{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:07:36Z","timestamp":1789193256509,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Scientific Research Projects Coordination Office","award":["TCD-2025-1075"],"award-info":[{"award-number":["TCD-2025-1075"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Folia Microbiol"],"DOI":"10.1007\/s12223-026-01592-1","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:12:07Z","timestamp":1789189927000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of luteolin and Lactobacillus rhamnosus on methicillin-resistant Staphylococcus aureus biofilm inhibition: in vitro and in silico molecular deployment studies"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-8191","authenticated-orcid":false,"given":"Sumeyye","family":"Baser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-0561","authenticated-orcid":false,"given":"Demet","family":"Celebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-9474","authenticated-orcid":false,"given":"Ozgur","family":"Celebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-6116","authenticated-orcid":false,"given":"Adem","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-2789","authenticated-orcid":false,"given":"Cuneyt","family":"Turkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"issue":"3","key":"1592_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/antibiotics11030389","volume":"11","author":"S Abdel-Shafi","year":"2022","unstructured":"Abdel-Shafi S, El-Serwy H, El-Zawahry Y, Zaki M, Sitohy B, Sitohy M (2022) The Association between icaA and icaB Genes, Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Staphylococci spp. Antibiotics 11(3):389","journal-title":"Antibiotics"},{"issue":"1","key":"1592_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1186\/s12866-024-03666-x","volume":"24","author":"AA Abdelaziz","year":"2024","unstructured":"Abdelaziz AA, Abo-Kamar AM, Ashour AE, Shaldam MA, Elekhnawy E (2024) Unveiling the antibacterial action of ambroxol against Staphylococcus aureus bacteria: in vitro, in vivo, and in silico investigation. BMC Microbiol 24(1):507","journal-title":"BMC Microbiol"},{"issue":"4","key":"1592_CR3","doi-asserted-by":"publisher","first-page":"103604","DOI":"10.1016\/j.sjbs.2023.103604","volume":"30","author":"BA Alghamdi","year":"2023","unstructured":"Alghamdi BA, Al-Johani I, Al-Shamrani JM, Alshamrani HM, Al-Otaibi BG, Almazmomi K, Yusof NY (2023) Antimicrobial resistance in methicillin-resistant Staphylococcus aureus. Saudi J Biol Sci 30(4):103604","journal-title":"Saudi J Biol Sci"},{"issue":"6","key":"1592_CR4","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.54005\/geneltip.1737789","volume":"35","author":"S Ba\u015fer","year":"2025","unstructured":"Ba\u015fer S, \u00c7elebi D, \u00c7elebi \u00d6, Gen\u00e7 S, Taghizadehghalehjoughi A (2025) Investigation of Bromelain, Inulin and Saccharomyces cerevisiae Effects Against Escherichia coli Infection Developed in Fibroblast Wound Model. Genel T\u0131p Dergisi 35(6):1254\u20131266","journal-title":"Genel T\u0131p Dergisi"},{"issue":"01","key":"1592_CR5","doi-asserted-by":"publisher","first-page":"e1498","DOI":"10.1590\/0102-672020190001e1498","volume":"33","author":"LF Campos","year":"2020","unstructured":"Campos LF, Tagliari E, Casagrande TAC, Noronha Ld, Campos ACL, Matias JEF (2020) Effects of probiotics supplementation on skin wound healing in diabetic rats. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo) 33(01):e1498","journal-title":"Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"},{"issue":"1","key":"1592_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cmdc.202000677","volume":"16","author":"S Cascioferro","year":"2021","unstructured":"Cascioferro S, Carbone D, Parrino B, Pecoraro C, Giovannetti E, Cirrincione G, Diana P (2021) Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections. ChemMedChem 16(1):65\u201380","journal-title":"ChemMedChem"},{"issue":"2","key":"1592_CR7","first-page":"237","volume":"31","author":"D Celebi","year":"2025","unstructured":"Celebi D, \u00c7ELEB\u0130 \u00d6, Baser S, Ari B, Ektas Kalayci S, Kara A (2025) Efficacy of oyocyanin isolated from Pseudomonas aeruginosa and Lactobacillus plantarum against methicillin resistant Staphylococcus aureus caused bovine mastitis. Kafkas Universitesi Veteriner Fakultesi Dergisi 31(2):237\u2013245","journal-title":"Kafkas Universitesi Veteriner Fakultesi Dergisi"},{"issue":"7","key":"1592_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/biomedicines9070761","volume":"9","author":"L-Y Chen","year":"2021","unstructured":"Chen L-Y, Cheng H-L, Kuan Y-H, Liang T-J, Chao Y-Y, Lin H-C (2021) Therapeutic potential of luteolin on impaired wound healing in streptozotocin-induced rats. Biomedicines 9(7):761","journal-title":"Biomedicines"},{"key":"1592_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fcimb.2012.00038","volume":"2","author":"D Cue","year":"2012","unstructured":"Cue D, Lei MG, Lee CY (2012) Genetic regulation of the intercellular adhesion locus in staphylococci. Front Cell Infect Microbiol 2:38","journal-title":"Front Cell Infect Microbiol"},{"issue":"14","key":"1592_CR10","doi-asserted-by":"publisher","first-page":"7602","DOI":"10.3390\/ijerph18147602","volume":"18","author":"M Idrees","year":"2021","unstructured":"Idrees M, Sawant S, Karodia N, Rahman A (2021) Staphylococcus aureus biofilm: morphology, genetics, pathogenesis and treatment strategies. Int J Environ Res Public Health 18(14):7602","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"1592_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41387-024-00320-3","volume":"14","author":"F Karimi","year":"2024","unstructured":"Karimi F, Montazeri-Najafabady N, Mohammadi F, Azadi A, Koohpeyma F, Gholami A (2024) A potential therapeutic strategy of an innovative probiotic formulation toward topical treatment of diabetic ulcer: an in vivo study. Nutr Diabetes 14(1):66","journal-title":"Nutr Diabetes"},{"issue":"1","key":"1592_CR12","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/pathogens13010076","volume":"13","author":"A Kaushik","year":"2024","unstructured":"Kaushik A, Kest H, Sood M, Steussy BW, Thieman C, Gupta S (2024) Biofilm producing methicillin-resistant Staphylococcus aureus (MRSA) infections in humans: clinical implications and management. Pathogens 13(1):76","journal-title":"Pathogens"},{"issue":"12","key":"1592_CR13","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1021\/acsinfecdis.3c00338","volume":"9","author":"J-G Li","year":"2023","unstructured":"Li J-G, Chen X-F, Lu T-Y, Zhang J, Dai S-H, Sun J, Liu Y-H, Liao X-P, Zhou Y-F (2023) Increased activity of \u03b2-lactam antibiotics in combination with carvacrol against MRSA bacteremia and catheter-associated biofilm infections. ACS Infect Dis 9(12):2482\u20132493","journal-title":"ACS Infect Dis"},{"issue":"3","key":"1592_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/antibiotics12030557","volume":"12","author":"MS Linz","year":"2023","unstructured":"Linz MS, Mattappallil A, Finkel D, Parker D (2023) Clinical impact of Staphylococcus aureus skin and soft tissue infections. Antibiotics 12(3):557","journal-title":"Antibiotics"},{"issue":"4","key":"1592_CR15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1995-7645(13)60053-X","volume":"6","author":"S Lodhi","year":"2013","unstructured":"Lodhi S, Singhai AK (2013) Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats. Asian Pac J Trop Med 6(4):253\u2013259","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"1592_CR16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12866-025-03873-0","volume":"25","author":"SA Mohamed","year":"2025","unstructured":"Mohamed SA, Eraqi WA, Georghiou PE, Zakaria MY (2025) Luteolin loaded PEGylated cerosomes: a novel treatment for MRSA skin infections. BMC Microbiol 25(1):182","journal-title":"BMC Microbiol"},{"issue":"4","key":"1592_CR17","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.3390\/ijms23042375","volume":"23","author":"BK Patel","year":"2022","unstructured":"Patel BK, Patel KH, Huang RY, Lee CN, Moochhala SM (2022) The gut-skin microbiota axis and its role in diabetic wound healing\u2014a review based on current literature. Int J Mol Sci 23(4):2375","journal-title":"Int J Mol Sci"},{"key":"1592_CR18","doi-asserted-by":"publisher","first-page":"104056","DOI":"10.1016\/j.micpath.2020.104056","volume":"142","author":"W Qian","year":"2020","unstructured":"Qian W, Liu M, Fu Y, Zhang J, Liu W, Li J, Li X, Li Y, Wang T (2020) Antimicrobial mechanism of luteolin against Staphylococcus aureus and Listeria monocytogenes and its antibiofilm properties. Microb Pathog 142:104056","journal-title":"Microb Pathog"},{"issue":"6","key":"1592_CR19","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ijantimicag.2013.08.003","volume":"42","author":"H Sikorska","year":"2013","unstructured":"Sikorska H, Smoragiewicz W (2013) Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections. Int J Antimicrob Agents 42(6):475\u2013481","journal-title":"Int J Antimicrob Agents"},{"issue":"8","key":"1592_CR20","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/pathogens10080970","volume":"10","author":"V Silva","year":"2021","unstructured":"Silva V, Almeida L, Gaio V, Cerca N, Manageiro V, Cani\u00e7a M, Capelo JL, Igrejas G, Poeta P (2021) Biofilm formation of multidrug-resistant MRSA strains isolated from different types of human infections. Pathogens 10(8):970","journal-title":"Pathogens"},{"issue":"12","key":"1592_CR21","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1021\/ci800166p","volume":"48","author":"OV Stroganov","year":"2008","unstructured":"Stroganov OV, Novikov FN, Stroylov VS, Kulkov V, Chilov GG (2008) Lead finder: An approach to improve accuracy of protein\u2013 ligand docking, binding energy estimation, and virtual screening. J Chem Inf Model 48(12):2371\u20132385","journal-title":"J Chem Inf Model"},{"issue":"1","key":"1592_CR22","first-page":"4476339","volume":"2022","author":"Y Sun","year":"2022","unstructured":"Sun Y, Sun F, Feng W, Wang Q, Liu F, Xia P, Qiu X (2022) Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis. Evidence\u2010Based. Complement Altern Med 2022(1):4476339","journal-title":"Complement Altern Med"},{"key":"1592_CR23","doi-asserted-by":"publisher","first-page":"686864","DOI":"10.3389\/fmicb.2021.686864","volume":"12","author":"L Wang","year":"2021","unstructured":"Wang L, Wang G, Qu H, Wang K, Jing S, Guan S, Su L, Li Q, Wang D (2021) Taxifolin, an inhibitor of sortase A, interferes with the adhesion of methicillin-resistant Staphylococcal aureus. Front Microbiol 12:686864","journal-title":"Front Microbiol"},{"issue":"3","key":"1592_CR24","doi-asserted-by":"publisher","first-page":"2403318","DOI":"10.1002\/adhm.202403318","volume":"14","author":"L Xu","year":"2025","unstructured":"Xu L, Lu B, Xie K, Fan W, Fang S, Zhu J, Yang J, Xu B (2025) Photothermal Nano-Immunotherapy Against Methicillin\u2010Resistant Staphylococcus aureus (MRSA) Biofilm Infections. Adv Healthc Mater 14(3):2403318","journal-title":"Adv Healthc Mater"},{"issue":"14","key":"1592_CR25","doi-asserted-by":"publisher","first-page":"4568","DOI":"10.3390\/molecules27144568","volume":"27","author":"C Yang","year":"2022","unstructured":"Yang C, Chen EA, Zhang Y (2022) Protein\u2013ligand docking in the machine-learning era. Molecules 27(14):4568","journal-title":"Molecules"},{"issue":"21","key":"1592_CR26","doi-asserted-by":"publisher","first-page":"5988","DOI":"10.1016\/j.bmc.2014.09.011","volume":"22","author":"D Zhulenkovs","year":"2014","unstructured":"Zhulenkovs D, Rudevica Z, Jaudzems K, Turks M, Leonchiks A (2014) Discovery and structure\u2013activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase. Bioorg Med Chem 22(21):5988\u20136003","journal-title":"Bioorg Med Chem"}],"container-title":["Folia Microbiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-026-01592-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12223-026-01592-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12223-026-01592-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:12:08Z","timestamp":1789189928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12223-026-01592-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":26,"alternative-id":["1592"],"URL":"https:\/\/doi.org\/10.1007\/s12223-026-01592-1","relation":{},"ISSN":["0015-5632","1874-9356"],"issn-type":[{"value":"0015-5632","type":"print"},{"value":"1874-9356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"31 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A standard bacterial strain was used in this study; ethical committee approval is not required.","order":1,"name":"Ethics","label":"Ethichal approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}