{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:00:04Z","timestamp":1788548404586,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2016YFC1202705,AWS16J020 and AWS15J006"],"award-info":[{"award-number":["2016YFC1202705,AWS16J020 and AWS15J006"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81572045, 81672001, and 81621005"],"award-info":[{"award-number":["81572045, 81672001, and 81621005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Fundamental Research Funds for the Central Universities and Research Projects on Biomedical Transformation of China-Japan Friendship Hospital","award":["PYBZ1820"],"award-info":[{"award-number":["PYBZ1820"]}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2018ZX10201001"],"award-info":[{"award-number":["2018ZX10201001"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China.","doi-asserted-by":"crossref","award":["31900489"],"award-info":[{"award-number":["31900489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12223-020-00775-8","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T01:02:39Z","timestamp":1602810159000},"page":"925-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biological characteristics and genome analysis of a novel phage vB_KpnP_IME279 infecting Klebsiella pneumoniae"],"prefix":"10.1007","volume":"65","author":[{"given":"Rongrong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqian","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilan","family":"Zhangxiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoxing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-6829","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"775_CR1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389\u20133402","journal-title":"Nucleic Acids Res"},{"key":"775_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1017\/S0195941700062603","volume":"6","author":"ST Bagley","year":"1985","unstructured":"Bagley ST (1985) Habitat association of Klebsiella species. Infect Control 6:52\u201358","journal-title":"Infect Control"},{"key":"775_CR3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0092-8674(00)81516-0","volume":"98","author":"SD Benson","year":"1999","unstructured":"Benson SD, Bamford JK, Bamford DH, Burnett RM (1999) Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures. Cell 98:825\u2013833","journal-title":"Cell"},{"key":"775_CR4","doi-asserted-by":"publisher","first-page":"e4982","DOI":"10.1371\/journal.pone.0004982","volume":"4","author":"S Brisse","year":"2009","unstructured":"Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P (2009) Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 4:e4982","journal-title":"PLoS One"},{"key":"775_CR5","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1128\/JCM.01924-13","volume":"51","author":"S Brisse","year":"2013","unstructured":"Brisse S, Passet V, Haugaard AB, Babosan A, Kassis-Chikhani N, Struve C, Decre D (2013) wzi gene sequencing, a rapid method for determination of capsular type for Klebsiella strains. J Clin Microbiol 51:4073\u20134078","journal-title":"J Clin Microbiol"},{"key":"775_CR6","first-page":"1120","volume":"85","author":"R Bruynoghe","year":"1921","unstructured":"Bruynoghe R, Maisin J (1921) Essais de th\u00e9rapeutique au moyen du bacteriophage. CR Soc Biol 85:1120\u20131121","journal-title":"CR Soc Biol"},{"key":"775_CR7","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s00284-017-1419-3","volume":"75","author":"Y Chen","year":"2018","unstructured":"Chen Y, Sun E, Song J, Yang L, Wu B (2018) Complete genome sequence of a novel T7-like bacteriophage from a Pasteurella multocida capsular type a isolate. Curr Microbiol 75:574\u2013579","journal-title":"Curr Microbiol"},{"key":"775_CR8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00284-016-1166-x","volume":"74","author":"AA Cisek","year":"2017","unstructured":"Cisek AA, Dabrowska I, Gregorczyk KP, Wyzewski Z (2017) Phage therapy in bacterial infections treatment: one hundred years after the discovery of bacteriophages. Curr Microbiol 74:277\u2013283","journal-title":"Curr Microbiol"},{"key":"775_CR9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.qco.0000216626.05821.40","volume":"19","author":"D Craven","year":"2006","unstructured":"Craven D (2006) What is healthcare-associated pneumonia, and how should it be treated? Curr Opin Infect Dis 19:153\u2013160","journal-title":"Curr Opin Infect Dis"},{"key":"775_CR10","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0042-6822(91)90981-G","volume":"183","author":"K Eppler","year":"1991","unstructured":"Eppler K, Wyckoff E, Goates J, Parr R, Casjens S (1991) Nucleotide sequence of the bacteriophage P22 genes required for DNA packaging. Virology 183:519\u2013538","journal-title":"Virology"},{"key":"775_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.sbi.2014.08.012","volume":"28","author":"TM Gloster","year":"2014","unstructured":"Gloster TM (2014) Advances in understanding glycosyltransferases from a structural perspective. Curr Opin Struct Biol 28:131\u2013141","journal-title":"Curr Opin Struct Biol"},{"key":"775_CR12","doi-asserted-by":"publisher","first-page":"6651","DOI":"10.1093\/nar\/gkv625","volume":"43","author":"TA Guilliam","year":"2015","unstructured":"Guilliam TA, Keen BA, Brissett NC, Doherty AJ (2015) Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. Nucleic Acids Res 43:6651\u20136664","journal-title":"Nucleic Acids Res"},{"key":"775_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1053\/sper.2002.36267","volume":"26","author":"A Gupta","year":"2002","unstructured":"Gupta A (2002) Hospital-acquired infections in the neonatal intensive care unit-Klebsiella pneumoniae. Semin Perinatol 26:340\u2013345","journal-title":"Semin Perinatol"},{"key":"775_CR14","first-page":"614","volume":"60","author":"SH Hooi","year":"2005","unstructured":"Hooi SH, Hooi ST (2005) Culture-proven bacterial keratitis in a Malaysian general hospital. Med J Malaysia 60:614\u2013623","journal-title":"Med J Malaysia"},{"key":"775_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1743-422X-10-76","volume":"10","author":"AM Kropinski","year":"2013","unstructured":"Kropinski AM, Waddell T, Meng J, Franklin K, Ackermann HW, Ahmed R, Mazzocco A, Yates J 3rd, Lingohr EJ, Johnson RP (2013) The host-range, genomics and proteomics of Escherichia coli O157:H7 bacteriophage rV5. Virol J 10:76","journal-title":"Virol J"},{"key":"775_CR16","doi-asserted-by":"publisher","first-page":"D708","DOI":"10.1093\/nar\/gkx932","volume":"46","author":"EJ Lefkowitz","year":"2018","unstructured":"Lefkowitz EJ, Dempsey DM, Hendrickson RC, Orton RJ, Siddell SG, Smith DB (2018) Virus taxonomy: the database of the international committee on taxonomy of viruses (ICTV). Nucleic Acids Res 46:D708\u2013d717","journal-title":"Nucleic Acids Res"},{"key":"775_CR17","doi-asserted-by":"publisher","first-page":"e62933","DOI":"10.1371\/journal.pone.0062933","volume":"8","author":"S Lu","year":"2013","unstructured":"Lu S, Le S, Tan Y, Zhu J, Li M, Rao X, Zou L, Li S, Wang J, Jin X, Huang G, Zhang L, Zhao X, Hu F (2013) Genomic and proteomic analyses of the terminally redundant genome of the Pseudomonas aeruginosa phage PaP1: establishment of genus PaP1-like phages. PLoS One 8:e62933","journal-title":"PLoS One"},{"key":"775_CR18","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.bbagen.2016.12.025","volume":"1861","author":"NA Patil","year":"2017","unstructured":"Patil NA, Basu B, Deobagkar DD, Apte SK, Deobagkar DN (2017) Putative DNA modification methylase DR_C0020 of Deinococcus radiodurans is an atypical SAM dependent C-5 cytosine DNA methylase. Biochim Biophys Acta 1861:593\u2013602","journal-title":"Biochim Biophys Acta"},{"key":"775_CR19","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.fm.2008.12.008","volume":"26","author":"V Pereira","year":"2009","unstructured":"Pereira V, Lopes C, Castro A, Silva J, Gibbs P, Teixeira P (2009) Characterization for enterotoxin production, virulence factors, and antibiotic susceptibility of Staphylococcus aureus isolates from various foods in Portugal. Food Microbiol 26:278\u2013282","journal-title":"Food Microbiol"},{"key":"775_CR20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.coviro.2018.09.004","volume":"31","author":"PE Prevelige Jr","year":"2018","unstructured":"Prevelige PE Jr, Cortines JR (2018) Phage assembly and the special role of the portal protein. Curr Opin Virol 31:66\u201373","journal-title":"Curr Opin Virol"},{"key":"775_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1128\/CMR.00001-07","volume":"20","author":"AM Queenan","year":"2007","unstructured":"Queenan AM, Bush K (2007) Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev 20:440\u2013458","journal-title":"Clin Microbiol Rev"},{"key":"775_CR22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1067\/mda.2003.8","volume":"49","author":"A Ronald","year":"2003","unstructured":"Ronald A (2003) The etiology of urinary tract infection: traditional and emerging pathogens. Disease-a-month 49:71\u201382","journal-title":"Disease-a-month"},{"key":"775_CR23","unstructured":"Shankar PR, Balasubramanium R (2014) Antimicrobial resistance: global report on surveillance 2014. Australas Med J (Online) 7:\u2013237"},{"key":"775_CR24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.sbi.2009.12.006","volume":"20","author":"S Sun","year":"2010","unstructured":"Sun S, Rao VB, Rossmann MG (2010) Genome packaging in viruses. Curr Opin Struct Biol 20:114\u2013120","journal-title":"Curr Opin Struct Biol"},{"key":"775_CR25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s11427-012-4277-z","volume":"55","author":"H Wang","year":"2012","unstructured":"Wang H, Jin S, Chen X, Gen X, He Y (2012) Target deletion of the AAA ATPase PpCDC48II in Physcomitrella patens results in freezing sensitivity after cold acclimation. Sci China Life Sci 55:150\u2013157","journal-title":"Sci China Life Sci"},{"key":"775_CR26","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1099\/vir.0.067553-0","volume":"95","author":"Y Wang","year":"2014","unstructured":"Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J, Zhou C, Tong Y (2014) Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium. J Gen Virol 95:2565\u20132575","journal-title":"J Gen Virol"},{"key":"775_CR27","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1007\/s11262-018-1608-6","volume":"54","author":"R Wang","year":"2018","unstructured":"Wang R, Xing S, Zhao F, Li P, Mi Z, Shi T, Liu H, Tong Y (2018) Characterization and genome analysis of novel phage vB_EfaP_IME195 infecting Enterococcus faecalis. Virus Genes 54:804\u2013811","journal-title":"Virus Genes"},{"key":"775_CR28","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1007\/s00705-019-04309-7","volume":"164","author":"R Wang","year":"2019","unstructured":"Wang R, Cong Y, Mi Z, Fan H, Shi T, Liu H, Tong Y (2019) Characterization and complete genome sequence analysis of phage GP4, a novel lytic Bcep22-like podovirus. Arch Virol 164:2339\u20132343","journal-title":"Arch Virol"},{"key":"775_CR29","first-page":"547","volume":"48","author":"B Weber-Dabrowska","year":"2000","unstructured":"Weber-Dabrowska B, Mulczyk M, Gorski A (2000) Bacteriophage therapy of bacterial infections: an update of our institute's experience. Arch Immunol Ther Exp 48:547\u2013551","journal-title":"Arch Immunol Ther Exp"},{"key":"775_CR30","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1749-4486.2009.01973.x","volume":"34","author":"A Wright","year":"2009","unstructured":"Wright A, Hawkins CH, Anggard EE, Harper DR (2009) A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol 34:349\u2013357","journal-title":"Clin Otolaryngol"},{"key":"775_CR31","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12223-018-0653-9","volume":"64","author":"M Yazdi","year":"2019","unstructured":"Yazdi M, Bouzari M, Ghaemi EA (2019) Isolation and characterization of a potentially novel Siphoviridae phage (vB_SsapS-104) with lytic activity against Staphylococcus saprophyticus isolated from urinary tract infection. Folia Microbiol 64:283\u2013294","journal-title":"Folia Microbiol"},{"key":"775_CR32","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1186\/s12864-015-1612-3","volume":"16","author":"X Zhang","year":"2015","unstructured":"Zhang X, Wang Y, Li S, An X, Pei G, Huang Y, Fan H, Mi Z, Zhang Z, Wang W, Chen Y, Tong Y (2015) A novel termini analysis theory using HTS data alone for the identification of Enterococcus phage EF4-like genome termini. BMC Genomics 16:414","journal-title":"BMC Genomics"},{"key":"775_CR33","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ygeno.2010.06.001","volume":"96","author":"J Zhu","year":"2010","unstructured":"Zhu J, Rao X, Tan Y, Xiong K, Hu Z, Chen Z, Jin X, Li S, Chen Y, Hu F (2010) Identification of lytic bacteriophage MmP1, assigned to a new member of T7-like phages infecting Morganella morganii. Genomics 96:167\u2013172","journal-title":"Genomics"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-020-00775-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-020-00775-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-020-00775-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:48:08Z","timestamp":1634345288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-020-00775-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["775"],"URL":"https:\/\/doi.org\/10.1007\/s12223-020-00775-8","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"assertion":[{"value":"28 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}}]}}