{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:53:41Z","timestamp":1791006821465,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T00:00:00Z","timestamp":1259798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s12253-009-9227-0","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T18:04:03Z","timestamp":1259777043000},"page":"403-411","source":"Crossref","is-referenced-by-count":61,"title":["Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction"],"prefix":"10.1007","volume":"16","author":[{"given":"Cheng-ming","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Din-bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-dan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-gan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,3]]},"reference":[{"key":"9227_CR1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","volume":"418","author":"SM Reppert","year":"2002","unstructured":"Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418:935\u2013941","journal-title":"Nature"},{"key":"9227_CR2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0092-8674(02)01225-4","volume":"111","author":"U Schibler","year":"2002","unstructured":"Schibler U, Sassone-Corsi P (2002) A web of circadian pacemakers. Cell 111:919\u2013922","journal-title":"Cell"},{"key":"9227_CR3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.genom.5.061903.175925","volume":"5","author":"PL Lowrey","year":"2004","unstructured":"Lowrey PL, Takahashi JS (2004) Mammalian circadian biology: Elucidating genome-wide levels of temporal organization. Ann Rev Genomics Hum Genet. 5:407\u2013441","journal-title":"Ann Rev Genomics Hum Genet."},{"key":"9227_CR4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/hmg\/ddl207","volume":"15","author":"CH Ko","year":"2006","unstructured":"Ko CH, Takahashi JS (2006) Molecular components of the mammalian circadian clock. Hum Mol Genet 15:271\u2013277","journal-title":"Hum Mol Genet"},{"key":"9227_CR5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/22118","volume":"400","author":"B Zheng","year":"1999","unstructured":"Zheng B, Larkin DW, Albrecht U et al (1999) The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400:169\u2013173","journal-title":"Nature"},{"key":"9227_CR6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0092-8674(01)00380-4","volume":"105","author":"B Zheng","year":"2001","unstructured":"Zheng B, Albrecht U, Kaasik K et al (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105:683\u2013694","journal-title":"Cell"},{"key":"9227_CR7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nrc1072","volume":"3","author":"L Fu","year":"2003","unstructured":"Fu L, Lee CC (2003) The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer. 3:350\u2013361","journal-title":"Nat Rev Cancer."},{"key":"9227_CR8","first-page":"7545","volume":"63","author":"L Canaple","year":"2003","unstructured":"Canaple L, Kakizawa T, Laudet V (2003) The days and nights of cancer cells. Cancer Res 63:7545\u20137552","journal-title":"Cancer Res"},{"key":"9227_CR9","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/carcin\/bgi075","volume":"26","author":"ST Chen","year":"2005","unstructured":"Chen ST, Choo KB (2005) HouM.F., Yeh K.T., Kuo S.J. and Chang J.G, Deregulated expression of the PER1; PER2 and PER3 genes in breast cancers. Carcinogenesis. 26:1241\u20131246","journal-title":"Carcinogenesis."},{"key":"9227_CR10","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1182\/blood-2005-01-0358","volume":"106","author":"S Gery","year":"2005","unstructured":"Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK (2005) and Koeffler H.P, Transcription profiling of C\/EBP targetsidentifies Per2 as a gene implicated in myeloid leukemia. Blood. 106:2827\u20132836","journal-title":"Blood."},{"key":"9227_CR11","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1038\/sj.onc.1210585","volume":"26","author":"S Gery","year":"2007","unstructured":"Gery S, Virk RK, Chumakov K, Yu A (2007) and Koeffler H.P, The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene. 26:7916\u20137920","journal-title":"Oncogene."},{"key":"9227_CR12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1349-7006.2006.00225.x","volume":"97","author":"H Hua","year":"2006","unstructured":"Hua H, Wang Z, Halberg F et al (2006) Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci. 97:589\u2013596","journal-title":"Cancer Sci."},{"key":"9227_CR13","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1349-7006.2006.00331.x","volume":"97","author":"Yang MingYu","year":"2006","unstructured":"MingYu Yang, Yi-Chang Liu, Sheng-Fung Lin et al (2006) Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3. Cancer Sci 97:1298\u20131307","journal-title":"Cancer Sci"},{"key":"9227_CR14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1101\/sqb.2007.72.030","volume":"72","author":"F L\u00e9vi","year":"2007","unstructured":"L\u00e9vi F, Filipski E, Iurisci I, Li XM, Innominato P (2007) Cross-talks between circadian timing system and cell division cycle determine cancer biology and therapeutics. Cold Spring Harb Symp Quant Biol 72:465\u2013475","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"9227_CR15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(02)00961-3","volume":"111","author":"L Fu","year":"2002","unstructured":"Fu L, Pelicano H, Liu J, Lee C (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111:41\u201350","journal-title":"Cell"},{"key":"9227_CR16","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.274.5293.1664","volume":"274","author":"SJ Elledge","year":"1996","unstructured":"Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274:1664\u20131672","journal-title":"Science"},{"key":"9227_CR17","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0092-8674(00)00202-6","volume":"103","author":"JV Shah","year":"2000","unstructured":"Shah JV, Cleveland DW (2000) Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 103:997\u20131000","journal-title":"Cell"},{"key":"9227_CR18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/thy.2006.16.161","volume":"16","author":"O Fluge","year":"2006","unstructured":"Fluge O, Bruland O, Akslen LA, Lillehaug JR, Varhaug JE (2006) Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 16:161\u2013175","journal-title":"Thyroid."},{"key":"9227_CR19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/00000478-200503000-00014","volume":"29","author":"DE Hansel","year":"2005","unstructured":"Hansel DE, Dhara S, Huang RC (2005) CDC2\/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol 29:390\u2013399","journal-title":"Am J Surg Pathol"},{"key":"9227_CR20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000012140","volume":"59","author":"Y Ito","year":"2000","unstructured":"Ito Y, Takeda T, Sakon M, Monden M, Tsujimoto M, Matsuura N (2000) Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma. Oncology 59:68\u201374","journal-title":"Oncology"},{"key":"9227_CR21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1086271","volume":"302","author":"T Matsuo","year":"2003","unstructured":"Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F (2003) and Okamura, H, Control mechanism of the circadian clock for timing of cell division in vivo. Science 302:255\u2013259","journal-title":"Science"},{"key":"9227_CR22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1096\/fj.04-2665fje","volume":"19","author":"TG Granda","year":"2005","unstructured":"Granda TG, Liu XH, Smaaland R, Cermakian N, Filipski E, Sassone-Corsi P, L\u00e9vi F (2005) Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J 19:304\u2013306","journal-title":"FASEB J"},{"key":"9227_CR23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein B, Lane D (2000) and Levine A.J, Surfing the p53 network. Nature 408:307\u2013310","journal-title":"Nature"},{"key":"9227_CR24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/jcb.20700","volume":"97","author":"G Liu","year":"2006","unstructured":"Liu G, Chen X (2006) Regulation of the p53 transcriptional activity. J. Cell. Biochem. 97:448\u2013458","journal-title":"J. Cell. Biochem."},{"key":"9227_CR25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1385\/MB:32:3:227","volume":"32","author":"GR Stark","year":"2006","unstructured":"Stark GR, Taylor WR (2006) Control of the G2\/M transition. Mol Biotechnol 32:227\u2013248","journal-title":"Mol Biotechnol"},{"key":"9227_CR26","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1091\/mbc.e07-11-1137","volume":"19","author":"R Hu","year":"2008","unstructured":"Hu R, Aplin AE (2008) Skp2 regulates G2\/M progression in a p53-dependent manner. Mol Biol Cell 19:4602\u20134610","journal-title":"Mol Biol Cell"},{"key":"9227_CR27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","volume":"411","author":"P Blum-Jensen","year":"2001","unstructured":"Blum-Jensen P, Hunter T (2001) Oncogenic kinase singaling. Nature 411:355\u2013365","journal-title":"Nature"},{"key":"9227_CR28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.semcancer.2006.07.015","volume":"16","author":"M Vira","year":"2006","unstructured":"Vira M, Henriksson M (2006) The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biof. 16:318\u2013330","journal-title":"Semin Cancer Biof."},{"key":"9227_CR29","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1073\/pnas.0701953104","volume":"104","author":"Ch Wu","year":"2007","unstructured":"Wu Ch, Riggelen J, Yetil A (2007) et a1, Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. PNAS. 104:13028\u201313033","journal-title":"PNAS."},{"key":"9227_CR30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","volume":"411","author":"GI Evan","year":"2001","unstructured":"Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342\u2013348","journal-title":"Nature"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-009-9227-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-009-9227-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-009-9227-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T06:39:12Z","timestamp":1559457552000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-009-9227-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["9227"],"URL":"https:\/\/doi.org\/10.1007\/s12253-009-9227-0","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,3]]}}}