{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:09:23Z","timestamp":1791324563719,"version":"4.3.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12253-011-9394-7","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T21:39:31Z","timestamp":1301521171000},"page":"859-866","source":"Crossref","is-referenced-by-count":36,"title":["Identification of PEG10 and TSG101 as Carcinogenesis, Progression, and Poor-Prognosis Related Biomarkers for Gallbladder Adenocarcinoma"],"prefix":"10.1007","volume":"17","author":[{"given":"Dong-cai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"9394_CR1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/geno.2001.6494","volume":"73","author":"R Ono","year":"2001","unstructured":"Ono R, Kobayashi S, Wagatsuma H et al (2001) A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. Genomics 73:232\u2013237","journal-title":"Genomics"},{"key":"9394_CR2","first-page":"3043","volume":"63","author":"H Okabe","year":"2003","unstructured":"Okabe H, Satoh S, Furukawa Y et al (2003) Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res 63:3043\u20133048","journal-title":"Cancer Res"},{"key":"9394_CR3","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/ijc.22929","volume":"121","author":"B Kainz","year":"2007","unstructured":"Kainz B, Shehata M, Bilban M et al (2007) Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia. Int J Cancer 121:1984\u20131993","journal-title":"Int J Cancer"},{"key":"9394_CR4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cancergencyto.2010.01.004","volume":"198","author":"K Tsuji","year":"2010","unstructured":"Tsuji K, Yasui K, Gen Y et al (2010) PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma. Cancer Genet Cytogenet 198:118\u2013125","journal-title":"Cancer Genet Cytogenet"},{"key":"9394_CR5","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.4049\/jimmunol.177.10.6713","volume":"177","author":"H Chunsong","year":"2006","unstructured":"Chunsong H, Yuling H, Li W et al (2006) CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23 + CD5+ B cells. J Immunol 177:6713\u20136722","journal-title":"J Immunol"},{"key":"9394_CR6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/0008-5472.CAN-05-1553","volume":"66","author":"CM Li","year":"2006","unstructured":"Li CM, Margolin AA, Salas M et al (2006) PEG10 is a c-MYC target gene in cancer cells. Cancer Res 66:665\u2013672","journal-title":"Cancer Res"},{"key":"9394_CR7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.canlet.2006.10.012","volume":"250","author":"WK Ip","year":"2007","unstructured":"Ip WK, Lai PB, Wong NL et al (2007) Identification of PEG10 as a progression related biomarker for hepatocellular carcinoma. Cancer Lett 250:284\u201391","journal-title":"Cancer Lett"},{"key":"9394_CR8","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1038\/sj.onc.1210362","volume":"26","author":"X Jie","year":"2007","unstructured":"Jie X, Lang C, Jian Q et al (2007) Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells. Oncogene 26:5741\u20135751","journal-title":"Oncogene"},{"key":"9394_CR9","doi-asserted-by":"crossref","first-page":"8482","DOI":"10.1074\/jbc.M409197200","volume":"280","author":"A Lux","year":"2005","unstructured":"Lux A, Beil C, Majety M et al (2005) Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. J Biol Chem 280:8482\u20138493","journal-title":"J Biol Chem"},{"key":"9394_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ng1699","volume":"38","author":"R Ono","year":"2006","unstructured":"Ono R, Nakamura K, Inoue K et al (2006) Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Nat Genet 38:101\u2013106","journal-title":"Nat Genet"},{"key":"9394_CR11","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1038\/sj.onc.1205612","volume":"21","author":"RT Liu","year":"2002","unstructured":"Liu RT, Huang CC, You HL et al (2002) Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas. Oncogene 21:4830\u20134837","journal-title":"Oncogene"},{"key":"9394_CR12","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1158\/1078-0432.CCR-07-0337","volume":"13","author":"TW Young","year":"2007","unstructured":"Young TW, Rosen DG, Mei FC et al (2007) Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Clin Cancer Res 13:3848\u20133854","journal-title":"Clin Cancer Res"},{"key":"9394_CR13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/gut.2003.021238","volume":"53","author":"N Koon","year":"2004","unstructured":"Koon N, Schneider-Stock R, Sarlomo-Rikala M et al (2004) Molecular targets for tumour progression in gastrointestinal stromal tumours. Gut 53:235\u2013240","journal-title":"Gut"},{"key":"9394_CR14","first-page":"46","volume":"25","author":"XR Ma","year":"2008","unstructured":"Ma XR, Edmund Sim UH, Pauline B et al (2008) Overexpression of WNT2 and TSG101 genes in colorectal carcinoma. Trop Biomed 25:46\u201357","journal-title":"Trop Biomed"},{"key":"9394_CR15","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.98.4.1619","volume":"98","author":"L Li","year":"2001","unstructured":"Li L, Liao J, Ruland J et al (2001) A TSG101\/MDM2 regulatory loop modulates MDM2 degradation and MDM2\/p53 feedback control. Proc Natl Acad Sci USA 98:1619\u20131624","journal-title":"Proc Natl Acad Sci USA"},{"key":"9394_CR16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)81111-3","volume":"85","author":"L Li","year":"1996","unstructured":"Li L, Cohen SN (1996) Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 85:319\u2013329","journal-title":"Cell"},{"key":"9394_CR17","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ijc.20014","volume":"109","author":"G Zhu","year":"2004","unstructured":"Zhu G, Gilchrist R, Borley N et al (2004) Reduction of TSG101 protein has a negative impact on tumor cell growth. Int J Cancer 109:541\u2013547","journal-title":"Int J Cancer"},{"key":"9394_CR18","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1128\/JVI.00094-06","volume":"80","author":"AA Bashirova","year":"2006","unstructured":"Bashirova AA, Bleiber G, Qi Y et al (2006) Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1. J Virol 80:6757\u20136763","journal-title":"J Virol"},{"key":"9394_CR19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2559.2008.03192.x","volume":"55","author":"RD Goldin","year":"2009","unstructured":"Goldin RD, Roa JC (2009) Gallbladder cancer: a morphological and molecular update. Histopathology 55:218\u2013229","journal-title":"Histopathology"},{"key":"9394_CR20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.dld.2009.12.008","volume":"42","author":"M Gatto","year":"2010","unstructured":"Gatto M, Bragazzi MC, Semeraro R et al (2010) Cholangiocarcinoma: update and future perspectives. Dig Liver Dis 42:253\u2013260","journal-title":"Dig Liver Dis"},{"key":"9394_CR21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.gtc.2010.02.006","volume":"39","author":"S Jayaraman","year":"2010","unstructured":"Jayaraman S, Jarnagin WR (2010) Management of gallbladder cancer. Gastroenterol Clin North Am 39:331\u2013342","journal-title":"Gastroenterol Clin North Am"},{"key":"9394_CR22","unstructured":"Maurya SK, Tewari M, Mishra RR (2010) Genetic abberations in gallbladder cancer. Surg Oncol Sep 28. [Epub ahead of print]"},{"key":"9394_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02893485","volume":"13","author":"Y Sanada","year":"2007","unstructured":"Sanada Y, Yoshida K, Ohara M, Tsutani Y (2007) Expression of orotate phosphoribosyltransferase (OPRT) in hepatobiliary and pancreatic carcinoma. Pathol Oncol Res 13:105\u2013113","journal-title":"Pathol Oncol Res"},{"key":"9394_CR24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02940312","volume":"13","author":"HJ Chang","year":"2007","unstructured":"Chang HJ, Yoo BC, Kim SW, Lee BL, Kim WH (2007) Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. Pathol Oncol Res 13:326\u2013335","journal-title":"Pathol Oncol Res"},{"key":"9394_CR25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12253-009-9150-4","volume":"15","author":"Z N\u00e9meth","year":"2009","unstructured":"N\u00e9meth Z, Sz\u00e1sz AM, Somor\u00e1cz A, T\u00e1trai P, N\u00e9meth J et al (2009) Zonula Occludens-1, Occludin, and E-cadherin Protein Expression in Biliary Tract cancers. Pathol Oncol Res 15:533\u2013539","journal-title":"Pathol Oncol Res"},{"key":"9394_CR26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1756-9966-28-65","volume":"28","author":"Q Li","year":"2009","unstructured":"Li Q, Yang Z (2009) Expression of phospho-ERK1\/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp& Clin Cancer Res 28:65\u201372","journal-title":"J Exp& Clin Cancer Res"},{"key":"9394_CR27","unstructured":"Li Q, Yang Z, Liu J, et al (2010). Expression of CDx2 and Hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic typr and clinical outcome. Pathol Oncol Res Dec 28. 2010 [Epub ahead of print]"},{"key":"9394_CR28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1517\/14656566.5.6.1271","volume":"5","author":"IA Malik","year":"2004","unstructured":"Malik IA (2004) Gallbladder cancer: current status. Expert Opin Pharmacother 5:1271\u20131277","journal-title":"Expert Opin Pharmacother"},{"key":"9394_CR29","first-page":"231","volume":"23","author":"S Tucek","year":"2010","unstructured":"Tucek S, Tomasek J, Hal\u00e1mkova J (2010) Bile duct malignancies. Klin Onkol 23:231\u2013241","journal-title":"Klin Onkol"},{"key":"9394_CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0304-3835(02)00264-1","volume":"185","author":"Y Zhao","year":"2002","unstructured":"Zhao Y, You H, Liu F et al (2002) Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells. Cancer Lett 185:211\u2013218","journal-title":"Cancer Lett"},{"key":"9394_CR31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4161\/cbt.3.6.847","volume":"3","author":"H Shen","year":"2004","unstructured":"Shen H, Pan Y, Han Z et al (2004) Reversal of multidrug resistance of gastric cancer cells by downregulation of TSG101 with TSG101siRNA. Cancer Biol Ther 3:561\u2013565","journal-title":"Cancer Biol Ther"},{"key":"9394_CR32","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1158\/0008-5472.CAN-04-1200","volume":"64","author":"CT Lee","year":"2004","unstructured":"Lee CT, Park KH, Yanagisawa K et al (2004) Combination therapy with conditionally replicating adenovirus and replication defective adenovirus. Cancer Res 64:6660\u20136665","journal-title":"Cancer Res"},{"key":"9394_CR33","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1158\/0008-5472.CAN-05-1515","volume":"66","author":"CT Lee","year":"2006","unstructured":"Lee CT, Lee YJ, Kwon SY et al (2006) In vivo imaging of adenovirus transduction and enhanced therapeutic efficacy of combination therapy with conditionally replicating adenovirus and adenovirus-p27. Cancer Res 66:372\u2013377","journal-title":"Cancer Res"},{"key":"9394_CR34","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1158\/1078-0432.CCR-03-0122","volume":"10","author":"Q Huang","year":"2004","unstructured":"Huang Q, Zhang X, Wang H et al (2004) A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clin Cancer Res 10:1439\u20131445","journal-title":"Clin Cancer Res"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9394-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-011-9394-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-011-9394-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:39:16Z","timestamp":1559443156000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-011-9394-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,1]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9394"],"URL":"https:\/\/doi.org\/10.1007\/s12253-011-9394-7","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,1]]}}}