{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:09:27Z","timestamp":1789708167674,"version":"4.0.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12223-025-01356-3","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:34:52Z","timestamp":1759988092000},"page":"1201-1216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Emerging contaminants in healthcare effluents: antibiotic resistance and virulence factor dissemination"],"prefix":"10.1007","volume":"70","author":[{"given":"Jaya","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zayera","family":"Naushad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpy","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmsheel","family":"Shrivastav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ved Vrat","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-4694","authenticated-orcid":false,"given":"Ravi Kant","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8575-6939","authenticated-orcid":false,"given":"Varun Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"1356_CR1","doi-asserted-by":"publisher","first-page":"100971","DOI":"10.1016\/j.disamonth.2020.100971","volume":"66","author":"MA Abushaheen","year":"2020","unstructured":"Abushaheen MA, Muzaheed FAJ, Alosaimi M, Mansy W, George M, Acharya S, Rathod S, Divakar DD, Jhugroo C, Vellappally S, Khan AA, Shaik J, Jhugroo P (2020) Antimicrobial resistance, mechanisms and its clinical significance. Dis Mon 66:100971. https:\/\/doi.org\/10.1016\/j.disamonth.2020.100971","journal-title":"Dis Mon"},{"key":"1356_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143192","volume":"761","author":"M Achak","year":"2021","unstructured":"Achak M, Alaoui Bakri S, Chhiti Y, M\u2019hamdi Alaoui FE, Barka N, Boumya W (2021) SARS-CoV-2 in hospital wastewater during outbreak of COVID-19: a review on detection, survival and disinfection technologies. Sci Total Environ 761:143192. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143192","journal-title":"Sci Total Environ"},{"key":"1356_CR3","doi-asserted-by":"publisher","unstructured":"Afoma UM, Malik J, Singh S, Mishra AK, Tomar LK, Tomar A, Verma VV, Mishra MK, Sharma VK (2025a) Characterization of azo dye-degrading Tistrella mobilis isolated from industrial effluents: a molecular perspective. Biologia 80:1\u201313. https:\/\/doi.org\/10.1007\/s11756-025-01957-w","DOI":"10.1007\/s11756-025-01957-w"},{"key":"1356_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s10393-025-01752-8","author":"UM Afoma","year":"2025","unstructured":"Afoma UM, Singh S, Mishra AK, Sharma CK, Gupta K, Mishra MK, Roy B, Verma VV, Sharma VK (2025) Integrating artificial intelligence in environmental monitoring: a paradigm shift in data-driven sustainability. EcoHealth. https:\/\/doi.org\/10.1007\/s10393-025-01752-8","journal-title":"EcoHealth"},{"key":"1356_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051847","volume":"21","author":"A Amaretti","year":"2020","unstructured":"Amaretti A, Righini L, Candeliere F, Musmeci E, Bonvicini F, Gentilomi GA, Rossi M, Raimondi S (2020) Antibiotic resistance, virulence factors, phenotyping, and genotyping of non-Escherichia coli Enterobacterales from the gut microbiota of healthy subjects. Int J Mol Sci 21:1847. https:\/\/doi.org\/10.3390\/ijms21051847","journal-title":"Int J Mol Sci"},{"key":"1356_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/pr12020339","volume":"12","author":"M Asheghmoalla","year":"2024","unstructured":"Asheghmoalla M, Mehrvar M (2024) Integrated and hybrid processes for the treatment of actual wastewaters containing micropollutants: a review on recent advances. Processes 12:339. https:\/\/doi.org\/10.3390\/pr12020339","journal-title":"Processes"},{"key":"1356_CR7","doi-asserted-by":"publisher","first-page":"24519","DOI":"10.1038\/s41598-021-04254-z","volume":"11","author":"F Baghal Asghari","year":"2021","unstructured":"Baghal Asghari F, Dehghani MH, Dehghanzadeh R, Farajzadeh D, Shanehbandi D, Mahvi AH, Yaghmaeian K, Rajabi A (2021) Performance evaluation of ozonation for removal of antibiotic-resistant Escherichia coli and Pseudomonas aeruginosa and genes from hospital wastewater. Sci Rep 11:24519. https:\/\/doi.org\/10.1038\/s41598-021-04254-z","journal-title":"Sci Rep"},{"key":"1356_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02603","volume":"8","author":"F Barancheshme","year":"2018","unstructured":"Barancheshme F, Munir M (2018) Strategies to combat antibiotic resistance in the wastewater treatment plants. Front Microbiol 8:2603. https:\/\/doi.org\/10.3389\/fmicb.2017.02603","journal-title":"Front Microbiol"},{"key":"1356_CR9","doi-asserted-by":"publisher","first-page":"383","DOI":"10.56294\/hl2024.383","volume":"3","author":"KL Behera","year":"2024","unstructured":"Behera KL, Taneja M, Faiz A, Hanumanthayya M, Sharma VK, Kore N, Antony M (2024) Environmental health interventions and their impact on quality of life. Health Lead Qual Life 3:383. https:\/\/doi.org\/10.56294\/hl2024.383","journal-title":"Health Lead Qual Life"},{"key":"1356_CR10","doi-asserted-by":"publisher","first-page":"28564","DOI":"10.3402\/iee.v5.28564","volume":"5","author":"B Berglund","year":"2015","unstructured":"Berglund B (2015) Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect Ecol Epidemiol 5:28564. https:\/\/doi.org\/10.3402\/iee.v5.28564","journal-title":"Infect Ecol Epidemiol"},{"key":"1356_CR11","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202131901105","volume":"319","author":"J Bouzid","year":"2021","unstructured":"Bouzid J, Jaouhar S, Zaid A, Bouhlou L, Chahlaoui A (2021) Evaluation of the bacteriological and physicochemical risk of hospital effluents: case of the mohamed v hospital in meknes. E3S Web Conf 319:01105. https:\/\/doi.org\/10.1051\/e3sconf\/202131901105","journal-title":"E3S Web Conf"},{"key":"1356_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","volume":"19","author":"A Cassini","year":"2019","unstructured":"Cassini A, H\u00f6gberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, Colomb-Cotinat M, Kretzschmar ME, Devleesschauwer B, Cecchini M, Ouakrim DA, Oliveira TC, Struelens MJ, Suetens C, Monnet DL (2019) Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis 19:56\u201366. https:\/\/doi.org\/10.1016\/S1473-3099(18)30605-4","journal-title":"Lancet Infect Dis"},{"key":"1356_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110664","volume":"194","author":"P Chaturvedi","year":"2021","unstructured":"Chaturvedi P, Shukla P, Giri BS, Chowdhary P, Chandra R, Gupta P, Pandey A (2021) Prevalence and hazardous impact of pharmaceutical and personal care products and antibiotics in environment: a review on emerging contaminants. Environ Res 194:110664. https:\/\/doi.org\/10.1016\/j.envres.2020.110664","journal-title":"Environ Res"},{"key":"1356_CR14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jgar.2021.03.024","volume":"25","author":"Z Cherak","year":"2021","unstructured":"Cherak Z, Loucif L, Moussi A, Rolain JM (2021) Carbapenemase-producing gram-negative bacteria in aquatic environments: a review. J Glob Antimicrob Resist 25:287\u2013309. https:\/\/doi.org\/10.1016\/j.jgar.2021.03.024","journal-title":"J Glob Antimicrob Resist"},{"key":"1356_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103730","volume":"21","author":"L Denzer","year":"2020","unstructured":"Denzer L, Schroten H, Schwerk C (2020) From gene to protein-how bacterial virulence factors manipulate host gene expression during infection. Int J Mol Sci 21:3730. https:\/\/doi.org\/10.3390\/ijms21103730","journal-title":"Int J Mol Sci"},{"key":"1356_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092709","volume":"19","author":"Y Dong","year":"2018","unstructured":"Dong Y, Wang Y, Liu J, Ma S, Awan F, Lu C, Liu Y (2018) Discovery of LahS as a global regulator of environmental adaptation and virulence in Aeromonas hydrophila. Int J Mol Sci 19:2709. https:\/\/doi.org\/10.3390\/ijms19092709","journal-title":"Int J Mol Sci"},{"key":"1356_CR17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/antibiotics9070431","volume":"9","author":"MD Ekwanzala","year":"2020","unstructured":"Ekwanzala MD, Lehutso RF, Kasonga TK, Dewar JB, Momba MNB (2020) Environmental dissemination of selected antibiotics from hospital wastewater to the aquatic environment. Antibiotics (Basel) 9:431. https:\/\/doi.org\/10.3390\/antibiotics9070431","journal-title":"Antibiotics (Basel)"},{"key":"1356_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3275101","volume":"2019","author":"R Elmountassir","year":"2019","unstructured":"Elmountassir R, Bennani B, Miyah Y, Fegousse A, El Mouhri G, Oumokhtar B, Khatouf M, Elkarrach K, Benjelloun Touimi G, Lahrichi A (2019) Microbiological and physicochemical characterization of hospital effluents before and after treatment with two types of sawdust. J Chem 2019:3275101. https:\/\/doi.org\/10.1155\/2019\/3275101","journal-title":"J Chem"},{"key":"1356_CR19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10661-023-11002-5","volume":"195","author":"S Fatimazahra","year":"2023","unstructured":"Fatimazahra S, Latifa M, Laila S, Monsif K (2023) Review of hospital effluents: special emphasis on characterization, impact, and treatment of pollutants and antibiotic resistance. Environ Monit Assess 195:393. https:\/\/doi.org\/10.1007\/s10661-023-11002-5","journal-title":"Environ Monit Assess"},{"key":"1356_CR20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2217\/fmb.15.128","volume":"11","author":"JR Feliciano","year":"2016","unstructured":"Feliciano JR, Grilo AM, Guerreiro SI, Sousa SA, Leit\u00e3o JH (2016) Hfq: a multifaceted RNA chaperone involved in virulence. Future Microbiol 11:137\u2013151. https:\/\/doi.org\/10.2217\/fmb.15.128","journal-title":"Future Microbiol"},{"key":"1356_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103687","volume":"21","author":"D Figaj","year":"2020","unstructured":"Figaj D, Czaplewska P, Przepi\u00f3ra T, Ambroziak P, Potrykus M, Skorko-Glonek J (2020) Lon protease is important for growth under stressful conditions and pathogenicity of the phytopathogen, bacterium Dickeya solani. Int J Mol Sci 21:3687. https:\/\/doi.org\/10.3390\/ijms21103687","journal-title":"Int J Mol Sci"},{"key":"1356_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105710","volume":"23","author":"V Guarnotta","year":"2022","unstructured":"Guarnotta V, Amodei R, Frasca F, Aversa A, Giordano C (2022) Impact of chemical endocrine disruptors and hormone modulators on the endocrine system. Int J Mol Sci 23:5710. https:\/\/doi.org\/10.3390\/ijms23105710","journal-title":"Int J Mol Sci"},{"key":"1356_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-024-04146-9","volume":"14","author":"K Gupta","year":"2024","unstructured":"Gupta K, Sharma VK (2024) Cutting-edge perspectives on biosurfactants: implications for antimicrobial and biomedical applications. 3 Biotech 14:297. https:\/\/doi.org\/10.1007\/s13205-024-04146-9","journal-title":"3 Biotech"},{"key":"1356_CR24","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1515\/revce-2017-0004","volume":"34","author":"OA Habeeb","year":"2018","unstructured":"Habeeb OA, Kanthasamy R, Ali GAM, Sethupathi S, Yunus RBM (2018) Hydrogen sulfide emission sources, regulations, and removal techniques: a review. Rev Chem Eng 34:837\u2013854. https:\/\/doi.org\/10.1515\/revce-2017-0004","journal-title":"Rev Chem Eng"},{"key":"1356_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.107047","volume":"159","author":"M Haenni","year":"2022","unstructured":"Haenni M, Dagot C, Chesneau O, Bibbal D, Labanowski J, Vialette M, Bouchard D, Martin-Laurent F, Calsat L, Nazaret S, Petit F, Pourcher AM, Togola A, Bachelot M, Topp E, Hocquet D (2022) Environmental contamination in a high-income country (France) by antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes: status and possible causes. Environ Int 159:107047. https:\/\/doi.org\/10.1016\/j.envint.2021.107047","journal-title":"Environ Int"},{"key":"1356_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140804","volume":"743","author":"N Hassoun-Kheir","year":"2020","unstructured":"Hassoun-Kheir N, Stabholz Y, Kreft JU, de la Cruz R, Romalde JL, Nesme J, S\u00f8rensen SJ, Smets BF, Graham D, Paul M (2020) Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: a systematic review. Sci Total Environ 743:140804. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.140804","journal-title":"Sci Total Environ"},{"key":"1356_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215393","volume":"20","author":"R Herold","year":"2019","unstructured":"Herold R, Schroten H, Schwerk C (2019) Virulence factors of meningitis-causing bacteria: enabling brain entry across the blood-brain barrier. Int J Mol Sci 20:5393. https:\/\/doi.org\/10.3390\/ijms20215393","journal-title":"Int J Mol Sci"},{"key":"1356_CR28","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1080\/15476286.2016.1201617","volume":"14","author":"AK Heroven","year":"2017","unstructured":"Heroven AK, Nuss AM, Dersch P (2017) RNA-based mechanisms of virulence control in Enterobacteriaceae. RNA Biol 14:471\u2013487. https:\/\/doi.org\/10.1080\/15476286.2016.1201617","journal-title":"RNA Biol"},{"key":"1356_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149150","volume":"797","author":"M Herraiz-Carbon\u00e9","year":"2021","unstructured":"Herraiz-Carbon\u00e9 M, Cotillas S, Lacasa E, Sainz de Baranda C, Riquelme E, Ca\u00f1izares P, Rodrigo MA, S\u00e1ez C (2021) A review on disinfection technologies for controlling the antibiotic resistance spread. Sci Total Environ 797:149150. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.149150","journal-title":"Sci Total Environ"},{"key":"1356_CR30","doi-asserted-by":"publisher","first-page":"102205","DOI":"10.1016\/j.jwpe.2021.102205","volume":"43","author":"SM Hocao\u011flu","year":"2021","unstructured":"Hocao\u011flu SM, Dursun M, Ba\u015ft\u00fcrk \u0130, Partal R (2021) Treatment-based hospital wastewater characterization and fractionation of pollutants. J Water Process Eng 43:102205. https:\/\/doi.org\/10.1016\/j.jwpe.2021.102205","journal-title":"J Water Process Eng"},{"key":"1356_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9727857","volume":"2022","author":"Y Jari","year":"2022","unstructured":"Jari Y, Roche N, Necibi MC, El Hajjaji S, Dhiba D, Chehbouni A (2022) Emerging pollutants in Moroccan wastewater: occurrence, impact, and removal technologies. J Chem 2022:9727857. https:\/\/doi.org\/10.1155\/2022\/9727857","journal-title":"J Chem"},{"key":"1356_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114025","volume":"21","author":"S Khaitlina","year":"2020","unstructured":"Khaitlina S, Bozhokina E, Tsaplina O, Efremova T (2020) Bacterial actin-specific endoproteases grimelysin and protealysin as virulence factors contributing to the invasive activities of Serratia. Int J Mol Sci 21:4025. https:\/\/doi.org\/10.3390\/ijms21114025","journal-title":"Int J Mol Sci"},{"key":"1356_CR33","doi-asserted-by":"publisher","first-page":"101990","DOI":"10.1016\/j.jwpe.2021.101990","volume":"41","author":"MT Khan","year":"2021","unstructured":"Khan MT, Shah IA, Ihsanullah I, Naushad M, Ali S, Shah SHA, Mohammad AW (2021) Hospital wastewater as a source of environmental contamination: an overview of management practices, environmental risks, and treatment processes. J Water Process Eng 41:101990. https:\/\/doi.org\/10.1016\/j.jwpe.2021.101990","journal-title":"J Water Process Eng"},{"key":"1356_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.553850","volume":"8","author":"M Kumar","year":"2020","unstructured":"Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Prakash A, Tiwari R (2020) Environmental endocrine-disrupting chemical exposure: role in non-communicable diseases. Front Public Health 8:553850. https:\/\/doi.org\/10.3389\/fpubh.2020.553850","journal-title":"Front Public Health"},{"key":"1356_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/w16172362","volume":"16","author":"N Lajqi Berisha","year":"2024","unstructured":"Lajqi Berisha N, Poceva Panovska A, Hajrulai-Musliu Z (2024) Antibiotic resistance and aquatic systems: importance in public health. Water 16:2362. https:\/\/doi.org\/10.3390\/w16172362","journal-title":"Water"},{"key":"1356_CR36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.watres.2017.01.010","volume":"111","author":"N Li","year":"2017","unstructured":"Li N, Sheng GP, Lu YZ, Zeng RJ, Yu HQ (2017) Removal of antibiotic resistance genes from wastewater treatment plant effluent by coagulation. Water Res 111:204\u2013212. https:\/\/doi.org\/10.1016\/j.watres.2017.01.010","journal-title":"Water Res"},{"key":"1356_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102946","volume":"19","author":"J Li","year":"2018","unstructured":"Li J, Zhang X, Li L, Liu J, Zhang Y, Pan H (2018) Proteomics analysis of SsNsd1-mediated compound appressoria formation in Sclerotinia sclerotiorum. Int J Mol Sci 19:2946. https:\/\/doi.org\/10.3390\/ijms19102946","journal-title":"Int J Mol Sci"},{"key":"1356_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2020.125483","volume":"285","author":"H Lin","year":"2021","unstructured":"Lin H, Sun W, Jin D, Yu Q, Yang Y, Zhang Z, Sun P, Ma J (2021) Effect of composting on the conjugative transmission of sulfonamide resistance and sulfonamide-resistant bacterial population. J Clean Prod 285:125483. https:\/\/doi.org\/10.1016\/j.jclepro.2020.125483","journal-title":"J Clean Prod"},{"key":"1356_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010069","volume":"21","author":"G Maisetta","year":"2019","unstructured":"Maisetta G, Grassi L, Esin S, Kaya E, Morelli A, Puppi D, Piras M, Chiellini F, Pifferi M, Batoni G (2019) Targeting Pseudomonas aeruginosa in the sputum of primary ciliary dyskinesia patients with a combinatorial strategy having antibacterial and anti-virulence potential. Int J Mol Sci 21:69. https:\/\/doi.org\/10.3390\/ijms21010069","journal-title":"Int J Mol Sci"},{"key":"1356_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2020.104812","volume":"9","author":"A Majumder","year":"2021","unstructured":"Majumder A, Gupta AK, Ghosal PS, Varma M (2021) A review on hospital wastewater treatment: a special emphasis on occurrence and removal of pharmaceutically active compounds, resistant microorganisms, and SARS-CoV-2. J Environ Chem Eng 9:104812. https:\/\/doi.org\/10.1016\/j.jece.2020.104812","journal-title":"J Environ Chem Eng"},{"key":"1356_CR41","doi-asserted-by":"publisher","first-page":"279","DOI":"10.28978\/nesciences.1646466","volume":"10","author":"HR Manjunath","year":"2025","unstructured":"Manjunath HR, Sharma VK, Guntaj J, Kolaventi SS (2025) Investigating the seasonal dynamics of zooplankton abundance in relation to water quality parameters. Nat Eng Sci 10:279\u2013289. https:\/\/doi.org\/10.28978\/nesciences.1646466","journal-title":"Nat Eng Sci"},{"key":"1356_CR42","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4068717","volume":"2019","author":"E Matuszczak","year":"2019","unstructured":"Matuszczak E, Komarowska MD, Debek W, Hermanowicz A (2019) The impact of bisphenol A on fertility, reproductive system, and development: a review of the literature. Int J Endocrinol 2019:4068717. https:\/\/doi.org\/10.1155\/2019\/4068717","journal-title":"Int J Endocrinol"},{"key":"1356_CR43","doi-asserted-by":"publisher","first-page":"221","DOI":"10.51758\/agjsr-03-2021-0027","volume":"39","author":"S Mehra","year":"2022","unstructured":"Mehra S, Tyagi C, Dudha N, Reddy YP, Manjhi J, Sharma VK, Tomar LK (2022) Molecular characterization and phylogenetic analysis of Pseudomonas aeruginosa obtained from wound infection. Arab Gulf J Sci Res 39:221\u2013235. https:\/\/doi.org\/10.51758\/agjsr-03-2021-0027","journal-title":"Arab Gulf J Sci Res"},{"key":"1356_CR44","doi-asserted-by":"publisher","unstructured":"Mehra S, Sharma VK, Tygai C, Tomar LK (2023) Ethnomedicinal pertinence and antibacterial prospective of Himalayan medicinal plants of Uttarakhand in India. In: Mishra MK, Kumari N (eds) Plants for immunity and conservation strategies. Springer, Singapore. https:\/\/doi.org\/10.1007\/978-981-99-2824-8_15","DOI":"10.1007\/978-981-99-2824-8_15"},{"key":"1356_CR45","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/antibiotics10111406","volume":"10","author":"M Miklasi\u0144ska-Majdanik","year":"2021","unstructured":"Miklasi\u0144ska-Majdanik M (2021) Mechanisms of resistance to macrolide antibiotics among Staphylococcus aureus. Antibiotics (Basel) 10:1406. https:\/\/doi.org\/10.3390\/antibiotics10111406","journal-title":"Antibiotics (Basel)"},{"key":"1356_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184613","volume":"20","author":"C Mittelberger","year":"2019","unstructured":"Mittelberger C, Stellmach H, Hause B, Kerschbamer C, Schlink K, Letschka T, Janik K (2019) A novel effector protein of apple proliferation phytoplasma disrupts cell integrity of Nicotiana spp. protoplasts. Int J Mol Sci 20:4613. https:\/\/doi.org\/10.3390\/ijms20184613","journal-title":"Int J Mol Sci"},{"key":"1356_CR47","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2436060","volume":"15","author":"Z Omole","year":"2024","unstructured":"Omole Z, Dorrell N, Elmi A, Nasher F, Gundogdu O, Wren BW (2024) Pathogenicity and virulence of Campylobacter jejuni: what do we really know? Virulence 15:2436060. https:\/\/doi.org\/10.1080\/21505594.2024.2436060","journal-title":"Virulence"},{"key":"1356_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e08845","volume":"8","author":"H Onohuean","year":"2022","unstructured":"Onohuean H, Agwu E, Nwodo UU (2022) Systematic review and meta-analysis of environmental vibrio species-antibiotic resistance. Heliyon 8:e08845. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e08845","journal-title":"Heliyon"},{"key":"1356_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2022.114609","volume":"308","author":"VK Parida","year":"2022","unstructured":"Parida VK, Sikarwar D, Majumder A, Gupta AK (2022) An assessment of hospital wastewater and biomedical waste generation, existing legislations, risk assessment, treatment processes, and scenario during COVID-19. J Environ Manag 308:114609. https:\/\/doi.org\/10.1016\/j.jenvman.2022.114609","journal-title":"J Environ Manag"},{"key":"1356_CR50","doi-asserted-by":"publisher","first-page":"219","DOI":"10.28978\/nesciences.1643508","volume":"10","author":"S Patil","year":"2025","unstructured":"Patil S, Asha Rajiv R, Sharma VK, Kumar D (2025) Exploring feeding ecology and trophic relationships in marine predators using lipid profiling. Natural and Engineering Sciences 10:219\u2013230. https:\/\/doi.org\/10.28978\/nesciences.1643508","journal-title":"Natural and Engineering Sciences"},{"key":"1356_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134023","volume":"697","author":"M Pazda","year":"2019","unstructured":"Pazda M, Kumirska J, Stepnowski P, Mulkiewicz E (2019) Antibiotic resistance genes identified in wastewater treatment plant systems-a review. Sci Total Environ 697:134023. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134023","journal-title":"Sci Total Environ"},{"key":"1356_CR52","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","volume":"4","author":"WC Reygaert","year":"2018","unstructured":"Reygaert WC (2018) An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol 4:482\u2013501. https:\/\/doi.org\/10.3934\/microbiol.2018.3.482","journal-title":"AIMS Microbiol"},{"key":"1356_CR53","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.3390\/ijms20225577","volume":"20","author":"J Roszkowiak","year":"2019","unstructured":"Roszkowiak J, Jajor P, Gu\u0142a G, Gubernator J, \u017bak A, Drulis-Kawa Z, Augustyniak D (2019) Interspecies outer membrane vesicles modulate the sensitivity of pathogenic bacteria and pathogenic yeasts to cationic peptides and serum complement. Int J Mol Sci 20:5577. https:\/\/doi.org\/10.3390\/ijms20225577","journal-title":"Int J Mol Sci"},{"key":"1356_CR54","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1128\/JVI.02823-13","volume":"88","author":"K Ruggero","year":"2014","unstructured":"Ruggero K, Guffanti A, Corradin A, Sharma VK, De Bellis G, Corti G, Grassi A, Zanovello P, Bronte V, Ciminale V, D\u2019Agostino DM (2014) Small noncoding RNAs in cells transformed by human T-cell leukemia virus type 1: a role for a tRNA fragment as a primer for reverse transcriptase. J Virol 88:3612\u20133622. https:\/\/doi.org\/10.1128\/JVI.02823-13","journal-title":"J Virol"},{"key":"1356_CR55","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1080\/15569543.2021.1922923","volume":"41","author":"G Sarizadeh","year":"2022","unstructured":"Sarizadeh G, Geravandi S, Takdastan A, Javanmaerdi P, Mohammadi MJ (2022) Efficiency of hospital wastewater treatment system in removal of level of toxic, microbial, and organic pollutant. Toxin Rev 41:721\u2013730. https:\/\/doi.org\/10.1080\/15569543.2021.1922923","journal-title":"Toxin Rev"},{"key":"1356_CR56","doi-asserted-by":"publisher","first-page":"102196","DOI":"10.1016\/j.jece.2018.02.004","volume":"8","author":"EA Serna-Galvis","year":"2020","unstructured":"Serna-Galvis EA, Salazar-Ospina L, Jim\u00e9nez JN, Pino NJ, Torres-Palma RA (2020) Elimination of carbapenem resistant Klebsiella pneumoniae in water by UV-C, UV-C\/persulfate and UV-C\/H\u2082O\u2082: evaluation of response to antibiotic, residual effect of the processes and removal of resistance gene. J Environ Chem Eng 8:102196. https:\/\/doi.org\/10.1016\/j.jece.2018.02.004","journal-title":"J Environ Chem Eng"},{"key":"1356_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126822","volume":"421","author":"G Sha","year":"2022","unstructured":"Sha G, Bi W, Zhang L, Chen T, Li X, Chen G, Wang L (2022) Dynamics and removal mechanisms of antibiotic and antibiotic resistance genes during the fermentation process of spectinomycin mycelial dregs: an integrated meta-omics study. J Hazard Mater 421:126822. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.126822","journal-title":"J Hazard Mater"},{"key":"1356_CR58","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jiph.2020.09.014","volume":"14","author":"VK Sharma","year":"2021","unstructured":"Sharma VK, Tomar LK, Tyagi C, Manjhi J, Reddy YP, Tiwari SK (2021) COVID-19 and anticoagulant-based therapeutics: approach with great promise. J Infect Public Health 14:681\u2013682. https:\/\/doi.org\/10.1016\/j.jiph.2020.09.014","journal-title":"J Infect Public Health"},{"key":"1356_CR59","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10787-010-0031-y","volume":"18","author":"SK Tiwari","year":"2010","unstructured":"Tiwari SK, Manoj G, Sharma V, Sivaram G, Saikant R, Bardia A, Sharma VK, Abid Z, Khan AA, Habeeb MA, Habibullah CM, Kumar BS, Nandan A (2010) Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels. Inflammopharmacology 18:59\u201364. https:\/\/doi.org\/10.1007\/s10787-010-0031-y","journal-title":"Inflammopharmacology"},{"key":"1356_CR60","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1590\/s1415-47572011005000003","volume":"34","author":"SK Tiwari","year":"2011","unstructured":"Tiwari SK, Sharma V, Sharma VK, Gopi M, Saikant R, Nandan A, Bardia A, Gunisetty S, Katikala P, Habeeb MA, Khan AA, Habibullah CM (2011) Phylogenetic analysis, based on EPIYA repeats in the cagA gene of Indian Helicobacter pylori, and the implications of sequence variation in tyrosine phosphorylation motifs on determining the clinical outcome. Genet Mol Biol 34:280\u2013285. https:\/\/doi.org\/10.1590\/s1415-47572011005000003","journal-title":"Genet Mol Biol"},{"key":"1356_CR61","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1186\/s12889-021-11478-1","volume":"21","author":"J Todedji","year":"2021","unstructured":"Todedji J, Sopoh G, Degbey C, Yessoufou A, Suanon F, Mama D (2021) Assessment of the quality of effluent management from university hospitals in the littoral department in Benin. BMC Public Health 21:1429. https:\/\/doi.org\/10.1186\/s12889-021-11478-1","journal-title":"BMC Public Health"},{"key":"1356_CR62","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/antibiotics10050593","volume":"10","author":"MF Varela","year":"2021","unstructured":"Varela MF, Stephen J, Lekshmi M, Ojha M, Wenzel N, Sanford LM, Hernandez AJ, Parvathi A, Kumar SH (2021) Bacterial resistance to antimicrobial agents. Antibiotics (Basel) 10:593. https:\/\/doi.org\/10.3390\/antibiotics10050593","journal-title":"Antibiotics (Basel)"},{"key":"1356_CR63","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.chemosphere.2019.05.009","volume":"230","author":"TK Vo","year":"2019","unstructured":"Vo TK, Bui XT, Chen SS, Nguyen PD, Cao ND, Vo TD, Nguyen TT, Nguyen TB (2019) Hospital wastewater treatment by sponge membrane bioreactor coupled with ozonation process. Chemosphere 230:377\u2013383. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.05.009","journal-title":"Chemosphere"},{"key":"1356_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.135249","volume":"704","author":"J Wang","year":"2020","unstructured":"Wang J, Chen H (2020) Catalytic ozonation for water and wastewater treatment: recent advances and perspective. Sci Total Environ 704:135249. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135249","journal-title":"Sci Total Environ"},{"key":"1356_CR65","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jhazmat.2015.05.028","volume":"299","author":"FH Wang","year":"2015","unstructured":"Wang FH, Qiao M, Chen Z, Su JQ, Zhu YG (2015) Antibiotic resistance genes in manure-amended soil and vegetables at harvest. J Hazard Mater 299:215\u2013221. https:\/\/doi.org\/10.1016\/j.jhazmat.2015.05.028","journal-title":"J Hazard Mater"},{"key":"1356_CR66","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev-publhealth-052120-101420","volume":"43","author":"AK Weaver","year":"2022","unstructured":"Weaver AK, Head JR, Gould CF, Carlton EJ, Remais JV (2022) Environmental factors influencing COVID-19 incidence and severity. Annu Rev Public Health 43:271\u2013291. https:\/\/doi.org\/10.1146\/annurev-publhealth-052120-101420","journal-title":"Annu Rev Public Health"},{"key":"1356_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020380","volume":"20","author":"X Yang","year":"2019","unstructured":"Yang X, Wang J, Feng Z, Zhang X, Wang X, Wu Q (2019) Relation of the pdxB-usg-truA-dedA operon and the truA gene to the intracellular survival of Salmonella enterica serovar Typhimurium. Int J Mol Sci 20:380. https:\/\/doi.org\/10.3390\/ijms20020380","journal-title":"Int J Mol Sci"},{"key":"1356_CR68","doi-asserted-by":"publisher","first-page":"57321","DOI":"10.1007\/s11356-021-14735-3","volume":"28","author":"S Yao","year":"2021","unstructured":"Yao S, Ye J, Yang Q, Hu Y, Zhang T, Jiang L, Munezero S, Lin K, Cui C (2021) Occurrence and removal of antibiotics, antibiotic resistance genes, and bacterial communities in hospital wastewater. Environ Sci Pollut Res Int 28:57321\u201357333. https:\/\/doi.org\/10.1007\/s11356-021-14735-3","journal-title":"Environ Sci Pollut Res Int"},{"key":"1356_CR69","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41396-021-01095-6","volume":"16","author":"Z Yu","year":"2022","unstructured":"Yu Z, Wang Y, Henderson IR, Guo J (2022) Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation. ISME 16:543\u2013554. https:\/\/doi.org\/10.1038\/s41396-021-01095-6","journal-title":"ISME"},{"key":"1356_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2025.123092","volume":"274","author":"W Zhao","year":"2025","unstructured":"Zhao W, Hou Y, Wei L, Wei W, Zhang K, Duan H, Ni BJ (2025) Chlorination-induced spread of antibiotic resistance genes in drinking water systems. Water Res 274:123092. https:\/\/doi.org\/10.1016\/j.watres.2025.123092","journal-title":"Water Res"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-025-01356-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-025-01356-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-025-01356-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:27:50Z","timestamp":1767587270000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-025-01356-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1356"],"URL":"https:\/\/doi.org\/10.1007\/s12223-025-01356-3","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This review article is a comprehensive analysis of existing literature and does not involve any experiments on humans, animals, or cell lines. Therefore, ethical approval was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}