{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:50:58Z","timestamp":1793224258091,"version":"4.5.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol. Sin."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans\nand nonhuman primates. The majority of ebolavirus species, most notably <jats:italic>Zaire ebolavirus<\/jats:italic>, can cause Ebola virus disease (EVD),\nformerly known as Ebola hemorrhagic fever, in humans. EVD is associated with\ncase-fatality rates as high as 90%, and there is currently no specific treatment or\nlicensed vaccine available against EVD. Understanding the molecular biology and\npathogenesis of ebolaviruses is important for the development of antiviral\ntherapeutics. Ebolavirus encodes several forms of glycoproteins (GPs), which have\nsome interesting characteristics, including the transcriptional editing coding\nstrategy and extensive O-glycosylation modification, clustered in the mucin-like\ndomain of GP1, full-length GP (GP<jats:sub>1,2<\/jats:sub>), and shed GP. In\naddition to the canonical role of the spike protein, GP<jats:sub>1,2<\/jats:sub>,\nin viral entry, ebolavirus GPs appear to have multiple additional functions, likely\ncontributing to the complex pathogenesis of the virus. Here, we review the roles of\nebolavirus GPs in viral pathogenesis. <\/jats:p>","DOI":"10.1007\/s12250-016-3850-1","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T10:53:07Z","timestamp":1479379987000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The roles of ebolavirus glycoproteins in viral\npathogenesis"],"prefix":"10.1016","volume":"32","author":[{"given":"Yun-Jia","family":"Ning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"3850_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.09.001","volume":"55","author":"AA Ansari","year":"2014","unstructured":"Ansari AA. 2014. Clinical features and pathobiology of Ebolavirus\ninfection. J Autoimmun, 55: 1\u20139.","journal-title":"J Autoimmun"},{"key":"3850_CR2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/vim.2014.0066","volume":"28","author":"J Audet","year":"2015","unstructured":"Audet J, Kobinger GP. 2015. Immune evasion in ebolavirus\ninfections. Viral Immunol, 28: 10\u201318.","journal-title":"Viral Immunol"},{"key":"3850_CR3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/7422","volume":"5","author":"S Baize","year":"1999","unstructured":"Baize S, Leroy EM, Georges-Courbot MC, Capron M, Lansoud-Soukate J,\nDebre P, Fisher-Hoch SP, McCormick JB, Georges AJ. 1999. Defective humoral\nresponses and extensive intravascular apoptosis are associated with fatal\noutcome in Ebola virusinfected patients. Nat Med, 5: 423\u2013426.","journal-title":"Nat Med"},{"key":"3850_CR4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2249.2002.01800.x","volume":"128","author":"S Baize","year":"2002","unstructured":"Baize S, Leroy EM, Georges AJ, Georges-Courbot MC, Capron M,\nBedjabaga I, Lansoud-Soukate J, Mavoungou E. 2002. Inflammatory responses in\nEbola virus-infected patients. Clin Exp Immunol, 128: 163\u2013168.","journal-title":"Clin Exp Immunol"},{"key":"3850_CR5","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.bbrc.2004.08.148","volume":"323","author":"LG Barrientos","year":"2004","unstructured":"Barrientos LG, Martin AM, Rollin PE, Sanchez A. 2004. Disulfide\nbond assignment of the Ebola virus secreted glycoprotein SGP. 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Isolation of potent\nneutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.\nScience, 351: 1078\u20131083.","journal-title":"Science"},{"key":"3850_CR9","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/v2112443","volume":"2","author":"P Borrow","year":"2010","unstructured":"Borrow P, Martinez-Sobrido L, de la Torre JC. 2010. Inhibition of\nthe type I interferon antiviral response during arenavirus infection. Viruses,\n2: 2443\u20132480.","journal-title":"Viruses"},{"key":"3850_CR10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.virol.2004.05.025","volume":"326","author":"CM Bosio","year":"2004","unstructured":"Bosio CM, Moore BD, Warfield KL, Ruthel G, Mohamadzadeh M, Aman MJ,\nBavari S. 2004. Ebola and Marburg virus-like particles activate human myeloid\ndendritic cells. 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