{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T22:12:08Z","timestamp":1794607928594,"version":"4.9.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol. Sin."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12250-021-00438-z","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T08:02:42Z","timestamp":1628582562000},"page":"1465-1474","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In Vitro Inhibition of Alphaviruses by Lycorine"],"prefix":"10.1016","volume":"36","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Lin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-3679","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-3162","authenticated-orcid":false,"given":"Lu-Qing","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-4071","authenticated-orcid":false,"given":"Han-Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"438_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.antiviral.2015.06.017","volume":"121","author":"R Abdelnabi","year":"2015","unstructured":"Abdelnabi R, Neyts J, Delang L (2015) Towards antivirals against chikungunya virus. Antivir Res 121:59\u201368","journal-title":"Antivir Res"},{"key":"438_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.idcr.2016.07.008","volume":"5","author":"AC Bandeira","year":"2016","unstructured":"Bandeira AC, Campos GS, Sardi SI, Rocha VF, Rocha GC (2016) Neonatal encephalitis due to chikungunya vertical transmission: first report in Brazil. IdCases 5:57\u201359","journal-title":"IdCases"},{"key":"438_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.antiviral.2003.09.005","volume":"61","author":"S Briolant","year":"2004","unstructured":"Briolant S, Garin D, Scaramozzino N, Jouan A, Crance JM (2004) In vitro inhibition of chikungunya and semliki forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination. Antivir Res 61:111\u2013117","journal-title":"Antivir Res"},{"key":"438_CR4","doi-asserted-by":"publisher","first-page":"14972","DOI":"10.1038\/srep14972","volume":"5","author":"D Chen","year":"2015","unstructured":"Chen D, Cai J, Cheng J, Jing C, Yin J, Jiang J, Peng Z, Hao X (2015) Design, synthesis and structure-activity relationship optimization of lycorine derivatives for HCV inhibition. Sci Rep 5:14972","journal-title":"Sci Rep"},{"key":"438_CR5","doi-asserted-by":"publisher","first-page":"e0006510","DOI":"10.1371\/journal.pntd.0006510","volume":"12","author":"D Contopoulos-Ioannidis","year":"2018","unstructured":"Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD (2018) Mother-to-child transmission of chikungunya virus: a systematic review and meta-analysis. PLoS Negl Trop Dis 12:e0006510","journal-title":"PLoS Negl Trop Dis"},{"key":"438_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.pneurobio.2009.12.006","volume":"91","author":"T Das","year":"2010","unstructured":"Das T, Jaffar-Bandjee MC, Hoarau JJ, Krejbich Trotot P, Denizot M, Lee-Pat-Yuen G, Sahoo R, Guiraud P, Ramful D, Robin S, Alessandri JL, Gauzere BA, Gasque P (2010) Chikungunya fever: CNS infection and pathologies of a re-emerging arbovirus. Prog Neurobiol 91:121\u2013129","journal-title":"Prog Neurobiol"},{"issue":"7","key":"438_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/v8070181","volume":"8","author":"CL Deng","year":"2016","unstructured":"Deng CL, Liu SQ, Zhou DG, Xu LL, Li XD, Zhang PT, Li PH, Ye HQ, Wei HP, Yuan ZM, Qin CF, Zhang B (2016) Development of neutralization assay using an eGFP chikungunya virus. Viruses 8(7):181","journal-title":"Viruses"},{"key":"438_CR8","doi-asserted-by":"publisher","first-page":"e2996","DOI":"10.1371\/journal.pntd.0002996","volume":"8","author":"P Gerardin","year":"2014","unstructured":"Gerardin P, Samperiz S, Ramful D, Boumahni B, Bintner M, Alessandri JL, Carbonnier M, Tiran-Rajaoefera I, Beullier G, Boya I, Noormahomed T, Okoi J, Rollot O, Cotte L, Jaffar-Bandjee MC, Michault A, Favier F, Kaminski M, Fourmaintraux A, Fritel X (2014) Neurocognitive outcome of children exposed to perinatal mother-to-child chikungunya virus infection: the CHIMERE cohort study on reunion island. PLoS Negl Trop Dis 8:e2996","journal-title":"PLoS Negl Trop Dis"},{"key":"438_CR9","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1128\/AAC.02274-15","volume":"60","author":"Y Guo","year":"2016","unstructured":"Guo Y, Wang Y, Cao L, Wang P, Qing J, Zheng Q, Shang L, Yin Z, Sun Y (2016) A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus. Antimicrob Agents Chemother 60:913\u2013924","journal-title":"Antimicrob Agents Chemother"},{"key":"438_CR10","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/irv.12035","volume":"7","author":"J He","year":"2013","unstructured":"He J, Qi WB, Wang L, Tian J, Jiao PR, Liu GQ, Ye WC, Liao M (2013) Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. Influenza Other Respir Viruses 7:922\u2013931","journal-title":"Influenza Other Respir Viruses"},{"key":"438_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41579-018-0117-x","volume":"17","author":"ZA Jaafar","year":"2019","unstructured":"Jaafar ZA, Kieft JS (2019) Viral RNA structure-based strategies to manipulate translation. Nat Rev Microbiol 17:110\u2013123","journal-title":"Nat Rev Microbiol"},{"key":"438_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1128\/AAC.01467-12","volume":"57","author":"P Kaur","year":"2013","unstructured":"Kaur P, Thiruchelvan M, Lee RC, Chen H, Chen KC, Ng ML, Chu JJ (2013) Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. Antimicrob Agents Chemother 57:155\u2013167","journal-title":"Antimicrob Agents Chemother"},{"key":"438_CR13","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1099\/vir.0.043752-0","volume":"93","author":"BM Kummerer","year":"2012","unstructured":"Kummerer BM, Grywna K, Glasker S, Wieseler J, Drosten C (2012) Construction of an infectious chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites. J Gen Virol 93:1991\u20131995","journal-title":"J Gen Virol"},{"key":"438_CR14","first-page":"e00720","volume":"93","author":"N Li","year":"2019","unstructured":"Li N, Zhang YN, Deng CL, Shi PY, Yuan ZM, Zhang B (2019) Replication-defective west nile virus with NS1 deletion as a new vaccine platform for flavivirus. J Virol 93:e00720\u2013e00719","journal-title":"J Virol"},{"key":"438_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/1743-422X-8-483","volume":"8","author":"J Liu","year":"2011","unstructured":"Liu J, Yang Y, Xu Y, Ma C, Qin C, Zhang L (2011) Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication. Virol J 8:483","journal-title":"Virol J"},{"key":"438_CR16","first-page":"1335","volume":"8","author":"JJ Nair","year":"2013","unstructured":"Nair JJ, Bastida J, Codina C, Viladomat F, Jv S (2013) Alkaloids of the South African amaryllidaceae: a review. Nat Prod Commun 8:1335\u20131350","journal-title":"Nat Prod Commun"},{"key":"438_CR17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrmicro2368","volume":"8","author":"O Schwartz","year":"2010","unstructured":"Schwartz O, Albert ML (2010) Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol 8:491\u2013500","journal-title":"Nat Rev Microbiol"},{"key":"438_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13046-018-0785-4","volume":"37","author":"J Shen","year":"2018","unstructured":"Shen J, Zhang T, Cheng Z, Zhu N, Wang H, Lin L, Wang Z, Yi H, Hu M (2018) Lycorine inhibits glioblastoma multiforme growth through EGFR suppression. J Exp Clin Cancer Res 37:157","journal-title":"J Exp Clin Cancer Res"},{"key":"438_CR19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00023-19","author":"L Shen","year":"2019","unstructured":"Shen L, Niu J, Wang C, Huang B, Wang W, Zhu N, Deng Y, Wang H, Ye F, Cen S, Tan W (2019) High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses. J Virol. https:\/\/doi.org\/10.1128\/JVI.00023-19","journal-title":"J Virol"},{"key":"438_CR20","doi-asserted-by":"publisher","first-page":"e0151616","DOI":"10.1371\/journal.pone.0151616","volume":"11","author":"A Utt","year":"2016","unstructured":"Utt A, Quirin T, Saul S, Hellstrom K, Ahola T, Merits A (2016) Versatile trans-replication systems for chikungunya virus allow functional analysis and tagging of every replicase protein. PLoS One 11:e0151616","journal-title":"PLoS One"},{"key":"438_CR21","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.4269\/ajtmh.17-0957","volume":"99","author":"BJD van Enter","year":"2018","unstructured":"van Enter BJD, Huibers MHW, van Rooij L, Steingrover R, van Hensbroek MB, Voigt RR, Hol J (2018) Perinatal outcomes in vertically infected neonates during a chikungunya outbreak on the island of curacao. Am J Trop Med Hyg 99:1415\u20131418","journal-title":"Am J Trop Med Hyg"},{"key":"438_CR22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fcimb.2019.00277","volume":"9","author":"H Wang","year":"2019","unstructured":"Wang H, Guo T, Yang Y, Yu L, Pan X, Li Y (2019) Lycorine derivative LY-55 inhibits EV71 and CVA16 replication through downregulating autophagy. Front Cell Infect Microbiol 9:277","journal-title":"Front Cell Infect Microbiol"},{"key":"438_CR23","doi-asserted-by":"publisher","first-page":"e7697","DOI":"10.7717\/peerj.7697","volume":"7","author":"L Yang","year":"2019","unstructured":"Yang L, Zhang JH, Zhang XL, Lao GJ, Su GM, Wang L, Li YL, Ye WC, He J (2019) Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection. PeerJ 7:e7697","journal-title":"PeerJ"},{"key":"438_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.virusres.2015.09.015","volume":"211","author":"PT Zhang","year":"2016","unstructured":"Zhang PT, Shan C, Li XD, Liu SQ, Deng CL, Ye HQ, Shang BD, Shi PY, Lv M, Shen BF, Qin CF, Zhang B (2016) Generation of a recombinant west nile virus stably expressing the gaussia luciferase for neutralization assay. Virus Res 211:17\u201324","journal-title":"Virus Res"},{"key":"438_CR25","first-page":"e00504","volume":"93","author":"YN Zhang","year":"2019","unstructured":"Zhang YN, Deng CL, Li JQ, Li N, Zhang QY, Ye HQ, Yuan ZM, Zhang B (2019) Infectious chikungunya virus (CHIKV) with a complete capsid deletion: a new approach for a CHIKV vaccine. J Virol 93:e00504-00519","journal-title":"J Virol"},{"key":"438_CR26","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1080\/22221751.2020.1772676","volume":"9","author":"YN Zhang","year":"2020","unstructured":"Zhang YN, Zhang QY, Li XD, Xiong J, Xiao SQ, Wang Z, Zhang ZR, Deng CL, Yang XL, Wei HP, Yuan ZM, Ye HQ, Zhang B (2020) Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture. Emerg Microbes Infect 9:1170\u20131173","journal-title":"Emerg Microbes Infect"},{"key":"438_CR27","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.virol.2008.11.003","volume":"384","author":"G Zou","year":"2009","unstructured":"Zou G, Puig-Basagoiti F, Zhang B, Qing M, Chen L, Pankiewicz KW, Felczak K, Yuan Z, Shi PY (2009) A single-amino acid substitution in west nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor. Virology 384:242\u2013252","journal-title":"Virology"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-021-00438-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12250-021-00438-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12250-021-00438-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T01:40:07Z","timestamp":1641260407000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12250-021-00438-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["438"],"URL":"https:\/\/doi.org\/10.1007\/s12250-021-00438-z","relation":{},"ISSN":["1674-0769","1995-820X"],"issn-type":[{"value":"1674-0769","type":"print"},{"value":"1995-820X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]},"assertion":[{"value":"8 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance With Ethical Standards"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal and Human Rights"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}