12192-021-01248-8_bb0080","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1007\/s12192-021-01248-8_bb0085","first-page":"7864","article-title":"Hydrogen sulfide protects lungs of rats with sepsis possibly by influencing thrombomodulin signaling pathways","volume":"11","author":"Lei","year":"2018","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"10.1007\/s12192-021-01248-8_bb0090","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00421-012-2584-5","article-title":"Treatment with exogenous hydrogen sulfide attenuates hyperoxia-induced acute lung injury in mice","volume":"113","author":"Li","year":"2013","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"10.1007\/s12192-021-01248-8_bb0095","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3892\/ijmm.2016.2701","article-title":"Neuroprotective effects of sodium hydrosulfide against \u03b2-amyloid-induced neurotoxicity","volume":"38","author":"Li","year":"2016","journal-title":"Int J Mol Med"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/2045-9912.184718","article-title":"Nitric oxide and hyperoxic acute lung injury","volume":"6","author":"Liu","year":"2016","journal-title":"Med Gas Res"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1440-1681.2007.04812.x","article-title":"Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats","volume":"35","author":"Lou","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"11","key":"10.1007\/s12192-021-01248-8_bb0110","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1007\/s10620-016-4280-5","article-title":"Hydrogen sulfide and carbon monoxide protect gastric mucosa compromised by mild stress against alendronate injury","volume":"61","author":"Magierowski","year":"2016","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1007\/s12192-021-01248-8_bb0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1471-4159.2010.06606.x","article-title":"Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis","volume":"113","author":"Mancuso","year":"2010","journal-title":"J Neurochem"},{"key":"10.1007\/s12192-021-01248-8_bb0120","doi-asserted-by":"crossref","first-page":"6501046","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and clinical significance of biomarkers of oxidative stress in humans","volume":"2017","author":"Marrocco","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1007\/s12192-021-01248-8_bb0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/jcp.15.4.374","article-title":"A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma","volume":"15","author":"Mattingly","year":"1962","journal-title":"J Clin Pathol"},{"key":"10.1007\/s12192-021-01248-8_bb0130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.intimp.2019.05.041","article-title":"Hydrogen sulfide inhibits apoptosis and protects the bronchial epithelium in an allergic inflammation mice model","volume":"73","author":"Mendes","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1007\/s12192-021-01248-8_bb0135","first-page":"117","article-title":"Modulation of hydrogen sulfide by vascular hypoxia","volume":"2","author":"Osmond","year":"2014","journal-title":"Hypoxia (auckland, NZ)"},{"issue":"4","key":"10.1007\/s12192-021-01248-8_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1586","article-title":"Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress","volume":"10","author":"Palumbo","year":"2020","journal-title":"Brain and Behavior"},{"key":"10.1007\/s12192-021-01248-8_bb0145","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fphys.2017.00128","article-title":"Mouse lung fibroblast resistance to fas-mediated apoptosis is dependent on the baculoviral inhibitor of apoptosis protein 4 and the cellular FLICE-inhibitory protein","volume":"8","author":"Predescu","year":"2017","journal-title":"Front Physiol"},{"issue":"6","key":"10.1007\/s12192-021-01248-8_bb0150","doi-asserted-by":"crossref","first-page":"9168","DOI":"10.1002\/jcp.27594","article-title":"Physiological and structural changes of the lung tissue in male albino rat exposed to immobilization stress","volume":"234","author":"Saber","year":"2019","journal-title":"J Cell Physiol"},{"issue":"7","key":"10.1007\/s12192-021-01248-8_bb0155","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/medicina56070350","article-title":"Behavioral and biochemical effects of Mukia madrespatana following single immobilization stress on rats","volume":"56","author":"Samad","year":"2020","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"10.1007\/s12192-021-01248-8_bb0160","doi-asserted-by":"crossref","first-page":"2645237","DOI":"10.1155\/2016\/2645237","article-title":"Protective effects of carvacrol against oxidative stress induced by chronic stress in rat's brain, liver, and kidney","volume":"2016","author":"Samarghandian","year":"2016","journal-title":"Biochem Res Int"},{"issue":"7","key":"10.1007\/s12192-021-01248-8_bb0165","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1007\/s12192-021-01248-8_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.017","article-title":"NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches","volume":"21","author":"Sivandzade","year":"2019","journal-title":"Redox Biol"},{"issue":"9","key":"10.1007\/s12192-021-01248-8_bb0175","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0046-8177(86)80646-3","article-title":"Pathologic features of long-standing \u201chealed\u201d bronchopulmonary dysplasia: a study of 28 3-to 40-month-old infants","volume":"17","author":"Stocker","year":"1986","journal-title":"Hum Pathol"},{"issue":"10","key":"10.1007\/s12192-021-01248-8_bb0180","doi-asserted-by":"crossref","first-page":"E1239","DOI":"10.1152\/ajpendo.00554.2011","article-title":"Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells","volume":"302","author":"Stojkov","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1007\/s12192-021-01248-8_bb0185","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3748\/wjg.v23.i1.87","article-title":"Hydrogen sulfide attenuates gastric mucosal injury induced by restraint water-immersion stress via activation of K(ATP) channel and NF-\u03baB dependent pathway","volume":"23","author":"Sun","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1007\/s12192-021-01248-8_bb0190","unstructured":"Suvarna KS, Layton C, Bancroft JD (2018) Bancroft's theory and practice of histological techniques E-Book. Elsevier Health Sciences,"},{"key":"10.1007\/s12192-021-01248-8_bb0195","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cbi.2014.10.002","article-title":"Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity","volume":"222","author":"Tan","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"Pt B","key":"10.1007\/s12192-021-01248-8_bb0200","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.nlm.2017.05.005","article-title":"Inactivation of basolateral amygdala prevents chronic immobilization stress-induced memory impairment and associated changes in corticosterone levels","volume":"142","author":"Tripathi","year":"2017","journal-title":"Neurobiol Learn Mem"},{"key":"10.1007\/s12192-021-01248-8_bb0205","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.12659\/MSM.915743","article-title":"The protective effects of protease inhibitor MG-132 on sepsis-induced acute lung rats and its possible mechanisms","volume":"25","author":"Wu","year":"2019","journal-title":"Med Sci Monit"},{"issue":"12","key":"10.1007\/s12192-021-01248-8_bb0210","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/aps.2013.96","article-title":"Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats","volume":"34","author":"Xu","year":"2013","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1007\/s12192-021-01248-8_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2249.2010.04156.x","article-title":"The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues","volume":"161","author":"Yildirim","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1007\/s12192-021-01248-8_bb0220","first-page":"1375","article-title":"Chronic restraint stress induces esophageal fibrosis with enhanced oxidative stress in a murine model","volume":"18","author":"Yisireyili","year":"2019","journal-title":"Exp Ther Med"},{"issue":"10","key":"10.1007\/s12192-021-01248-8_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110688","article-title":"Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis","volume":"9","author":"Zayachkivska","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1007\/s12192-021-01248-8_bb0230","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000453210","article-title":"H2S attenuates LPS-induced acute lung injury by reducing oxidative\/nitrative stress and inflammation","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1007\/s12192-021-01248-8_bb0235","doi-asserted-by":"crossref","first-page":"593407","DOI":"10.1155\/2015\/593407","article-title":"Hydrogen sulfide as a potential therapeutic target in fibrosis","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1007\/s12192-021-01248-8_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196897","article-title":"Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-\u03baB pathway","volume":"13","author":"Zhang","year":"2018","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1007\/s12192-021-01248-8_bb0245","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/jcmm.12254","article-title":"Inhibitory effects of hydrogen sulphide on pulmonary fibrosis in smoking rats via attenuation of oxidative stress and inflammation","volume":"18","author":"Zhou","year":"2014","journal-title":"J Cell Mol Med"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-021-01248-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12192-021-01248-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523000937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523000937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-021-01248-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:17:43Z","timestamp":1761182263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523000937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1355814523000937"],"URL":"https:\/\/doi.org\/10.1007\/s12192-021-01248-8","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NF\u03baB\/iNOS, and HIF-1\u03b1 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-021-01248-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}