{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:01:45Z","timestamp":1792594905031,"version":"4.5.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s12223-023-01033-3","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T10:03:17Z","timestamp":1673344997000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Role of oral and gut microbiota in childhood obesity"],"prefix":"10.1007","volume":"68","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-3716","authenticated-orcid":false,"given":"Shaochen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"1033_CR1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.5114\/aoms.2011.23418","volume":"7","author":"N Abdallah Ismail","year":"2011","unstructured":"Abdallah Ismail N, Ragab SH, Abd Elbaky A et al (2011) Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults. Arch Med Sci 7:501\u2013507","journal-title":"Arch Med Sci"},{"key":"1033_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/MCG.0000000000000410","volume":"50","author":"M Agrawal","year":"2016","unstructured":"Agrawal M, Aroniadis OC, Brandt LJ et al (2016) The long-term efficacy and safety of fecal microbiota transplant for recurrent, severe, and complicated Clostridium difficile infection in 146 elderly individuals. J Clin Gastroenterol 50:403\u2013407","journal-title":"J Clin Gastroenterol"},{"key":"1033_CR3","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","volume":"146","author":"LG Albenberg","year":"2014","unstructured":"Albenberg LG, Wu GD (2014) Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology 146:1564\u20131572","journal-title":"Gastroenterology"},{"key":"1033_CR4","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3389\/fped.2020.00429","volume":"8","author":"DS Araujo","year":"2020","unstructured":"Araujo DS, Klein MI, Scudine KGO et al (2020) Salivary microbiological and gingival health status evaluation of adolescents with overweight and obesity: a cluster analysis. Front Pediatr 8:429","journal-title":"Front Pediatr"},{"key":"1033_CR5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3389\/fphys.2019.00704","volume":"10","author":"DA Argueta","year":"2019","unstructured":"Argueta DA, Perez PA, Makriyannis A, DiPatrizio NV (2019) Cannabinoid CB1 receptors inhibit gut-brain satiation signaling in diet-induced obesity. Front Physiol 10:704","journal-title":"Front Physiol"},{"key":"1033_CR6","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1038\/srep04828","volume":"4","author":"K Arimatsu","year":"2014","unstructured":"Arimatsu K, Yamada H, Miyazawa H et al (2014) Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep 4:4828","journal-title":"Sci Rep"},{"key":"1033_CR7","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","volume":"101","author":"F B\u00e4ckhed","year":"2004","unstructured":"B\u00e4ckhed F, Ding H, Wang T et al (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101:15718\u201315723","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1033_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1882926","volume":"13","author":"B Balakrishnan","year":"2021","unstructured":"Balakrishnan B, Selvaraju V, Chen J et al (2021) Ethnic variability associating gut and oral microbiome with obesity in children. Gut Microbes 13:1\u201315","journal-title":"Gut Microbes"},{"key":"1033_CR9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00018-015-2083-z","volume":"73","author":"PV Bauer","year":"2016","unstructured":"Bauer PV, Hamr SC, Duca FA (2016) Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota. Cell Mol Life Sci 73:737\u2013755","journal-title":"Cell Mol Life Sci"},{"key":"1033_CR10","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1128\/AEM.00342-14","volume":"80","author":"A Bergstr\u00f6m","year":"2014","unstructured":"Bergstr\u00f6m A, Skov TH, Bahl MI et al (2014) Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol 80:2889\u20132900","journal-title":"Appl Environ Microbiol"},{"key":"1033_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1757-4749-5-10","volume":"5","author":"L Bervoets","year":"2013","unstructured":"Bervoets L, Van Hoorenbeeck K, Kortleven I et al (2013) Differences in gut microbiota composition between obese and lean children: a cross-sectional study. Gut Pathog 5:10","journal-title":"Gut Pathog"},{"key":"1033_CR12","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1902\/jop.2014.140070","volume":"85","author":"UG Bhat","year":"2014","unstructured":"Bhat UG, Ilievski V, Unterman TG, Watanabe K (2014) Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic \u03b2 cell line MIN6. J Periodontol 85:1629\u20131636","journal-title":"J Periodontol"},{"key":"1033_CR13","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1136\/gutjnl-2015-309897","volume":"66","author":"V Blasco-Baque","year":"2017","unstructured":"Blasco-Baque V, Garidou L, Pomi\u00e9 C et al (2017) Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut 66:872\u2013885","journal-title":"Gut"},{"key":"1033_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13073-016-0303-2","volume":"8","author":"CL Boulang\u00e9","year":"2016","unstructured":"Boulang\u00e9 CL, Neves AL, Chilloux J et al (2016) Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med 8:42","journal-title":"Genome Med"},{"key":"1033_CR15","unstructured":"Bureau of Disease Prevention and Control, National Health and Wellness Commission of the PRC (2022) Report on the status of nutrition and chronic diseases in China. People\u2019s Medical Publishing House, Beijing"},{"key":"1033_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238910","volume":"15","author":"L de Caldeira","year":"2020","unstructured":"de Caldeira L, F, Borba HH, Tonin FS, et al (2020) Fecal microbiota transplantation in inflammatory bowel disease patients: a systematic review and meta-analysis. PLoS ONE 15:e0238910","journal-title":"PLoS ONE"},{"key":"1033_CR17","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani PD, Amar J, Iglesias MA et al (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761\u20131772","journal-title":"Diabetes"},{"key":"1033_CR18","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","volume":"57","author":"PD Cani","year":"2008","unstructured":"Cani PD, Bibiloni R, Knauf C et al (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57:1470\u20131481","journal-title":"Diabetes"},{"key":"1033_CR19","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","volume":"130","author":"EM Cardoso","year":"2018","unstructured":"Cardoso EM, Reis C, Manzanares-C\u00e9spedes MC (2018) Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgrad Med 130:98\u2013104","journal-title":"Postgrad Med"},{"key":"1033_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2014.11.010","volume":"17","author":"RN Carmody","year":"2015","unstructured":"Carmody RN, Gerber GK, Luevano JM et al (2015) Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe 17:72\u201384","journal-title":"Cell Host Microbe"},{"key":"1033_CR21","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/j.1600-051X.2011.01717.x","volume":"38","author":"DM Castillo","year":"2011","unstructured":"Castillo DM, S\u00e1nchez-Beltr\u00e1n MC, Castellanos JE et al (2011) Detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. J Clin Periodontol 38:418\u2013427","journal-title":"J Clin Periodontol"},{"key":"1033_CR22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4291\/wjgp.v6.i4.110","volume":"6","author":"CK Chakraborti","year":"2015","unstructured":"Chakraborti CK (2015) New-found link between microbiota and obesity. World J Gastrointest Pathophysiol 6:110\u2013119","journal-title":"World J Gastrointest Pathophysiol"},{"key":"1033_CR23","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8317","volume":"8","author":"X Chen","year":"2020","unstructured":"Chen X, Sun H, Jiang F et al (2020) Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing. PeerJ 8:e8317","journal-title":"PeerJ"},{"key":"1033_CR24","doi-asserted-by":"publisher","first-page":"14030","DOI":"10.1038\/s41598-018-31866-9","volume":"8","author":"SJC Craig","year":"2018","unstructured":"Craig SJC, Blankenberg D, Parodi ACL et al (2018) Child weight gain trajectories linked to oral microbiota composition. Sci Rep 8:14030","journal-title":"Sci Rep"},{"key":"1033_CR25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.redox.2017.11.002","volume":"14","author":"E Cremonini","year":"2018","unstructured":"Cremonini E, Wang Z, Bettaieb A et al (2018) (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol 14:588\u2013599","journal-title":"Redox Biol"},{"key":"1033_CR26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"LA David","year":"2014","unstructured":"David LA, Maurice CF, Carmody RN et al (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505:559\u2013563","journal-title":"Nature"},{"key":"1033_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.nut.2018.07.017","volume":"59","author":"JM Davison","year":"2019","unstructured":"Davison JM, Wischmeyer PE (2019) Probiotic and synbiotic therapy in the critically ill: State of the art. Nutrition 59:29\u201336","journal-title":"Nutrition"},{"key":"1033_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134893","volume":"10","author":"B Di Luccia","year":"2015","unstructured":"Di Luccia B, Crescenzo R, Mazzoli A et al (2015) Rescue of fructose-induced metabolic syndrome by antibiotics or faecal transplantation in a rat model of obesity. PLoS ONE 10:e0134893","journal-title":"PLoS ONE"},{"key":"1033_CR29","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s40264-019-00809-2","volume":"42","author":"X Ding","year":"2019","unstructured":"Ding X, Li Q, Li P et al (2019) Long-term safety and efficacy of fecal microbiota transplant in active ulcerative colitis. Drug Saf 42:869\u2013880","journal-title":"Drug Saf"},{"key":"1033_CR30","doi-asserted-by":"publisher","first-page":"E3221","DOI":"10.3390\/nu12103221","volume":"12","author":"TS Dong","year":"2020","unstructured":"Dong TS, Luu K, Lagishetty V et al (2020) A high protein calorie restriction diet alters the gut microbiome in obesity. Nutrients 12:E3221","journal-title":"Nutrients"},{"key":"1033_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s13679-017-0261-z","volume":"6","author":"KA Erion","year":"2017","unstructured":"Erion KA, Corkey BE (2017) Hyperinsulinemia: a cause of obesity? Curr Obes Rep 6:178\u2013186","journal-title":"Curr Obes Rep"},{"key":"1033_CR32","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3389\/fped.2020.00369","volume":"8","author":"S Esposito","year":"2020","unstructured":"Esposito S, Biscarini A, Federici B et al (2020) Role of small intestinal bacterial overgrowth (SIBO) and inflammation in obese children. Front Pediatr 8:369","journal-title":"Front Pediatr"},{"key":"1033_CR33","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s12519-020-00341-9","volume":"16","author":"MF Faienza","year":"2020","unstructured":"Faienza MF, Chiarito M, Molina-Molina E et al (2020) Childhood obesity, cardiovascular and liver health: a growing epidemic with age. World J Pediatr 16:438\u2013445","journal-title":"World J Pediatr"},{"key":"1033_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232739","volume":"15","author":"H Fretheim","year":"2020","unstructured":"Fretheim H, Chung BK, Didriksen H et al (2020) Fecal microbiota transplantation in systemic sclerosis: a double-blind, placebo-controlled randomized pilot trial. PLoS ONE 15:e0232739","journal-title":"PLoS ONE"},{"key":"1033_CR35","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1007\/s13238-018-0548-1","volume":"9","author":"L Gao","year":"2018","unstructured":"Gao L, Xu T, Huang G et al (2018) Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell 9:488\u2013500","journal-title":"Protein Cell"},{"key":"1033_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2020.102248","volume":"70","author":"A Gasmi Benahmed","year":"2021","unstructured":"Gasmi Benahmed A, Gasmi A, Do\u015fa A et al (2021) Association between the gut and oral microbiome with obesity. Anaerobe 70:102248","journal-title":"Anaerobe"},{"key":"1033_CR37","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1210\/en.2008-0059","volume":"149","author":"H Ge","year":"2008","unstructured":"Ge H, Li X, Weiszmann J et al (2008) Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 149:4519\u20134526","journal-title":"Endocrinology"},{"key":"1033_CR38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1079\/NRR200479","volume":"17","author":"GR Gibson","year":"2004","unstructured":"Gibson GR, Probert HM, Loo JV et al (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259\u2013275","journal-title":"Nutr Res Rev"},{"key":"1033_CR39","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.1124234","volume":"312","author":"SR Gill","year":"2006","unstructured":"Gill SR, Pop M, Deboy RT et al (2006) Metagenomic analysis of the human distal gut microbiome. Science 312:1355\u20131359","journal-title":"Science"},{"key":"1033_CR40","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","volume":"113","author":"EZ Gomaa","year":"2020","unstructured":"Gomaa EZ (2020) Human gut microbiota\/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek 113:2019\u20132040","journal-title":"Antonie Van Leeuwenhoek"},{"key":"1033_CR41","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/nutrit\/nuv004","volume":"73","author":"C Graham","year":"2015","unstructured":"Graham C, Mullen A, Whelan K (2015) Obesity and the gastrointestinal microbiota: a review of associations and mechanisms. Nutr Rev 73:376\u2013385","journal-title":"Nutr Rev"},{"key":"1033_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","volume":"98","author":"DT Graves","year":"2019","unstructured":"Graves DT, Corr\u00eaa JD, Silva TA (2019) The oral microbiota is modified by systemic diseases. J Dent Res 98:148\u2013156","journal-title":"J Dent Res"},{"key":"1033_CR43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fphys.2011.00094","volume":"2","author":"S Grenham","year":"2011","unstructured":"Grenham S, Clarke G, Cryan JF, Dinan TG (2011) Brain-gut-microbe communication in health and disease. Front Physiol 2:94","journal-title":"Front Physiol"},{"key":"1033_CR44","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1902\/jop.2013.130117","volume":"85","author":"P G\u00fcm\u00fc\u015f","year":"2014","unstructured":"G\u00fcm\u00fc\u015f P, Nizam N, Lappin DF, Buduneli N (2014a) Saliva and serum levels of B-cell activating factors and tumor necrosis factor-\u03b1 in patients with periodontitis. J Periodontol 85:270\u2013280","journal-title":"J Periodontol"},{"key":"1033_CR45","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1902\/jop.2013.130281","volume":"85","author":"P G\u00fcm\u00fc\u015f","year":"2014","unstructured":"G\u00fcm\u00fc\u015f P, Nizam N, Nalbantsoy A et al (2014b) Saliva and serum levels of pentraxin-3 and interleukin-1\u03b2 in generalized aggressive or chronic periodontitis. J Periodontol 85:e40-46","journal-title":"J Periodontol"},{"key":"1033_CR46","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3390\/jcm10020330","volume":"10","author":"R Hassouneh","year":"2021","unstructured":"Hassouneh R, Bajaj JS (2021) Gut microbiota modulation and fecal transplantation: an overview on innovative strategies for hepatic encephalopathy treatment. J Clin Med 10:330","journal-title":"J Clin Med"},{"key":"1033_CR47","first-page":"37","volume":"33","author":"SE Hussey","year":"2012","unstructured":"Hussey SE, Liang H, Costford SR et al (2012) TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep 33:37\u201347","journal-title":"Biosci Rep"},{"key":"1033_CR48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12326","volume":"83","author":"S Jepsen","year":"2000","unstructured":"Jepsen S, Suvan J, Deschner J (2000) The association of periodontal diseases with metabolic syndrome and obesity. Periodontol 83:125\u2013153","journal-title":"Periodontol"},{"key":"1033_CR49","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1038\/s41598-019-42183-0","volume":"9","author":"D-W Kang","year":"2019","unstructured":"Kang D-W, Adams JB, Coleman DM et al (2019) Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota. Sci Rep 9:5821","journal-title":"Sci Rep"},{"key":"1033_CR50","doi-asserted-by":"crossref","unstructured":"Kato T, Yamazaki K, Nakajima M, et al (2018) Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome. mSphere 3:e00460\u201318","DOI":"10.1128\/mSphere.00460-18"},{"key":"1033_CR51","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/ncomms2852","volume":"4","author":"I Kimura","year":"2013","unstructured":"Kimura I, Ozawa K, Inoue D et al (2013) The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 4:1829","journal-title":"Nat Commun"},{"key":"1033_CR52","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/qjmed\/hcx152","volume":"111","author":"D Kinlen","year":"2018","unstructured":"Kinlen D, Cody D, O\u2019Shea D (2018) Complications of obesity. QJM 111:437\u2013443","journal-title":"QJM"},{"key":"1033_CR53","doi-asserted-by":"publisher","first-page":"E84","DOI":"10.3390\/medicina55040084","volume":"55","author":"RJ Klement","year":"2019","unstructured":"Klement RJ, Pazienza V (2019) Impact of different types of diet on gut microbiota profiles and cancer prevention and treatment. Medicina (kaunas) 55:E84","journal-title":"Medicina (kaunas)"},{"key":"1033_CR54","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.3390\/nu7042237","volume":"7","author":"PT Koleva","year":"2015","unstructured":"Koleva PT, Bridgman SL, Kozyrskyj AL (2015) The infant gut microbiome: evidence for obesity risk and dietary intervention. Nutrients 7:2237\u20132260","journal-title":"Nutrients"},{"key":"1033_CR55","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/odi.12509","volume":"23","author":"K Krishnan","year":"2017","unstructured":"Krishnan K, Chen T, Paster BJ (2017) A practical guide to the oral microbiome and its relation to health and disease. Oral Dis 23:276\u2013286","journal-title":"Oral Dis"},{"key":"1033_CR56","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.mayocp.2016.09.017","volume":"92","author":"S Kumar","year":"2017","unstructured":"Kumar S, Kelly AS (2017) Review of childhood obesity: from epidemiology, etiology, and comorbidities to clinical assessment and treatment. Mayo Clin Proc 92:251\u2013265","journal-title":"Mayo Clin Proc"},{"key":"1033_CR57","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1113\/JP275277","volume":"596","author":"T-C Lee","year":"2018","unstructured":"Lee T-C, Huang Y-C, Lu Y-Z et al (2018) Hypoxia-induced intestinal barrier changes in balloon-assisted enteroscopy. J Physiol 596:3411\u20133424","journal-title":"J Physiol"},{"key":"1033_CR58","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.30415","volume":"3","author":"KSW Leong","year":"2020","unstructured":"Leong KSW, Jayasinghe TN, Wilson BC et al (2020) Effects of fecal microbiome transfer in adolescents with obesity: the gut bugs randomized controlled trial. JAMA Netw Open 3:e2030415","journal-title":"JAMA Netw Open"},{"key":"1033_CR59","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1073\/pnas.0504978102","volume":"102","author":"RE Ley","year":"2005","unstructured":"Ley RE, B\u00e4ckhed F, Turnbaugh P et al (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102:11070\u201311075","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1033_CR60","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12020-015-0560-7","volume":"50","author":"Y Liang","year":"2015","unstructured":"Liang Y, Hou D, Zhao X et al (2015) Childhood obesity affects adult metabolic syndrome and diabetes. Endocrine 50:87\u201392","journal-title":"Endocrine"},{"key":"1033_CR61","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1902\/jop.2005.76.11-S.2106","volume":"76","author":"BG Loos","year":"2005","unstructured":"Loos BG (2005) Systemic markers of inflammation in periodontitis. J Periodontol 76:2106\u20132115","journal-title":"J Periodontol"},{"key":"1033_CR62","doi-asserted-by":"publisher","first-page":"1487741","DOI":"10.1080\/20002297.2018.1487741","volume":"10","author":"TGB Louren\u03c2o","year":"2018","unstructured":"Louren\u03c2o TGB, Spencer SJ, Alm EJ, Colombo APV (2018) Defining the gut microbiota in individuals with periodontal diseases: an exploratory study. J Oral Microbiol 10:1487741","journal-title":"J Oral Microbiol"},{"key":"1033_CR63","doi-asserted-by":"crossref","unstructured":"Mameli C, Cattaneo C, Panelli S et al (2019) Taste perception and oral microbiota are associated with obesity in children and adolescents. PLoS One 14:e0221656","DOI":"10.1371\/journal.pone.0221656"},{"key":"1033_CR64","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12960","volume":"21","author":"N Manohar","year":"2020","unstructured":"Manohar N, Hayen A, Fahey P, Arora A (2020) Obesity and dental caries in early childhood: a systematic review and meta-analyses. Obes Rev 21:e12960","journal-title":"Obes Rev"},{"key":"1033_CR65","doi-asserted-by":"publisher","first-page":"E1021","DOI":"10.3390\/nu9091021","volume":"9","author":"P Markowiak","year":"2017","unstructured":"Markowiak P, \u015ali\u017cewska K (2017) Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9:E1021","journal-title":"Nutrients"},{"key":"1033_CR66","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/cix1085","volume":"66","author":"LC McDonald","year":"2018","unstructured":"McDonald LC, Gerding DN, Johnson S et al (2018) Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 66:e1\u2013e48","journal-title":"Clin Infect Dis"},{"key":"1033_CR67","first-page":"2","volume":"4","author":"NA Mervish","year":"2019","unstructured":"Mervish NA, Hu J, Hagan LA et al (2019) Associations of the oral microbiota with obesity and menarche in inner city girls. J Child Obes 4:2","journal-title":"J Child Obes"},{"key":"1033_CR68","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bpg.2014.07.005","volume":"28","author":"CP Moran","year":"2014","unstructured":"Moran CP, Shanahan F (2014) Gut microbiota and obesity: role in aetiology and potential therapeutic target. Best Pract Res Clin Gastroenterol 28:585\u2013597","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"1033_CR69","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3920\/bm2015.0062","volume":"7","author":"R Nagpal","year":"2016","unstructured":"Nagpal R, Kumar M, Yadav AK et al (2016) Gut microbiota in health and disease: an overview focused on metabolic inflammation. Benef Microbes 7:181\u2013194","journal-title":"Benef Microbes"},{"key":"1033_CR70","doi-asserted-by":"crossref","unstructured":"Nakajima M, Arimatsu K, Kato T et al (2015) Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver. PLoS One 10:e0134234","DOI":"10.1371\/journal.pone.0134234"},{"key":"1033_CR71","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1053\/j.gastro.2017.05.055","volume":"153","author":"AC Nicolucci","year":"2017","unstructured":"Nicolucci AC, Hume MP, Mart\u00ednez I et al (2017) Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity. Gastroenterology 153:711\u2013722","journal-title":"Gastroenterology"},{"key":"1033_CR72","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijmm.2009.08.005","volume":"300","author":"TA Oelschlaeger","year":"2010","unstructured":"Oelschlaeger TA (2010) Mechanisms of probiotic actions - A review. Int J Med Microbiol 300:57\u201362","journal-title":"Int J Med Microbiol"},{"key":"1033_CR73","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fmicb.2016.00200","volume":"7","author":"V Patrone","year":"2016","unstructured":"Patrone V, Vajana E, Minuti A et al (2016) Postoperative changes in fecal bacterial communities and fermentation products in obese patients undergoing bilio-intestinal bypass. Front Microbiol 7:200","journal-title":"Front Microbiol"},{"key":"1033_CR74","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature18309","volume":"534","author":"RJ Perry","year":"2016","unstructured":"Perry RJ, Peng L, Barry NA et al (2016) Acetate mediates a microbiome-brain-\u03b2-cell axis to promote metabolic syndrome. Nature 534:213\u2013217","journal-title":"Nature"},{"key":"1033_CR75","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00018-014-1762-5","volume":"72","author":"A P\u0142\u00f3ciennikowska","year":"2015","unstructured":"P\u0142\u00f3ciennikowska A, Hromada-Judycka A, Borz\u0119cka K, Kwiatkowska K (2015) Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling. Cell Mol Life Sci 72:557\u2013581","journal-title":"Cell Mol Life Sci"},{"key":"1033_CR76","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/obr.12535","volume":"18","author":"Y-H Quek","year":"2017","unstructured":"Quek Y-H, Tam WWS, Zhang MWB, Ho RCM (2017) Exploring the association between childhood and adolescent obesity and depression: a meta-analysis: depression and obesity in childhood and adolescence. Obes Rev 18:742\u2013754","journal-title":"Obes Rev"},{"key":"1033_CR77","doi-asserted-by":"publisher","first-page":"1241214","DOI":"10.1126\/science.1241214","volume":"341","author":"VK Ridaura","year":"2013","unstructured":"Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214","journal-title":"Science"},{"key":"1033_CR78","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3390\/ijerph120100162","volume":"12","author":"M Sanchez","year":"2014","unstructured":"Sanchez M, Panahi S, Tremblay A (2014) Childhood obesity: a role for gut microbiota? Int J Environ Res Public Health 12:162\u2013175","journal-title":"Int J Environ Res Public Health"},{"key":"1033_CR79","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1600-0765.2010.01335.x","volume":"46","author":"I Saygun","year":"2011","unstructured":"Saygun I, Nizam N, Keskiner I et al (2011) Salivary infectious agents and periodontal disease status. J Periodontal Res 46:235\u2013239","journal-title":"J Periodontal Res"},{"key":"1033_CR80","doi-asserted-by":"publisher","first-page":"7078","DOI":"10.1128\/AEM.70.12.7078-7085.2004","volume":"70","author":"M Schachtsiek","year":"2004","unstructured":"Schachtsiek M, Hammes WP, Hertel C (2004) Characterization of Lactobacillus coryniformis DSM 20001T surface protein Cpf mediating coaggregation with and aggregation among pathogens. Appl Environ Microbiol 70:7078\u20137085","journal-title":"Appl Environ Microbiol"},{"key":"1033_CR81","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.physbeh.2017.02.027","volume":"173","author":"T Sen","year":"2017","unstructured":"Sen T, Cawthon CR, Ihde BT et al (2017) Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiol Behav 173:305\u2013317","journal-title":"Physiol Behav"},{"key":"1033_CR82","doi-asserted-by":"publisher","first-page":"E222","DOI":"10.3390\/nu12010222","volume":"12","author":"IN Sergeev","year":"2020","unstructured":"Sergeev IN, Aljutaily T, Walton G, Huarte E (2020) Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12:E222","journal-title":"Nutrients"},{"key":"1033_CR83","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1016\/j.clnu.2021.06.002","volume":"40","author":"A Solito","year":"2021","unstructured":"Solito A, Bozzi Cionci N, Calgaro M et al (2021) Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial. Clin Nutr 40:4585\u20134594","journal-title":"Clin Nutr"},{"key":"1033_CR84","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s13238-018-0546-3","volume":"9","author":"L Sun","year":"2018","unstructured":"Sun L, Ma L, Ma Y et al (2018) Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives. Protein Cell 9:397\u2013403","journal-title":"Protein Cell"},{"key":"1033_CR85","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/ajg.2013.4","volume":"108","author":"CM Surawicz","year":"2013","unstructured":"Surawicz CM, Brandt LJ, Binion DG et al (2013) Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 108:478\u2013498","journal-title":"Am J Gastroenterol"},{"key":"1033_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204724","volume":"13","author":"J Tam","year":"2018","unstructured":"Tam J, Hoffmann T, Fischer S et al (2018) Obesity alters composition and diversity of the oral microbiota in patients with type 2 diabetes mellitus independently of glycemic control. PLoS ONE 13:e0204724","journal-title":"PLoS ONE"},{"key":"1033_CR87","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.chom.2015.04.006","volume":"17","author":"P Vangay","year":"2015","unstructured":"Vangay P, Ward T, Gerber JS et al (2015) Antibiotics, pediatric dysbiosis, and disease. Cell Host Microbe 17:553\u2013564","journal-title":"Cell Host Microbe"},{"key":"1033_CR88","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","volume":"143","author":"A Vrieze","year":"2012","unstructured":"Vrieze A, Van Nood E, Holleman F et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913\u2013916","journal-title":"Gastroenterology"},{"key":"1033_CR89","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","volume":"69","author":"WG Wade","year":"2013","unstructured":"Wade WG (2013) The oral microbiome in health and disease. Pharmacol Res 69:137\u2013143","journal-title":"Pharmacol Res"},{"key":"1033_CR90","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.metabol.2018.12.001","volume":"92","author":"S Weihrauch-Bl\u00fcher","year":"2019","unstructured":"Weihrauch-Bl\u00fcher S, Schwarz P, Klusmann J-H (2019) Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood. Metabolism 92:147\u2013152","journal-title":"Metabolism"},{"key":"1033_CR91","unstructured":"World Health Organization (2021) Obesity and overweight. Fact sheets. Accessed 9 June 2021"},{"key":"1033_CR92","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.1208344","volume":"334","author":"GD Wu","year":"2011","unstructured":"Wu GD, Chen J, Hoffmann C et al (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334:105\u2013108","journal-title":"Science"},{"key":"1033_CR93","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/oby.2011.305","volume":"20","author":"CC Zeigler","year":"2012","unstructured":"Zeigler CC, Persson GR, Wondimu B et al (2012) Microbiota in the oral subgingival biofilm is associated with obesity in adolescence. Obesity (silver Spring) 20:157\u2013164","journal-title":"Obesity (silver Spring)"},{"key":"1033_CR94","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ebiom.2015.07.007","volume":"2","author":"C Zhang","year":"2015","unstructured":"Zhang C, Yin A, Li H et al (2015) Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children. EBioMedicine 2:968\u2013984","journal-title":"EBioMedicine"},{"key":"1033_CR95","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ismej.2009.112","volume":"4","author":"C Zhang","year":"2010","unstructured":"Zhang C, Zhang M, Wang S et al (2010) Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4:232\u2013241","journal-title":"ISME J"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-023-01033-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-023-01033-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-023-01033-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T04:02:27Z","timestamp":1681531347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-023-01033-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1033"],"URL":"https:\/\/doi.org\/10.1007\/s12223-023-01033-3","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"15 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}