{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:28:04Z","timestamp":1767961684731,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s12253-010-9327-x","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T15:02:24Z","timestamp":1294326144000},"page":"493-502","source":"Crossref","is-referenced-by-count":29,"title":["Elevated Expression of Thymosin \u03b24, Vascular Endothelial Growth Factor (VEGF), and Hypoxia Inducible Factor (HIF)-1\u03b1 in Early-Stage Cervical Cancers"],"prefix":"10.1007","volume":"17","author":[{"given":"Nam Soo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Jeong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ok","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung Yeol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Rim","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Hyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee Sun","family":"Ock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Jae","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"9327_CR1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1073\/pnas.78.2.1162","volume":"78","author":"TL Low","year":"1981","unstructured":"Low TL, Hu SK, Goldstein AL (1981) Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces deoxynucleotidy l transferase activity in thymocyte populations. Proc Natl Acad Sci USA 78:1162\u20131166","journal-title":"Proc Natl Acad Sci USA"},{"key":"9327_CR2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0076-6879(85)16015-5","volume":"116","author":"TL Low","year":"1985","unstructured":"Low TL, Goldstein AL (1985) Thymic hormones: an overview. Methods Enzymol 116:213\u2013219","journal-title":"Methods Enzymol"},{"key":"9327_CR3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/bies.950160706","volume":"16","author":"D Safer","year":"1994","unstructured":"Safer D, Nachmias VT (1994) Beta thymosins as actin binding peptides. BioEssays 16:473\u2013479","journal-title":"BioEssays"},{"key":"9327_CR4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0021-9258(18)54179-X","volume":"268","author":"FX Yu","year":"1993","unstructured":"Yu FX, Lin SC, Morrison-Bogorad M et al (1993) Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J Biol Chem 268:502\u2013509","journal-title":"J Biol Chem"},{"key":"9327_CR5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cm.970270103","volume":"27","author":"FX Yu","year":"1994","unstructured":"Yu FX, Lin SC, Morrison-Bogorad M et al (1994) Effects of thymosin beta 4 and thymosin beta 10 on actin structures in living cells. Cell Motil Cytoskeleton 27:13\u201325","journal-title":"Cell Motil Cytoskeleton"},{"key":"9327_CR6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1009041911493","volume":"3","author":"DS Grant","year":"1999","unstructured":"Grant DS, Rose W, Yaen C et al (1999) Thymosin beta 4 enhances endothelial cell differentiation and angiogenesis. Angiogenesis 3:125\u2013135","journal-title":"Angiogenesis"},{"key":"9327_CR7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mad.2003.11.005","volume":"125","author":"D Philp","year":"2004","unstructured":"Philp D, Goldstein AL, Kleinman HK (2004) Thymosin beta 4 promotes angiogenesis, wound healing and hair follicle development. Mech Ageing Dev 125:113\u2013115","journal-title":"Mech Ageing Dev"},{"key":"9327_CR8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1196\/annals.1415.009","volume":"1112","author":"D Philp","year":"2007","unstructured":"Philp D, St-Surin S, Cha HJ et al (2007) Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann NY Acad Sci 1112:95\u2013103","journal-title":"Ann NY Acad Sci"},{"key":"9327_CR9","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0006-2952(99)00030-1","volume":"57","author":"K Iguchi","year":"1999","unstructured":"Iguchi K, Usami Y, Hirano K et al (1999) Decreased thymosin beta 4 in apoptosis induced by a variety of antitumor drugs. Biochem Pharmacol 57:1105\u20131111","journal-title":"Biochem Pharmacol"},{"key":"9327_CR10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/15419060009015002","volume":"7","author":"M Niu","year":"2007","unstructured":"Niu M, Nachmias VT (2007) Increased resistance to apoptosis in cells overexpressing thymosin beta four: a role for focal adhesion kinase pp 125FAK. Cell Adhes Commun 7:311\u2013320","journal-title":"Cell Adhes Commun"},{"key":"9327_CR11","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/71002","volume":"5","author":"JD Young","year":"1999","unstructured":"Young JD, Lawrence AJ, MacLean AG et al (1999) Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nat Med 5:1424\u20131427","journal-title":"Nat Med"},{"key":"9327_CR12","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/jnci\/djg100","volume":"95","author":"HJ Cha","year":"2003","unstructured":"Cha HJ, Jeong MJ, Kleinman HK (2003) Role of thymosin beta 4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 95:1674\u20131680","journal-title":"J Natl Cancer Inst"},{"key":"9327_CR13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0002-9440(10)64910-3","volume":"160","author":"T Kobayashi","year":"2002","unstructured":"Kobayashi T, Okada F, Fujii N et al (2002) Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells. Am J Pathol 160:869\u2013882","journal-title":"Am J Pathol"},{"key":"9327_CR14","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1038\/sj.onc.1207888","volume":"23","author":"WS Wang","year":"2004","unstructured":"Wang WS, Chen PM, Hsiao HL et al (2004) Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23:6666\u20136671","journal-title":"Oncogene"},{"key":"9327_CR15","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/sj.onc.1210078","volume":"26","author":"HC Huang","year":"2007","unstructured":"Huang HC, Hu CH, Tang MC et al (2007) Thymosin beta 4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 26:2781\u20132790","journal-title":"Oncogene"},{"key":"9327_CR16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1196\/annals.1415.005","volume":"1112","author":"LI Larsson","year":"2007","unstructured":"Larsson LI, Holck S (2007) Localization of thymosin beta-4 in tumors. Ann NY Acad Sci 1112:317\u2013325","journal-title":"Ann NY Acad Sci"},{"key":"9327_CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.humpath.2006.06.025","volume":"38","author":"LI Larsson","year":"2007","unstructured":"Larsson LI, Holck S (2007) Occurrence of thymosin beta 4 in human breast cancer cells and in other cell types of the tumor microenvironment. Hum Pathol 38:114\u2013119","journal-title":"Hum Pathol"},{"key":"9327_CR18","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","volume":"22","author":"P Ji","year":"2003","unstructured":"Ji P, Diederichs S, Wang W et al (2003) MALAT-1, a novel noncoding RNA, and thymosin beta 4 predict metastasis and survival at early-stage non-small cell lung cancer. Oncogene 22:8031\u20138041","journal-title":"Oncogene"},{"key":"9327_CR19","first-page":"254","volume":"31","author":"YT Jia","year":"2009","unstructured":"Jia YT, Li ZX, Liu M et al (2009) Endostar reduces the growth and metastasis by inhibiting angiogenesis and lymphangiogenesis in nude mouse models of human cervical cancer. Zhonghua Zhong Liu Za Zhi 31:254\u2013257","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"9327_CR20","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1586\/era.09.58","volume":"9","author":"LJ Willmott","year":"2009","unstructured":"Willmott LJ, Monk BJ (2009) Cervical cancer therapy: current, future and anti-angiogensis targeted treatment. Expert Rev Anticancer Ther 9:895\u2013903","journal-title":"Expert Rev Anticancer Ther"},{"key":"9327_CR21","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/35020106","volume":"406","author":"EA Clark","year":"2000","unstructured":"Clark EA, Golub TR, Lander ES et al (2000) Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406:532\u2013535","journal-title":"Nature"},{"key":"9327_CR22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00432-002-0332-7","volume":"128","author":"AM Otto","year":"2002","unstructured":"Otto AM, Mqller CSG, Huff T et al (2002) Chemotherapeutic drugs change actin skeleton organization and the expression of betathymosins in human breast cancer cells. J Cancer Res Clin Oncol 128:247\u2013256","journal-title":"J Cancer Res Clin Oncol"},{"key":"9327_CR23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1993.1682","volume":"193","author":"T Yamamoto","year":"1993","unstructured":"Yamamoto T, Gotoh M, Kitajima M et al (1993) Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas. Biochem Biophys Res Commun 193:706\u2013710","journal-title":"Biochem Biophys Res Commun"},{"key":"9327_CR24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ygyno.2009.09.033","volume":"116","author":"BJ Monk","year":"2010","unstructured":"Monk BJ, Willmott LJ, Sumner DA (2010) Anti-angiogenesis agents in metastatic or recurrent cervical cancer. Gynecol Oncol 116:181\u2013186","journal-title":"Gynecol Oncol"},{"key":"9327_CR25","first-page":"179","volume":"31","author":"IV Goncharuk","year":"2009","unstructured":"Goncharuk IV, Vorobjova LI, Lukyanova NY et al (2009) Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival. Exp Oncol 31:179\u2013181","journal-title":"Exp Oncol"},{"key":"9327_CR26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1749-6632.2009.04891.x","volume":"1171","author":"JH No","year":"2009","unstructured":"No JH, Jo H, Kim SH et al (2009) Expression of vascular endothelial growth factor and hypoxia inducible factor-1alpha in cervical neoplasia. Ann NY Acad Sci 1171:105\u2013110","journal-title":"Ann NY Acad Sci"},{"key":"9327_CR27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/exer.2001.1125","volume":"74","author":"G Sosne","year":"2002","unstructured":"Sosne G, Szliter EA, Barrett R et al (2002) Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res 74:293\u2013299","journal-title":"Exp Eye Res"},{"key":"9327_CR28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.exer.2006.12.004","volume":"48","author":"G Sosne","year":"2007","unstructured":"Sosne G, Qiu P, Christopherson PL et al (2007) Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway. Exp Eye Res 48:663\u2013669","journal-title":"Exp Eye Res"},{"key":"9327_CR29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S1567-5769(03)00024-9","volume":"3","author":"M Badamchian","year":"2003","unstructured":"Badamchian M, Fagarasan MO, Danne RL et al (2003) Thymosin beta 4 reduces lethality and downregulates inflammatorymediators in endotoxin-induced septic shock. Int Immunopharmacol 3:1225\u20131233","journal-title":"Int Immunopharmacol"},{"key":"9327_CR30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3109\/00016348209156596","volume":"61","author":"V Falk","year":"1982","unstructured":"Falk V, Lundgren N, Quarfordt L et al (1982) Primary surgical treatment of carcinoma stage I of the uterine cervix. Acta Obstet Gynecol Scand 61:481\u2013486","journal-title":"Acta Obstet Gynecol Scand"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-010-9327-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-010-9327-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-010-9327-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:44:28Z","timestamp":1637109868000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-010-9327-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["9327"],"URL":"https:\/\/doi.org\/10.1007\/s12253-010-9327-x","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,7]]}}}