{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:13:24Z","timestamp":1783484004144,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12223-025-01291-3","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T12:57:28Z","timestamp":1751115448000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of andrographolide from Andrographis paniculata against drug-resistant and H37Rv strains of Mycobacterium tuberculosis"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5094-7265","authenticated-orcid":false,"given":"Jelin","family":"Vilvest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C. John","family":"Milton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Yagoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedike","family":"Balakrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"issue":"7","key":"1291_CR1","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/ptr.5338","volume":"29","author":"AO Aro","year":"2015","unstructured":"Aro AO, Dzoyem JP, Hlokwe TM, Eloff JN, McGaw LJ (2015) Some South African Rubiaceae tree leaf extracts have antimycobacterial activity against pathogenic and non-pathogenic Mycobacterium species. Phytother Res 29(7):1004\u20131010. https:\/\/doi.org\/10.1002\/ptr.5338","journal-title":"Phytother Res"},{"issue":"3","key":"1291_CR2","first-page":"812","volume":"4","author":"L Bernaitis","year":"2013","unstructured":"Bernaitis L, Shenoy VP, Ashok M, Mithun Nath MN, Shenoy RP (2013) Effects of selective medicinal plants against multi-drug resistant Mycobacterium tuberculosis strains. Res J Pharm Biol Chem Sci 4(3):812\u2013817","journal-title":"Res J Pharm Biol Chem Sci"},{"issue":"3","key":"1291_CR3","first-page":"393","volume":"8","author":"S Bhopale","year":"2023","unstructured":"Bhopale S, Borkar A, Deshmukh N, Musale S, More R (2023) A review on anti-tubercular plants and current trends. Int J Res Technol Innov 8(3):393\u2013398","journal-title":"Int J Res Technol Innov"},{"key":"1291_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2180-6-23","volume":"6","author":"K Brudey","year":"2006","unstructured":"Brudey K, Driscoll JR, Rigouts L, Prodinger WM, Gori A, Al-Hajoj SA et al (2006) Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiol 6:23. https:\/\/doi.org\/10.1186\/1471-2180-6-23","journal-title":"BMC Microbiol"},{"key":"1291_CR5","unstructured":"Burgos RA, Hidalgo MA, Carretta MD et al (2009) Immunomodulatory activities induced by Andrographis paniculata. In: Govil JN, Singh VK (eds) Recent Progress in Medicinal Plants (vol 24), Standardization of Herbal\/Ayurvedic Formulations. Studium Press, Houston (Texas), pp 425-\u2013441"},{"key":"1291_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1749-8546-5-17","volume":"5","author":"WW Chao","year":"2010","unstructured":"Chao WW, Lin BF (2010) Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med 5:17. https:\/\/doi.org\/10.1186\/1749-8546-5-17","journal-title":"Chin Med"},{"key":"1291_CR7","doi-asserted-by":"publisher","first-page":"1149418","DOI":"10.3389\/fmicb.2023.1149418","volume":"14","author":"S Chetri","year":"2023","unstructured":"Chetri S (2023) The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: urgent need for an improved new generation of EPIs. Front Microbiol 14:1149418. https:\/\/doi.org\/10.3389\/fmicb.2023.1149418","journal-title":"Front Microbiol"},{"key":"1291_CR8","doi-asserted-by":"publisher","first-page":"e2408028","DOI":"10.4014\/jmb.2408.08028","volume":"35","author":"GS Dafur","year":"2024","unstructured":"Dafur GS, Harun A, Kub TNT, Bakar RA, Harun A (2024) A systematic review on the antimicrobial activity of andrographolide. J Microbiol Biotechnol 35:e2408028. https:\/\/doi.org\/10.4014\/jmb.2408.08028","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"1291_CR9","first-page":"1","volume":"1","author":"A Dhiman","year":"2012","unstructured":"Dhiman A, Goyal J, Sharma K, Nanda A, Dhiman S (2012) A review on medicinal prospectives of Andrographis paniculata Nees. J Pharm Sci Innov 1(1):1\u20134","journal-title":"J Pharm Sci Innov"},{"key":"1291_CR10","doi-asserted-by":"publisher","first-page":"103351","DOI":"10.1016\/j.jksus.2023.103351","volume":"36","author":"V Duraipandiyan","year":"2024","unstructured":"Duraipandiyan V, Savarimuthu I, Khan IA, Alodaini HA, Hatamleh AA, Antony S (2024) Antimycobacterial activity of plant compounds against extensively drug-resistant (XDR-TB) Mycobacterium tuberculosis. J King Saud Univ Sci 36:103351. https:\/\/doi.org\/10.1016\/j.jksus.2023.103351","journal-title":"J King Saud Univ Sci"},{"issue":"4","key":"1291_CR11","first-page":"33","volume":"7","author":"R Gopinath","year":"2016","unstructured":"Gopinath R, Sneha S, Manickan E (2016) Anti-mycobacterial activity of Acalypha indica and Andrographis paniculata, the Indian medicinal plants against Mycobacterium tuberculosis (MTB). Int J Pharmacy Pharmacol Res 7(4):33\u201343","journal-title":"Int J Pharmacy Pharmacol Res"},{"issue":"7","key":"1291_CR12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S1473-3099(18)30181-4","volume":"18","author":"NA Ismail","year":"2018","unstructured":"Ismail NA, Mvusi L, Nanoo A, Dreyer AW, Omar SV, Babatunde S et al (2018) Prevalence of drug-resistant tuberculosis and imputed burden in South Africa: a national and sub-national cross-sectional survey. Lancet Infect Dis 18(7):779\u2013787. https:\/\/doi.org\/10.1016\/S1473-3099(18)30181-4","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"1291_CR13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.4155\/fmc-2018-0378","volume":"11","author":"VB Makane","year":"2019","unstructured":"Makane VB, Krishna VS, Krishna EV, Shukla M, Mahizhaveni B, Misra S et al (2019) Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis. Future Med Chem 11(6):499\u2013510. https:\/\/doi.org\/10.4155\/fmc-2018-0378","journal-title":"Future Med Chem"},{"issue":"3","key":"1291_CR14","first-page":"771","volume":"2","author":"RM Mariita","year":"2010","unstructured":"Mariita RM, Okemo PO, Orodho JA, Kirimuhuzya C, Otieno JN, Magadula JJ (2010) Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea causing bacteria, and Candida albicans. Int J Phytomed 2(3):771\u2013791","journal-title":"Int J Phytomed"},{"issue":"3","key":"1291_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4103\/0974-8490.65511","volume":"2","author":"RM Mariita","year":"2010","unstructured":"Mariita RM, Orodho JA, Okemo PO, Mbugua PK (2010) Antifungal, antibacterial and antimycobacterial activity of Entada abysinnica Steudel ex A Rich (Fabaceae) methanol extract. Pharmacogn Res 2(3):163\u2013168. https:\/\/doi.org\/10.4103\/0974-8490.65511","journal-title":"Pharmacogn Res"},{"issue":"1","key":"1291_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.chembiol.2013.11.011","volume":"21","author":"H Marrakchi","year":"2014","unstructured":"Marrakchi H, Lan\u00e9elle MA, Daff\u00e9 M (2014) Mycolic acids: structures, biosynthesis, and beyond. Chem Biol 21(1):67\u201385. https:\/\/doi.org\/10.1016\/j.chembiol.2013.11.011","journal-title":"Chem Biol"},{"issue":"2","key":"1291_CR17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1351\/pac199870020365","volume":"70","author":"LA Mitscher","year":"1998","unstructured":"Mitscher LA, Baker WR (1998) A search for novel chemotherapy against tuberculosis amongst natural products. Pure Appl Chem 70(2):365\u2013271. https:\/\/doi.org\/10.1351\/pac199870020365","journal-title":"Pure Appl Chem"},{"key":"1291_CR18","unstructured":"Mukherjee PK (2002) Quality control of herbal drugs. 1st edn. Business Horizon Pharmaceutical Publishers, New Delhi, pp 380\u2013422"},{"key":"1291_CR19","doi-asserted-by":"crossref","unstructured":"Nadkarni KM (1976) Indian Materia Medica. Vol 1. Popular Prakashan, Bombay, p 1142","DOI":"10.1136\/bmj.1.6018.1142"},{"issue":"3","key":"1291_CR20","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"DJ Newman","year":"2020","unstructured":"Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J Nat Prod 83(3):770\u2013803. https:\/\/doi.org\/10.1021\/acs.jnatprod.9b01285","journal-title":"J Nat Prod"},{"issue":"3","key":"1291_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S2222-1808(14)60509-0","volume":"4","author":"A Okhuarobo","year":"2014","unstructured":"Okhuarobo A, Falodun JE, Erharuyi O, Imieje V, Falodun A, Langer P (2014) Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology. Asian Pac J Trop Dis 4(3):213\u2013222","journal-title":"Asian Pac J Trop Dis"},{"issue":"2","key":"1291_CR22","first-page":"523","volume":"2","author":"K Pandya","year":"2012","unstructured":"Pandya K, Patel P, Patel G, Parikh V (2012) In vitro antimycobacterial study of essential oil of few selected plants. Int J Univ Pharm Life Sci 2(2):523\u2013529","journal-title":"Int J Univ Pharm Life Sci"},{"key":"1291_CR23","doi-asserted-by":"publisher","unstructured":"Prabu A, Hassan S, Prabuseenivasan SAS, Hanna LE, Kumar V (2015) Andrographolide: a potent antituberculosis compound that targets Aminoglycoside 2\u2032-N-acetyltransferase in Mycobacterium tuberculosis. J Mol Graph Model 61:133\u2013140. https:\/\/doi.org\/10.1016\/j.jmgm.2015.07.001","DOI":"10.1016\/j.jmgm.2015.07.001"},{"key":"1291_CR24","doi-asserted-by":"publisher","unstructured":"Riaz M, Zia M, Saad B (2016) Anthocyanins and human health: biomolecular and therapeutic aspects. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-26456-1","DOI":"10.1007\/978-3-319-26456-1"},{"key":"1291_CR25","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S1473-3099(16)30247-0","volume":"16","author":"S Satyanarayana","year":"2016","unstructured":"Satyanarayana S, Kwan A, Daniels B et al (2016) Use of standardised patients to assess antibiotic dispensing for tuberculosis by pharmacies in urban India: a cross-sectional study. Lancet Infect Dis 16:1261\u20131268. https:\/\/doi.org\/10.1016\/S1473-3099(16)30247-0","journal-title":"Lancet Infect Dis"},{"key":"1291_CR26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.phymed.2009.12.001","volume":"17","author":"RC Saxena","year":"2010","unstructured":"Saxena RC, Singh R, Kumar P et al (2010) A randomized double-blind placebo-controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine 17:178\u2013185","journal-title":"Phytomedicine"},{"issue":"6","key":"1291_CR27","first-page":"2405","volume":"7","author":"MCS Tan","year":"2016","unstructured":"Tan MCS, Oyong GG, Shen CC, Ragasa CY (2016) Chemical composition of Andrographis paniculata (Burm.f.) Nees. Res J Pharm Biol Chem Sci 7(6):2405\u20132408","journal-title":"Res J Pharm Biol Chem Sci"},{"key":"1291_CR28","doi-asserted-by":"publisher","first-page":"S685","DOI":"10.1016\/S2222-1808(12)60244-8","volume":"2","author":"KV Tawde","year":"2012","unstructured":"Tawde KV, Gacche RN, Pund MM (2012) Evaluation of selected Indian traditional folk medicinal plants against Mycobacterium tuberculosis with antioxidant and cytotoxicity study. Asian Pac J Trop Dis 2:S685\u2013S691","journal-title":"Asian Pac J Trop Dis"},{"key":"1291_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.biopha.2017.08.071","volume":"95","author":"E Toppo","year":"2017","unstructured":"Toppo E, Darvin SS, Esakkimuthu S, Nayak MK, Balakrishna K, Sivasankaran K, Pandikumar P, Ignacimuthu S, Al-Dhabi NA (2017) Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease. Biomed Pharmacother 95:402\u2013411. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.071","journal-title":"Biomed Pharmacother"},{"key":"1291_CR30","doi-asserted-by":"publisher","first-page":"108858","DOI":"10.1016\/j.exppara.2024.108858","volume":"267","author":"J Vilvest","year":"2024","unstructured":"Vilvest J, Milton MCJ, Yagoo A, Balakrishna K (2024) Structural elucidation of andrographolide from Andrographis paniculata and its ovicidal, larvicidal, and pupicidal activities against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Exp Parasitol 267:108858. https:\/\/doi.org\/10.1016\/j.exppara.2024.108858","journal-title":"Exp Parasitol"},{"key":"1291_CR31","unstructured":"World Health Organization (2001) Global tuberculosis control: surveillance, planning, financing. World TB report 2001.\u00a0WHO\/CDS\/TB\/2001.287. World Health Organization, Geneva"},{"key":"1291_CR32","volume-title":"Global tuberculosis report 2023","author":"World Health Organization","year":"2023","unstructured":"World Health Organization (2023) Global tuberculosis report 2023. World Health Organization, Geneva"},{"key":"1291_CR33","doi-asserted-by":"publisher","first-page":"105800","DOI":"10.1016\/j.yrtph.2025.105800","volume":"158","author":"A Yagoo","year":"2025","unstructured":"Yagoo A, Milton MCJ, Vilvest J, Jessie AAA, Balakrishna K (2025) Isolation and investigation of anti-tubercular ilicic acid from Sphaeranthus indicus against Mycobacterium tuberculosis H37Rv and MDR strains. Regul Toxicol Pharmacol 158:105800. https:\/\/doi.org\/10.1016\/j.yrtph.2025.105800","journal-title":"Regul Toxicol Pharmacol"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-025-01291-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-025-01291-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-025-01291-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:09Z","timestamp":1783480629000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-025-01291-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1291"],"URL":"https:\/\/doi.org\/10.1007\/s12223-025-01291-3","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"4 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}