{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:25:51Z","timestamp":1792808751015,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s12192-023-01323-2","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:02:31Z","timestamp":1674622951000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of endoplasmic reticulum stress in endometriosis"],"prefix":"10.1016","volume":"28","author":[{"given":"Hussein Riyadh Abdul Kareem","family":"Al-Hetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Darweesh","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir F.","family":"Eremin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer Mohsen","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-2296","authenticated-orcid":false,"given":"Abduladheem Turki","family":"Jalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Al-Dulimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasanain A.J.","family":"Gharban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usman Faryad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan Mahmood","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12192-023-01323-2_bb0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fmolb.2019.00011","article-title":"Structure and molecular mechanism of ER stress signaling by the unfolded protein response signal activator IRE1","volume":"6","author":"Adams","year":"2019","journal-title":"Front Mol Biosci"},{"issue":"354","key":"10.1007\/s12192-023-01323-2_bb0015","first-page":"e1","article-title":"Clinical diagnosis of endometriosis: a call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1007\/s12192-023-01323-2_bb0020","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.2174\/0929867323666160425113705","article-title":"An update on phytochemicals in molecular target therapy of cancer: potential inhibitory effect on telomerase activity","volume":"23","author":"Alibakhshi","year":"2016","journal-title":"Curr Med Chem"},{"key":"10.1007\/s12192-023-01323-2_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/PAP.0000000000000288","article-title":"Endometriosis: a comprehensive review","volume":"28","author":"Arafah","year":"2021","journal-title":"Adv Anat Pathol"},{"key":"10.1007\/s12192-023-01323-2_bb0030","first-page":"11","article-title":"Endometriosis and ovarian cancer: an integrative review (endometriosis and ovarian cancer)","volume":"18","author":"Brilhante","year":"2017","journal-title":"Asian Pac J Cancer Prev: APJCP"},{"key":"10.1007\/s12192-023-01323-2_bb0035","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1210\/en.2006-1692","article-title":"Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis","volume":"148","author":"Burney","year":"2007","journal-title":"Endocrinology"},{"key":"10.1007\/s12192-023-01323-2_bb0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/molehr\/gat091","article-title":"Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts","volume":"20","author":"Choi","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"10.1007\/s12192-023-01323-2_bb0045","first-page":"101","article-title":"Involvement of endoplasmic reticulum stress in regulation of endometrial stromal cell invasiveness: possible role in pathogenesis of endometriosis","volume":"25","author":"Choi","year":"2019","journal-title":"MHR: Basic Sci Reprod Med"},{"key":"10.1007\/s12192-023-01323-2_bb0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/molehr\/gaz064","article-title":"Dienogest regulates apoptosis, proliferation, and invasiveness of endometriotic cyst stromal cells via endoplasmic reticulum stress induction","volume":"26","author":"Choi","year":"2020","journal-title":"Mol Hum Reprod"},{"key":"10.1007\/s12192-023-01323-2_bb0055","doi-asserted-by":"crossref","first-page":"gaab002","DOI":"10.1093\/molehr\/gaab002","article-title":"Nuclear factor-kappa B signaling in endometriotic stromal cells is not inhibited by progesterone owing to an aberrant endoplasmic reticulum stress response: a possible role for an altered inflammatory process in endometriosis","volume":"27","author":"Choi","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"10.1007\/s12192-023-01323-2_bb0060","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/ptr.5908","article-title":"Emerging importance of phytochemicals in regulation of stem cells fate via signaling pathways","volume":"31","author":"Dadashpour","year":"2017","journal-title":"Phytother Res"},{"key":"10.1007\/s12192-023-01323-2_bb0065","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.fertnstert.2012.06.021","article-title":"Nuclear factor\u2013kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology","volume":"98","author":"Gonz\u00e1lez-Ramos","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1007\/s12192-023-01323-2_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1095\/biolreprod.110.089532","article-title":"Bidirectional interaction between unfolded-protein-response key protein HSPA5 and estrogen signaling in human endometrium","volume":"85","author":"Guzel","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1007\/s12192-023-01323-2_bb0075","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1002\/jcp.27212","article-title":"Silibinin-induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesions","volume":"234","author":"Ham","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1007\/s12192-023-01323-2_bb0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1007\/s12192-023-01323-2_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol Cell"},{"key":"10.1007\/s12192-023-01323-2_bb0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1007\/s12192-023-01323-2_bb0095","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection","volume":"9","author":"Hu","year":"2019","journal-title":"Front Immunol"},{"key":"10.1007\/s12192-023-01323-2_bb0100","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/332462a0","article-title":"The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins","volume":"332","author":"Kozutsumi","year":"1988","journal-title":"Nature"},{"key":"10.1007\/s12192-023-01323-2_bb0105","article-title":"Efficacy of anti-VEGF\/VEGFR agents on animal models of endometriosis: a systematic review and meta-analysis","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1007\/s12192-023-01323-2_bb0110","article-title":"Dienogest as a maintenance treatment for endometriosis following surgery: a systematic review and meta-analysis","volume":"8","author":"Liu","year":"2021","journal-title":"Front Med"},{"key":"10.1007\/s12192-023-01323-2_bb0115","first-page":"582","article-title":"Oxidative stress statues in serum and follicular fluid of women with endometriosis","volume":"18","author":"Nasiri","year":"2016","journal-title":"Cell J (yakhteh)"},{"key":"10.1007\/s12192-023-01323-2_bb0120","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s43032-020-00164-z","article-title":"Endometriosis: the role of iron overload and ferroptosis","volume":"27","author":"Ng","year":"2020","journal-title":"Reprod Sci"},{"issue":"8","key":"10.1007\/s12192-023-01323-2_bb0125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41580-022-00504-8","article-title":"End of the road: from the ER to the proteasome","volume":"23","author":"Olzmann","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1007\/s12192-023-01323-2_bb0130","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000076691","article-title":"Indices of oxidative stress in eutopic and ectopic endometria of women with endometriosis","volume":"57","author":"\u00d6ner-\u0130yido\u011fan","year":"2004","journal-title":"Gynecol Obstet Invest"},{"key":"10.1007\/s12192-023-01323-2_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13669-017-0187-1","article-title":"Endometriosis: epidemiology, diagnosis and clinical management","volume":"6","author":"Parasar","year":"2017","journal-title":"Curr Obstet Gynecol Rep"},{"key":"10.1007\/s12192-023-01323-2_bb0140","first-page":"842","article-title":"Naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating MAPK and AKT signal transduction pathways in endometriosis cells","volume":"23","author":"Park","year":"2017","journal-title":"MHR: Basic Sci Reprod Med"},{"key":"10.1007\/s12192-023-01323-2_bb0145","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/jcp.26054","article-title":"Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells","volume":"233","author":"Park","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1007\/s12192-023-01323-2_bb0150","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/ptr.6677","article-title":"5, 7-Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway","volume":"34","author":"Park","year":"2020","journal-title":"Phytother Res"},{"key":"10.1007\/s12192-023-01323-2_bb0155","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2147\/IJWH.S66824","article-title":"Endometriosis and ovarian cancer: links, risks, and challenges faced","volume":"7","author":"Pavone","year":"2015","journal-title":"Int J Women's Health"},{"key":"10.1007\/s12192-023-01323-2_bb0160","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2147\/OTT.S189001","article-title":"TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway","volume":"12","author":"Qu","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1007\/s12192-023-01323-2_bb0165","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/biology10050384","article-title":"The unfolded protein response: an overview","volume":"10","author":"Read","year":"2021","journal-title":"Biology"},{"key":"10.1007\/s12192-023-01323-2_bb0170","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12185-016-2016-0","article-title":"Endoplasmic-reticulum stress pathway-associated mechanisms of action of proteasome inhibitors in multiple myeloma","volume":"104","author":"Ri","year":"2016","journal-title":"Int J Hematol"},{"key":"10.1007\/s12192-023-01323-2_bb0175","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/jcp.26770","article-title":"Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level","volume":"234","author":"Ryu","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1007\/s12192-023-01323-2_bb0180","doi-asserted-by":"crossref","first-page":"19384","DOI":"10.1002\/jcp.28666","article-title":"The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: basic science and new insights based on gene expression","volume":"234","author":"Samimi","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1007\/s12192-023-01323-2_bb0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1007\/s12192-023-01323-2_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12622","article-title":"Abnormal peritoneal regulation of chemokine activation\u2014the role of IL-8 in pathogenesis of endometriosis","volume":"77","author":"Sikora","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1007\/s12192-023-01323-2_bb0195","doi-asserted-by":"crossref","first-page":"179515","DOI":"10.1155\/2014\/179515","article-title":"Theories on the pathogenesis of endometriosis","volume":"2014","author":"Sourial","year":"2014","journal-title":"Int J Reprod Med"},{"key":"10.1007\/s12192-023-01323-2_bb0200","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2741\/e277","article-title":"Apoptosis and Endometriosis","volume":"3","author":"Taniguchi","year":"2011","journal-title":"Front Bioscience-Elite"},{"key":"10.1007\/s12192-023-01323-2_bb0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bpobgyn.2018.06.002","article-title":"Endometriosis and infertility: insights into the causal link and management strategies","volume":"51","author":"Tomassetti","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1007\/s12192-023-01323-2_bb0210","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1177\/1933719115592713","article-title":"Pathogenetic mechanisms of deep infiltrating endometriosis","volume":"22","author":"Tosti","year":"2015","journal-title":"Reprod Sci"},{"key":"10.1007\/s12192-023-01323-2_bb0215","first-page":"3267","article-title":"Defining the genetic profile of endometriosis","volume":"17","author":"Vassilopoulou","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1007\/s12192-023-01323-2_bb0220","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00404-016-4195-6","article-title":"Regulation of apoptotic pathways during endometriosis: from the molecular basis to the future perspectives","volume":"294","author":"Vetvicka","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"10.1007\/s12192-023-01323-2_bb0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/ph15040401","article-title":"Regulation of the homeostatic unfolded protein response in diabetic nephropathy","volume":"15","author":"Wang","year":"2022","journal-title":"Pharmaceuticals"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-023-01323-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12192-023-01323-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523000706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814523000706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12192-023-01323-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:18:04Z","timestamp":1761182284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814523000706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1355814523000706"],"URL":"https:\/\/doi.org\/10.1007\/s12192-023-01323-2","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of endoplasmic reticulum stress in endometriosis","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12192-023-01323-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 THE AUTHOR(S). Published by Elsevier Inc on behalf of Cell Stress Society International","name":"copyright","label":"Copyright"}]}}