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The growing resistance of fungi to conventional antifungal agents demands the development of new and effective antifungal strategies. Organosolv lignin-capped silver-based nanoparticles constitute a promising strategy, combining the antifungal activity of metallic silver with the biocompatibility and sustainability of organosolv lignin. In this context, we report a fast green photochemical method for synthesizing plasmonic silver\/silver chloride nanoparticles capped with organosolv lignin (OL\/Ag\/AgCl-NPs) for antifungal applications. The OL\/Ag\/AgCl-NPs possess a well-defined spherical three-layered architecture, comprising a semiconductor AgCl core, an intermediate metallic silver surface, and a thin outer organosolv lignin layer. The cytotoxicity of the OL\/Ag\/AgCl-NPs in VERO cells was confirmed to be concentration-dependent. Crucially, cells exposed to toxic doses recovered metabolic activity comparable to controls, suggesting potentially reversible cytotoxic effects. The broad-spectrum antifungal agent Amphotericin B (AmB) effectively inhibited the growth of pathogenic\n                    <jats:italic>Nakaseomyces glabratus<\/jats:italic>\n                    (formerly\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    ) and\n                    <jats:italic>Pichia kudriavzevii<\/jats:italic>\n                    (formerly\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    ), both displaying a minimum inhibitory concentration (MIC) of 0.19\u00a0\u00b5g\/mL. In contrast, pathogenic\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    exhibited resistance to AmB. Notably, OL\/Ag\/AgCl-NPs exhibited remarkable antifungal activity against\n                    <jats:italic>N. glabratus<\/jats:italic>\n                    ,\n                    <jats:italic>P. kudriavzevii<\/jats:italic>\n                    , and AmB-resistant\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    , with MIC values of 1.09\u00a0\u00b5g\/mL, 2.18\u00a0\u00b5g\/mL, and 2.18\u00a0\u00b5g\/mL, respectively. Moreover, the results revealed that the OL\/Ag\/AgCl-NPs exhibited a fungistatic effect against\n                    <jats:italic>N. glabratus<\/jats:italic>\n                    and\n                    <jats:italic>P. kudriavzevii<\/jats:italic>\n                    , while exhibited a fungicidal effect against the AmB-resistant\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . These findings are particularly relevant given the challenge of treating resistant fungal infections and may contribute to the development of new therapeutic strategies. This study advances organosolv lignin-based nanomaterials, offering a promising platform for future biomedical applications.\n                  <\/jats:p>","DOI":"10.1007\/s12223-026-01432-2","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:44:40Z","timestamp":1771652680000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fungicidal efficacy of green-synthesized organosolv lignin-capped silver-based nanoparticles against amphotericin B-resistant Candida tropicalis"],"prefix":"10.1007","author":[{"given":"Di\u00f3genes G. da S.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Brito","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pereira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Furlan","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli","family":"Colussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Michelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Arnaldo R.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Dias","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-3488","authenticated-orcid":false,"given":"Wanius","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"1432_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12010-024-05035-w","volume":"197","author":"MA Abu-Tahon","year":"2025","unstructured":"Abu-Tahon MA, Alshammari FA, Shahhat IM et al (2025) Eco-friendly synthesis, characterization, and biomedical applications of biosynthesized bimetallic silver-gold nanoparticles by culture supernatant of Aspergillus Niger. 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