{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:41:19Z","timestamp":1783633279951,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T00:00:00Z","timestamp":1301961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12253-011-9385-8","type":"journal-article","created":{"date-parts":[[2011,4,3]],"date-time":"2011-04-03T23:32:31Z","timestamp":1301873551000},"page":"801-808","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Cytogenetic Characterization in Four Pediatric Pheochromocytomas and Paragangliomas"],"prefix":"10.1007","volume":"17","author":[{"given":"Ales","family":"Vicha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Holzerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krepelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Musil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Prochazka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sumerauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kodet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Eckschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jarosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,5]]},"reference":[{"key":"9385_CR1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00467-008-0888-9","volume":"24","author":"B Havekes","year":"2009","unstructured":"Havekes B, Romijn JA, Eisenhofer G et al (2009) Update on pediatric pheochromocytoma. Pediatr Nephrol 24:943\u2013950","journal-title":"Pediatr Nephrol"},{"key":"9385_CR2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0140-6736(05)67139-5","volume":"366","author":"JW Lenders","year":"2005","unstructured":"Lenders JW, Eisenhofer G, Mannelli M et al (2005) Phaeochromocytoma. Lancet 366:665\u2013675","journal-title":"Lancet"},{"key":"9385_CR3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.humpath.2006.02.002","volume":"37","author":"S Lemeta","year":"2006","unstructured":"Lemeta S, Salmenkivi K, Pylkkanen L et al (2006) Frequent loss of heterozygosity at 6q in pheochromocytoma. Hum Pathol 37:749\u2013754","journal-title":"Hum Pathol"},{"key":"9385_CR4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1053\/jpsu.2001.21612","volume":"36","author":"AO Ciftci","year":"2001","unstructured":"Ciftci AO, Tanyel FC, Senocak ME et al (2001) Pheochromocytoma in children. J Pediatr Surg 36:447\u2013452","journal-title":"J Pediatr Surg"},{"key":"9385_CR5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0094-0143(05)70088-4","volume":"27","author":"JH Ross","year":"2000","unstructured":"Ross JH (2000) Pheochromocytoma. Special considerations in children. Urol Clin North Am 27:393\u2013402","journal-title":"Urol Clin North Am"},{"key":"9385_CR6","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archsurg.1990.01410200036004","volume":"125","author":"MG Caty","year":"1990","unstructured":"Caty MG, Coran AG, Geagen M et al (1990) Current diagnosis and treatment of pheochromocytoma in children. Experience with 22 consecutive tumors in 14 patients. Arch Surg 125:978\u2013981","journal-title":"Arch Surg"},{"key":"9385_CR7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1677\/erc.1.00829","volume":"11","author":"G Eisenhofer","year":"2004","unstructured":"Eisenhofer G, Bornstein SR, Brouwers FM et al (2004) Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer 11:423\u2013436","journal-title":"Endocr Relat Cancer"},{"key":"9385_CR8","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/cncr.23812","volume":"113","author":"H Huang","year":"2008","unstructured":"Huang H, Abraham J, Hung E et al (2008) Treatment of malignant pheochromocytoma\/paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18 patients. Cancer 113:2020\u20132028","journal-title":"Cancer"},{"key":"9385_CR9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1196\/annals.1353.017","volume":"1073","author":"RR Krijger De","year":"2006","unstructured":"De Krijger RR, Petri BJ, Van Nederveen FH et al (2006) Frequent genetic changes in childhood pheochromocytomas. Ann NY Acad Sci 1073:166\u2013176","journal-title":"Ann NY Acad Sci"},{"key":"9385_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","volume":"69","author":"D Astuti","year":"2001","unstructured":"Astuti D, Latif F, Dallol A et al (2001) Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 69:49\u201354","journal-title":"Am J Hum Genet"},{"key":"9385_CR11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-2007-970407","volume":"115","author":"M Mannelli","year":"2007","unstructured":"Mannelli M, Simi L, Gagliano MS et al (2007) Genetics and biology of pheochromocytoma. Exp Clin Endocrinol Diabetes 115:160\u2013165","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"9385_CR12","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1056\/NEJM199311183292103","volume":"329","author":"HP Neumann","year":"1993","unstructured":"Neumann HP, Berger DP, Sigmund G et al (1993) Pheochromocytomas, multiple endocrine neoplasia type 2, and von Hippel-Lindau disease. N Engl J Med 329:1531\u20131538","journal-title":"N Engl J Med"},{"key":"9385_CR13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1136\/jmg.32.12.934","volume":"32","author":"C Eng","year":"1995","unstructured":"Eng C, Crossey PA, Mulligan LM et al (1995) Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas. J Med Genet 32:934\u2013937","journal-title":"J Med Genet"},{"key":"9385_CR14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.14310\/horm.2002.1219","volume":"8","author":"Z Erlic","year":"2009","unstructured":"Erlic Z, Neumann HP (2009) Familial pheochromocytoma. Hormones (Athens) 8:29\u201338","journal-title":"Hormones (Athens)"},{"key":"9385_CR15","unstructured":"McNicol AM, Young WF Jr., Kawashma A, Komminoth P, Tischler AS (2004) Benign phaeochromocytoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds). WHO classification of tumours: pathology and genetics of tumours of endocrine organs. Lyon7 International Agency for Research on Cancer (IARC) 151\u20135"},{"key":"9385_CR16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0046-8177(85)80107-6","volume":"16","author":"LJ Medeiros","year":"1985","unstructured":"Medeiros LJ, Wolf BC, Balogh K et al (1985) Adrenal pheochromocytoma: a clinicopathologic review of 60 cases. Hum Pathol 16:580\u2013589","journal-title":"Hum Pathol"},{"key":"9385_CR17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0025-7125(16)30088-8","volume":"79","author":"SS Werbel","year":"1995","unstructured":"Werbel SS, Ober KP (1995) Pheochromocytoma. Update on diagnosis, localization, and management. Med Clin North Am 79:131\u2013153","journal-title":"Med Clin North Am"},{"key":"9385_CR18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1055\/s-0029-1231025","volume":"41","author":"R Adjalle","year":"2009","unstructured":"Adjalle R, Plouin PF, Pacak K et al (2009) Treatment of malignant pheochromocytoma. Horm Metab Res 41:687\u2013696","journal-title":"Horm Metab Res"},{"key":"9385_CR19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0002-9440(10)64547-6","volume":"157","author":"H Dannenberg","year":"2000","unstructured":"Dannenberg H, Speel EJ, Zhao J et al (2000) Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas. Am J Pathol 157:353\u2013359","journal-title":"Am J Pathol"},{"key":"9385_CR20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)64769-4","volume":"156","author":"E Edstrom","year":"2000","unstructured":"Edstrom E, Mahlamaki E, Nord B et al (2000) Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology. Am J Pathol 156:651\u2013659","journal-title":"Am J Pathol"},{"key":"9385_CR21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/gcc.20323","volume":"45","author":"A Hering","year":"2006","unstructured":"Hering A, Guratowska M, Bucsky P et al (2006) Characteristic genomic imbalances in pediatric pheochromocytoma. Genes Chromosom Cancer 45:602\u2013607","journal-title":"Genes Chromosom Cancer"},{"key":"9385_CR22","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.onc.1205149","volume":"21","author":"WO Lui","year":"2002","unstructured":"Lui WO, Chen J, Glasker S et al (2002) Selective loss of chromosome 11 in pheochromocytomas associated with the VHL syndrome. Oncogene 21:1117\u20131122","journal-title":"Oncogene"},{"key":"9385_CR23","doi-asserted-by":"crossref","unstructured":"Musil Z, Puchmajerova A, Krepelova A, et al. Paraganglioma in a 13-year-old girl: a novel SDHB gene mutation in the family? Cancer Genet Cytogenet 197:189\u201392","DOI":"10.1016\/j.cancergencyto.2009.11.010"},{"key":"9385_CR24","first-page":"415","volume":"52","author":"J Bedrnicek","year":"2005","unstructured":"Bedrnicek J, Vicha A, Jarosova M et al (2005) Characterization of drug-resistant neuroblastoma cell lines by comparative genomic hybridization. Neoplasma 52:415\u2013419","journal-title":"Neoplasma"},{"key":"9385_CR25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<418::AID-HUMU3>3.0.CO;2-2","volume":"15","author":"RM Hofstra","year":"2000","unstructured":"Hofstra RM, Wu Y, Stulp RP et al (2000) RET and GDNF gene scanning in Hirschsprung patients using two dual denaturing gel systems. Hum Mutat 15:418\u2013429","journal-title":"Hum Mutat"},{"key":"9385_CR26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/modpathol.3801013","volume":"21","author":"BJ Petri","year":"2008","unstructured":"Petri BJ, Speel EJ, Korpershoek E et al (2008) Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas. Mod Pathol 21:407\u2013413","journal-title":"Mod Pathol"},{"key":"9385_CR27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1677\/ERC-08-0241","volume":"16","author":"FH Nederveen van","year":"2009","unstructured":"van Nederveen FH, Korpershoek E, deLeeuw RJ et al (2009) Array-comparative genomic hybridization in sporadic benign pheochromocytomas. Endocr Relat Cancer 16:505\u2013513","journal-title":"Endocr Relat Cancer"},{"key":"9385_CR28","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1172\/JCI115186","volume":"87","author":"S Khosla","year":"1991","unstructured":"Khosla S, Patel VM, Hay ID et al (1991) Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. J Clin Invest 87:1691\u20131699","journal-title":"J Clin Invest"},{"key":"9385_CR29","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1038\/sj.onc.1207591","volume":"23","author":"EF Hensen","year":"2004","unstructured":"Hensen EF, Jordanova ES, van Minderhout IJ et al (2004) Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families. Oncogene 23:4076\u20134083","journal-title":"Oncogene"},{"key":"9385_CR30","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/10428190701824551","volume":"49","author":"B Burkhardt","year":"2008","unstructured":"Burkhardt B, Moericke A, Klapper W et al (2008) Pediatric precursor T lymphoblastic leukemia and lymphoblastic lymphoma: differences in the common regions with loss of heterozygosity at chromosome 6q and their prognostic impact. Leuk Lymphoma 49:451\u2013461","journal-title":"Leuk Lymphoma"},{"key":"9385_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1440-1827.2008.02246.x","volume":"58","author":"M Nakano","year":"2008","unstructured":"Nakano M, Takahashi H, Shiraishi T et al (2008) Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q, 8p and 13q. Pathol Int 58:415\u2013420","journal-title":"Pathol Int"},{"key":"9385_CR32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/S0002-9440(10)65495-8","volume":"155","author":"EJ Speel","year":"1999","unstructured":"Speel EJ, Richter J, Moch H et al (1999) Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization. Am J Pathol 155:1787\u20131794","journal-title":"Am J Pathol"},{"key":"9385_CR33","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/modpathol.3800160","volume":"17","author":"C August","year":"2004","unstructured":"August C, August K, Schroeder S et al (2004) CGH and CD 44\/MIB-1 immunohistochemistry are helpful to distinguish metastasized from nonmetastasized sporadic pheochromocytomas. Mod Pathol 17:1119\u20131128","journal-title":"Mod Pathol"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9385-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-011-9385-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9385-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T16:59:36Z","timestamp":1560099576000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-011-9385-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,5]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9385"],"URL":"https:\/\/doi.org\/10.1007\/s12253-011-9385-8","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,5]]}}}