{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:57:00Z","timestamp":1790301420542,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s12223-010-0084-8","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T19:22:10Z","timestamp":1286997730000},"page":"508-514","source":"Crossref","is-referenced-by-count":19,"title":["Innate immunity to Legionella and toll-like receptors \u2014 review"],"prefix":"10.1007","volume":"55","author":[{"given":"M.","family":"Palusinska-Szysz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Janczarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,13]]},"reference":[{"key":"84_CR1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/IAI.73.1.352-361.2005","volume":"73","author":"M. Akamine","year":"2005","unstructured":"Akamine M., Higa F., Arakaki N., Kawakami K., Takeda K., Akira S., Saito A.: Differential roles of Toll-like receptors 2 and 4 in vitro responses of macrophages to Legionella pneumophila. Infect.Immun. 73, 352\u2013361 (2005).","journal-title":"Infect.Immun."},{"key":"84_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1000361","volume":"5","author":"A. Akhter","year":"2009","unstructured":"Akhter A., Gavrilin M.A., Frantz L., Washington S., Ditty C., Limoli D., Day C., Sarkar A., Newland C., Butchar J., Marsh C., Wewers M.D., Tridandapani S., Kanneganti T.D., Amer A.O.: Caspase-7 activation by the Nlrc4\/ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog. 5, 1\u201313 (2009).","journal-title":"PLoS Pathog."},{"key":"84_CR3","doi-asserted-by":"crossref","first-page":"35217","DOI":"10.1074\/jbc.M604933200","volume":"281","author":"A. Amer","year":"2006","unstructured":"Amer A., Franchi L., Kanneganti T.D., Body-Malapel M., Ozoren N., Brady G., Meshinchi S., Jagirdar R., Gewirtz A., Akira S., Nunez G.: Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J.Biol.Chem. 281, 35217\u201335223 (2006).","journal-title":"J.Biol.Chem."},{"key":"84_CR4","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1128\/IAI.02049-05","volume":"74","author":"K.A. Archer","year":"2006","unstructured":"Archer K.A., Roy C.R.: MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires\u2019 disease. Infect.Immun. 74, 3325\u20133333 (2006).","journal-title":"Infect.Immun."},{"key":"84_CR5","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1128\/IAI.00025-07","volume":"75","author":"R. Asare","year":"2007","unstructured":"Asare R., Santic M., Gobin I., Doric M., Suttles J., Graham J.E., Price C.D., Abu Kwaik Y.: Genetic susceptibility and caspase activation in mouse and human macrophages are distinct for Legionella longbeachae and L. pneumophila. Infect.Immun. 75, 1933\u20131945 (2007).","journal-title":"Infect.Immun."},{"key":"84_CR6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1183\/09031936.05.00025405","volume":"25","author":"R. Bals","year":"2005","unstructured":"Bals R.: Lipopolysaccharide and the lung: a story of love and hate. Eur.Respir.J. 25, 776\u2013777 (2005).","journal-title":"Eur.Respir.J."},{"key":"84_CR7","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/IAI.01489-07","volume":"76","author":"U. Bhan","year":"2008","unstructured":"Bhan U., Trujillo G., Lyn-Kew K., Newstead M.W., Zeng X., Hogaboam C.M., Krieg A.M., Standiford T.: Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Infect.Immun. 76, 2895\u20132904 (2008).","journal-title":"Infect.Immun."},{"key":"84_CR8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/09680519050110020401","volume":"11","author":"S. Braedel-Ruoff","year":"2005","unstructured":"Braedel-Ruoff S., Faigle M., Hilf N., Neumeister B., Schild H.: Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2. J.Endotoxin Res. 11, 89\u201396 (2005).","journal-title":"J.Endotoxin Res."},{"key":"84_CR9","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.4049\/jimmunol.157.11.5002","volume":"157","author":"J.K. Brieland","year":"1996","unstructured":"Brieland J.K., Heath L.A., Huffnagle G.B., Remick D.G., Mcclain M.S., Hurley M.C., Kunkel R.K., Fantone J.C., Engleberg C.: Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host. J.Immunol. 157, 5002\u20135008 (1996).","journal-title":"J.Immunol."},{"key":"84_CR10","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1128\/IAI.00248-09","volume":"77","author":"Y. Bulut","year":"2009","unstructured":"Bulut Y., Shimada K., Wong M.H., Chen S., Gray P., Alsabeh R., Doherty T.R., Crother T.R., Arditi M.: Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway. Infect.Immun. 77, 2683\u20132690 (2009).","journal-title":"Infect.Immun."},{"key":"84_CR11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1128\/IAI.01382-08","volume":"77","author":"C.L. Case","year":"2009","unstructured":"Case C.L., Shin S., Roy C.R.: Asc and Ipaf inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infect.Immun. 77, 1981\u20131991 (2009).","journal-title":"Infect.Immun."},{"key":"84_CR12","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1128\/IAI.69.4.2116-2122.2001","volume":"69","author":"C. Dietrich","year":"2001","unstructured":"Dietrich C., Heuner K., Brand B.C., Hacker J., Steinert M.: Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells. Infect.Immun. 69, 2116\u20132122 (2001).","journal-title":"Infect.Immun."},{"key":"84_CR13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng1065","volume":"33","author":"E. Diez","year":"2003","unstructured":"Diez E., Lee S.H., Gauthier S., Yaraghi Z., Tremblay M., Vidal S., Gros P.: Birc1e is the gene within the lgn1 locus associated with resistance to Legionella pneumophila. Nat.Genet. 33, 55\u201360 (2003).","journal-title":"Nat.Genet."},{"key":"84_CR14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/MMBR.56.1.32-60.1992","volume":"56","author":"J.N. Dowling","year":"1992","unstructured":"Dowling J.N., Saha A.K., Glew R.H.: Virulence factors of the family Legionellaceae. Microbiol.Rev. 56, 32\u201360 (1992).","journal-title":"Microbiol.Rev."},{"key":"84_CR15","unstructured":"Euzeby J.P.: List of bacterial names with standing in nomenclature: http:\/\/www.bacterio.cict.fr\/ (2009)."},{"key":"84_CR16","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/CMR.15.3.506-526.2002","volume":"15","author":"B.S. Fields","year":"2002","unstructured":"Fields B.S., Benson R.F., Besser R.E.: Legionella and Legionnaires\u2019 disease: 25 years of investigation. Clin.Microbiol.Rev. 15, 506\u2013526 (2002).","journal-title":"Clin.Microbiol.Rev."},{"key":"84_CR17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/spid.2002.127206","volume":"13","author":"H. Friedman","year":"2002","unstructured":"Friedman H., Yamamoto Y., Klein T.W.: Legionella pneumophila pathogenesis and immunity. Semin.Pediatr.Infect.Dis. 13, 273\u2013279 (2002).","journal-title":"Semin.Pediatr.Infect.Dis."},{"key":"84_CR18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1099\/jmm.0.46913-0","volume":"56","author":"E.T. Fuse","year":"2007","unstructured":"Fuse E.T., Tateda K., Kikuchi Y., Matsumoto T., Gondaira F., Azuma A., Kudoh S., Standiford T.J., Yamaguchi K.: Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model. J.Med.Microbiol. 56, 305\u2013312 (2007).","journal-title":"J.Med.Microbiol."},{"key":"84_CR19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1242\/jcs.00212","volume":"116","author":"R. Girard","year":"2003","unstructured":"Girard R., Pedron T., Uematsu S., Ballov V., Chignard M., Akira S., Chaby R.: Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J.Cell Sci. 116, 293\u2013302 (2003).","journal-title":"J.Cell Sci."},{"key":"84_CR20","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1101\/gr.10.8.1158","volume":"10","author":"J.D. Growney","year":"2000","unstructured":"Growney J.D., Dietrich W.F.: High resolution genetic and physical map of the Lgn1 interval in C57BL\/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Genome Res. 10, 1158\u20131171 (2000).","journal-title":"Genome Res."},{"key":"84_CR21","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1084\/jem.20031220","volume":"198","author":"T.R. Hawn","year":"2003","unstructured":"Hawn T.R., Verbon A., Lettinga K.D., Zhao L.P., Li S.S., Laws R.J., Skerrett S.J., Beutler B., Schroeder L., Nachman A., Ozinsky A., Smith K.D., Aderem A.: A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires\u2019 disease. J.Exp.Med. 198, 1563\u20131572 (2003).","journal-title":"J.Exp.Med."},{"key":"84_CR22","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1073\/pnas.0409831102","volume":"102","author":"T.R. Hawn","year":"2005","unstructured":"Hawn T.R., Verbon A., Janer M., Zhao L.P., Beutler B., Aderem A.: Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires\u2019 disease. Proc.Nat.Acad.Sci.USA 102, 2487\u20132489 (2005).","journal-title":"Proc.Nat.Acad.Sci.USA"},{"key":"84_CR23","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1086\/504525","volume":"193","author":"T.R. Hawn","year":"2006","unstructured":"Hawn T.R., Smith K.D., Aderem A., Skerrett S.J.: Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila. J.Infect.Dis. 193, 1693\u20131702 (2006).","journal-title":"J.Infect.Dis."},{"key":"84_CR24","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.4049\/jimmunol.179.10.6981","volume":"179","author":"T.R. Hawn","year":"2007","unstructured":"Hawn T.R., Berrington W.R., Smith J.A., Uematsu S., Akira S., Aderem A., Smith K.D., Skerrett S.J.: Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J.Immunol. 179, 6981\u20136987 (2007).","journal-title":"J.Immunol."},{"key":"84_CR25","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/IAI.70.3.1604-1608.2002","volume":"70","author":"K. Heuner","year":"2002","unstructured":"Heuner K., Dietrich C., Skirwan C., Steinert M., Hacker J.: Influence of the alternative sigma(28) factor on virulence and flagellum expression of Legionella pneumophila. Infect.Immun. 70, 1604\u20131608 (2002).","journal-title":"Infect.Immun."},{"key":"84_CR26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1078\/1438-4221-00259","volume":"293","author":"K. Heuner","year":"2003","unstructured":"Heuner K., Steinert M.: The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype. Internat.J.Med.Microbiol. 293, 133\u2013143 (2003).","journal-title":"Internat.J.Med.Microbiol."},{"key":"84_CR27","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/IAI.58.10.3380-3387.1990","volume":"58","author":"P.S. Hoffman","year":"1990","unstructured":"Hoffman P.S., Houston L., Butler C.A.: Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen L. pneumophila-infected HeLa cells. Infect.Immun. 58, 3380\u20133387 (1990).","journal-title":"Infect.Immun."},{"key":"84_CR28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1084\/jem.153.2.398","volume":"153","author":"M.A. Horwitz","year":"1981","unstructured":"Horwitz M.A., Silverstein S.C.: Interaction of the Legionnaires\u2019 disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication. J.Exp. Med. 153, 398\u2013406 (1981).","journal-title":"J.Exp. Med."},{"key":"84_CR29","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1002\/eji.200737591","volume":"37","author":"N. Joller","year":"2007","unstructured":"Joller N., Sporri R., Hilbi H., Oxenius A.: Induction and protective role of antibodies in L. pneumophila infection. Eur.J.Immunol. 37, 3414\u20133423 (2007).","journal-title":"Eur.J.Immunol."},{"key":"84_CR30","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.4049\/jimmunol.172.3.1727","volume":"172","author":"T. Kikuchi","year":"2004","unstructured":"Kikuchi T., Kobayashi T., Gomi K., Suzuki T., Tokue Y., Watanabe A., Nukiwa T.: Dendritic cells pulsed with live and dead Legionella pneumophila elicit distinct immune responses. J.Immunol. 172, 1727\u20131734 (2004).","journal-title":"J.Immunol."},{"key":"84_CR31","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1128\/JCM.41.7.2974-2979.2003","volume":"41","author":"M.J. Kim","year":"2003","unstructured":"Kim M.J., Sohn J.W., Park D.W., Park S.C., Chun B.C.: Characterization of a lipoprotein common to Legionella species as a urinary broad-spectrum antigen for diagnosis of Legionnaires\u2019 disease. J.Clin.Microbiol. 41, 2974\u20132979 (2003).","journal-title":"J.Clin.Microbiol."},{"key":"84_CR32","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.4049\/jimmunol.178.12.8022","volume":"178","author":"M. Lamkanfi","year":"2007","unstructured":"Lamkanfi M., Amer A., Kanneganti T.D., Munoz-Planillo R., Chen G., Vandenabeele P., Fortier A., Gros P., Nunez G.: The Nod-like receptor family member Naip5\/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J.Immunol. 178, 8022\u20138027 (2007).","journal-title":"J.Immunol."},{"key":"84_CR33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1086\/341780","volume":"186","author":"K.D. Lettinga","year":"2002","unstructured":"Lettinga K.D., Florquin S., Speelman P., van Ketel R., van der Poll T., Verbon A.: Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model. J.Infect.Dis. 186, 570\u2013573 (2002).","journal-title":"J.Infect.Dis."},{"key":"84_CR34","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ni.1646","volume":"9","author":"K.L. Lightfield","year":"2008","unstructured":"Lightfield K.L., Persson J., Brubaker S.W., Witte C.E., von Moltke J., Dunipace E.A., Henry T., Sun Y.H., Cado D., Dietrich W.F., Monack D.M., Tsolis R.M., Vance R.E.: Critical role of Naip5 in inflammasome activation by a conserved C-terminal domain of flagellin. Nat.Immunol. 9, 1171\u20131178 (2008).","journal-title":"Nat.Immunol."},{"key":"84_CR35","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/IAI.01011-08","volume":"77","author":"V.P. Losick","year":"2009","unstructured":"Losick V.P., Stephan K., Smirnowa I.I., Isberg R.R., Poltorak A.: A hemidominant Naip5 allele in mouse strain MOLF\/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infect.Immun. 77, 196\u2013204 (2009).","journal-title":"Infect.Immun."},{"key":"84_CR36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","volume":"449","author":"R. Medzhitov","year":"2007","unstructured":"Medzhitov R.: Recognition of microorganisms and activation of the immune response. Nature 449, 819\u2013826 (2007).","journal-title":"Nature"},{"key":"84_CR37","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1128\/IAI.73.9.5720-5734.2005","volume":"73","author":"A.B. Molofsky","year":"2005","unstructured":"Molofsky A.B., Shetron-Rama L.M., Swanson M.S.: Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect.Immun. 73, 5720\u20135734 (2005).","journal-title":"Infect.Immun."},{"key":"84_CR38","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1128\/AEM.63.4.1219-1224.1997","volume":"63","author":"B. Neumeister","year":"1997","unstructured":"Neumeister B., Sch\u00f6niger S., Faigle M., Eichner M., Dietz K.: Multiplication of different Legionella species in Mono Mac 6 and in Acanthamoeba castellanii. Appl.Environ.Microbiol. 63, 1219\u20131224 (1997).","journal-title":"Appl.Environ.Microbiol."},{"key":"84_CR39","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1128\/IAI.66.9.4151-4157.1998","volume":"66","author":"B. Neumeister","year":"1998","unstructured":"Neumeister B., Faigle M., Sommer M., Z\u00e4hringer U., Stelter F., Menzel R., Sch\u00fctt C., Northoff H.: Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14. Infect.Immun. 66, 4151\u20134157 (1998).","journal-title":"Infect.Immun."},{"key":"84_CR40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1128\/IAI.01011-06","volume":"75","author":"C.A. Newton","year":"2007","unstructured":"Newton C.A., Perkins I., Widen R.H., Friedman H., Klein T.W.: Role of toll-like receptor 9 in Legionella pneumophila-induced interleukin-12p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice. Infect.Immun. 75, 146\u2013151 (2007).","journal-title":"Infect.Immun."},{"key":"84_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1086\/516258","volume":"26","author":"M.L. Pedro-Botet","year":"1998","unstructured":"Pedro-Botet M.L., Sabria-Leal M., Sopena N., Manterola J.M., Padilla E., Dominguez J., Morera J., Tudela P.: Role of immunosuppression in the evolution of Legionnaires\u2019 disease. Clin.Infect.Dis. 26, 14\u201319 (1998).","journal-title":"Clin.Infect.Dis."},{"key":"84_CR42","first-page":"175","volume":"2","author":"T. Ren","year":"2006","unstructured":"Ren T., Zamboni D.S., Roy C.R., Dietrich W.F., Vance R.E.: Flagellin-deficient Legionella mutants evade caspase-1 and Naip5-mediated macrophage immunity. PLoS Pathog. 2, 175\u2013183 (2006).","journal-title":"PLoS Pathog."},{"key":"84_CR43","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1128\/IAI.62.12.5689-5693.1994","volume":"62","author":"C. Retzlaff","year":"1994","unstructured":"Retzlaff C., Yamamoto Y., Hoffman P.S., Friedman H., Klein T.W.: Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infect.Immun. 62, 5689\u20135693 (1994).","journal-title":"Infect.Immun."},{"key":"84_CR44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2567.1996.d01-735.x","volume":"89","author":"C. Retzlaff","year":"1996","unstructured":"Retzlaff C., Yamamoto Y., Okubo S., Hoffman P.S., Friedman H., Klein T.W.: Legionella pneumophila-heat shock protein induced increase of interleukin-1\u03b2 mRNA involves protein kinase C signaling in macrophages. Immunology 89, 281\u2013288 (1996).","journal-title":"Immunology"},{"key":"84_CR45","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1128\/IAI.01950-06","volume":"75","author":"J. Rogers","year":"2007","unstructured":"Rogers J., Hakki A., Perkins I., Newton C., Widen R., Burdash N., Klein T., Friedman H.: Legionella pneumophila infection upregulates dendritic cell Toll-like receptor 2(TLR2)\/TLR4 expression and key maturation markers. Infect.Immun. 75, 3205\u20133208 (2007).","journal-title":"Infect.Immun."},{"key":"84_CR46","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1017\/S0950268808001684","volume":"137","author":"M. Rudbeck","year":"2009","unstructured":"Rudbeck M., Molbak K., Uldum S.A.: Dynamics of Legionella antibody levels during 1 year in a healthy population. Epidemiol. Infect. 137, 1013\u20131018 (2009).","journal-title":"Epidemiol. Infect."},{"key":"84_CR47","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1128\/IAI.00147-07","volume":"75","author":"M. Santic","year":"2007","unstructured":"Santic M., Asare R., Doric M., Abu Kwaik Y.: Host-dependent trigger of caspases and apoptosis by Legionella pneumophila. Infect. Immun. 75, 2903\u20132913 (2007).","journal-title":"Infect. Immun."},{"key":"84_CR48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3858\/emm.2009.41.10.075","volume":"41","author":"H.K. Shim","year":"2009","unstructured":"Shim H.K., Kim J.Y., Kim M.J., Sim H.S., Park D.W., Sohn J.W., Kim M.J.: Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages. Exp.Mol.Med. 41, 687\u2013694 (2009).","journal-title":"Exp.Mol.Med."},{"key":"84_CR49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1099\/0022-1317-51-3-225","volume":"51","author":"Y. Shinozawa","year":"2002","unstructured":"Shinozawa Y., Matsumoto T., Uchida K., Tsujimoto S., Iwakura Y., Yamaguchi K.: Role of interferon-\u03b3 in inflammatory responses in murine respiratory infection with Legionella pneumophila. J.Med.Microbiol. 51, 225\u2013230 (2002).","journal-title":"J.Med.Microbiol."},{"key":"84_CR50","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4049\/jimmunol.160.1.316","volume":"160","author":"M. Susa","year":"1998","unstructured":"Susa M., Ticac B., Rukavina T., Doric M., Marre R.: Legionella pneumophila infection in intratracheally inoculated T cell-depleted or nondepleted A\/J mice J.Immunol. 160, 316\u2013321 (1998).","journal-title":"J.Immunol."},{"key":"84_CR51","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4049\/jimmunol.166.5.3355","volume":"166","author":"K. Tateda","year":"2001","unstructured":"Tateda K., Moore T.A., Deng J.C., Newstead M.W., Zeng X., Matsukawa A., Swanson M.S., Yamaguchi K., Standiford T.J.: Early recruitment of neutrophils determines subsequent T1\/T2 host responses in a murine model of Legionella pneumophila pneumonia. J.Immunol. 166, 3355\u20133361 (2001a).","journal-title":"J.Immunol."},{"key":"84_CR52","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1128\/IAI.69.4.2017-2024.2001","volume":"69","author":"K. Tateda","year":"2001","unstructured":"Tateda K., Moore T.A., Newstead M.W., Tsai W.C., Zeng X., Deng J.C., Chen G., Reddy R., Yamaguchi K., Standiford T.J.: Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells. Infect.Immun. 69, 2017\u20132024 (2001b).","journal-title":"Infect.Immun."},{"key":"84_CR53","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.4049\/jimmunol.180.10.6808","volume":"180","author":"M. Vinzing","year":"2008","unstructured":"Vinzing M., Eitel J., Lippmann J., Hocke A.C., Zahlten J., Slevogt H., Dje N\u2019Guessan P., G\u00fcnther S., Schmeck B., Hippenstiel S., Flieger A., Suttorp N., Opitz B.J.: NAIP and Ipaf control Legionella pneumophila replication in human cells. J.Immunol. 180, 6808\u20136815 (2008).","journal-title":"J.Immunol."},{"key":"84_CR54","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/IAI.62.8.3454-3462.1994","volume":"62","author":"R. Weeratna","year":"1994","unstructured":"Weeratna R., Stamler D.A., Edelstein P.H., Ripley M., Marrie T., Hoskin D., Hoffman P.S.: Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60. Infect.Immun. 62, 3454\u20133462 (1994).","journal-title":"Infect.Immun."},{"key":"84_CR55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/IAI.00070-09","volume":"78","author":"N.N. Whitfield","year":"2010","unstructured":"Whitfield N.N., Byrne B.G., Swanson M.S.: Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis. Infect.Immun. 78, 423\u2013432 (2010).","journal-title":"Infect.Immun."},{"key":"84_CR56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0960-9822(02)01359-3","volume":"13","author":"E.K. Wright","year":"2003","unstructured":"Wright E.K., Goodart S.A., Growney J.D., Hadinoto V., Endrizzi M.G., Long E.M., Sadigh K., Abney A.L., Bernstein-Hanley I., Dietrich W.F.: Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13, 27\u201336 (2003).","journal-title":"Curr. Biol."},{"key":"84_CR57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/104454902753604970","volume":"21","author":"W.S. Yoon","year":"2002","unstructured":"Yoon W.S., Park S.H., Park Y.K., Park S.C., Sin J.I., Kim M.J.: Comparison of responses elicited by immunization with a Legionella species common lipoprotein delivered as naked DNA or recombinant protein. DNA Cell Biol. 21, 99\u2013107 (2002).","journal-title":"DNA Cell Biol."},{"key":"84_CR58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1574-6968.1991.tb04970.x","volume":"4","author":"S. Yoshida","year":"1991","unstructured":"Yoshida S., Goto Y., Miyamoto H., Fujio H., Mizuguchi Y.: Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol.Immunol. 4, 51\u201356 (1991).","journal-title":"FEMS Microbiol.Immunol."},{"key":"84_CR59","first-page":"113","volume":"392","author":"U. Z\u00e4hringer","year":"1995","unstructured":"Z\u00e4hringer U., Knirel A.Y., Lindner B., Helbig J.H., Sonesson A., Marre R., Rietschel E.T.: The lipopolysaccharide of Legionella pneumophila serogroup 1 (strain Philadelphia 1): chemical structure and biological significance. Progr.Clin.Biol.Res. 392, 113\u2013139 (1995).","journal-title":"Progr.Clin.Biol.Res."},{"key":"84_CR60","doi-asserted-by":"crossref","first-page":"21046","DOI":"10.1074\/jbc.M313370200","volume":"279","author":"U. Z\u00e4hringer","year":"2004","unstructured":"Z\u00e4hringer U., Lindner B., Knirel A.Y., van den Akker W.M., Hiestand R., Heine H., Dehio C.: Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T. J.Biol.Chem. 279, 21046\u201321054 (2004).","journal-title":"J.Biol.Chem."},{"key":"84_CR61","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ni1305","volume":"7","author":"D.S. Zamboni","year":"2006","unstructured":"Zamboni D.S., Kobayashi K.S., Kohlsdorf T., Ogura Y., Long E.M., Vance R.E., Kuida K., Mariathasan S., Dixit V.M., Flavell R.A., Dietrich W.F., Roy C.R.: The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat.Immunol. 7, 318\u2013325 (2006).","journal-title":"Nat.Immunol."}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-010-0084-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12223-010-0084-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-010-0084-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T20:17:28Z","timestamp":1685823448000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12223-010-0084-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["84"],"URL":"https:\/\/doi.org\/10.1007\/s12223-010-0084-8","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}