{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:58:38Z","timestamp":1788379118338,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12223-020-00845-x","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T06:02:37Z","timestamp":1620194557000},"page":"623-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cell surface heat shock protein-mediated entry of tumor cell-adapted rotavirus into U-937 cells"],"prefix":"10.1007","volume":"66","author":[{"given":"Jos\u00e9","family":"Rico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-6345","authenticated-orcid":false,"given":"Carlos","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"845_CR1","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1128\/JVI.01787-14","volume":"89","author":"CF Arias","year":"2015","unstructured":"Arias CF, Silva-Ayala D, L\u00f3pez S (2015) Rotavirus entry: a deep journey into the cell with several exits. J Virol 89:890\u2013893. https:\/\/doi.org\/10.1128\/JVI.01787-14","journal-title":"J Virol"},{"key":"845_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ebiom.2016.06.046","volume":"9","author":"CJ Breitbach","year":"2016","unstructured":"Breitbach CJ, Lichty BD, Bell JC (2016) Oncolytic viruses: therapeutics with an identity crisis. EBioMedicine 9:31\u201336. https:\/\/doi.org\/10.1016\/j.ebiom.2016.06.046","journal-title":"EBioMedicine"},{"key":"845_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.tibs.2016.01.003","volume":"41","author":"SK Calderwood","year":"2016","unstructured":"Calderwood SK, Gong J (2016) Heat shock proteins promote cancer: it\u2019s a protection racket. Trends Biochem Sci 41:311\u2013323. https:\/\/doi.org\/10.1016\/j.tibs.2016.01.003","journal-title":"Trends Biochem Sci"},{"key":"845_CR4","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.3390\/ijms18091978","volume":"18","author":"S Chatterjee","year":"2017","unstructured":"Chatterjee S, Burns T (2017) Targeting heat shock proteins in cancer: a promising therapeutic approach. Int J Mol Sci 18:1978. https:\/\/doi.org\/10.3390\/ijms18091978","journal-title":"Int J Mol Sci"},{"key":"845_CR5","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1128\/jvi.76.3.1109-1123.2002","volume":"76","author":"M Ciarlet","year":"2002","unstructured":"Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK (2002) VLA-2 (\u03b12\u03b21) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol 76:1109\u20131123. https:\/\/doi.org\/10.1128\/jvi.76.3.1109-1123.2002","journal-title":"J Virol"},{"key":"845_CR6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1379\/CSC-99r.1","volume":"10","author":"DR Ciocca","year":"2005","unstructured":"Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86\u2013103. https:\/\/doi.org\/10.1379\/CSC-99r.1","journal-title":"Cell Stress Chaperones"},{"issue":"Pt 1","key":"845_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1042\/bj3000201","volume":"300","author":"G Elia","year":"1994","unstructured":"Elia G, Santoro MG (1994) Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem J 300(Pt 1):201\u2013209. https:\/\/doi.org\/10.1042\/bj3000201","journal-title":"Biochem J"},{"key":"845_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1128\/jvi.37.1.156-160.1981","volume":"37","author":"RT Espejo","year":"1981","unstructured":"Espejo RT, L\u00f3pez S, Arias C (1981) Structural polypeptides of simian rotavirus SA11 and the effect of trypsin. J Virol 37:156\u2013160","journal-title":"J Virol"},{"key":"845_CR9","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1093\/nar\/gki526","volume":"33","author":"D Gadelle","year":"2005","unstructured":"Gadelle D, Bocs C, Graille M, Forterre P (2005) Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res 33:2310\u20132317. https:\/\/doi.org\/10.1093\/nar\/gki526","journal-title":"Nucleic Acids Res"},{"key":"845_CR10","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1007\/s00705-007-1055-5","volume":"152","author":"DF Gualtero","year":"2007","unstructured":"Gualtero DF, Guzm\u00e1n F, Acosta O, Guerrero CA (2007) Amino acid domains 280\u2013297 of VP6 and 531\u2013554 of VP4 are implicated in heat shock cognate protein hsc70-mediated rotavirus infection. Arch Virol 152:2183\u20132196. https:\/\/doi.org\/10.1007\/s00705-007-1055-5","journal-title":"Arch Virol"},{"key":"845_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.5501\/wjv.v5.i2.38","volume":"5","author":"CA Guerrero","year":"2016","unstructured":"Guerrero CA, Acosta O (2016) Inflammatory and oxidative stress in rotavirus infection. World J Virol 5:38. https:\/\/doi.org\/10.5501\/wjv.v5.i2.38","journal-title":"World J Virol"},{"key":"845_CR12","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1128\/JVI.76.8.4096-4102.2002","volume":"76","author":"CA Guerrero","year":"2002","unstructured":"Guerrero CA, Bouyssounade D, Zarate S, Isa P, Lopez T, Espinosa R, Romero P, Mendez E, Lopez S, Arias CF (2002) Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol 76:4096\u20134102. https:\/\/doi.org\/10.1128\/JVI.76.8.4096-4102.2002","journal-title":"J Virol"},{"key":"845_CR13","doi-asserted-by":"publisher","first-page":"e0147666","DOI":"10.1371\/journal.pone.0147666","volume":"11","author":"CA Guerrero","year":"2016","unstructured":"Guerrero CA, Guerrero RA, Silva E, Acosta O, Barreto E (2016) Experimental adaptation of rotaviruses to tumor cell lines. PLoS One 11:e0147666. https:\/\/doi.org\/10.1371\/journal.pone.0147666","journal-title":"PLoS One"},{"key":"845_CR14","doi-asserted-by":"publisher","first-page":"14644","DOI":"10.1073\/pnas.250299897","volume":"97","author":"CA Guerrero","year":"2000","unstructured":"Guerrero CA, M\u00e9ndez E, Z\u00e1rate S, Isa P, L\u00f3pez S, Arias CF (2000) Integrin \u03b1v\u03b23 mediates rotavirus cell entry. Proc Natl Acad Sci 97:14644\u201314649. https:\/\/doi.org\/10.1073\/pnas.250299897","journal-title":"Proc Natl Acad Sci"},{"key":"845_CR15","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1128\/jvi.74.20.9362-9371.2000","volume":"74","author":"CA Guerrero","year":"2000","unstructured":"Guerrero CA, Z\u00e1rate S, Corkidi G, L\u00f3pez S, Arias CF (2000) Biochemical characterization of rotavirus receptors in MA104 cells. J Virol 74:9362\u20139371. https:\/\/doi.org\/10.1128\/jvi.74.20.9362-9371.2000","journal-title":"J Virol"},{"key":"845_CR16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1128\/jvi.74.1.228-236.2000","volume":"74","author":"MJ Hewish","year":"2000","unstructured":"Hewish MJ, Takada Y, Coulson BS (2000) Integrins \u03b12\u03b21 and \u03b14\u03b21 can mediate SA11 rotavirus attachment and entry into cells. J Virol 74:228\u2013236. https:\/\/doi.org\/10.1128\/jvi.74.1.228-236.2000","journal-title":"J Virol"},{"key":"845_CR17","doi-asserted-by":"publisher","unstructured":"Hill C, Carlisle R (2019) Achieving systemic delivery of oncolytic viruses. Expert Opin Drug Deliv 1\u201314. https:\/\/doi.org\/10.1080\/17425247.2019.1617269","DOI":"10.1080\/17425247.2019.1617269"},{"key":"845_CR18","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fonc.2017.00195","volume":"7","author":"A Howells","year":"2017","unstructured":"Howells A, Marelli G, Lemoine NR, Wang Y (2017) Oncolytic viruses-interaction of virus and tumor cells in the battle to eliminate cancer. Front Oncol 7:195. https:\/\/doi.org\/10.3389\/fonc.2017.00195","journal-title":"Front Oncol"},{"key":"845_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3109\/07853899908995889","volume":"31","author":"M Jatella","year":"1999","unstructured":"Jatella M (1999) Heat shock proteins as cellular lifeguard. Ann Med 31:261. https:\/\/doi.org\/10.3109\/07853899908995889","journal-title":"Ann Med"},{"key":"845_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/OV.S218494","volume":"8","author":"N Jayawardena","year":"2019","unstructured":"Jayawardena N, Burga LN, Poirier JT, Bostina M (2019) Virus\u2013receptor interactions: structural insights for oncolytic virus development. Oncolytic Virotherapy 8:39. https:\/\/doi.org\/10.2147\/OV.S218494","journal-title":"Oncolytic Virotherapy"},{"key":"845_CR21","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1159\/000080882","volume":"47","author":"S Jindadamrongwech","year":"2004","unstructured":"Jindadamrongwech S, Smith DR (2004) Virus overlay protein binding assay (VOPBA) reveals serotype specific heterogeneity of dengue virus binding proteins on HepG2 human liver cells. Intervirology 47:370. https:\/\/doi.org\/10.1159\/000080882","journal-title":"Intervirology"},{"key":"845_CR22","doi-asserted-by":"publisher","first-page":"e1683","DOI":"10.7717\/peerj.1683","volume":"4","author":"CY Kao","year":"2016","unstructured":"Kao CY, Yang PM, Wu MH, Huang CC, Lee YC, Lee KH (2016) Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells. PeerJ 4:e1683. https:\/\/doi.org\/10.7717\/peerj.1683","journal-title":"PeerJ"},{"key":"845_CR23","doi-asserted-by":"publisher","first-page":"7507","DOI":"10.1038\/s41598-019-43556-1","volume":"9","author":"M Klimczak","year":"2019","unstructured":"Klimczak M, Biecek P, Zylicz A, Zylicz M (2019) Heat shock proteins create a signature to predict the clinical outcome in breast cancer. Sci Rep 9:7507. https:\/\/doi.org\/10.1038\/s41598-019-43556-1","journal-title":"Sci Rep"},{"key":"845_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.5483\/bmbrep.2017.50.8.107","volume":"50","author":"E Lee","year":"2017","unstructured":"Lee E, Lee DH (2017) Emerging roles of protein disulfide isomerase in cancer. BMB Rep 50:401. https:\/\/doi.org\/10.5483\/bmbrep.2017.50.8.107","journal-title":"BMB Rep"},{"key":"845_CR25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1021\/bi00377a012","volume":"26","author":"PH Lin","year":"1987","unstructured":"Lin PH, Selinfreund R, Wakshull E, Wharton W (1987) Rapid and efficient purification of plasma membrane from cultured cells: characterization of epidermal growth factor binding. Biochemistry 26:731\u2013736. https:\/\/doi.org\/10.1021\/bi00377a012","journal-title":"Biochemistry"},{"key":"845_CR26","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.pharmthera.2012.08.014","volume":"136","author":"T Liu","year":"2012","unstructured":"Liu T, Daniels CK, Cao S (2012) Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential. Pharmacol Ther 136:354\u2013374. https:\/\/doi.org\/10.1016\/j.pharmthera.2012.08.014","journal-title":"Pharmacol Ther"},{"key":"845_CR27","doi-asserted-by":"publisher","first-page":"927","DOI":"10.4155\/fmc.12.50","volume":"4","author":"Z Nahleh","year":"2012","unstructured":"Nahleh Z, Tfayli A, Najm A, El Sayed A, Nahle Z (2012) Heat shock proteins in cancer: targeting the \u2018chaperones.\u2019 Future Med Chem 4:927\u2013935. https:\/\/doi.org\/10.4155\/fmc.12.50","journal-title":"Future Med Chem"},{"key":"845_CR28","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.3892\/ol.2018.8076","volume":"15","author":"B Pan","year":"2018","unstructured":"Pan B, Guo J, Liao Q, Zhao Y (2018) \u03b21 and \u03b23 integrins in breast, prostate and pancreatic cancer: A novel implication. Oncol Lett 15:5412\u20135416. https:\/\/doi.org\/10.3892\/ol.2018.8076","journal-title":"Oncol Lett"},{"key":"845_CR29","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.omto.2019.03.001","volume":"13","author":"TM Pearl","year":"2019","unstructured":"Pearl TM, Markert JM, Cassady KA, Ghonime MG (2019) Oncolytic virus-based cytokine expression to improve immune activity in brain and solid tumors. Mol Ther Oncolytics 13:14. https:\/\/doi.org\/10.1016\/j.omto.2019.03.001","journal-title":"Mol Ther Oncolytics"},{"key":"845_CR30","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40425-018-0458-z","volume":"6","author":"J Raja","year":"2018","unstructured":"Raja J, Ludwig JM, Gettinger SN, Schalper KA, Kim HS (2018) Oncolytic virus immunotherapy: future prospects for oncology. J Immunother Cancer 6:140. https:\/\/doi.org\/10.1186\/s40425-018-0458-z","journal-title":"J Immunother Cancer"},{"key":"845_CR31","first-page":"4339","volume":"20","author":"Y Rong","year":"2000","unstructured":"Rong Y, Yang EB, Zhang K, Mack P (2000) Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression. Anticancer Res 20:4339\u20134345","journal-title":"Anticancer Res"},{"key":"845_CR32","doi-asserted-by":"publisher","unstructured":"Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N (2017) Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer. Oncotarget 8:103543. https:\/\/doi.org\/10.18632\/oncotarget.21569","DOI":"10.18632\/oncotarget.21569"},{"key":"845_CR33","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1371\/journal.pone.0078443","volume":"18","author":"TG Santos","year":"2017","unstructured":"Santos TG, Martins V, Hajj G (2017) Unconventional secretion of heat shock proteins in cancer. Int J Mol Sci 18:946. https:\/\/doi.org\/10.1371\/journal.pone.0078443","journal-title":"Int J Mol Sci"},{"key":"845_CR34","doi-asserted-by":"publisher","first-page":"e78443","DOI":"10.1371\/journal.pone.0078443","volume":"8","author":"R Schlecht","year":"2013","unstructured":"Schlecht R, Scholz SR, Dahmen H, Wegener A, Sirrenberg C, Musil D, Bomke J, Eggenweiler HM, Mayer MP, Bukau B (2013) Functional analysis of Hsp70 inhibitors. PLoS One 8:e78443. https:\/\/doi.org\/10.1371\/journal.pone.0078443","journal-title":"PLoS One"},{"key":"845_CR35","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1371\/journal.pone.0078443","volume":"81","author":"J Schneider-Schaulies","year":"2000","unstructured":"Schneider-Schaulies J (2000) Cellular receptors for viruses: links to tropism and pathogenesis. J Gen Virol 81:1413\u20131429. https:\/\/doi.org\/10.1371\/journal.pone.0078443","journal-title":"J Gen Virol"},{"key":"845_CR36","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.tips.2016.11.009","volume":"38","author":"J Wu","year":"2017","unstructured":"Wu J, Liu T, Rios Z, Mei Q, Lin X, Cao S (2017) Heat shock proteins and cancer. Trends Pharmacol Sci 38:226\u2013256. https:\/\/doi.org\/10.1016\/j.tips.2016.11.009","journal-title":"Trends Pharmacol Sci"},{"key":"845_CR37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.drudis.2013.10.017","volume":"19","author":"S Xu","year":"2014","unstructured":"Xu S, Sankar S, Neamati N (2014) Protein disulfide isomerase: a promising target for cancer therapy. Drug Discov Today 19:222\u2013240. https:\/\/doi.org\/10.1016\/j.drudis.2013.10.017","journal-title":"Drug Discov Today"},{"key":"845_CR38","doi-asserted-by":"publisher","first-page":"7345","DOI":"10.2147\/IJN.S93758","volume":"10","author":"R Yang","year":"2015","unstructured":"Yang R, Tang Q, Miao F, An Y, Li M, Han Y, Wang X, Wang J, Liu P, Chen R (2015) Inhibition of heat-shock protein 90 sensitizes liver cancer stem-like cells to magnetic hyperthermia and enhances anti-tumor effect on hepatocellular carcinoma-burdened nude mice. Int J Nanomedicine 10:7345\u20137358. https:\/\/doi.org\/10.2147\/IJN.S93758","journal-title":"Int J Nanomedicine"},{"key":"845_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/OV.S176523","volume":"8","author":"SS Zainutdinov","year":"2019","unstructured":"Zainutdinov SS, Kochneva GV, Netesov SV, Chumakov PM, Matveeva OV (2019) Directed evolution as a tool for the selection of oncolytic RNA viruses with desired phenotypes. Oncolytic Virotherapy 8:9. https:\/\/doi.org\/10.2147\/OV.S176523","journal-title":"Oncolytic Virotherapy"},{"key":"845_CR40","doi-asserted-by":"publisher","first-page":"7254","DOI":"10.1128\/JVI.77.13.7254-7260.2003","volume":"77","author":"S Z\u00e1rate","year":"2003","unstructured":"Z\u00e1rate S, Cuadras MA, Espinosa R, Romero P, Ju\u00e1rez KO, Camacho-Nuez M, Arias CF, L\u00f3pez S (2003) Interaction of rotaviruses with Hsc70 during cell entry is mediated by VP5. J Virol 77:7254\u20137260. https:\/\/doi.org\/10.1128\/JVI.77.13.7254-7260.2003","journal-title":"J Virol"},{"key":"845_CR41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/viro.2000.0660","volume":"278","author":"S Z\u00e1rate","year":"2000","unstructured":"Z\u00e1rate S, Espinosa R, Romero P, Guerrero CA, Arias CF, L\u00f3pez S (2000) Integrin \u03b12\u03b21 mediates the cell attachment of the rotavirus neuraminidase-resistant variant nar3. Virology 278:50\u201354. https:\/\/doi.org\/10.1006\/viro.2000.0660","journal-title":"Virology"},{"key":"845_CR42","doi-asserted-by":"publisher","first-page":"10839","DOI":"10.1128\/JVI.78.20.10839-10847.2004","volume":"78","author":"S Z\u00e1rate","year":"2004","unstructured":"Z\u00e1rate S, Romero P, Espinosa R, Arias CF, L\u00f3pez S (2004) VP7 mediates the interaction of rotaviruses with integrin \u03b1v\u03b23 through a novel integrin-binding site. J Virol 78:10839\u201310847. https:\/\/doi.org\/10.1128\/JVI.78.20.10839-10847.2004","journal-title":"J Virol"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-020-00845-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-020-00845-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-020-00845-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T06:22:19Z","timestamp":1626934939000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-020-00845-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["845"],"URL":"https:\/\/doi.org\/10.1007\/s12223-020-00845-x","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"assertion":[{"value":"14 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors. The authors declare no conflict of interests with any organization.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}