{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:34:08Z","timestamp":1785832448710,"version":"3.56.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s12223-024-01164-1","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T11:02:01Z","timestamp":1713870121000},"page":"1247-1254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antifungal and antibiofilm effect of duloxetine hydrochloride against Cryptococcus neoformans and Cryptococcus gattii"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-5810","authenticated-orcid":false,"given":"Amanda Rodrigues","family":"Rehem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-7041","authenticated-orcid":false,"given":"Let\u00edcia Rampazzo","family":"da Gama Viveiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-9289","authenticated-orcid":false,"given":"Evelyn Luzia","family":"De Souza Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-885X","authenticated-orcid":false,"given":"Paulo Henrique Fonseca","family":"do Carmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-9278","authenticated-orcid":false,"given":"Newton Soares","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-6856","authenticated-orcid":false,"given":"Juliana Campos","family":"Junqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-6653","authenticated-orcid":false,"given":"Liliana","family":"Scorzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"12","key":"1164_CR1","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1128\/EC.00103-15","volume":"14","author":"F Almeida","year":"2015","unstructured":"Almeida F, Wolf JM, Casadevall A (2015) Virulence-associated enzymes of Cryptococcus neoformans. Eukaryot Cell 14(12):1173\u20131185. https:\/\/doi.org\/10.1128\/EC.00103-15","journal-title":"Eukaryot Cell"},{"key":"1164_CR2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0108","author":"R Almeida-Paes","year":"2023","unstructured":"Almeida-Paes R, Frases S (2023) Repurposing drugs for fungal infections: advantages and limitations. Future Microbiol. https:\/\/doi.org\/10.2217\/fmb-2023-0108","journal-title":"Future Microbiol"},{"issue":"8","key":"1164_CR3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3390\/jof9080783","volume":"9","author":"V Alves","year":"2023","unstructured":"Alves V, Martins PH, Miranda B, de Andrade IB, Pereira L, Maeda CT, de Sousa Ara\u00fajo GR, Frases S (2023) Assessing the in vitro potential of glatiramer acetate (copaxone\u00ae) as a chemotherapeutic candidate for the treatment of Cryptococcus neoformans\u00a0infection. J Fungi 9(8):783. https:\/\/doi.org\/10.3390\/jof9080783","journal-title":"J Fungi"},{"key":"1164_CR4","unstructured":"Arendrup MC, Meletiadis J, Mouton JW, Lagrou K, Hamal P, Guinea J, AFST\/ESCMID\/EUCAST (2017) EUCAST DEFINITIVE DOCUMENT E.DEF 7.3.1. Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts. 1\u201321. https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/AFST\/Files\/EUCAST_E_Def_7_3_1_Yeast_testing__definitive.pdf"},{"issue":"3","key":"1164_CR5","doi-asserted-by":"publisher","first-page":"e0150457","DOI":"10.1371\/journal.pone.0150457","volume":"11","author":"JO Barbosa","year":"2016","unstructured":"Barbosa JO, Rossoni RD, Vilela SFG, De Alvarenga JA, Velloso MDS, Prata MCDA, Jorge AOC, Junqueira JC (2016) Streptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans. PLoS ONE 11(3):e0150457. https:\/\/doi.org\/10.1371\/journal.pone.0150457","journal-title":"PLoS ONE"},{"key":"1164_CR6","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1208\/s12248-009-9146-8","volume":"11","author":"F Borrelli","year":"2009","unstructured":"Borrelli F, Izzo AA (2009) Herb\u2013drug interactions with St John\u2019s wort (Hypericum perforatum): an update on clinical observations. AAPS J 11:710\u2013727. https:\/\/doi.org\/10.1208\/s12248-009-9146-8","journal-title":"AAPS J"},{"issue":"4","key":"1164_CR7","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s10534-014-9743-6","volume":"27","author":"MI Cassetta","year":"2014","unstructured":"Cassetta MI, Marzo T, Fallani S, Novelli A, Messori L (2014) Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections. Biometals 27(4):787\u2013791. https:\/\/doi.org\/10.1007\/s10534-014-9743-6","journal-title":"Biometals"},{"issue":"11","key":"1164_CR8","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.3390\/jof8111234","volume":"8","author":"DB Chastain","year":"2022","unstructured":"Chastain DB, Kung VM, Vargas Barahona L, Jackson BT, Golpayegany S, Franco-Paredes C, Thompson GR, Henao-Mart\u00ednez AF (2022) Characteristics and outcomes of cryptococcosis among patients with and without COVID-19. J Fungi 8(11):1234. https:\/\/doi.org\/10.3390\/jof8111234","journal-title":"J Fungi"},{"issue":"4","key":"1164_CR9","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/cid\/ciy971","volume":"69","author":"T Chen","year":"2019","unstructured":"Chen T, Mwenge L, Lakhi S, Chanda D, Mwaba P, Molloy SF, Gheorghe A, Griffiths UK, Heyderman RS, Kanyama C, Kouanfack C, Mfinanga S, Chan AK, Temfack E, Kivuyo S, Hosseinipour MC, Lortholary O, Loyse A, Jaffar S, Niessen LW (2019) Healthcare costs and life-years gained from treatments within the advancing cryptococcal meningitis treatment for africa (ACTA) trial on cryptococcal meningitis: a comparison of antifungal induction strategies in sub-saharan africa. Clin Infect Dis 69(4):588\u2013595. https:\/\/doi.org\/10.1093\/cid\/ciy971","journal-title":"Clin Infect Dis"},{"key":"1164_CR10","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.micpath.2017.04.008","volume":"107","author":"RA Costa Silva","year":"2017","unstructured":"Costa Silva RA, da Silva CR, de Andrade Neto JB, da Silva AR, Campos RS, Sampaio LS, do Nascimento FBSA, da Silva Gaspar B, da Cruz Fonseca SG, Josino MAA, Grangeiro TB, Gaspar DM, de Lucena DF, de Moraes MO, Cavalcanti BC, Nobre J\u00fanior HV (2017) In vitro anti-Candida activity of selective serotonin reuptake inhibitors against fluconazole-resistant strains and their activity against biofilm-forming isolates. Microb Pathog 107:341\u2013348. https:\/\/doi.org\/10.1016\/j.micpath.2017.04.008","journal-title":"Microb Pathog"},{"issue":"4","key":"1164_CR11","doi-asserted-by":"publisher","first-page":"101431","DOI":"10.1016\/j.mycmed.2023.101431","volume":"33","author":"CR da Silva","year":"2023","unstructured":"da Silva CR, do Amaral Valente S\u00e1 LG, Ferreira TL, Leit\u00e3o AC, de Farias Cabral VP, Rodrigues DS, Barbosa AD, Moreira LEA, Filho HLP, de Andrade Neto JB, Rios MEF, Cavalcanti BC, Magalh\u00e3es HIF, de Moraes MO, Nobre HV (2023) Antifungal activity of selective serotonin reuptake inhibitors against Cryptococcus spp and their possible mechanism of action. J Med Mycol 33(4):101431. https:\/\/doi.org\/10.1016\/j.mycmed.2023.101431","journal-title":"J Med Mycol"},{"issue":"4","key":"1164_CR12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3724\/abbs.2023011","volume":"55","author":"H Deng","year":"2023","unstructured":"Deng H, Song J, Huang Y, Yang C, Zang X, Zhou Y, Li H, Dai B, Xue X (2023) Combating increased antifungal drug resistance in Cryptococcus, what should we do in the future? Acta Biochim Biophys Sin 55(4):540\u2013547. https:\/\/doi.org\/10.3724\/abbs.2023011","journal-title":"Acta Biochim Biophys Sin"},{"issue":"6","key":"1164_CR13","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1128\/JCM.00064-13","volume":"51","author":"X Feng","year":"2013","unstructured":"Feng X, Fu X, Ling B, Wang L, Liao W, Yao Z (2013) Development of a singleplex PCR assay for rapid identification and differentiation of Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans, Cryptococcus gattii, and hybrids. J Clin Microbiol 51(6):1920\u20131923. https:\/\/doi.org\/10.1128\/JCM.00064-13","journal-title":"J Clin Microbiol"},{"issue":"1","key":"1164_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106807","volume":"62","author":"GJC Freitas","year":"2023","unstructured":"Freitas GJC, Ribeiro NQ, Gouveia-Eufrasio L, Emidio ECP, Guimar\u00e3es GM, C\u00e9sar IC, Paix\u00e3o TA, Oliveira JBS, Caza M, Kronstad JW, Santos DA (2023) Antimalarials and amphotericin B interact synergistically and are new options to treat cryptococcosis. Int J Antimicrob Agents 62(1):106807. https:\/\/doi.org\/10.1016\/j.ijantimicag.2023.106807","journal-title":"Int J Antimicrob Agents"},{"issue":"5","key":"1164_CR15","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/S0190-9622(98)70482-7","volume":"38","author":"KC Hazen","year":"1998","unstructured":"Hazen KC (1998) Fungicidal versus fungistatic activity of terbinafine and itraconazole: An in vitro comparison. J Am Acad Dermatol 38(5):S37\u2013S44. https:\/\/doi.org\/10.1016\/S0190-9622(98)70482-7","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"1164_CR16","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3390\/ph15040482","volume":"15","author":"A Kane","year":"2022","unstructured":"Kane A, Carter DA (2022) Augmenting azoles with drug synergy to expand the antifungal toolbox. Pharmaceuticals 15(4):482. https:\/\/doi.org\/10.3390\/ph15040482","journal-title":"Pharmaceuticals"},{"issue":"12","key":"1164_CR17","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/myc.12995","volume":"62","author":"A Katende","year":"2019","unstructured":"Katende A, Mbwanji G, Faini D, Nyuri A, Kalinjuma AV, Mnzava D, Hullsiek KH, Rhein J, Weisser M, Meya DB, Boulware DR, Letang E (2019) Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania. Mycoses 62(12):1127\u20131132. https:\/\/doi.org\/10.1111\/myc.12995","journal-title":"Mycoses"},{"issue":"4","key":"1164_CR18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","volume":"26","author":"R Laniado-Labor\u00edn","year":"2009","unstructured":"Laniado-Labor\u00edn R, Cabrales-Vargas MN (2009) Amphotericin B: side effects and toxicity. Rev Iberoam Micol 26(4):223\u2013227. https:\/\/doi.org\/10.1016\/j.riam.2009.06.003","journal-title":"Rev Iberoam Micol"},{"issue":"3","key":"1164_CR19","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1128\/AAC.50.3.1021-1033.2006","volume":"50","author":"LR Martinez","year":"2006","unstructured":"Martinez LR, Casadevall A (2006) Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro. Antimicrob Agents Chemother 50(3):1021\u20131033. https:\/\/doi.org\/10.1128\/AAC.50.3.1021-1033.2006","journal-title":"Antimicrob Agents Chemother"},{"key":"1164_CR20","doi-asserted-by":"publisher","unstructured":"Martinez LR, Casadevall A (2015) Biofilm formation by Cryptococcus neoformans. Microbiol Spectr 3(3). https:\/\/doi.org\/10.1128\/microbiolspec.MB-0006-2014","DOI":"10.1128\/microbiolspec.MB-0006-2014"},{"issue":"2","key":"1164_CR21","doi-asserted-by":"publisher","first-page":"e20211021","DOI":"10.1590\/0001-3765202220211021","volume":"94","author":"RT Menezes","year":"2022","unstructured":"Menezes RT, Pereira TC, Junqueira JC, Oliveira LD, Scorzoni L (2022) Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans. Anais Da Academia Brasileira de Ci\u00eancias 94(2):e20211021. https:\/\/doi.org\/10.1590\/0001-3765202220211021","journal-title":"Anais Da Academia Brasileira de Ci\u00eancias"},{"issue":"12","key":"1164_CR22","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nrd2961","volume":"8","author":"B Munos","year":"2009","unstructured":"Munos B (2009) Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discovery 8(12):959\u2013968. https:\/\/doi.org\/10.1038\/nrd2961","journal-title":"Nat Rev Drug Discovery"},{"issue":"1","key":"1164_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1080\/07853890.2021.2017474","volume":"54","author":"S Nochaiwong","year":"2022","unstructured":"Nochaiwong S, Ruengorn C, Awiphan R, Chai-Adisaksopha C, Tantraworasin A, Phosuya C, Kanjanarat P, Chongruksut W, Sood MM, Thavorn K (2022) Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med 54(1):80\u201397. https:\/\/doi.org\/10.1080\/07853890.2021.2017474","journal-title":"Ann Med"},{"issue":"4","key":"1164_CR24","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1208\/s12248-012-9390-1","volume":"14","author":"TI Oprea","year":"2012","unstructured":"Oprea TI, Mestres J (2012) Drug repurposing: far beyond new targets for old drugs. AAPS J 14(4):759\u2013763. https:\/\/doi.org\/10.1208\/s12248-012-9390-1","journal-title":"AAPS J"},{"key":"1164_CR25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jad.2015.08.073","volume":"189","author":"M Paulzen","year":"2016","unstructured":"Paulzen M, Gr\u00fcnder G, Veselinovic T, Wolf B, Hiemke C, Lammertz SE (2016) Duloxetine enters the brain\u2013But why is it not found in the cerebrospinal fluid. J Affect Disord 189:159\u2013163. https:\/\/doi.org\/10.1016\/j.jad.2015.08.073","journal-title":"J Affect Disord"},{"issue":"2","key":"1164_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.mimet.2007.11.010","volume":"72","author":"E Peeters","year":"2008","unstructured":"Peeters E, Nelis HJ, Coenye T (2008) Comparison of multiple methods for quantification of microbial biofilms grown in microtiter plates. J Microbiol Methods 72(2):157\u2013165. https:\/\/doi.org\/10.1016\/j.mimet.2007.11.010","journal-title":"J Microbiol Methods"},{"issue":"2","key":"1164_CR27","doi-asserted-by":"publisher","first-page":"ftab001","DOI":"10.1093\/femspd\/ftab001","volume":"79","author":"TC Pereira","year":"2021","unstructured":"Pereira TC, De Menezes RT, De Oliveira HC, De Oliveira LD, Scorzoni L (2021) In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans. Pathog Dis 79(2):ftab001. https:\/\/doi.org\/10.1093\/femspd\/ftab001","journal-title":"Pathog Dis"},{"issue":"50","key":"1164_CR28","doi-asserted-by":"publisher","first-page":"48317","DOI":"10.1021\/acsomega.3c07676","volume":"8","author":"G Periyasami","year":"2023","unstructured":"Periyasami G, Karuppiah P, Karthikeyan P, Palaniappan S (2023) Anti-infective efficacy of duloxetine against catheter-associated urinary tract infections caused by gram-positive bacteria. ACS \u00d4mega 8(50):48317\u201348325. https:\/\/doi.org\/10.1021\/acsomega.3c07676","journal-title":"ACS \u00d4mega"},{"issue":"6","key":"1164_CR29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00131746-200411000-00006","volume":"10","author":"SH Preskorn","year":"2004","unstructured":"Preskorn SH (2004) Duloxetine. J Psychiatr Pract 10(6):375\u2013385. https:\/\/doi.org\/10.1097\/00131746-200411000-00006","journal-title":"J Psychiatr Pract"},{"issue":"12","key":"1164_CR30","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/S1473-3099(22)00499-6","volume":"22","author":"R Rajasingham","year":"2022","unstructured":"Rajasingham R, Govender NP, Jordan A, Loyse A, Shroufi A, Denning DW, Meya DB, Chiller TM, Boulware DR (2022) The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis. Lancet Infect Dis 22(12):1748\u20131755. https:\/\/doi.org\/10.1016\/S1473-3099(22)00499-6","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"1164_CR31","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1600-0447.2001.00263.x","volume":"104","author":"MH Rapaport","year":"2008","unstructured":"Rapaport MH, Wolkow R, Rubin A, Hackett E, Pollack M, Ota KY (2008) Sertraline treatment of panic disorder: results of a long-term study. Acta Psychiatr Scand 104(4):289\u2013298. https:\/\/doi.org\/10.1111\/j.1600-0447.2001.00263.x","journal-title":"Acta Psychiatr Scand"},{"key":"1164_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105521","volume":"166","author":"SS Rathore","year":"2022","unstructured":"Rathore SS, Sathiyamoorthy J, Lalitha C, Ramakrishnan J (2022) A holistic review on Cryptococcus neoformans. Microb Pathog 166:105521. https:\/\/doi.org\/10.1016\/j.micpath.2022.105521","journal-title":"Microb Pathog"},{"issue":"3","key":"1164_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ijantimicag.2019.06.020","volume":"54","author":"NQ Ribeiro","year":"2019","unstructured":"Ribeiro NQ, Santos APN, Em\u00eddio ECP, Costa MC, Freitas GJC, Carmo PHF, Silva MF, de Brito CB, de Souza DG, Paix\u00e3o TA, Santos DA (2019) Pioglitazone as an adjuvant of amphotericin B for the treatment of cryptococcosis. Int J Antimicrob Agents 54(3):301\u2013308. https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.06.020","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"1164_CR34","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/cpdd.759","volume":"9","author":"S Rizea-Savu","year":"2020","unstructured":"Rizea-Savu S, Duna SN, Ghita A, Iordachescu A, Chirila M (2020) The effect of food on the single-dose bioavailability and tolerability of the highest marketed strength of duloxetine. Clin Pharmacol Drug Dev 9(7):797\u2013804. https:\/\/doi.org\/10.1002\/cpdd.759","journal-title":"Clin Pharmacol Drug Dev"},{"key":"1164_CR35","doi-asserted-by":"publisher","unstructured":"Rodrigues DS, Cabral VPF, Barbosa AD, S\u00e1 LGDAV, Moreira LEA, de Andrade Neto JB, da Silva CR, de Moraes MO, Silva J, Marinho ES, Dos Santos HS, da Costa \u00c9RM, Silveira MJCB, E Silva LH, Nobre J\u00fanior HV (2023) Sertraline has in vitro activity against both mature and forming biofilms of different Candida species. J Med Microbiol 72(2). https:\/\/doi.org\/10.1099\/jmm.0.001664.\u00a0PMID: 36762524","DOI":"10.1099\/jmm.0.001664"},{"issue":"5","key":"1164_CR36","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12223-016-0449-8","volume":"61","author":"L Rossato","year":"2016","unstructured":"Rossato L, Loreto \u00c9S, Zanette RA, Chassot F, Santurio JM, Alves SH (2016) In vitro synergistic effects of chlorpromazine and sertraline in combination with amphotericin B against Cryptococcus neoformans var. grubii. Folia Microbiologica 61(5):399\u2013403. https:\/\/doi.org\/10.1007\/s12223-016-0449-8","journal-title":"Folia Microbiologica"},{"issue":"12","key":"1164_CR37","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1007\/s13346-022-01172-z","volume":"12","author":"HF Salem","year":"2022","unstructured":"Salem HF, Ali AA, Rabea YK, El-Ela FIA, Khallaf RA (2022) Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal. Drug Deliv Transl Res 12(12):3083\u20133103. https:\/\/doi.org\/10.1007\/s13346-022-01172-z","journal-title":"Drug Deliv Transl Res"},{"key":"1164_CR38","doi-asserted-by":"publisher","first-page":"101628","DOI":"10.1016\/j.jddst.2020.101628","volume":"57","author":"KA Spandana","year":"2020","unstructured":"Spandana KA, Bhaskaran M, Karri VR, Natarajan J (2020) A comprehensive review of nano drug delivery system in the treatment of CNS disorders. J Drug Deliv Sci Technol 57:101628. https:\/\/doi.org\/10.1016\/j.jddst.2020.101628","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"1164_CR39","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/mmy\/myv109","volume":"54","author":"RDJ Trevi\u00f1o-Rangel","year":"2016","unstructured":"Trevi\u00f1o-Rangel RDJ, Villanueva-Lozano H, Hern\u00e1ndez-Rodr\u00edguez P, Mart\u00ednez-Res\u00e9ndez MF, Garc\u00eda-Ju\u00e1rez J, Rodr\u00edguez-Rocha H, Gonz\u00e1lez GM (2016) Activity of sertraline against Cryptococcus neoformans: in vitro and in vivo assays. Med Mycol 54(3):280\u2013286. https:\/\/doi.org\/10.1093\/mmy\/myv109","journal-title":"Med Mycol"},{"issue":"4","key":"1164_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jflm.2010.02.002","volume":"17","author":"EL Vey","year":"2010","unstructured":"Vey EL, Kovelman I (2010) Adverse events, toxicity and post-mortem data on duloxetine: case reports and literature survey. J Forensic Leg Med 17(4):175\u2013185. https:\/\/doi.org\/10.1016\/j.jflm.2010.02.002","journal-title":"J Forensic Leg Med"},{"issue":"11","key":"1164_CR41","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nrd1555","volume":"3","author":"AB Waitekus","year":"2004","unstructured":"Waitekus AB, Kirkpatrick P (2004) Duloxetine hydrochloride. Nat Rev Drug Discov 3(11):907\u2013908. https:\/\/doi.org\/10.1038\/nrd1555","journal-title":"Nat Rev Drug Discov"},{"key":"1164_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.859049","author":"Y Wang","year":"2022","unstructured":"Wang Y, Pawar S, Dutta O, Wang K, Rivera A, Xue C (2022) Macrophage mediated immunomodulation during cryptococcus pulmonary infection. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2022.859049","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"1164_CR43","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1128\/AAC.00212-12","volume":"56","author":"B Zhai","year":"2012","unstructured":"Zhai B, Wu C, Wang L, Sachs MS, Lin X (2012) The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrob Agents Chemother 56(7):3758\u20133766. https:\/\/doi.org\/10.1128\/AAC.00212-12","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-024-01164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-024-01164-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-024-01164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:13:36Z","timestamp":1729059216000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-024-01164-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1164"],"URL":"https:\/\/doi.org\/10.1007\/s12223-024-01164-1","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"assertion":[{"value":"24 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}