{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:46:26Z","timestamp":1771613186035,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T00:00:00Z","timestamp":1302652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s12253-011-9376-9","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T11:05:57Z","timestamp":1302606357000},"page":"721-727","source":"Crossref","is-referenced-by-count":26,"title":["Differential Biomarker Expression in Head and Neck Cancer Correlates with Anatomical Localization"],"prefix":"10.1007","volume":"17","author":[{"given":"L\u00e1szl\u00f3","family":"Tam\u00e1s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Szentk\u00fati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nika","family":"Er\u0151s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9l","family":"D\u00e1nos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di\u00e1na","family":"Brauswetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Szende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivett","family":"Zs\u00e1kovics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Kren\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,4,13]]},"reference":[{"key":"9376_CR1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02904689","volume":"4","author":"G R\u00e9p\u00e1ssy","year":"1998","unstructured":"R\u00e9p\u00e1ssy G, Cs F-H, Juh\u00e1sz A et al (1998) Expression of invasion markers CD44v6\/v3, NM23 and MMP in laryngeal and hypopharyngeal carcinoma. Pathol Oncol Res 4:14\u201321","journal-title":"Pathol Oncol Res"},{"key":"9376_CR2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1067\/mhn.2001.116187","volume":"125","author":"J Lukits","year":"2001","unstructured":"Lukits J, Tim\u00e1r J, Juh\u00e1sz A et al (2001) Progression difference between cancers of the larynx and hypopharynx is not due to tumor size and vascularization. Otolaryngol Head Neck Surg 125:18\u201322","journal-title":"Otolaryngol Head Neck Surg"},{"key":"9376_CR3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24\u201335","journal-title":"N Engl J Med"},{"key":"9376_CR4","first-page":"1133","volume":"28","author":"H Dahlstrand","year":"2008","unstructured":"Dahlstrand H, N\u00e4sman A, Romanitan M et al (2008) Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer. Anticancer Res 28:1133\u20131138","journal-title":"Anticancer Res"},{"key":"9376_CR5","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.hoc.2008.08.006","volume":"22","author":"L Vidal","year":"2008","unstructured":"Vidal L, Gillison ML (2008) Human papillomavirus in HNSCC: recognition of a distinct disease type. Hematol Oncol Clin North Am 22:1125\u20131142","journal-title":"Hematol Oncol Clin North Am"},{"key":"9376_CR6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/j.1460-2075.1995.tb07026.x","volume":"14","author":"D Parry","year":"1995","unstructured":"Parry D, Bates S, Mann DJ et al (1995) Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4\/MTS1 tumour suppressor gene product. EMBO J 14:503\u2013511","journal-title":"EMBO J"},{"key":"9376_CR7","first-page":"5","volume":"58","author":"T Andl","year":"1998","unstructured":"Andl T, Kahn T, Pfuhl A et al (1998) Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res 58:5\u201313","journal-title":"Cancer Res"},{"key":"9376_CR8","first-page":"4103","volume":"27","author":"CH Chung","year":"2010","unstructured":"Chung CH, Raben D (2010) p16 expression as a predictive biomarker of hypoxic cell-sensitizing agents in oropharyngeal. Cancer J Clin Oncol 27:4103\u20134104","journal-title":"Cancer J Clin Oncol"},{"key":"9376_CR9","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1200\/JCO.2009.23.1670","volume":"27","author":"W Shi","year":"2009","unstructured":"Shi W, Kato H, Perez-Ordonez B et al (2009) Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma. J Clin Oncol 27:6213\u20136221","journal-title":"J Clin Oncol"},{"key":"9376_CR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijrobp.2009.02.015","volume":"74","author":"CS Kong","year":"2009","unstructured":"Kong CS, Narasimhan B, Cao H et al (2009) The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 74:553\u2013561","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9376_CR11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAI.0b013e318162f8aa","volume":"16","author":"E Stelkovics","year":"2008","unstructured":"Stelkovics E, Korom I, Marczinovits I et al (2008) Collagen XVII\/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy. Appl Immunohistochem Mol Morphol 16:433\u2013441","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"9376_CR12","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/modpathol.3800220","volume":"17","author":"K Nilsson","year":"2004","unstructured":"Nilsson K, Svensson S, Landberg G (2004) Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. Mod Pathol 17:1464\u20131474","journal-title":"Mod Pathol"},{"issue":"9","key":"9376_CR13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/01.MP.0000085760.74313.DD","volume":"16","author":"L Ai","year":"2003","unstructured":"Ai L, Stephenson KK, Ling W et al (2003) The p16 (CDKN2a\/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases. Mod Pathol 16(9):944\u2013950","journal-title":"Mod Pathol"},{"issue":"17","key":"9376_CR14","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1158\/1078-0432.CCR-04-0448","volume":"10","author":"PM Weinberger","year":"2004","unstructured":"Weinberger PM, Yu Z, Haffty BG et al (2004) Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin Cancer Res 10(17):5684\u20135691","journal-title":"Clin Cancer Res"},{"key":"9376_CR15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0360-3016(00)00573-3","volume":"48","author":"DM Aebersold","year":"2000","unstructured":"Aebersold DM, Beer KT, Laissue J et al (2000) Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx. Int J Radiat Oncol Biol Phys 48:17\u201325","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9376_CR16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/00005537-200006000-00024","volume":"110","author":"C Sittel","year":"2000","unstructured":"Sittel C, Eckel HE, Damm M et al (2000) Ki67 (MIB1), p53, and lewis-X (LeuM1) as prognostic factors of recurrence in T1 and T2 laryngeal carcinoma. Laryngoscope 110:1012\u20131017","journal-title":"Laryngoscope"},{"issue":"21","key":"9376_CR17","first-page":"5997","volume":"52","author":"KD Somers","year":"1992","unstructured":"Somers KD, Merrick MA, Lopez ME et al (1992) Frequent p53 mutations in head and neck cancer. Cancer Res 52(21):5997\u20136000","journal-title":"Cancer Res"},{"issue":"8","key":"9376_CR18","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/hed.10274","volume":"25","author":"CR Bradford","year":"2003","unstructured":"Bradford CR, Zhu S, Ogawa H et al (2003) P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines. Head Neck 25(8):654\u2013661","journal-title":"Head Neck"},{"issue":"7","key":"9376_CR19","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1200\/JCO.2000.18.7.1465","volume":"18","author":"A Cabelguenne","year":"2000","unstructured":"Cabelguenne A, Blons H, de Waziers I et al (2000) p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series. J Clin Oncol 18(7):1465\u20131473","journal-title":"J Clin Oncol"},{"issue":"2","key":"9376_CR20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1200\/JCO.2000.18.2.385","volume":"18","author":"S Temam","year":"2000","unstructured":"Temam S, Flahault A, P\u00e9ri\u00e9 S et al (2000) p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck. J Clin Oncol 18(2):385\u2013394","journal-title":"J Clin Oncol"},{"issue":"24","key":"9376_CR21","first-page":"7350","volume":"62","author":"KK Ang","year":"2002","unstructured":"Ang KK, Berkey BA, Tu X et al (2002) Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62(24):7350\u20137356","journal-title":"Cancer Res"},{"issue":"17","key":"9376_CR22","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1200\/JCO.2005.04.8306","volume":"24","author":"S Kalyankrishna","year":"2006","unstructured":"Kalyankrishna S, Grandis JR (2006) Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 24(17):2666\u20132672","journal-title":"J Clin Oncol"},{"issue":"11","key":"9376_CR23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/jnci\/90.11.824","volume":"90","author":"JR Grandis","year":"1998","unstructured":"Grandis JR, Melhem MF, Gooding WE et al (1998) Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90(11):824\u2013832","journal-title":"J Natl Cancer Inst"},{"issue":"25","key":"9376_CR24","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1200\/JCO.2005.02.857","volume":"23","author":"DA Eberhard","year":"2005","unstructured":"Eberhard DA, Johnson BE, Amler LC et al (2005) Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23(25):5900\u20135909","journal-title":"J Clin Oncol"},{"key":"9376_CR25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrd3135","volume":"7","author":"I Pet\u00e1k","year":"2010","unstructured":"Pet\u00e1k I, Schwab R, Orfi I et al (2010) Integrating molecular diagnostics into anticancer drug discovery. Nat Rev Drug Discov 7:523\u2013535","journal-title":"Nat Rev Drug Discov"},{"key":"9376_CR26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00464017","volume":"245","author":"G R\u00e9p\u00e1ssy","year":"1988","unstructured":"R\u00e9p\u00e1ssy G, Czigner J, Rib\u00e1ri O et al (1988) The barrier-like role of activated connective tissue against the spread of supraglottic laryngeal carcinoma. Arch Otorhinolaryngol 245:151\u2013154","journal-title":"Arch Otorhinolaryngol"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9376-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-011-9376-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9376-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T23:38:19Z","timestamp":1560123499000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-011-9376-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,13]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["9376"],"URL":"https:\/\/doi.org\/10.1007\/s12253-011-9376-9","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,13]]}}}