{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:26:58Z","timestamp":1793946418540,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol. Sin."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12250-021-00415-6","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T04:02:32Z","timestamp":1625544152000},"page":"1421-1430","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus"],"prefix":"10.1016","volume":"36","author":[{"given":"Mengxin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-2499","authenticated-orcid":false,"given":"Guiqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"415_CR1","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.3390\/v7102891","volume":"7","author":"F Chen","year":"2015","unstructured":"Chen F, Zhu Y, Wu M, Ku X, Ye S, Li Z, Guo X, He Q (2015) Comparative genomic analysis of classical and variant virulent parental\/attenuated strains of porcine epidemic diarrhea virus. Viruses 7:5525\u20135538","journal-title":"Viruses"},{"key":"415_CR2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virusres.2016.09.003","volume":"226","author":"B Choudhury","year":"2016","unstructured":"Choudhury B, Dastjerdi A, Doyle N, Frossard JP, Steinbach F (2016) From the field to the lab-an European view on the global spread of PEDV. Virus Res 226:40\u201349","journal-title":"Virus Res"},{"key":"415_CR3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S1359-6446(03)02831-9","volume":"8","author":"M Congreve","year":"2003","unstructured":"Congreve M, Carr R, Murray C, Jhoti H (2003) A \u2018Rule of Three\u2019 for fragment-based lead discovery? Drug Discov Today 8:876\u2013877","journal-title":"Drug Discov Today"},{"key":"415_CR4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","volume":"17","author":"J Cui","year":"2019","unstructured":"Cui J, Li F, Shi ZL (2019) Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 17:181\u2013192","journal-title":"Nat Rev Microbiol"},{"key":"415_CR5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetmic.2016.11.029","volume":"206","author":"V Gerdts","year":"2017","unstructured":"Gerdts V, Zakhartchouk A (2017) Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses. Vet Microbiol 206:45\u201351","journal-title":"Vet Microbiol"},{"key":"415_CR6","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1021\/jm050548m","volume":"48","author":"AK Ghosh","year":"2005","unstructured":"Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD (2005) Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. J Med Chem 48:6767\u20136771","journal-title":"J Med Chem"},{"key":"415_CR7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virusres.2007.02.015","volume":"133","author":"V Grum-Tokars","year":"2008","unstructured":"Grum-Tokars V, Ratia K, Begaye A, Baker SC, Mesecar AD (2008) Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. Virus Res 133:63\u201373","journal-title":"Virus Res"},{"key":"415_CR8","first-page":"11","volume":"7","author":"YR Guo","year":"2020","unstructured":"Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y (2020) The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 7:11","journal-title":"Mil Med Res"},{"key":"415_CR9","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1128\/jcm.26.11.2235-2239.1988","volume":"26","author":"M Hofmann","year":"1988","unstructured":"Hofmann M, Wyler R (1988) Propagation of the virus of porcine epidemic diarrhea in cell culture. J Clin Microbiol 26:2235\u20132239","journal-title":"J Clin Microbiol"},{"key":"415_CR10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14756366.2019.1690480","volume":"35","author":"S Jo","year":"2020","unstructured":"Jo S, Kim S, Shin DH, Kim MS (2020) Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem 35:145\u2013151","journal-title":"J Enzyme Inhib Med Chem"},{"key":"415_CR11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tvjl.2015.02.017","volume":"204","author":"K Jung","year":"2015","unstructured":"Jung K, Saif LJ (2015) Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. Vet J 204:134\u2013143","journal-title":"Vet J"},{"key":"415_CR12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ejmech.2018.03.004","volume":"150","author":"ACG Kankanamalage","year":"2018","unstructured":"Kankanamalage ACG, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC (2018) Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem 150:334\u2013346","journal-title":"Eur J Med Chem"},{"key":"415_CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.antiviral.2012.11.005","volume":"97","author":"Y Kim","year":"2013","unstructured":"Kim Y, Mandadapu SR, Groutas WC, Chang KO (2013) Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease. Antiviral Res 97:161\u2013168","journal-title":"Antiviral Res"},{"key":"415_CR14","doi-asserted-by":"crossref","first-page":"e1005531","DOI":"10.1371\/journal.ppat.1005531","volume":"12","author":"Y Kim","year":"2016","unstructured":"Kim Y, Liu H, Kankanamalage ACG, Weerasekara S, Hua DH, Groutas WC, Chang KO, Pedersen NC (2016) Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor. PLoS Pathog 12:e1005531","journal-title":"PLoS Pathog"},{"key":"415_CR15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/0300985814522077","volume":"51","author":"A Kipar","year":"2014","unstructured":"Kipar A, Meli ML (2014) Feline infectious peritonitis: still an enigma? Vet Pathol 51:505\u2013526","journal-title":"Vet Pathol"},{"key":"415_CR16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.antiviral.2017.02.007","volume":"141","author":"V Kumar","year":"2017","unstructured":"Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH (2017) Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL(Pro) inhibitors. Antiviral Res 141:101\u2013106","journal-title":"Antiviral Res"},{"key":"415_CR17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.virusres.2016.05.016","volume":"226","author":"SN Langel","year":"2016","unstructured":"Langel SN, Paim FC, Lager KM, Vlasova AN, Saif LJ (2016) Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts. Virus Res 226:93\u2013107","journal-title":"Virus Res"},{"key":"415_CR18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3201\/eid1803.120002","volume":"18","author":"W Li","year":"2012","unstructured":"Li W, Li H, Liu Y, Pan Y, Deng F, Song Y, Tang X, He Q (2012) New variants of porcine epidemic diarrhea virus, China, 2011. Emerg Infect Dis 18:1350\u20131353","journal-title":"Emerg Infect Dis"},{"key":"415_CR19","doi-asserted-by":"crossref","first-page":"e0006629","DOI":"10.1371\/journal.pntd.0006629","volume":"12","author":"J Mokaya","year":"2018","unstructured":"Mokaya J, McNaughton AL, Hadley MJ, Beloukas A, Geretti AM, Goedhals D, Matthews PC (2018) A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent action. PLoS Negl Trop Dis 12:e0006629","journal-title":"PLoS Negl Trop Dis"},{"key":"415_CR20","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1038\/s41598-018-27890-4","volume":"8","author":"S Omoto","year":"2018","unstructured":"Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S (2018) Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep 8:9633","journal-title":"Sci Rep"},{"key":"415_CR21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jfms.2008.09.008","volume":"11","author":"NC Pedersen","year":"2009","unstructured":"Pedersen NC (2009) A review of feline infectious peritonitis virus infection: 1963\u20132008. J Feline Med Surg 11:225\u2013258","journal-title":"J Feline Med Surg"},{"key":"415_CR22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tvjl.2014.04.016","volume":"201","author":"NC Pedersen","year":"2014","unstructured":"Pedersen NC (2014) An update on feline infectious peritonitis: diagnostics and therapeutics. Vet J 201:133\u2013141","journal-title":"Vet J"},{"key":"415_CR23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01317606","volume":"58","author":"MB Pensaert","year":"1978","unstructured":"Pensaert MB, de Bouck P (1978) A new coronavirus-like particle associated with diarrhea in swine. Arch Virol 58:243\u2013247","journal-title":"Arch Virol"},{"key":"415_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2016.05.030","volume":"226","author":"MB Pensaert","year":"2016","unstructured":"Pensaert MB, Martelli P (2016) Porcine epidemic diarrhea: a retrospect from Europe and matters of debate. Virus Res 226:1\u20136","journal-title":"Virus Res"},{"key":"415_CR25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.antiviral.2018.10.015","volume":"160","author":"KD Perera","year":"2018","unstructured":"Perera KD, Kankanamalage ACG, Rathnayake AD, Honeyfield A, Groutas W, Chang KO, Kim Y (2018) Protease inhibitors broadly effective against feline, ferret and mink coronaviruses. Antiviral Res 160:79\u201386","journal-title":"Antiviral Res"},{"key":"415_CR26","doi-asserted-by":"crossref","first-page":"108398","DOI":"10.1016\/j.vetmic.2019.108398","volume":"237","author":"KD Perera","year":"2019","unstructured":"Perera KD, Rathnayake AD, Liu H, Pedersen NC, Groutas WC, Chang KO, Kim Y (2019) Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor. Vet Microbiol 237:108398","journal-title":"Vet Microbiol"},{"key":"415_CR27","doi-asserted-by":"crossref","first-page":"e1002331","DOI":"10.1371\/journal.ppat.1002331","volume":"7","author":"S Pfefferle","year":"2011","unstructured":"Pfefferle S, Sch\u00f6pf J, K\u00f6gl M, Friedel CC, M\u00fcller MA, Carbajo-Lozoya J, Stellberger T, von Dall\u2019Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Z\u00fcst R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, P\u00f6hlmann S, Haas J, Drosten C, von Brunn A (2011) The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog 7:e1002331","journal-title":"PLoS Pathog"},{"key":"415_CR28","doi-asserted-by":"crossref","first-page":"6595","DOI":"10.1021\/acs.jmedchem.5b01461","volume":"59","author":"T Pillaiyar","year":"2016","unstructured":"Pillaiyar T, Manickam M, Namasivayam V, Hayashi Y, Jung SH (2016) An overview of severe acute respiratory syndrome-coronavirus (SARS-CoV) 3CL protease inhibitors: peptidomimetics and small molecule chemotherapy. J Med Chem 59:6595\u20136628","journal-title":"J Med Chem"},{"key":"415_CR29","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1016\/j.bmc.2010.09.035","volume":"18","author":"YB Ryu","year":"2010","unstructured":"Ryu YB, Jeong HJ, Kim JH, Kim YM, Park JY, Kim D, Nguyen TT, Park SJ, Chang JS, Park KH, Rho MC, Lee WS (2010) Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. Bioorg Med Chem 18:7940\u20137947","journal-title":"Bioorg Med Chem"},{"key":"415_CR30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12985-019-1182-0","volume":"16","author":"D Schoeman","year":"2019","unstructured":"Schoeman D, Fielding BC (2019) Coronavirus envelope protein: current knowledge. Virol J 16:69","journal-title":"Virol J"},{"key":"415_CR31","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1128\/JVI.03065-15","volume":"90","author":"Y Shi","year":"2016","unstructured":"Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, Luo R, Wang D, Fu ZF, Xiao S, Peng G (2016) A dimerization-dependent mechanism drives the endoribonuclease function of porcine reproductive and respiratory syndrome virus nsp11. J Virol 90:4579\u20134592","journal-title":"J Virol"},{"key":"415_CR32","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1016\/j.bmc.2005.05.065","volume":"13","author":"JJ Shie","year":"2005","unstructured":"Shie JJ, Fang JM, Kuo TH, Kuo CJ, Liang PH, Huang HJ, Wu YT, Jan JT, Cheng YS, Wong CH (2005) Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha, beta-unsaturated esters. Bioorg Med Chem 13:5240\u20135252","journal-title":"Bioorg Med Chem"},{"key":"415_CR33","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1016\/j.bmc.2015.06.039","volume":"23","author":"SE St John","year":"2015","unstructured":"St John SE, Tomar S, Stauffer SR, Mesecar AD (2015) Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4\u2013The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorg Med Chem 23:6036\u20136048","journal-title":"Bioorg Med Chem"},{"key":"415_CR34","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/JVI.06754-11","volume":"86","author":"CC Stobart","year":"2012","unstructured":"Stobart CC, Lee AS, Lu X, Denison MR (2012) Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. J Virol 86:4801\u20134810","journal-title":"J Virol"},{"key":"415_CR35","doi-asserted-by":"crossref","first-page":"104697","DOI":"10.1016\/j.antiviral.2019.104697","volume":"174","author":"S Theerawatanasirikul","year":"2020","unstructured":"Theerawatanasirikul S, Kuo CJ, Phetcharat N, Lekcharoensuk P (2020) In silico and in vitro analysis of small molecules and natural compounds targeting the 3CL protease of feline infectious peritonitis virus. Antiviral Res 174:104697","journal-title":"Antiviral Res"},{"key":"415_CR36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.virusres.2016.05.026","volume":"226","author":"D Wang","year":"2016","unstructured":"Wang D, Fang L, Xiao S (2016) Porcine epidemic diarrhea in China. Virus Res 226:7\u201313","journal-title":"Virus Res"},{"key":"415_CR37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2018.12.001","volume":"34","author":"Q Wang","year":"2019","unstructured":"Wang Q, Vlasova AN, Kenney SP, Saif LJ (2019) Emerging and re-emerging coronaviruses in pigs. Curr Opin Virol 34:39\u201349","journal-title":"Curr Opin Virol"},{"key":"415_CR38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/vr.100.12.243","volume":"100","author":"EN Wood","year":"1977","unstructured":"Wood EN (1977) An apparently new syndrome of porcine epidemic diarrhoea. Vet Rec 100:243\u2013244","journal-title":"Vet Rec"},{"key":"415_CR39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1099\/jgv.0.001216","volume":"100","author":"W Xie","year":"2019","unstructured":"Xie W, Ao C, Yang Y, Liu Y, Liang R, Zeng Z, Ye G, Xiao S, Fu ZF, Dong W, Peng G (2019) Two critical N-terminal epitopes of the nucleocapsid protein contribute to the cross-reactivity between porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus. J Gen Virol 100:206\u2013216","journal-title":"J Gen Virol"},{"key":"415_CR40","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1021\/jm0603926","volume":"49","author":"S Yang","year":"2006","unstructured":"Yang S, Chen SJ, Hsu MF, Wu JD, Tseng CT, Liu YF, Chen HC, Kuo CW, Wu CS, Chang LW, Chen WC, Liao SY, Chang TY, Hung HH, Shr HL, Liu CY, Huang YA, Chang LY, Hsu JC, Peters CJ, Wang AH, Hsu MC (2006) Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor. J Med Chem 49:4971\u20134980","journal-title":"J Med Chem"},{"key":"415_CR41","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s00705-014-2102-7","volume":"159","author":"DQ Yang","year":"2014","unstructured":"Yang DQ, Ge FF, Ju HB, Wang J, Liu J, Ning K, Liu PH, Zhou JP, Sun QY (2014) Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China. Arch Virol 159:2777\u20132785","journal-title":"Arch Virol"},{"key":"415_CR42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.virol.2016.04.018","volume":"494","author":"G Ye","year":"2016","unstructured":"Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, Fu ZF, Peng G (2016) Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology 494:225\u2013235","journal-title":"Virology"},{"key":"415_CR43","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/v12020240","volume":"12","author":"G Ye","year":"2020","unstructured":"Ye G, Wang X, Tong X, Shi Y, Fu ZF, Peng G (2020) Structural basis for inhibiting porcine epidemic diarrhea virus replication with the 3C-like protease inhibitor GC376. Viruses 12:240","journal-title":"Viruses"},{"key":"415_CR45","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.antiviral.2011.08.001","volume":"92","author":"L Zhu","year":"2011","unstructured":"Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R (2011) Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res 92:204\u2013212","journal-title":"Antiviral Res"},{"key":"415_CR46","first-page":"57","volume":"287","author":"J Ziebuhr","year":"2005","unstructured":"Ziebuhr J (2005) The coronavirus replicase. Curr Top Microbiol Immunol 287:57\u201394","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-021-00415-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12250-021-00415-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-021-00415-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T01:40:06Z","timestamp":1641260406000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12250-021-00415-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["415"],"URL":"https:\/\/doi.org\/10.1007\/s12250-021-00415-6","relation":{},"ISSN":["1674-0769","1995-820X"],"issn-type":[{"value":"1674-0769","type":"print"},{"value":"1995-820X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"19 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The authors have no ethical issues relevant to this work to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}