{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:47:12Z","timestamp":1791247632631,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s12253-013-9603-7","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T22:22:49Z","timestamp":1363904569000},"page":"461-474","source":"Crossref","is-referenced-by-count":46,"title":["Galectin-3 Accelerates the Progression of Oral Tongue Squamous Cell Carcinoma via a Wnt\/\u03b2-catenin-Dependent Pathway"],"prefix":"10.1007","volume":"19","author":[{"given":"Li-Ping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Min","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"9603_CR1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/hed.21022","volume":"31","author":"JS Cooper","year":"2009","unstructured":"Cooper JS, Porter K, Mallin K et al (2009) National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck 31:748\u2013758","journal-title":"Head Neck"},{"key":"9603_CR2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.oraloncology.2005.06.015","volume":"42","author":"I Chitapanarux","year":"2006","unstructured":"Chitapanarux I, Lorvidhaya V, Sittitrai P et al (2006) Oral cavity cancers at a young age: analysis of patient, tumor and treatment characteristics in Chiang Mai University Hospital. Oral Oncol 42:83\u201388","journal-title":"Oral Oncol"},{"key":"9603_CR3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V","volume":"80","author":"H Hiratsuka","year":"1997","unstructured":"Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G (1997) Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer 80:351\u2013356","journal-title":"Cancer"},{"key":"9603_CR4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<207::AID-HED1>3.0.CO;2-9","volume":"22","author":"LP Kowalski","year":"2000","unstructured":"Kowalski LP, Bagietto R, Lara JR, Santos RL, Silva JJ, Magrin J (2000) Prognostic significance of the distribution of neck node metastasis from oral carcinoma. Head Neck 22:207\u2013214","journal-title":"Head Neck"},{"key":"9603_CR5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0278-2391(03)00149-6","volume":"61","author":"WL Lo","year":"2003","unstructured":"Lo WL, Kao SY, Chi LY, Wong YK, Chang RC (2003) Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg 61:751\u2013758","journal-title":"J Oral Maxillofac Surg"},{"key":"9603_CR6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-4165(02)00310-0","volume":"1572","author":"DN Cooper","year":"2002","unstructured":"Cooper DN (2002) Galectinomics: finding themes in complexity. Biochim Biophys Acta 1572:209\u2013231","journal-title":"Biochim Biophys Acta"},{"key":"9603_CR7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/glycob\/9.10.979","volume":"9","author":"DN Cooper","year":"1999","unstructured":"Cooper DN, Barondes SH (1999) God must love galectins; he made so many of them. Glycobiology 9:979\u2013984","journal-title":"Glycobiology"},{"key":"9603_CR8","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/S1462399408000719","volume":"10","author":"RY Yang","year":"2008","unstructured":"Yang RY, Rabinovich GA, Liu FT (2008) Galectins: structure, function and therapeutic potential. Expert Rev Mol Med 10:e17","journal-title":"Expert Rev Mol Med"},{"key":"9603_CR9","first-page":"305","volume":"9","author":"A Krzeslak","year":"2004","unstructured":"Krzeslak A, Lipinska A (2004) Galectin-3 as a multifunctional protein. Cell Mol Biol Lett 9:305\u2013328","journal-title":"Cell Mol Biol Lett"},{"key":"9603_CR10","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2353\/ajpath.2010.090353","volume":"176","author":"CG Chiu","year":"2010","unstructured":"Chiu CG, Strugnell SS, Griffith OL et al (2010) Diagnostic utility of galectin-3 in thyroid cancer. Am J Pathol 176:2067\u20132081","journal-title":"Am J Pathol"},{"key":"9603_CR11","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2353\/ajpath.2009.080816","volume":"174","author":"Y Wang","year":"2009","unstructured":"Wang Y, Nangia-Makker P, Tait L, Balan V, Hogan V, Pienta KJ, Raz A (2009) Regulation of prostate cancer progression by galectin-3. Am J Pathol 174:1515\u20131523","journal-title":"Am J Pathol"},{"key":"9603_CR12","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1158\/0008-5472.CAN-09-1096","volume":"69","author":"Q Zhao","year":"2009","unstructured":"Zhao Q, Guo X, Nash GB, Stone PC, Hilkens J, Rhodes JM, Yu LG (2009) Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface. Cancer Res 69:6799\u20136806","journal-title":"Cancer Res"},{"key":"9603_CR13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1369\/jhc.2010.955237","volume":"58","author":"M Hill","year":"2010","unstructured":"Hill M, Mazal D, Biron VA et al (2010) A novel clinically relevant animal model for studying galectin-3 and its ligands during colon carcinogenesis. J Histochem Cytochem 58:553\u2013565","journal-title":"J Histochem Cytochem"},{"key":"9603_CR14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1369\/jhc.2009.952960","volume":"57","author":"FA Miranda","year":"2009","unstructured":"Miranda FA, Hassumi MK, Guimaraes MC et al (2009) Galectin-3 overexpression in invasive laryngeal carcinoma, assessed by computer-assisted analysis. J Histochem Cytochem 57:665\u2013673","journal-title":"J Histochem Cytochem"},{"key":"9603_CR15","first-page":"4635","volume":"6","author":"Y Honjo","year":"2000","unstructured":"Honjo Y, Inohara H, Akahani S et al (2000) Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin Cancer Res 6:4635\u20134640","journal-title":"Clin Cancer Res"},{"key":"9603_CR16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.prp.2011.02.004","volume":"207","author":"PM Alves","year":"2011","unstructured":"Alves PM, Godoy GP, Gomes DQ et al (2011) Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue. Pathol Res Pract 207:236\u2013240","journal-title":"Pathol Res Pract"},{"key":"9603_CR17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/(SICI)1097-0215(20000215)85:4<545::AID-IJC17>3.0.CO;2-N","volume":"85","author":"P Matarrese","year":"2000","unstructured":"Matarrese P, Fusco O, Tinari N et al (2000) Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties. Int J Cancer 85:545\u2013554","journal-title":"Int J Cancer"},{"key":"9603_CR18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2353\/ajpath.2008.070583","volume":"173","author":"M Giannopoulou","year":"2008","unstructured":"Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y (2008) Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol 173:30\u201341","journal-title":"Am J Pathol"},{"key":"9603_CR19","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1074\/jbc.M807001200","volume":"284","author":"CR Kliment","year":"2009","unstructured":"Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD (2009) Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem 284:3537\u20133545","journal-title":"J Biol Chem"},{"key":"9603_CR20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BC20060020","volume":"98","author":"L Duan","year":"2006","unstructured":"Duan L, Yao J, Wu X, Fan M (2006) Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. Biol Cell 98:479\u2013490","journal-title":"Biol Cell"},{"key":"9603_CR21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.yexmp.2009.11.004","volume":"88","author":"AC Fracalossi","year":"2010","unstructured":"Fracalossi AC, Silva MS, Oshima CT, Ribeiro DA (2010) Wnt\/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Exp Mol Pathol 88:176\u2013183","journal-title":"Exp Mol Pathol"},{"key":"9603_CR22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/10454411010120020501","volume":"12","author":"ML Lo","year":"2001","unstructured":"Lo ML (2001) A possible role for the WNT-1 pathway in oral carcinogenesis. Crit Rev Oral Biol Med 12:152\u2013165","journal-title":"Crit Rev Oral Biol Med"},{"key":"9603_CR23","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1126\/science.1071549","volume":"296","author":"RT Moon","year":"2002","unstructured":"Moon RT, Bowerman B, Boutros M, Perrimon N (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296:1644\u20131646","journal-title":"Science"},{"key":"9603_CR24","doi-asserted-by":"crossref","first-page":"8598","DOI":"10.1074\/jbc.M111.322800","volume":"287","author":"D Yan","year":"2012","unstructured":"Yan D, Avtanski D, Saxena NK, Sharma D (2012) Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt\/GSK3- and MTA1\/Wnt1 protein-dependent pathways. J Biol Chem 287:8598\u20138612","journal-title":"J Biol Chem"},{"key":"9603_CR25","doi-asserted-by":"crossref","first-page":"e23899","DOI":"10.1371\/journal.pone.0023899","volume":"6","author":"S Howard","year":"2011","unstructured":"Howard S, Deroo T, Fujita Y, Itasaki N (2011) A positive role of cadherin in Wnt\/beta-catenin signalling during epithelial-mesenchymal transition. PLoS One 6:e23899","journal-title":"PLoS One"},{"key":"9603_CR26","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/jcs.00623","volume":"116","author":"Y Kawano","year":"2003","unstructured":"Kawano Y, Kypta R (2003) Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627\u20132634","journal-title":"J Cell Sci"},{"key":"9603_CR27","doi-asserted-by":"crossref","first-page":"e30359","DOI":"10.1371\/journal.pone.0030359","volume":"7","author":"KA Kocemba","year":"2012","unstructured":"Kocemba KA, Groen RW, van Andel H, Kersten MJ, Mahtouk K, Spaargaren M, Pals ST (2012) Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma. PLoS One 7:e30359","journal-title":"PLoS One"},{"key":"9603_CR28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","volume":"5","author":"FT Liu","year":"2005","unstructured":"Liu FT, Rabinovich GA (2005) Galectins as modulators of tumour progression. Nat Rev Cancer 5:29\u201341","journal-title":"Nat Rev Cancer"},{"key":"9603_CR29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.oraloncology.2006.12.014","volume":"44","author":"S Saussez","year":"2008","unstructured":"Saussez S, Lorfevre F, Lequeux T et al (2008) The determination of the levels of circulating galectin-1 and -3 in HNSCC patients could be used to monitor tumor progression and\/or responses to therapy. Oral Oncol 44:86\u201393","journal-title":"Oral Oncol"},{"key":"9603_CR30","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1158\/0008-5472.CAN-04-1816","volume":"64","author":"T Shimura","year":"2004","unstructured":"Shimura T, Takenaka Y, Tsutsumi S, Hogan V, Kikuchi A, Raz A (2004) Galectin-3, a novel binding partner of beta-catenin. Cancer Res 64:6363\u20136367","journal-title":"Cancer Res"},{"key":"9603_CR31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archotol.133.5.503","volume":"133","author":"PM Weinberger","year":"2007","unstructured":"Weinberger PM, Adam BL, Gourin CG et al (2007) Association of nuclear, cytoplasmic expression of galectin-3 with beta-catenin\/Wnt-pathway activation in thyroid carcinoma. Arch Otolaryngol Head Neck Surg 133:503\u2013510","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"9603_CR32","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1158\/0008-5472.CAN-08-4153","volume":"69","author":"S Song","year":"2009","unstructured":"Song S, Mazurek N, Liu C et al (2009) Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res 69:1343\u20131349","journal-title":"Cancer Res"},{"key":"9603_CR33","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/eji.200738118","volume":"38","author":"FJ Staal","year":"2008","unstructured":"Staal FJ, Sen JM (2008) The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol 38:1788\u20131794","journal-title":"Eur J Immunol"},{"key":"9603_CR34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","volume":"20","author":"CY Logan","year":"2004","unstructured":"Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781\u2013810","journal-title":"Annu Rev Cell Dev Biol"},{"key":"9603_CR35","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1083\/jcb.200710050","volume":"180","author":"XQ Gan","year":"2008","unstructured":"Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L (2008) Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol 180:1087\u20131100","journal-title":"J Cell Biol"},{"key":"9603_CR36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/dev.01573","volume":"132","author":"MC Hu","year":"2005","unstructured":"Hu MC, Rosenblum ND (2005) Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 132:215\u2013225","journal-title":"Development"},{"key":"9603_CR37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mc.20311","volume":"46","author":"G Udhayakumar","year":"2007","unstructured":"Udhayakumar G, Jayanthi V, Devaraj N, Devaraj H (2007) Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer. Mol Carcinog 46:807\u2013817","journal-title":"Mol Carcinog"},{"key":"9603_CR38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-61779-498-8_3","volume":"836","author":"M Rahmani","year":"2012","unstructured":"Rahmani M, Carthy JM, McManus BM (2012) Mapping of the Wnt\/beta-catenin\/TCF response elements in the human versican promoter. Methods Mol Biol 836:35\u201352","journal-title":"Methods Mol Biol"},{"key":"9603_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2010.12.070","volume":"406","author":"J Zeilstra","year":"2011","unstructured":"Zeilstra J, Joosten SP, Wensveen FM et al (2011) WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer. Biochem Biophys Res Commun 406:1\u20136","journal-title":"Biochem Biophys Res Commun"},{"key":"9603_CR40","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/emboj.2009.153","volume":"28","author":"R Sancho","year":"2009","unstructured":"Sancho R, Nateri AS, de Vinuesa AG, Aguilera C, Nye E, Spencer-Dene B, Behrens A (2009) JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 28:1843\u20131854","journal-title":"EMBO J"},{"key":"9603_CR41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1158\/1541-7786.MCR-09-0027","volume":"7","author":"A Saadeddin","year":"2009","unstructured":"Saadeddin A, Babaei-Jadidi R, Spencer-Dene B, Nateri AS (2009) The links between transcription, beta-catenin\/JNK signaling, and carcinogenesis. Mol Cancer Res 7:1189\u20131196","journal-title":"Mol Cancer Res"},{"key":"9603_CR42","first-page":"1","volume":"1653","author":"RH Giles","year":"2003","unstructured":"Giles RH, van Es JH, Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653:1\u201324","journal-title":"Biochim Biophys Acta"},{"key":"9603_CR43","doi-asserted-by":"crossref","first-page":"e27490","DOI":"10.1371\/journal.pone.0027490","volume":"6","author":"R Levy","year":"2011","unstructured":"Levy R, Biran A, Poirier F, Raz A, Kloog Y (2011) Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA. PLoS One 6:e27490","journal-title":"PLoS One"},{"key":"9603_CR44","doi-asserted-by":"crossref","first-page":"34922","DOI":"10.1074\/jbc.M312697200","volume":"279","author":"G Elad-Sfadia","year":"2004","unstructured":"Elad-Sfadia G, Haklai R, Balan E, Kloog Y (2004) Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J Biol Chem 279:34922\u201334930","journal-title":"J Biol Chem"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-013-9603-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-013-9603-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-013-9603-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T03:02:32Z","timestamp":1644634952000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-013-9603-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["9603"],"URL":"https:\/\/doi.org\/10.1007\/s12253-013-9603-7","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}