{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:56:28Z","timestamp":1790218588524,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol. Sin."],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12250-019-00097-1","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T15:02:45Z","timestamp":1553526165000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Early Pattern of Epstein-Barr Virus Infection in Gastric Epithelial Cells by \u201cCell-in-cell\u201d"],"prefix":"10.1016","volume":"34","author":[{"given":"Wenxing","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lielian","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxiu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-1217","authenticated-orcid":false,"given":"Jianhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"97_CR1","doi-asserted-by":"publisher","first-page":"e0171827","DOI":"10.1371\/journal.pone.0171827","volume":"12","author":"N Arora","year":"2017","unstructured":"Arora N, Alsaied O, Dauer P, Majumder K, Modi S, Giri B, Dudeja V, Banerjee S, Von Hoff D, Saluja A (2017) Downregulation of sp1 by minnelide leads to decrease in hsp70 and decrease in tumor burden of gastric cancer. PLoS ONE 12:e0171827","journal-title":"PLoS ONE"},{"key":"97_CR2","doi-asserted-by":"publisher","first-page":"7201","DOI":"10.1073\/pnas.0602077103","volume":"103","author":"GW Bornkamm","year":"2006","unstructured":"Bornkamm GW, Behrends U, Mautner J (2006) The infectious kiss: newly infected b cells deliver epstein-barr virus to epithelial cells. Proc Natl Acad Sci USA 103:7201\u20137202","journal-title":"Proc Natl Acad Sci USA"},{"key":"97_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1353\/hub.2004.0016","volume":"76","author":"M Chakravorty","year":"2004","unstructured":"Chakravorty M, Ghosh A, Choudhury A, Santra A, Hembrum J, Roychoudhury S (2004) Ethnic differences in allele distribution for the il8 and il1b genes in populations from eastern india. Hum Biol 76:153\u2013159","journal-title":"Hum Biol"},{"key":"97_CR4","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.3892\/ijo.2015.3126","volume":"47","author":"L Chen","year":"2015","unstructured":"Chen L, Yuan W, Chen Z, Wu S, Ge J, Chen J, Chen Z (2015) Vasoactive intestinal peptide represses activation of tumor-associated macrophages in gastric cancer via regulation of tnfalpha, il-6, il-12 and inos. Int J Oncol 47:1361\u20131370","journal-title":"Int J Oncol"},{"key":"97_CR5","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41564-017-0081-7","volume":"3","author":"J Chen","year":"2018","unstructured":"Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R (2018) Ephrin receptor a2 is a functional entry receptor for epstein-barr virus. Nat Microbiol 3:172\u2013180","journal-title":"Nat Microbiol"},{"key":"97_CR6","first-page":"5","volume":"60","author":"SR Choi","year":"2009","unstructured":"Choi SR, Lee SA, Kim YJ, Ok CY, Lee HJ, Hahm KB (2009) Role of heat shock proteins in gastric inflammation and ulcer healing. J Physiol Pharmacol 60:5\u201317","journal-title":"J Physiol Pharmacol"},{"key":"97_CR7","doi-asserted-by":"publisher","first-page":"6825","DOI":"10.1128\/JVI.76.13.6825-6831.2002","volume":"76","author":"JM Chong","year":"2002","unstructured":"Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga S, Hippo Y, Aburatani H, Funata N, Fukayama M (2002) Interleukin-1beta expression in human gastric carcinoma with epstein-barr virus infection. J Virol 76:6825\u20136831","journal-title":"J Virol"},{"key":"97_CR8","doi-asserted-by":"crossref","unstructured":"Cohen JI, Fauci AS, Varmus H, Nabel GJ (2011) Epstein-barr virus: an important vaccine target for cancer prevention. Sci Transl Med 3: 107fs107","DOI":"10.1126\/scitranslmed.3002878"},{"key":"97_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.2174\/1871525711311020008","volume":"11","author":"N Dehne","year":"2013","unstructured":"Dehne N, Fuhrmann D, Brune B (2013) Hypoxia-inducible factor (hif) in hormone signaling during health and disease. Cardiovasc Hematol Agents Med Chem 11:125\u2013135","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"97_CR10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/jmv.20896","volume":"79","author":"L Ding","year":"2007","unstructured":"Ding L, Li L, Yang J, Zhou S, Li W, Tang M, Shi Y, Yi W, Cao Y (2007) Latent membrane protein 1 encoded by epstein-barr virus induces telomerase activity via p16ink4a\/rb\/e2f1 and jnk signaling pathways. J Med Virol 79:1153\u20131163","journal-title":"J Med Virol"},{"key":"97_CR11","doi-asserted-by":"publisher","first-page":"367","DOI":"10.7314\/APJCP.2013.14.1.367","volume":"14","author":"Y Ding","year":"2013","unstructured":"Ding Y, Li XR, Yang KY, Huang LH, Hu G, Gao K (2013) Proteomics analysis of gastric epithelial ags cells infected with epstein-barr virus. Asian Pac J Cancer Prev 14:367\u2013372","journal-title":"Asian Pac J Cancer Prev"},{"key":"97_CR12","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.3748\/wjg.v21.i11.3174","volume":"21","author":"S Gambhir","year":"2015","unstructured":"Gambhir S, Vyas D, Hollis M, Aekka A, Vyas A (2015) Nuclear factor kappa b role in inflammation associated gastrointestinal malignancies. World J Gastroenterol 21:3174\u20133183","journal-title":"World J Gastroenterol"},{"key":"97_CR13","first-page":"1147","volume":"43","author":"G Henle","year":"1969","unstructured":"Henle G, Henle W, Clifford P, Diehl V, Kafuko GW, Kirya BG, Klein G, Morrow RH, Munube GM, Pike P, Tukei PM, Ziegler JL (1969) Antibodies to epstein-barr virus in burkitt\u2019s lymphoma and control groups. J Natl Cancer Inst 43:1147\u20131157","journal-title":"J Natl Cancer Inst"},{"key":"97_CR104","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s12032-015-0711-y","volume":"32","author":"TZ Hu","year":"2015","unstructured":"Hu TZ, Huang LH, Xu CX, Liu XM, Wang Y, Xiao J, Zhou L, Luo L, Jiang XX (2015) Expressional profiles of transcription factors in the progression of helicobacter pylori\u2010associated gastric carcinoma based on protein\/DNA array analysis. Med Oncol 32:265","journal-title":"Med Oncol"},{"key":"97_CR14","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1038\/sj.onc.1207867","volume":"23","author":"YS Hwang","year":"2004","unstructured":"Hwang YS, Jeong M, Park JS, Kim MH, Lee DB, Shin BA, Mukaida N, Ellis LM, Kim HR, Ahn BW, Jung YD (2004) Interleukin-1beta stimulates il-8 expression through map kinase and ros signaling in human gastric carcinoma cells. Oncogene 23:6603\u20136611","journal-title":"Oncogene"},{"key":"97_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00428-013-1461-x","volume":"463","author":"HW Lee","year":"2013","unstructured":"Lee HW, Lee EH, Kim SH, Roh MS, Jung SB, Choi YC (2013) Heat shock protein 70 (hsp70) expression is associated with poor prognosis in intestinal type gastric cancer. Virchows Arch 463:489\u2013495","journal-title":"Virchows Arch"},{"key":"97_CR16","first-page":"604","volume":"33","author":"L Li","year":"2014","unstructured":"Li L, Zhang Y, Guo BB, Chan FK, Tao Q (2014) Oncogenic induction of cellular high cpg methylation by epstein-barr virus in malignant epithelial cells. Chin J Cancer 33:604\u2013608","journal-title":"Chin J Cancer"},{"key":"97_CR17","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1128\/JVI.01921-15","volume":"90","author":"Y Li","year":"2016","unstructured":"Li Y, Long X, Huang L, Yang M, Yuan Y, Wang Y, Delecluse HJ, Kuang E (2016) Epstein-barr virus bzlf1-mediated downregulation of proinflammatory factors is essential for optimal lytic viral replication. J Virol 90:887\u2013903","journal-title":"J Virol"},{"key":"97_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tox.2016.07.003","volume":"361\u2013362","author":"S Lian","year":"2016","unstructured":"Lian S, Xia Y, Ung TT, Khoi PN, Yoon HJ, Kim NH, Kim KK, Jung YD (2016) Carbon monoxide releasing molecule-2 ameliorates il-1beta-induced il-8 in human gastric cancer cells. Toxicology 361\u2013362:24\u201338","journal-title":"Toxicology"},{"key":"97_CR19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s12250-017-4073-9","volume":"32","author":"L Liu","year":"2017","unstructured":"Liu L, Zhou Q, Xie Y, Zuo L, Zhu F, Lu J (2017) Extracellular vesicles: novel vehicles in herpesvirus infection. Virol Sin 32:349\u2013356","journal-title":"Virol Sin"},{"key":"97_CR20","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/labinvest.2009.130","volume":"90","author":"JH Lu","year":"2010","unstructured":"Lu JH, Tang YL, Yu HB, Zhou JH, Fu CY, Zeng X, Yu ZY, Yin HL, Wu MH, Zhang JY, Li XL, Li GY (2010) Epstein-barr virus facilitates the malignant potential of immortalized epithelial cells: from latent genome to viral production and maintenance. Lab Invest 90:196\u2013209","journal-title":"Lab Invest"},{"key":"97_CR21","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1159\/000479749","volume":"9","author":"Y Lu","year":"2017","unstructured":"Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q, Ma J (2017) Epstein-barr virus mir-bart6-3p inhibits the rig-i pathway. J Innate Immun 9:574\u2013586","journal-title":"J Innate Immun"},{"key":"97_CR22","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1007\/s00018-012-0989-2","volume":"69","author":"K Ludigs","year":"2012","unstructured":"Ludigs K, Parfenov V, Du Pasquier RA, Guarda G (2012) Type i ifn-mediated regulation of il-1 production in inflammatory disorders. Cell Mol Life Sci 69:3395\u20133418","journal-title":"Cell Mol Life Sci"},{"key":"97_CR23","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.3748\/wjg.v20.i14.3916","volume":"20","author":"K Matsusaka","year":"2014","unstructured":"Matsusaka K, Funata S, Fukayama M, Kaneda A (2014) DNA methylation in gastric cancer, related to helicobacter pylori and epstein-barr virus. World J Gastroenterol 20:3916\u20133926","journal-title":"World J Gastroenterol"},{"key":"97_CR24","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.159.12.6164","volume":"159","author":"SR McColl","year":"1997","unstructured":"McColl SR, Roberge CJ, Larochelle B, Gosselin J (1997) EBV induces the production and release of il-8 and macrophage inflammatory protein-1 alpha in human neutrophils. J Immunol 159:6164\u20136168","journal-title":"J Immunol"},{"key":"97_CR25","doi-asserted-by":"publisher","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","volume":"5","author":"DR McIlwain","year":"2013","unstructured":"McIlwain DR, Berger T, Mak TW (2013) Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 5:a008656","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"97_CR26","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.3390\/v6104047","volume":"6","author":"A Morales-Sanchez","year":"2014","unstructured":"Morales-Sanchez A, Fuentes-Panana EM (2014) Human viruses and cancer. Viruses 6:4047\u20134079","journal-title":"Viruses"},{"key":"97_CR27","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/rmv.1780","volume":"24","author":"T Murata","year":"2014","unstructured":"Murata T, Tsurumi T (2014) Switching of EBV cycles between latent and lytic states. Rev Med Virol 24:142\u2013153","journal-title":"Rev Med Virol"},{"key":"97_CR102","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/JVI.61.5.1416-1420.1987","volume":"61","author":"GR Nemerow","year":"1987","unstructured":"Nemerow GR, Mold C, Schwend VK, Tollefson V, Cooper NR (1987) Identification of gp350 as the viral glycoprotein mediating attachment of epstein-barr virus (ebv) to the ebv\/c3d receptor of b cells: sequence homology of gp350 and c3 complement fragment c3d. J Virol 61:1416\u20131420","journal-title":"J Virol"},{"key":"97_CR103","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0092-8674(89)90240-7","volume":"56","author":"GR Nemerow","year":"1989","unstructured":"Nemerow GR, Houghten RA, Moore MD, Cooper NR (1989) Identification of an epitope in the major envelope protein of epstein-barr virus that mediates viral binding to the b lymphocyte ebv receptor (cr2). Cell 56:369\u2013377","journal-title":"Cell"},{"key":"97_CR28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/cr.2015.50","volume":"25","author":"C Ni","year":"2015","unstructured":"Ni C, Chen Y, Zeng M, Pei R, Du Y, Tang L, Wang M, Hu Y, Zhu H, He M, Wei X, Wang S, Ning X, Wang M, Wang J, Ma L, Chen X, Sun Q, Tang H, Wang Y, Wang X (2015) In-cell infection: a novel pathway for epstein-barr virus infection mediated by cell-in-cell structures. Cell Res 25:785\u2013800","journal-title":"Cell Res"},{"key":"97_CR29","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.cell.2007.10.040","volume":"131","author":"M Overholtzer","year":"2007","unstructured":"Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS (2007) A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 131:966\u2013979","journal-title":"Cell"},{"key":"97_CR30","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1074\/jbc.M113.507194","volume":"289","author":"ER Pereira","year":"2014","unstructured":"Pereira ER, Frudd K, Awad W, Hendershot LM (2014) Endoplasmic reticulum (er) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (hif-1) transcriptional activity on targets like vascular endothelial growth factor (vegf). J Biol Chem 289:3352\u20133364","journal-title":"J Biol Chem"},{"key":"97_CR31","doi-asserted-by":"publisher","first-page":"e57420","DOI":"10.1371\/journal.pone.0057420","volume":"8","author":"DM Queiroz","year":"2013","unstructured":"Queiroz DM, Rocha AM, Melo FF, Rocha GA, Teixeira KN, Carvalho SD, Bittencourt PF, Castro LP, Crabtree JE (2013) Increased gastric il-1beta concentration and iron deficiency parameters in h. Pylori infected children. PLoS One 8:e57420","journal-title":"PLoS One"},{"key":"97_CR32","doi-asserted-by":"publisher","first-page":"364","DOI":"10.5539\/gjhs.v7n3p364","volume":"7","author":"E Savitri","year":"2015","unstructured":"Savitri E, Haryana MS (2015) Expression of interleukin-8, interleukin-10 and epstein-barr viral-load as prognostic indicator in nasopharyngeal carcinoma. Glob J Health Sci 7:364\u2013372","journal-title":"Glob J Health Sci"},{"key":"97_CR101","doi-asserted-by":"publisher","first-page":"7065","DOI":"10.1073\/pnas.0510512103","volume":"103","author":"CD Shannon-Lowe","year":"2006","unstructured":"Shannon-Lowe CD, Neuhierl B, Baldwin G, Rickinson AB, Delecluse HJ (2006) Resting b cells as a transfer vehicle for epstein-barr virus infection of epithelial cells. Proc Natl Acad Sci USA 103:7065\u20137070","journal-title":"Proc Natl Acad Sci USA"},{"key":"97_CR33","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.3892\/ijo.2015.2856","volume":"46","author":"A Shinozaki-Ushiku","year":"2015","unstructured":"Shinozaki-Ushiku A, Kunita A, Fukayama M (2015) Update on epstein-barr virus and gastric cancer (review). Int J Oncol 46:1421\u20131434","journal-title":"Int J Oncol"},{"key":"97_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/toxins9040119","volume":"9","author":"O Sokolova","year":"2017","unstructured":"Sokolova O, Naumann M (2017) NF-kappaB signaling in gastric cancer. Toxins (Basel) 9:119","journal-title":"Toxins (Basel)"},{"key":"97_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF00571929","volume":"5","author":"K Takada","year":"1991","unstructured":"Takada K, Horinouchi K, Ono Y, Aya T, Osato T, Takahashi M, Hayasaka S (1991) An epstein-barr virus-producer line akata: establishment of the cell line and analysis of viral DNA. Virus Genes 5:147\u2013156","journal-title":"Virus Genes"},{"key":"97_CR36","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1017\/erm.2015.13","volume":"17","author":"Y Tao","year":"2015","unstructured":"Tao Y, Shi Y, Jia J, Jiang Y, Yang L, Cao Y (2015) Novel roles and therapeutic targets of epstein-barr virus-encoded latent membrane protein 1-induced oncogenesis in nasopharyngeal carcinoma. Expert Rev Mol Med 17:e15","journal-title":"Expert Rev Mol Med"},{"key":"97_CR37","doi-asserted-by":"publisher","first-page":"16544","DOI":"10.1073\/pnas.1400818111","volume":"111","author":"RM Temple","year":"2014","unstructured":"Temple RM, Zhu J, Budgeon L, Christensen ND, Meyers C, Sample CE (2014) Efficient replication of epstein-barr virus in stratified epithelium in vitro. Proc Natl Acad Sci USA 111:16544\u201316549","journal-title":"Proc Natl Acad Sci USA"},{"key":"97_CR100","doi-asserted-by":"crossref","unstructured":"Tsao SW, Tsang CM (2017) Epstein-barr virus infection and nasopharyngeal carcinoma. Philos Trans R Soc Lond B Biol Sci 372:20160270","DOI":"10.1098\/rstb.2016.0270"},{"key":"97_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/rmv.441","volume":"15","author":"T Tsurumi","year":"2005","unstructured":"Tsurumi T, Fujita M, Kudoh A (2005) Latent and lytic epstein-barr virus replication strategies. Rev Med Virol 15:3\u201315","journal-title":"Rev Med Virol"},{"key":"97_CR39","doi-asserted-by":"crossref","unstructured":"Tu C, Zeng Z, Qi P, Li X, Yu Z, Guo C, Xiong F, Xiang B, Zhou M, Gong Z, Liao Q, Yu J, He Y, Zhang W, Li X, Li Y, Li G, Xiong W (2017) Genome-wide analysis of 18 epstein-barr viruses isolated from primary nasopharyngeal carcinoma biopsy specimens. J Virol 91","DOI":"10.1128\/JVI.00301-17"},{"key":"97_CR40","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.virusres.2016.01.003","volume":"213","author":"HL Yao","year":"2016","unstructured":"Yao HL, Song J, Sun P, Song QQ, Sheng LJ, Chi MM, Han J (2016) Gene expression analysis during recovery process indicates the mechanism for innate immune injury and repair from coxsackievirus b3-induced myocarditis. Virus Res 213:314\u2013321","journal-title":"Virus Res"},{"key":"97_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3892\/or.2012.2089","volume":"29","author":"Y Yin","year":"2013","unstructured":"Yin Y, Si X, Gao Y, Gao L, Wang J (2013) The nuclear factor-kappab correlates with increased expression of interleukin-6 and promotes progression of gastric carcinoma. Oncol Rep 29:34\u201338","journal-title":"Oncol Rep"},{"key":"97_CR42","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nrc1452","volume":"4","author":"LS Young","year":"2004","unstructured":"Young LS, Rickinson AB (2004) Epstein-barr virus: 40\u00a0years on. Nat Rev Cancer 4:757\u2013768","journal-title":"Nat Rev Cancer"},{"key":"97_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jviromet.2011.06.015","volume":"176","author":"Z Yu","year":"2011","unstructured":"Yu Z, Lu J, Yu H, Yan Q, Zuo L, Li G (2011) A precise excision of the complete epstein-barr virus genome in a plasmid based on a bacterial artificial chromosome. J Virol Methods 176:103\u2013107","journal-title":"J Virol Methods"},{"key":"97_CR44","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1128\/JVI.05901-11","volume":"86","author":"H Yu","year":"2012","unstructured":"Yu H, Lu J, Zuo L, Yan Q, Yu Z, Li X, Huang J, Zhao L, Tang H, Luo Z, Liao Q, Zeng Z, Zhang J, Li G (2012) Epstein-barr virus downregulates microrna 203 through the oncoprotein latent membrane protein 1: a contribution to increased tumor incidence in epithelial cells. J Virol 86:3088\u20133099","journal-title":"J Virol"},{"key":"97_CR45","doi-asserted-by":"publisher","first-page":"e62284","DOI":"10.1371\/journal.pone.0062284","volume":"8","author":"G Zhang","year":"2013","unstructured":"Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW (2013) Enhanced il-6\/il-6r signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells. PLoS ONE 8:e62284","journal-title":"PLoS ONE"},{"key":"97_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41564-017-0093-3","volume":"3","author":"H Zhang","year":"2018","unstructured":"Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, He JY, Li MZ, Liu YM, Zhou AJ, Zhong Q, Zeng YX, Kieff E, Zhang Z, Gewurz BE, Zhao B, Zeng MS (2018) Ephrin receptor a2 is an epithelial cell receptor for epstein-barr virus entry. Nat Microbiol 3:1\u20138","journal-title":"Nat Microbiol"},{"key":"97_CR47","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.3892\/or.2016.4544","volume":"35","author":"G Zhao","year":"2016","unstructured":"Zhao G, Zhu G, Huang Y, Zheng W, Hua J, Yang S, Zhuang J, Ye J (2016) Il-6 mediates the signal pathway of jak-stat3-vegf-c promoting growth, invasion and lymphangiogenesis in gastric cancer. Oncol Rep 35:1787\u20131795","journal-title":"Oncol Rep"},{"key":"97_CR48","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/labinvest.2014.105","volume":"94","author":"Y Zheng","year":"2014","unstructured":"Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, Luo Z, Liu X, Zhou Y, Xiong W, Ma J, Li G (2014) Lactoferrin suppresses the epstein-barr virus-induced inflammatory response by interfering with pattern recognition of tlr2 and tlr9. Lab Invest 94:1188\u20131199","journal-title":"Lab Invest"},{"key":"97_CR49","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1139\/w2012-041","volume":"58","author":"C Zhu","year":"2012","unstructured":"Zhu C, Wu Y, Chen S, Yu M, Zeng Y, You X, Xiao J, Wang S (2012) Protective immune responses in mice induced by intramuscular and intranasal immunization with a mycoplasma pneumoniae p1c DNA vaccine. Can J Microbiol 58:644\u2013652","journal-title":"Can J Microbiol"},{"key":"97_CR50","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12250-017-3996-5","volume":"32","author":"L Zuo","year":"2017","unstructured":"Zuo L, Yue W, Du S, Xin S, Zhang J, Liu L, Li G, Lu J (2017a) An update: epstein-barr virus and immune evasion via microrna regulation. Virol Sin 32:175\u2013187","journal-title":"Virol Sin"},{"key":"97_CR51","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41389-017-0005-7","volume":"6","author":"LL Zuo","year":"2017","unstructured":"Zuo LL, Zhang J, Liu LZ, Zhou Q, Du SJ, Xin SY, Ning ZP, Yang J, Yu HB, Yue WX, Wang J, Zhu FX, Li GY, Lu JH (2017b) Cadherin 6 is activated by epstein-barr virus lmp1 to mediate emt and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis 6:402","journal-title":"Oncogenesis"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-019-00097-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12250-019-00097-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-019-00097-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:16:21Z","timestamp":1694726181000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12250-019-00097-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["97"],"URL":"https:\/\/doi.org\/10.1007\/s12250-019-00097-1","relation":{},"ISSN":["1674-0769","1995-820X"],"issn-type":[{"value":"1674-0769","type":"print"},{"value":"1995-820X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,25]]},"assertion":[{"value":"16 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Medical Ethics Review Committees of Xiangya Hospital, Central South University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal and Human Rights Statement"}}]}}