{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:50:59Z","timestamp":1777899059605,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,7,19]],"date-time":"2015-07-19T00:00:00Z","timestamp":1437264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","award":["2012KYA050"],"award-info":[{"award-number":["2012KYA050"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Project of Zhejiang Province Medicine Plan"},{"name":"The Key Project of Zhejiang Province Science and Technology Plan"},{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health Prev Med"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s12199-015-0477-z","type":"journal-article","created":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T14:37:33Z","timestamp":1437230253000},"page":"369-378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesothelin (MSLN) methylation and soluble mesothelin-related protein levels in a Chinese asbestos-exposed population"],"prefix":"10.1007","volume":"20","author":[{"given":"Min","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,19]]},"reference":[{"key":"477_CR1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/j.1349-7006.2012.02366.x","volume":"103","author":"EK Park","year":"2012","unstructured":"Park EK, Takahashi K, Jiang Y, Movahed M, Kameda T. Elimination of asbestos use and asbestos-related diseases: an unfinished story. Cancer Sci. 2012;103:1751\u20135.","journal-title":"Cancer Sci"},{"key":"477_CR2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1179\/1077352512Z.00000000021","volume":"18","author":"MN Courtice","year":"2012","unstructured":"Courtice MN, Lin S, Wang X. An updated review on asbestos and related diseases in China. Int J Occup Environ Health. 2012;18:247\u201353.","journal-title":"Int J Occup Environ Health"},{"key":"477_CR3","doi-asserted-by":"crossref","first-page":"e71899","DOI":"10.1371\/journal.pone.0071899","volume":"8","author":"X Wang","year":"2013","unstructured":"Wang X, Yano E, Lin S, Yu IT, Lan Y, Tse LA, et al. Cancer mortality in Chinese chrysotile asbestos miners: exposure-response relationships. PLoS One. 2013;8:e71899.","journal-title":"PLoS One"},{"key":"477_CR4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mrgentox.2008.06.011","volume":"655","author":"M Amati","year":"2008","unstructured":"Amati M, Tomasetti M, Mariotti L, Tarquini LM, Valentino M, Santarelli L. Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk. Mutat Res. 2008;655:52\u20138.","journal-title":"Mutat Res"},{"key":"477_CR5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5491\/SHAW.2012.3.1.17","volume":"3","author":"EK Park","year":"2012","unstructured":"Park EK, Yates DH, Creaney J, Thomas PS, Robinson BW, Johnson AR. Association of biomarker levels with severity of asbestos-related diseases. Saf Health Work. 2012;3:17\u201321.","journal-title":"Saf Health Work."},{"key":"477_CR6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1158\/1055-9965.EPI-08-0422","volume":"18","author":"PJA Rodriguez","year":"2009","unstructured":"Rodriguez PJA, Rodriguez BE, Rodriguez RD, Alfageme MI, Quero MA, Diego RC, et al. Serum levels of soluble mesothelin-related peptides in malignant and nonmalignant asbestos-related pleural disease: relation with past asbestos exposure. Cancer Epidemiol Biomark Prev. 2009;18:646\u201350.","journal-title":"Cancer Epidemiol Biomark Prev."},{"key":"477_CR7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1155\/2013\/874212","volume":"35","author":"J Creaney","year":"2013","unstructured":"Creaney J, Sneddon S, Dick IM, Dare H, Boudville N, Musk AW, et al. Comparison of the diagnostic accuracy of the MSLN gene products, mesothelin and megakaryocyte potentiating factor, as biomarkers for mesothelioma in pleural effusions and serum. Dis Markers. 2013;35:119\u201327.","journal-title":"Dis Markers"},{"key":"477_CR8","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1164\/rccm.200802-258OC","volume":"178","author":"EK Park","year":"2008","unstructured":"Park EK, Sandrini A, Yates DH, Creaney J, Robinson BW, Thomas PS, et al. Soluble mesothelin-related protein in an asbestos-exposed population: the dust diseases board cohort study. Am J Respir Crit Care Med. 2008;178:832\u20137.","journal-title":"Am J Respir Crit Care Med"},{"key":"477_CR9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1515\/CCLM.2010.165","volume":"48","author":"EK Park","year":"2010","unstructured":"Park EK, Thomas PS, Creaney J, Johnson AR, Robinson BW, Yates DH. Factors affecting soluble mesothelin related protein levels in an asbestos-exposed population. Clin Chem Lab Med. 2010;48:869\u201374.","journal-title":"Clin Chem Lab Med"},{"key":"477_CR10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5301\/JBM.2011.8332","volume":"26","author":"A Cristaudo","year":"2011","unstructured":"Cristaudo A, Foddis R, Bonotti A, Simonini S, Vivaldi A, Guglielmi G, et al. Two novel polymorphisms in 5\u2032 flanking region of the mesothelin gene are associated with soluble mesothelin-related peptide (SMRP) levels. Int J Biol Marker. 2011;26:117\u201323.","journal-title":"Int J Biol Marker"},{"key":"477_CR11","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.humpath.2010.03.002","volume":"41","author":"K Tan","year":"2010","unstructured":"Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, et al. Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. Hum Pathol. 2010;41:1330\u20138.","journal-title":"Hum Pathol"},{"key":"477_CR12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4161\/epi.6.8.16074","volume":"6","author":"HH Nelson","year":"2011","unstructured":"Nelson HH, Almquist LM, LaRocca JL, Plaza SL, Lambert-Messerlian GM, Sugarbaker DJ, et al. The relationship between tumor MSLN methylation and serum mesothelin (SMRP) in mesothelioma. Epigenetics. 2011;6:1029\u201334.","journal-title":"Epigenetics"},{"key":"477_CR13","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1158\/0008-5472.CAN-10-0190","volume":"70","author":"BC Christensen","year":"2010","unstructured":"Christensen BC, Houseman EA, Poage GM, Godleski JJ, Bueno R, Sugarbaker DJ, et al. Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma. Cancer Res. 2010;70:5686\u201394.","journal-title":"Cancer Res"},{"key":"477_CR14","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1349-7006.2011.02180.x","volume":"103","author":"M Fujii","year":"2012","unstructured":"Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, et al. Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma. Cancer Sci. 2012;103:510\u20134.","journal-title":"Cancer Sci"},{"key":"477_CR15","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s13277-012-0462-8","volume":"33","author":"R Hama","year":"2012","unstructured":"Hama R, Watanabe Y, Shinada K, Yamada Y, Ogata Y, Yoshida Y, et al. Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma. Tumour Biol. 2012;33:2031\u201340.","journal-title":"Tumour Biol"},{"key":"477_CR16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1158\/0008-5472.CAN-08-2586","volume":"69","author":"BC Christensen","year":"2009","unstructured":"Christensen BC, Houseman EA, Godleski JJ, Marsit CJ, Longacker JL, Roelofs CR, et al. Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res. 2009;69:227\u201334.","journal-title":"Cancer Res"},{"key":"477_CR17","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/ajim.22239","volume":"56","author":"A Miller","year":"2013","unstructured":"Miller A, Warshaw R, Nezamis J. Diffusing capacity and forced vital capacity in 5,003 asbestos-exposed workers: relationships to interstitial fibrosis (ILO profusion score) and pleural thickening. Am J Ind Med. 2013;56:1383\u201393.","journal-title":"Am J Ind Med"},{"key":"477_CR18","doi-asserted-by":"crossref","first-page":"e79675","DOI":"10.1371\/journal.pone.0079675","volume":"8","author":"X Liu","year":"2013","unstructured":"Liu X, Wang Y, Wang C, Shi C, Cheng C, Chen J, et al. A new equation to estimate glomerular filtration rate in Chinese elderly population. PLoS One. 2013;8:e79675.","journal-title":"PLoS One"},{"key":"477_CR19","author":"P Jakubec","year":"2014","unstructured":"Jakubec P, Pelclova D, Smolkova P, Kolek V, Nakladalova M. Significance of serum mesothelin in an asbestos-exposed population in the Czech Republic. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014. doi: 10.5507\/bp.2014.015 .","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub."},{"key":"477_CR20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jso.23116","volume":"106","author":"QM Yu","year":"2012","unstructured":"Yu QM, Wang XB, Luo J, Wang S, Fang XH, Yu JL, et al. CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer. J Surg Oncol. 2012;106:765\u201371.","journal-title":"J Surg Oncol"},{"key":"477_CR21","doi-asserted-by":"crossref","first-page":"9055","DOI":"10.1158\/0008-5472.CAN-07-0474","volume":"67","author":"T Hucl","year":"2007","unstructured":"Hucl T, Brody JR, Gallmeier E, Iacobuzio-Donahue CA, Farrance IK, Kern SE. High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif. Cancer Res. 2007;67:9055\u201365.","journal-title":"Cancer Res"},{"key":"477_CR22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"LC Li","year":"2002","unstructured":"Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics. 2002;18:1427\u201331.","journal-title":"Bioinformatics"},{"key":"477_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/crj.12028","volume":"8","author":"S Prazakova","year":"2014","unstructured":"Prazakova S, Thomas PS, Sandrini A, Yates DH. Asbestos and the lung in the 21st century: an update. Clin Respir J. 2014;8:1\u201310.","journal-title":"Clin Respir J"},{"key":"477_CR24","first-page":"351","volume":"104","author":"G Mastrangelo","year":"2013","unstructured":"Mastrangelo G, Marangi G, Ballarin MN, Bellini E, De Marzo N, Eder M, et al. Post-occupational health surveillance of asbestos workers. Med Lav. 2013;104:351\u20138.","journal-title":"Med Lav"},{"key":"477_CR25","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.3390\/ijerph10115629","volume":"10","author":"E Goswami","year":"2013","unstructured":"Goswami E, Craven V, Dahlstrom DL, Alexander D, Mowat F. Domestic asbestos exposure: a review of epidemiologic and exposure data. Int J Environ Res Public Health. 2013;10:5629\u201370.","journal-title":"Int J Environ Res Public Health"},{"key":"477_CR26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00408-013-9526-9","volume":"192","author":"M Bayram","year":"2014","unstructured":"Bayram M, Dongel I, Akbas A, Benli I, Akkoyunlu ME, Bakan ND. Serum biomarkers in patients with mesothelioma and pleural plaques and healthy subjects exposed to naturally occurring asbestos. Lung. 2014;192:197\u2013203.","journal-title":"Lung"},{"key":"477_CR27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00420-013-0853-1","volume":"87","author":"MK Felten","year":"2014","unstructured":"Felten MK, Khatab K, Knoll L, Schettgen T, Muller-Berndorff H, Kraus T. Changes of mesothelin and osteopontin levels over time in formerly asbestos-exposed power industry workers. Int Arch Occup Environ Health. 2014;87:195\u2013204.","journal-title":"Int Arch Occup Environ Health"},{"key":"477_CR28","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/JTO.0b013e31820db377","volume":"6","author":"K Hollevoet","year":"2011","unstructured":"Hollevoet K, Van Cleemput J, Thimpont J, De Vuyst P, Bosquee L, Nackaerts K, et al. Serial measurements of mesothelioma serum biomarkers in asbestos-exposed individuals: a prospective longitudinal cohort study. J Thorac Oncol. 2011;6:889\u201395.","journal-title":"J Thorac Oncol"},{"key":"477_CR29","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/carcin\/bgn169","volume":"29","author":"S Umemura","year":"2008","unstructured":"Umemura S, Fujimoto N, Hiraki A, Gemba K, Takigawa N, Fujiwara K, et al. Aberrant promoter hypermethylation in serum DNA from patients with silicosis. Carcinogenesis. 2008;29:1845\u20139.","journal-title":"Carcinogenesis"},{"key":"477_CR30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1164\/rccm.201302-0257OC","volume":"188","author":"SB Markowitz","year":"2013","unstructured":"Markowitz SB, Levin SM, Miller A, Morabia A. Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. Am J Respir Crit Care Med. 2013;188:90\u20136.","journal-title":"Am J Respir Crit Care Med"},{"key":"477_CR31","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/oem.2005.020834","volume":"62","author":"A Reid","year":"2005","unstructured":"Reid A, de Klerk N, Ambrosini GL, Olsen N, Pang SC, Berry G, et al. The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone. Occup Environ Med. 2005;62:885\u20139.","journal-title":"Occup Environ Med"},{"key":"477_CR32","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/oem.2004.018531","volume":"62","author":"A Reid","year":"2005","unstructured":"Reid A, de Klerk N, Ambrosini G, Olsen N, Pang SC, Musk AW. The additional risk of malignant mesothelioma in former workers and residents of Wittenoom with benign pleural disease or asbestosis. Occup Environ Med. 2005;62:665\u20139.","journal-title":"Occup Environ Med"},{"key":"477_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/oem.2009.049205","volume":"67","author":"A Cristaudo","year":"2010","unstructured":"Cristaudo A, Foddis R, Bonotti A, Simonini S, Vivaldi A, Guglielmi G, et al. Polymorphisms in the putative micro-RNA-binding sites of mesothelin gene are associated with serum levels of mesothelin-related protein. Occup Environ Med. 2010;67:233\u20136.","journal-title":"Occup Environ Med"},{"key":"477_CR34","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1097\/JTO.0000000000000322","volume":"9","author":"S Garritano","year":"2014","unstructured":"Garritano S, De Santi C, Silvestri R, Melaiu O, Cipollini M, Barone E, et al. A common polymorphism within MSLN affects miR-611 binding site and soluble mesothelin levels in healthy people. J Thorac Oncol. 2014;9:1662\u20138.","journal-title":"J Thorac Oncol"}],"container-title":["Environmental Health and Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12199-015-0477-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12199-015-0477-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12199-015-0477-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T09:29:18Z","timestamp":1691832558000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12199-015-0477-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,19]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["477"],"URL":"https:\/\/doi.org\/10.1007\/s12199-015-0477-z","relation":{},"ISSN":["1342-078X","1347-4715"],"issn-type":[{"value":"1342-078X","type":"print"},{"value":"1347-4715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,19]]}}}