{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:58:45Z","timestamp":1694638725156},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s12223-010-0019-4","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T02:08:31Z","timestamp":1274148511000},"page":"126-132","source":"Crossref","is-referenced-by-count":4,"title":["Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum"],"prefix":"10.1007","volume":"55","author":[{"given":"R.","family":"\u0160mid\u00e1k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jop\u010d\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kralovi\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gajdo\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kormanec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Timko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tur\u0148a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,19]]},"reference":[{"key":"19_CR1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.mi.46.100192.002333","volume":"46","author":"Y. Aharonowitz","year":"1992","unstructured":"Aharonowitz Y., Cohen G., Mart\u00edn J.F.: Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Ann.Rev.Microbiol. 46, 461\u2013495 (1992).","journal-title":"Ann.Rev.Microbiol"},{"key":"19_CR2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00332235","volume":"216","author":"J.L. Barredo","year":"1989","unstructured":"Barredo J.L., Cantoral J.M., Alvarez E., D\u00edez B., Mart\u00edn J.F.: Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78. Mol.Gen.Genet. 216, 91\u201398 (1989).","journal-title":"Mol.Gen.Genet"},{"key":"19_CR3","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1128\/jb.174.11.3789-3799.1992","volume":"174","author":"A.A. Brakhage","year":"1992","unstructured":"Brakhage A.A., Browne P., Turner G.: Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose. J.Bacteriol. 174, 3789\u20133799 (1992).","journal-title":"J.Bacteriol"},{"key":"19_CR4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/MMBR.62.3.547-585.1998","volume":"62","author":"A.A. Brakhage","year":"1998","unstructured":"Brakhage A.A.: Molecular regulation of \u03b2-lactam biosynthesis in filamentous fungi. Microbiol.Mol.Biol.Rev. 62, 547\u2013585 (1998).","journal-title":"Microbiol.Mol.Biol.Rev"},{"key":"19_CR5","first-page":"45","volume":"88","author":"A.A. Brakhage","year":"2004","unstructured":"Brakhage A.A., Spr\u00f6te P., Al-Abdallah Q., Gehrke A., Plattner H., T\u00fcncher A.: Regulation of penicillin biosynthesis in filamentous fungi. Adv.Biochem.Eng.Biotechnol. 88, 45\u201390 (2004).","journal-title":"Adv.Biochem.Eng.Biotechnol"},{"key":"19_CR6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF00315786","volume":"27","author":"Y.W. Chu","year":"1995","unstructured":"Chu Y.W., Renno D., Saunders G.: Detection of a protein which binds specifically to the upstream region of the pcbAB gene in Penicillium chrysogenum. Curr.Genet. 27, 184\u2013189 (1995).","journal-title":"Curr.Genet"},{"key":"19_CR7","doi-asserted-by":"crossref","first-page":"16358","DOI":"10.1016\/S0021-9258(17)46231-4","volume":"256","author":"B. D\u00edez","year":"1990","unstructured":"D\u00edez B., Guti\u00e9rez S., Barredo J.L., van Solingen P., Lucia H.M., van der Voort L.H.M., Mart\u00edn J.F.: The cluster of penicillin biosynthesis gene. Identification and characterization of the pcbAB gene encoding the \u03b1-(aminoadipylcysteinyl)-valine synthetase and linkage to the pcbC and pen DE genes. J.Biol.Chem. 256, 16358\u201316365 (1990).","journal-title":"J.Biol.Chem"},{"key":"19_CR8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00253-003-1274-y","volume":"61","author":"R.P. Elander","year":"2003","unstructured":"Elander R.P.: Industrial production of \u03b1-lactam antibiotics. Appl.Microbiol.Biotechnol. 61, 385\u2013392 (2003).","journal-title":"Appl.Microbiol.Biotechnol"},{"key":"19_CR9","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/AEM.60.12.4432-4439.1994","volume":"60","author":"B. Feng","year":"1994","unstructured":"Feng B., Friedlin E., Marzluf G.A.: A reporter gene analysis of penicillin biosynthesis gene expression in Penicillium chrysogenum and its regulation by nitrogen and glucose catabolite repression. Appl.Environ.Microbiol. 60, 4432\u20134439 (1994).","journal-title":"Appl.Environ.Microbiol"},{"key":"19_CR10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00352104","volume":"27","author":"B. Feng","year":"1995","unstructured":"Feng B., Friedlin E., Marzluf G.A.: Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. Curr.Genet. 27, 351\u2013358 (1995).","journal-title":"Curr.Genet"},{"key":"19_CR11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF00290139","volume":"246","author":"J.M. Fern\u00e1ndez-Ca\u00f1\u00f3n","year":"1995","unstructured":"Fern\u00e1ndez-Ca\u00f1\u00f3n J.M., Pe\u00f1alva M.A.: Overexpression of two penicillin structural genes in Aspergillus nidulans. Mol.Gen.Genet. 246, 110\u2013118 (1995).","journal-title":"Mol.Gen.Genet"},{"key":"19_CR12","first-page":"137","volume":"88","author":"N. Gunnarsson","year":"2004","unstructured":"Gunnarsson N., Eliasson A., Nielsen J.: Control of fluxes towards antibiotics and the role of primary metabolism in production of antibiotics. Adv.Biochem.Eng.Biotechnol. 88, 137\u2013178 (2004).","journal-title":"Adv.Biochem.Eng.Biotechnol"},{"key":"19_CR13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00282642","volume":"225","author":"S. Guti\u00e9rrez","year":"1991","unstructured":"Guti\u00e9rrez S., D\u00edez B., Alvarez E., Barredo J.L., Mart\u00edn J.F.: Expression of the penDE gene of Penicillium chrysogenum encoding isopenicillin N acyltransferase in Cephalosporium acremonium: production of benzylpenicillin by the transformants. Mol.Gen.Genet. 225, 56\u201364 (1991).","journal-title":"Mol.Gen.Genet"},{"key":"19_CR14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1001861025070","volume":"75","author":"S. Guti\u00e9rrez","year":"1999","unstructured":"Guti\u00e9rrez S., Fierro F., Casqueiro J., Mart\u00edn J.F.: Gene organization and plasticity of the \u03b2-lactam genes in different filamentous fungi. Antonie van Leeuwenhoek 75, 81\u201394 (1999).","journal-title":"Antonie van Leeuwenhoek"},{"key":"19_CR15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1385\/1-59259-233-3:481","volume-title":"Nuclease Methods and Protocols: Methods in Molecular Biology","author":"J. Kormanec","year":"2001","unstructured":"Kormanec J.: Analyzing the developmental expression of sigma factors with S1-nuclease mapping, pp. 481\u2013494 in C.H. Chein (Ed.): Nuclease Methods and Protocols: Methods in Molecular Biology. Humana Press, Totowa (NJ, USA) 2001."},{"key":"19_CR16","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1074\/jbc.275.4.2423","volume":"275","author":"K. Kosalkov\u00e1","year":"2000","unstructured":"Kosalkov\u00e1 K., Marcos A.T., Fierro F., Hernando-Rico V., Guti\u00e9rrez S., Mart\u00edn J.F.: A novel heptameric sequence (TTA GTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum. J.Biol.Chem. 275, 2423\u20132430 (2000).","journal-title":"J.Biol.Chem"},{"key":"19_CR17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00294-007-0157-7","volume":"52","author":"K. Kosalkov\u00e1","year":"2007","unstructured":"Kosalkov\u00e1 K., Rodr\u00edguez-S\u00e1iz M., Barredo J.L., Mart\u00edn J.F.: Binding of the PTA1 transcriptional activator to the divergent promoter region of the first two genes of the penicillin pathway in different Penicillium species. Curr.Genet. 52, 229\u2013237 (2007).","journal-title":"Curr.Genet"},{"key":"19_CR18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biochi.2008.09.004","volume":"91","author":"K. Kosalkov\u00e1","year":"2009","unstructured":"Kosalkov\u00e1 K., Garc\u00eda-Estrada C., Ull\u00e1n R.V., Godio R.P., Feltrer R., Teijeira F., Mauriz E., Mart\u00edn J.F.: The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. Biochimie 91, 214\u2013225 (2009).","journal-title":"Biochimie"},{"key":"19_CR19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02873590","volume":"46","author":"E. Leiter","year":"2001","unstructured":"Leiter E., Emri T., Gy\u00e9m\u00e1nt G., Nagy I., P\u00f3csi I., Winkelmann G., P\u00f3csi I.: Penicillin V production by Penicillium chrysogenum in the presence of Fe3+ and in low-iron culture medium. Folia Microbiol. 46, 127\u2013132 (2001).","journal-title":"Folia Microbiol"},{"key":"19_CR20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00290581","volume":"249","author":"O. Litzka","year":"1995","unstructured":"Litzka O., Bergh K.T., Brakhage A.A.: Analysis of the regulation of Aspergillus nidulans penicillin biosynthesis gene aat (penDE) encoding acyl coenzyme A:6-aminopenicillanic acid acyltransferase. Mol.Gen.Genet. 249, 557\u2013569 (1995).","journal-title":"Mol.Gen.Genet"},{"key":"19_CR21","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1128\/JB.182.9.2355-2362.2000","volume":"182","author":"J.F. Mart\u00edn","year":"2000","unstructured":"Mart\u00edn J.F.: Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region. J.Bacteriol. 182, 2355\u20132362 (2000).","journal-title":"J.Bacteriol"},{"key":"19_CR22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF02874191","volume":"9","author":"P. Nemec","year":"1964","unstructured":"Nemec P., Bar\u00e1th Z., Betina V., Kutkov\u00e1 M.: Antibiotic activity of fungi isolated from soil samples from Indonesia. Folia Microbiol. 9, 383\u2013386 (1964).","journal-title":"Folia Microbiol"},{"key":"19_CR23","doi-asserted-by":"crossref","DOI":"10.1142\/3195","volume-title":"Physiological engineering aspects of Penicillium chrysogenum","author":"J. Nielsen","year":"1997","unstructured":"Nielsen J.: Physiological engineering aspects of Penicillium chrysogenum. World Scientific Publishing, Singapore 1997."},{"key":"19_CR24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.mi.41.100187.000411","volume":"41","author":"J. N\u00fcesch","year":"1987","unstructured":"N\u00fcesch J., Heim J., Treichler H.-J.: The biosynthesis of sulfur containing \u03b2-lactam antibiotics, Ann.Rev.Microbiol. 41, 51\u201375 (1987).","journal-title":"Ann.Rev.Microbiol"},{"key":"19_CR25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1365-2958.1993.tb01746.x","volume":"9","author":"B. P\u00e9rez-Esteban","year":"1993","unstructured":"P\u00e9rez-Esteban B., Orejas M., G\u00f3mez-Pardo E., Pe\u00f1alva M.A.: Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements. Mol.Microbiol. 9, 881\u2013895 (1993).","journal-title":"Mol.Microbiol"},{"key":"19_CR26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.7164\/antibiotics.37.781","volume":"37","author":"G. Revilla","year":"1984","unstructured":"Revilla G., L\u00f3pez-Nieto M.J., Luengo J.M., Mart\u00edn J.F.: Carbon catabolite repression of penicillin biosynthesis by Penicillium chrysogenum. J.Antibiot. 37, 781\u2013789 (1984).","journal-title":"J.Antibiot"},{"key":"19_CR27","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.fgb.2005.01.014","volume":"42","author":"M. Rodr\u00edguez-S\u00e1iz","year":"2005","unstructured":"Rodr\u00edguez-S\u00e1iz M., D\u00edez B., Barredo J.L.: Why did the Fleming strain fail in penicillin industry? Fungal Genet.Biol. 42, 464\u2013470(2005).","journal-title":"Fungal Genet.Biol"},{"key":"19_CR28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1099\/mic.0.28744-0","volume":"152","author":"H. Skovierova","year":"2006","unstructured":"Skovierova H., Rowley G., Rezuchova B., Homerova D., Lewis C., Roberts M., Kormanec J.: Identification of the \u03c3E regulon of Salmonella enterica serovar Typhimurium. Microbiology 152, 1347\u20131359 (2006).","journal-title":"Microbiology"},{"key":"19_CR29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/j.1460-2075.1990.tb08168.x","volume":"9","author":"D.J. Smith","year":"1990","unstructured":"Smith D.J., Bumham M.K.R., Bull J.H., Hodgson J.E., Ward J.M., Browne P., Brown J., Barton B., Earl A.J., Turner G.: \u03b2-Lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes. EMBO J. 9, 741\u2013747 (1990a).","journal-title":"EMBO J"},{"key":"19_CR30","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/j.1460-2075.1990.tb07461.x","volume":"9","author":"D.J. Smith","year":"1990","unstructured":"Smith D.J., Earl A.J., Turner G.: The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421 073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases. EMBO J. 9, 2743\u20132750 (1990b).","journal-title":"EMBO J"},{"key":"19_CR31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02816527","volume":"40","author":"J. Sp\u00ed\u017eek","year":"1995","unstructured":"Sp\u00ed\u017eek J., Tich\u00fd P.: Some aspects of overproduction of secondary metabolites. Folia Microbiol. 40, 43\u201350 (1995).","journal-title":"Folia Microbiol"},{"key":"19_CR32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/1097-0290(20000220)72:4<379::AID-BIT1000>3.0.CO;2-5","volume":"72","author":"H.B. Theilgaard","year":"2001","unstructured":"Theilgaard H.B., van den Berg M., Mulder C., Bovenberg R., Nielsen J.: Quantitative analysis of Penicillium chrysogenum Wis54-1255 transformants overexpressing the penicillin biosynthetic genes. Biotechnol.Bioeng. 72, 379\u2013388 (2001).","journal-title":"Biotechnol.Bioeng"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-010-0019-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12223-010-0019-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-010-0019-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T22:58:14Z","timestamp":1635375494000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12223-010-0019-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["19"],"URL":"https:\/\/doi.org\/10.1007\/s12223-010-0019-4","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}