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There are 4 serotypes of DENV that\ncause human disease through transmission by mosquito vectors. DENV infection results\nin a broad spectrum of clinical symptoms, ranging from mild fever to dengue\nhemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome\n(DSS) and death. Researchers have made unremitting efforts over the last\nhalf-century to understand DHF pathogenesis. DHF is probably caused by multiple\nfactors, such as virus-specific antibodies, viral antigens and host immune\nresponses. This review summarizes the current progress of studies on DHF\npathogenesis, which may provide important information for achieving effective\ncontrol of dengue in the future. <\/jats:p>","DOI":"10.1007\/s12250-016-3855-9","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T10:53:15Z","timestamp":1479379995000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Progress towards understanding the pathogenesis of dengue\nhemorrhagic fever"],"prefix":"10.1016","volume":"32","author":[{"given":"Xiaojing","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"3855_CR1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4269\/ajtmh.2006.75.1113","volume":"75","author":"M Alvarez","year":"2006","unstructured":"Alvarez M, Rodriguez-Roche R, Bernardo L, Vazquez S, Morier L,\nGonzalez D, Castro O, Kouri G, Halstead SB, Guzman MG. 2006. 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