{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:20Z","timestamp":1787169920692,"version":"build-2736575974"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["122Z018"],"award-info":[{"award-number":["122Z018"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"DOI":"10.1007\/s12223-026-01556-5","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:27:03Z","timestamp":1784352423000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-wide analysis of the Escherichia coli Keio collection reveals genetic determinants associated with ferulic acid responses"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-2912","authenticated-orcid":false,"given":"Merve","family":"Sezer K\u00fcrk\u00e7\u00fc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0401","authenticated-orcid":false,"given":"Hatice","family":"\u00d6zt\u00fcrkel Kabaka\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-5728","authenticated-orcid":false,"given":"Kadriye Asl\u0131han","family":"Onat Ta\u015fdelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8110-5466","authenticated-orcid":false,"given":"Esra","family":"Dibek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-4116","authenticated-orcid":false,"given":"Bekir","family":"\u00c7\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"1556_CR1","doi-asserted-by":"publisher","first-page":"20086","DOI":"10.1074\/JBC.M117.806240","volume":"292","author":"S Agrawal","year":"2017","unstructured":"Agrawal S et al (2017) A genome-wide screen in Escherichia coli reveals that ubiquinone is a key antioxidant for metabolism of long-chain fatty acids. J Biol Chem 292:20086\u201320099. https:\/\/doi.org\/10.1074\/JBC.M117.806240","journal-title":"J Biol Chem"},{"key":"1556_CR2","doi-asserted-by":"publisher","first-page":"106365","DOI":"10.1016\/j.archoralbio.2025.106365","volume":"178","author":"D Ando","year":"2025","unstructured":"Ando D et al (2025) Ferulic acid suppresses Porphyromonas gingivalis biofilm formation via the inhibition of autoinducer-2 production and receptor activity. Arch Oral Biol 178:106365. https:\/\/doi.org\/10.1016\/j.archoralbio.2025.106365","journal-title":"Arch Oral Biol"},{"key":"1556_CR3","doi-asserted-by":"publisher","unstructured":"Aoki-Kinoshita KF, Kanehisa M (2007) Gene annotation and pathway mapping in KEGG. Humana Press. 396:71\u201391. https:\/\/doi.org\/10.1007\/978-1-59745-515-2_6","DOI":"10.1007\/978-1-59745-515-2_6"},{"key":"1556_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050","author":"T Baba","year":"2006","unstructured":"Baba T et al (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol;2. https:\/\/doi.org\/10.1038\/msb4100050","journal-title":"Mol Syst Biol;2"},{"key":"1556_CR5","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s10096-025-05183-9","volume":"44","author":"A Babayeva","year":"2025","unstructured":"Babayeva A, \u00c7\u00f6l B (2025) Genome-wide screening of the Escherichia coli Keio knockout collection identifies genetic determinants of epetraborole hypersusceptibility. Eur J Clin Microbiol Infect Dis 44:2167\u20132182. https:\/\/doi.org\/10.1007\/s10096-025-05183-9","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1556_CR6","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1016\/J.FEBSLET.2006.06.045","volume":"580","author":"M Blokesch","year":"2006","unstructured":"Blokesch M, B\u00f6ck A (2006) Properties of the [NiFe]-hydrogenase maturation protein HypD. FEBS Lett 580:4065\u20134068. https:\/\/doi.org\/10.1016\/J.FEBSLET.2006.06.045","journal-title":"FEBS Lett"},{"key":"1556_CR7","doi-asserted-by":"publisher","first-page":"7960","DOI":"10.1093\/NAR\/GKU508","volume":"42","author":"D Bouvier","year":"2014","unstructured":"Bouvier D et al (2014) TtcA a new tRNA-thioltransferase with an Fe-S cluster. Nucleic Acids Res 42:7960\u20137970. https:\/\/doi.org\/10.1093\/NAR\/GKU508","journal-title":"Nucleic Acids Res"},{"key":"1556_CR8","doi-asserted-by":"publisher","first-page":"16414","DOI":"10.1074\/jbc.M001854200","volume":"275","author":"T Caldas","year":"2000","unstructured":"Caldas T et al (2000) The FtsJ\/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. J Biol Chem 275:16414\u201316419. https:\/\/doi.org\/10.1074\/jbc.M001854200","journal-title":"J Biol Chem"},{"key":"1556_CR9","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1111\/jam.1516","volume":"131","author":"R Chauhan","year":"2021","unstructured":"Chauhan R et al (2021) Multivariate analysis of adaptive response to ferulic acid and p-coumaric acid after physiological stresses in Cronobacter sakazakii. J Appl Microbiol 131:3069\u20133080. https:\/\/doi.org\/10.1111\/jam.1516","journal-title":"J Appl Microbiol"},{"key":"1556_CR10","doi-asserted-by":"publisher","unstructured":"Choe D et al (2025) Rapid identification of key antibiotic resistance genes in E. coli using high-resolution genome-scale CRISPRi screening. iScience 28(5). https:\/\/doi.org\/10.1016\/j.isci.2025.112435","DOI":"10.1016\/j.isci.2025.112435"},{"key":"1556_CR11","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.1007\/s12011-024-04129-0","volume":"202","author":"B \u00c7\u00f6l","year":"2024","unstructured":"\u00c7\u00f6l B, Sezer K\u00fcrk\u00e7\u00fc M, Dibek E (2024) Genome-wide screens identify genes responsible for intrinsic boric acid resistance in Escherichia coli. Biol Trace Elem Res 202:5771\u20135793. https:\/\/doi.org\/10.1007\/s12011-024-04129-0","journal-title":"Biol Trace Elem Res"},{"key":"1556_CR12","doi-asserted-by":"publisher","first-page":"6640","DOI":"10.1073\/pnas.120163297","volume":"97","author":"KA Datsenko","year":"2000","unstructured":"Datsenko KA, Wanner BL (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97:6640\u20136645. https:\/\/doi.org\/10.1073\/pnas.120163297","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1556_CR13","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.3168\/jds.2014-8890","volume":"98","author":"M De Boer","year":"2015","unstructured":"De Boer M et al (2015) Minimum inhibitory concentrations of selected antimicrobials against Escherichia coli and Trueperella pyogenes of bovine uterine origin. J Dairy Sci 98:4427\u20134438. https:\/\/doi.org\/10.3168\/jds.2014-8890","journal-title":"J Dairy Sci"},{"key":"1556_CR14","doi-asserted-by":"publisher","unstructured":"de Carvalho SP et al (2025) Bioconversion of ferulic acid to 4-vinylguaiacol by ferulic acid decarboxylase from Brucella intermedia TG 3.48. Processes 13(10). https:\/\/doi.org\/10.3390\/pr13103367","DOI":"10.3390\/pr13103367"},{"key":"1556_CR15","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1021\/BI401429B","volume":"53","author":"VC Derocco","year":"2014","unstructured":"Derocco VC et al (2014) Dynamics of MutS-mismatched DNA complexes are predictive of their repair phenotypes. Biochemistry 53:2043\u20132052. https:\/\/doi.org\/10.1021\/BI401429B","journal-title":"Biochemistry"},{"key":"1556_CR16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00217-024-04642-5","volume":"251","author":"E Dibek","year":"2025","unstructured":"Dibek E et al (2025) Genome-wide screen of Escherichia coli Keio mutant line identifies genes related to propolis effect. Eur Food Res Technol 251:429\u2013448. https:\/\/doi.org\/10.1007\/s00217-024-04642-5","journal-title":"Eur Food Res Technol"},{"key":"1556_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/jipb.13054","volume":"63","author":"NQ Dong","year":"2021","unstructured":"Dong NQ, Lin HX (2021) Contribution of phenylpropanoid metabolism to plant development and plant\u2013environment interactions. J Integr Plant Biol 63:180\u2013209. https:\/\/doi.org\/10.1111\/jipb.13054","journal-title":"J Integr Plant Biol"},{"key":"1556_CR18","doi-asserted-by":"publisher","first-page":"129262","DOI":"10.1016\/j.biortech.2023.129262","volume":"384","author":"SSW Effendi","year":"2023","unstructured":"Effendi SSW, Ng IS (2023) High value ferulic acid biosynthesis using modular design and spent coffee ground in engineered Escherichia coli chassis. Bioresour Technol 384:129262. https:\/\/doi.org\/10.1016\/j.biortech.2023.129262","journal-title":"Bioresour Technol"},{"key":"1556_CR19","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1073\/PNAS.1114944109","volume":"109","author":"T Eicher","year":"2012","unstructured":"Eicher T et al (2012) Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A 109:5687\u20135692. https:\/\/doi.org\/10.1073\/PNAS.1114944109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1556_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/J.1365-2958.2006.05221.X","volume":"61","author":"RE Feissner","year":"2006","unstructured":"Feissner RE et al (2006) ABC transporter-mediated release of a haem chaperone allows cytochrome c biogenesis. Mol Microbiol 61:219\u2013231. https:\/\/doi.org\/10.1111\/J.1365-2958.2006.05221.X","journal-title":"Mol Microbiol"},{"key":"1556_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.molp.2014.11.008","volume":"8","author":"NJ Gallage","year":"2015","unstructured":"Gallage NJ, M\u00f8ller BL (2015) Vanillin-bioconversion and bioengineering of the most popular plant flavor and its de novo biosynthesis in the vanilla orchid. Mol Plant 8:40\u201357. https:\/\/doi.org\/10.1016\/j.molp.2014.11.008","journal-title":"Mol Plant"},{"key":"1556_CR22","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3390\/GENES9070344","volume":"9","author":"N Gugala","year":"2018","unstructured":"Gugala N et al (2018) Using a chemical genetic screen to enhance our understanding of the antibacterial properties of silver. Genes 9:344. https:\/\/doi.org\/10.3390\/GENES9070344","journal-title":"Genes"},{"key":"1556_CR23","doi-asserted-by":"publisher","first-page":"6149","DOI":"10.1021\/JA807551E","volume":"131","author":"V Gupta","year":"2009","unstructured":"Gupta V et al (2009) Native Escherichia coli SufA, coexpressed with SufBCDSE, purifies as a [2Fe-2S] protein and acts as an Fe-S transporter to Fe-S target enzymes. J Am Chem Soc 131:6149\u20136153. https:\/\/doi.org\/10.1021\/JA807551E","journal-title":"J Am Chem Soc"},{"key":"1556_CR24","doi-asserted-by":"publisher","unstructured":"Han J et al (2023) Piperine: chemistry and biology. Toxins 15(12). https:\/\/doi.org\/10.3390\/toxins15120696","DOI":"10.3390\/toxins15120696"},{"key":"1556_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2008","unstructured":"Huang DW, Sherman BT, Lempicki RA (2008) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357. https:\/\/doi.org\/10.1038\/nprot.2008.211","journal-title":"Nat Protoc"},{"key":"1556_CR26","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1128\/JB.184.14.3879-3885.2002","volume":"184","author":"M Hube","year":"2002","unstructured":"Hube M, Blokesch M, B\u00f6ck A (2002) Network of hydrogenase maturation in Escherichia coli: role of accessory proteins HypA and HybF. J Bacteriol 184:3879\u20133885. https:\/\/doi.org\/10.1128\/JB.184.14.3879-3885.2002","journal-title":"J Bacteriol"},{"key":"1556_CR27","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1046\/J.1432-1033.2003.03683.X","volume":"270","author":"W Ismail","year":"2003","unstructured":"Ismail W et al (2003) Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur J Biochem 270:3047\u20133054. https:\/\/doi.org\/10.1046\/J.1432-1033.2003.03683.X","journal-title":"Eur J Biochem"},{"key":"1556_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.biortech.2015.10.009","volume":"199","author":"LJ J\u00f6nsson","year":"2016","unstructured":"J\u00f6nsson LJ, Mart\u00edn C (2016) Pretreatment of lignocellulose: formation of inhibitory by-products and strategies for minimizing their effects. Bioresour Technol 199:103\u2013112. https:\/\/doi.org\/10.1016\/j.biortech.2015.10.009","journal-title":"Bioresour Technol"},{"key":"1556_CR29","doi-asserted-by":"publisher","first-page":"11160","DOI":"10.1074\/jbc.M900070200","volume":"284","author":"Y Katsuyama","year":"2009","unstructured":"Katsuyama Y et al (2009) Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J Biol Chem 284:11160\u201311170. https:\/\/doi.org\/10.1074\/jbc.M900070200","journal-title":"J Biol Chem"},{"key":"1556_CR31","doi-asserted-by":"publisher","unstructured":"Keseler IM et al (2017) The EcoCyc database: reflecting new knowledge about Escherichia coli K-12. Nucleic Acids Res 45-D550. https:\/\/doi.org\/10.1093\/NAR\/GKW1003","DOI":"10.1093\/NAR\/GKW1003"},{"key":"1556_CR30","doi-asserted-by":"publisher","first-page":"711077","DOI":"10.3389\/FMICB.2021.711077","volume":"12","author":"IM Keseler","year":"2021","unstructured":"Keseler IM et al (2021) The EcoCyc database in 2021. Front Microbiol 12:711077. https:\/\/doi.org\/10.3389\/FMICB.2021.711077","journal-title":"Front Microbiol"},{"key":"1556_CR32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/DNARES\/DSI012","volume":"12","author":"M Kitagawa","year":"2005","unstructured":"Kitagawa M et al (2005) Complete set of ORF clones of Escherichia coli ASKA library: unique resources for biological research. DNA Res 12:291\u2013299. https:\/\/doi.org\/10.1093\/DNARES\/DSI012","journal-title":"DNA Res"},{"key":"1556_CR33","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/MBO3.108","volume":"2","author":"SG Kozmin","year":"2013","unstructured":"Kozmin SG, Stepchenkova EI, Schaaper RM (2013) TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification. MicrobiologyOpen 2:743\u2013755. https:\/\/doi.org\/10.1002\/MBO3.108","journal-title":"MicrobiologyOpen"},{"key":"1556_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.procbio.2024.12.012","volume":"149","author":"D Krishnan","year":"2025","unstructured":"Krishnan D, Rameshpathy M (2025) A renewable natural resource for ferulic acid; an efficient precursor in biotechnological production of vanillin and strategies to enhance the yield of bio-vanillin from ferulic acid\u2014review. Process Biochem 149:181\u2013191. https:\/\/doi.org\/10.1016\/j.procbio.2024.12.012","journal-title":"Process Biochem"},{"key":"1556_CR36","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.btre.2014.09.002","volume":"4","author":"N Kumar","year":"2014","unstructured":"Kumar N, Pruthi V (2014) Potential applications of ferulic acid from natural sources. Biotechnol Rep 4:86\u201393. https:\/\/doi.org\/10.1016\/j.btre.2014.09.002","journal-title":"Biotechnol Rep"},{"issue":"11","key":"1556_CR35","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.3390\/molecules26113447","volume":"26","author":"H Kumar","year":"2021","unstructured":"Kumar H et al (2021) Applications of fruit polyphenols and their functionalized nanoparticles against foodborne bacteria: a mini review. Molecules 26(11):3447. https:\/\/doi.org\/10.3390\/molecules26113447","journal-title":"Molecules"},{"key":"1556_CR37","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.bbrc.2006.06.009","volume":"346","author":"SJ Lee","year":"2006","unstructured":"Lee SJ, Ko Jhyeong, Kang HY, Lee Y (2006) Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli. Biochem Biophys Res Commun 346:1009\u20131015. https:\/\/doi.org\/10.1016\/j.bbrc.2006.06.009","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"1556_CR38","doi-asserted-by":"publisher","first-page":"7474","DOI":"10.3390\/ijms26157474","volume":"26","author":"S Leontakianakou","year":"2025","unstructured":"Leontakianakou S, Adlercreutz P, Nordberg Karlsson E (2025) Fantastic ferulic acid esterases and their functions. Int J Mol Sci 26(15):7474. https:\/\/doi.org\/10.3390\/ijms26157474","journal-title":"Int J Mol Sci"},{"key":"1556_CR39","doi-asserted-by":"publisher","unstructured":"Lobiuc A et al (2023) Future antimicrobials: natural and functionalized phenolics. Molecules 28(3). https:\/\/doi.org\/10.3390\/molecules28031114","DOI":"10.3390\/molecules28031114"},{"key":"1556_CR40","doi-asserted-by":"publisher","first-page":"11937","DOI":"10.1074\/JBC.M117.789164","volume":"292","author":"L Loiseau","year":"2017","unstructured":"Loiseau L et al (2017) The UbiK protein is an accessory factor necessary for bacterial ubiquinone biosynthesis and forms a complex with the ubiquinone biogenesis factor UbiJ. J Biol Chem 292:11937\u201311950. https:\/\/doi.org\/10.1074\/JBC.M117.789164","journal-title":"J Biol Chem"},{"key":"1556_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox10020188","volume":"10","author":"M Makarewicz","year":"2021","unstructured":"Makarewicz M et al (2021) The interactions between polyphenols and microorganisms, especially gut microbiota. Antioxidants 10:1\u201370. https:\/\/doi.org\/10.3390\/antiox10020188","journal-title":"Antioxidants"},{"key":"1556_CR42","doi-asserted-by":"publisher","first-page":"8009","DOI":"10.1073\/PNAS.0903229106","volume":"106","author":"JC Malinverni","year":"2009","unstructured":"Malinverni JC, Silhavy TJ (2009) An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc Natl Acad Sci U S A 106:8009\u20138014. https:\/\/doi.org\/10.1073\/PNAS.0903229106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1556_CR43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.fct.2013.12.024","volume":"65","author":"C Mancuso","year":"2014","unstructured":"Mancuso C, Santangelo R (2014) Ferulic acid: pharmacological and toxicological aspects. Food Chem Toxicol 65:185\u2013195. https:\/\/doi.org\/10.1016\/j.fct.2013.12.024","journal-title":"Food Chem Toxicol"},{"key":"1556_CR44","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1093\/OXFORDJOURNALS.JBCHEM.A022641","volume":"127","author":"H Mihara","year":"2000","unstructured":"Mihara H et al (2000) Kinetic and mutational studies of three NifS homologs from Escherichia coli: mechanistic difference between L-cysteine desulfurase and L-selenocysteine lyase reactions. J Biochem 127:559\u2013567. https:\/\/doi.org\/10.1093\/OXFORDJOURNALS.JBCHEM.A022641","journal-title":"J Biochem"},{"key":"1556_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/NATURE05076","volume":"443","author":"S Murakami","year":"2006","unstructured":"Murakami S et al (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443:173\u2013179. https:\/\/doi.org\/10.1038\/NATURE05076","journal-title":"Nature"},{"key":"1556_CR46","doi-asserted-by":"publisher","unstructured":"Norris V et al (2023) The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in bacteria. FEMS Microbiol Rev 47(6). https:\/\/doi.org\/10.1093\/FEMSRE\/FUAC049","DOI":"10.1093\/FEMSRE\/FUAC049"},{"key":"1556_CR47","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0303-2647(98)00017-3","volume":"47","author":"H Ogata","year":"1998","unstructured":"Ogata H et al (1998) Computation with the KEGG pathway database. BioSystems 47:119\u2013128. https:\/\/doi.org\/10.1016\/S0303-2647(98)00017-3","journal-title":"BioSystems"},{"key":"1556_CR48","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.biortech.2019.01.064","volume":"278","author":"DM Oliveira","year":"2019","unstructured":"Oliveira DM et al (2019) Feruloyl esterases: biocatalysts to overcome biomass recalcitrance and for the production of bioactive compounds. Bioresour Technol 278:408\u2013423. https:\/\/doi.org\/10.1016\/j.biortech.2019.01.064","journal-title":"Bioresour Technol"},{"key":"1556_CR49","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.21597\/jist.885898","volume":"11","author":"KA Onat","year":"2021","unstructured":"Onat KA, Sezer M, \u00c7\u00f6l B (2021) Some biological activities of phenolic compounds cinnamic acid, caffeic acid and p-coumaric acid. J Inst Sci Technol 11:2587\u20132598. https:\/\/doi.org\/10.21597\/jist.885898","journal-title":"J Inst Sci Technol"},{"key":"1556_CR50","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11274-023-03841-8","volume":"40","author":"KA Onat Ta\u015fdelen","year":"2023","unstructured":"Onat Ta\u015fdelen KA et al (2023) Functional groups matter: metabolomics analysis of Escherichia coli exposed to trans-cinnamic acid and its derivatives unveils common and unique targets. World J Microbiol Biotechnol 40:47. https:\/\/doi.org\/10.1007\/s11274-023-03841-8","journal-title":"World J Microbiol Biotechnol"},{"key":"1556_CR51","doi-asserted-by":"publisher","unstructured":"Onat Ta\u015fdelen KA et al (2026) Differential cytotoxicity of hydroxycinnamic acids in cancer cells: structure\u2013activity insights from a broad panel of cell lines. Cell Biochem Funct 44. https:\/\/doi.org\/10.1002\/cbf.70241","DOI":"10.1002\/cbf.70241"},{"key":"1556_CR52","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/J.1365-2958.2004.04025.X","volume":"52","author":"FW Outten","year":"2004","unstructured":"Outten FW, Djaman O, Storz G (2004) A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli. Mol Microbiol 52:861\u2013872. https:\/\/doi.org\/10.1111\/J.1365-2958.2004.04025.X","journal-title":"Mol Microbiol"},{"key":"1556_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2022.e00717","author":"PG Pinheiro","year":"2022","unstructured":"Pinheiro PG et al (2022) Ferulic acid derivatives inhibiting Staphylococcus aureus tetK and MsrA efflux pumps. Biotechnol Rep 34. https:\/\/doi.org\/10.1016\/j.btre.2022.e00717","journal-title":"Biotechnol Rep 34"},{"key":"1556_CR55","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41477-019-0474-0","volume":"5","author":"T Pluskal","year":"2019","unstructured":"Pluskal T et al (2019) The biosynthetic origin of psychoactive kavalactones in kava. Nat Plants 5:867\u2013878. https:\/\/doi.org\/10.1038\/s41477-019-0474-0","journal-title":"Nat Plants"},{"key":"1556_CR53","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1128\/JB.135.1.45-53.1978","volume":"135","author":"JS PParkinson","year":"1978","unstructured":"PParkinson JS (1978) Complementation analysis and deletion mapping of Escherichia coli mutants defective in chemotaxis. J Bacteriol 135:45\u201353. https:\/\/doi.org\/10.1128\/JB.135.1.45-53.1978","journal-title":"J Bacteriol"},{"key":"1556_CR56","doi-asserted-by":"publisher","unstructured":"Pratyusha S (2022) Phenolic compounds in the plant development and defense: an overview. IntechOpen. https:\/\/doi.org\/10.5772\/intechopen.102873","DOI":"10.5772\/intechopen.102873"},{"key":"1556_CR57","doi-asserted-by":"publisher","unstructured":"Purushothaman JR, Rizwanullah M (2024) Ferulic acid: a comprehensive review. Cureus 16. https:\/\/doi.org\/10.7759\/cureus.68063","DOI":"10.7759\/cureus.68063"},{"key":"1556_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/separations11070204","author":"K Pyrzynska","year":"2024","unstructured":"Pyrzynska K (2024) Ferulic acid\u2014a brief review of its extraction, bioavailability and biological activity. Sep 11. https:\/\/doi.org\/10.3390\/separations11070204","journal-title":"Sep 11"},{"key":"1556_CR59","doi-asserted-by":"publisher","first-page":"14264","DOI":"10.1111\/jfbc.14264","volume":"46","author":"A Rana","year":"2022","unstructured":"Rana A et al (2022) Health benefits of polyphenols: a concise review. J Food Biochem 46:14264. https:\/\/doi.org\/10.1111\/jfbc.14264","journal-title":"J Food Biochem"},{"key":"1556_CR60","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1128\/JB.143.1.513-515.1980","volume":"143","author":"F Richaud","year":"1980","unstructured":"Richaud F et al (1980) Regulation of aspartokinase III synthesis in Escherichia coli: isolation of mutants containing lysC-lac fusions. J Bacteriol 143:513\u2013515. https:\/\/doi.org\/10.1128\/JB.143.1.513-515.1980","journal-title":"J Bacteriol"},{"key":"1556_CR61","doi-asserted-by":"publisher","unstructured":"Robinson A et al (2015) Regulation of mutagenic DNA polymerase V activation in space and time. PLoS Genet 11. https:\/\/doi.org\/10.1371\/JOURNAL.PGEN.1005482","DOI":"10.1371\/JOURNAL.PGEN.1005482"},{"key":"1556_CR63","unstructured":"Sambrook J, Russell DW (2001) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press. https:\/\/www.scirp.org\/reference\/ReferencesPapers?ReferenceID=1765722"},{"key":"1556_CR64","doi-asserted-by":"publisher","first-page":"95","DOI":"10.28979\/jarnas.1645815","volume":"11","author":"M Sezer K\u00fcrk\u00e7\u00fc","year":"2025","unstructured":"Sezer K\u00fcrk\u00e7\u00fc M, Gen\u00e7 D, \u00c7\u00f6l B (2025a) Caffeic acid\u2019s influence on the viability and apoptosis of a diverse array of cancer cell lines. J Adv Res Nat Appl Sci 11:95\u2013106. https:\/\/doi.org\/10.28979\/jarnas.1645815","journal-title":"J Adv Res Nat Appl Sci"},{"key":"1556_CR65","doi-asserted-by":"publisher","unstructured":"Sezer K\u00fcrk\u00e7\u00fc M et al (2025b) Genome-wide screen using Escherichia coli Keio knockout mutant line reveals genes related to the antimicrobial properties of trans-cinnamic acid. World J Microbiol Biotechnol 41. https:\/\/doi.org\/10.1007\/s11274-025-04506-4","DOI":"10.1007\/s11274-025-04506-4"},{"key":"1556_CR66","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1074\/jbc.m704400200","volume":"283","author":"RE Silversmith","year":"2008","unstructured":"Silversmith RE et al (2008) Kinetic characterization of catalysis by the chemotaxis phosphatase CheZ. J Biol Chem 283:756\u2013765. https:\/\/doi.org\/10.1074\/jbc.m704400200","journal-title":"J Biol Chem"},{"key":"1556_CR62","doi-asserted-by":"publisher","unstructured":"Saier MH et al (2016) The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res 44\u2013D379. https:\/\/doi.org\/10.1093\/NAR\/GKV1103","DOI":"10.1093\/NAR\/GKV1103"},{"key":"1556_CR67","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1021\/BI400302V","volume":"52","author":"ST Stripp","year":"2013","unstructured":"Stripp ST et al (2013) HypD is the scaffold protein for Fe-(CN)2CO cofactor assembly in [NiFe]-hydrogenase maturation. Biochemistry 52:3289\u20133296. https:\/\/doi.org\/10.1021\/BI400302V","journal-title":"Biochemistry"},{"key":"1556_CR68","doi-asserted-by":"publisher","unstructured":"Szklarczyk D et al (2017) The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res 45\u2013D368. https:\/\/doi.org\/10.1093\/nar\/gkw937","DOI":"10.1093\/nar\/gkw937"},{"key":"1556_CR69","doi-asserted-by":"publisher","first-page":"14390","DOI":"10.1073\/PNAS.1005399107","volume":"107","author":"R Teufel","year":"2010","unstructured":"Teufel R et al (2010) Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A 107:14390\u201314395. https:\/\/doi.org\/10.1073\/PNAS.1005399107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1556_CR70","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1128\/AEM.03996-12","volume":"79","author":"J Theisen","year":"2013","unstructured":"Theisen J, Zylstra GJ, Yee N (2013) Genetic evidence for a molybdopterin-containing tellurate reductase. Appl Environ Microbiol 79:3171\u20133175. https:\/\/doi.org\/10.1128\/AEM.03996-12","journal-title":"Appl Environ Microbiol"},{"key":"1556_CR71","doi-asserted-by":"publisher","unstructured":"Thong S et al (2016) Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. eLife 5. https:\/\/doi.org\/10.7554\/ELIFE.19042","DOI":"10.7554\/ELIFE.19042"},{"key":"1556_CR72","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1016\/J.FEBSLET.2013.09.016","volume":"587","author":"K Trchounian","year":"2013","unstructured":"Trchounian K, Trchounian A (2013) Escherichia coli multiple [Ni-Fe]-hydrogenases are sensitive to osmotic stress during glycerol fermentation but at different pHs. FEBS Lett 587:3562\u20133566. https:\/\/doi.org\/10.1016\/J.FEBSLET.2013.09.016","journal-title":"FEBS Lett"},{"key":"1556_CR74","doi-asserted-by":"publisher","first-page":"7196","DOI":"10.1128\/JB.186.21.7196-7204.2004","volume":"186","author":"TK Van Dyk","year":"2004","unstructured":"Van Dyk TK et al (2004) Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve? J Bacteriol 186:7196\u20137204. https:\/\/doi.org\/10.1128\/JB.186.21.7196-7204.2004","journal-title":"J Bacteriol"},{"key":"1556_CR73","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/J.1365-2958.1994.TB01313.X","volume":"14","author":"U von Freiesleben","year":"1994","unstructured":"von Freiesleben U, Rasmussen KV, Schaechter M (1994) SeqA limits DnaA activity in replication from oriC in Escherichia coli. Mol Microbiol 14:763\u2013772. https:\/\/doi.org\/10.1111\/J.1365-2958.1994.TB01313.X","journal-title":"Mol Microbiol"},{"key":"1556_CR75","doi-asserted-by":"publisher","unstructured":"Wagih O et al (2013) SGAtools: one-stop analysis and visualization of array-based genetic interaction screens. Nucleic Acids Res 41. https:\/\/doi.org\/10.1093\/nar\/gkt400","DOI":"10.1093\/nar\/gkt400"},{"key":"1556_CR76","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0944-5013(11)80016-9","volume":"150","author":"HM Walkenhorst","year":"1995","unstructured":"Walkenhorst HM, Hemschemeier SK, Eichenlaub R (1995) Molecular analysis of the molybdate uptake operon, modABCD, of Escherichia coli and modR, a regulatory gene. Microbiol Res 150:347\u2013361. https:\/\/doi.org\/10.1016\/S0944-5013(11)80016-9","journal-title":"Microbiol Res"},{"key":"1556_CR77","doi-asserted-by":"publisher","first-page":"10412","DOI":"10.1073\/PNAS.0911586107","volume":"107","author":"JC Waller","year":"2010","unstructured":"Waller JC et al (2010) A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life. Proc Natl Acad Sci U S A 107:10412\u201310417. https:\/\/doi.org\/10.1073\/PNAS.0911586107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1556_CR78","doi-asserted-by":"publisher","first-page":"24011","DOI":"10.3390\/ijms161024011","volume":"16","author":"GW Yang","year":"2015","unstructured":"Yang GW, Jiang JS, Lu WQ (2015) Ferulic acid exerts anti-angiogenic and anti-tumor activity by targeting fibroblast growth factor receptor 1-mediated angiogenesis. Int J Mol Sci 16:24011\u201324031. https:\/\/doi.org\/10.3390\/ijms161024011","journal-title":"Int J Mol Sci"},{"key":"1556_CR79","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1159\/000491755","volume":"31","author":"K Zdu\u0144ska","year":"2018","unstructured":"Zdu\u0144ska K et al (2018) Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol 31:332\u2013336. https:\/\/doi.org\/10.1159\/000491755","journal-title":"Skin Pharmacol Physiol"},{"key":"1556_CR80","doi-asserted-by":"publisher","unstructured":"Zhang Z et al (2025) Antibiofilm inhibitor ferulic acid as an antibacterial synergist against Escherichia coli. Biomolecules 15. https:\/\/doi.org\/10.3390\/biom15091253","DOI":"10.3390\/biom15091253"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-026-01556-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-026-01556-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-026-01556-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:27:05Z","timestamp":1784352425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-026-01556-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":80,"alternative-id":["1556"],"URL":"https:\/\/doi.org\/10.1007\/s12223-026-01556-5","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"11 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}