{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:15:56Z","timestamp":1780514156556,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s12253-013-9732-z","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T09:43:32Z","timestamp":1387359812000},"page":"215-220","source":"Crossref","is-referenced-by-count":7,"title":["Gliomatosis Cerebri Type 1 with Extensive Involvement of the Spinal Cord and BRAF V600E Mutation"],"prefix":"10.1007","volume":"20","author":[{"given":"Ivan","family":"Fernandez-Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Quirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona L.","family":"Norwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi A.","family":"Sibtain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Laxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Bodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"9732_CR1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/brain\/61.2.170","volume":"61","author":"S Nevin","year":"1938","unstructured":"Nevin S (1938) Gliomatosis cerebri. Brain 61:170\u2013191","journal-title":"Brain"},{"issue":"2","key":"9732_CR2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11060-005-5263-0","volume":"76","author":"S Taillibert","year":"2006","unstructured":"Taillibert S, Chodkiewicz C, Laigle-Donadey F, Napolitano M, Cartalat-Carel S, Sanson M (2006) Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol 76(2):201\u2013205. doi: 10.1007\/s11060-005-5263-0","journal-title":"J Neurooncol"},{"issue":"4","key":"9732_CR3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ana.10297","volume":"52","author":"U Herrlinger","year":"2002","unstructured":"Herrlinger U, Felsberg J, Kuker W, Bornemann A, Plasswilm L, Knobbe CB, Strik H, Wick W, Meyermann R, Dichgans J, Bamberg M, Reifenberger G, Weller M (2002) Gliomatosis cerebri: molecular pathology and clinical course. Ann Neurol 52(4):390\u2013399. doi: 10.1002\/ana.10297","journal-title":"Ann Neurol"},{"issue":"1","key":"9732_CR4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11060-012-1030-1","volume":"112","author":"RP Thomas","year":"2013","unstructured":"Thomas RP, Xu LW, Lober RM, Li G, Nagpal S (2013) The incidence and significance of multiple lesions in glioblastoma. J Neurooncol 112(1):91\u201397. doi: 10.1007\/s11060-012-1030-1","journal-title":"J Neurooncol"},{"key":"9732_CR5","first-page":"92","volume-title":"Pathology and genetics of tumours of the nervous system","author":"PLBJ Lantos","year":"2000","unstructured":"Lantos PLBJ (2000) Gliomatosis cerebri. In: Kleihues P, Cavence WK (eds) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 92\u201393"},{"issue":"6","key":"9732_CR6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.2353\/jmoldx.2010.090237","volume":"12","author":"P Setty","year":"2010","unstructured":"Setty P, Hammes J, Rothamel T, Vladimirova V, Kramm CM, Pietsch T, Waha A (2010) A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples. J Mol Diagn 12(6):750\u2013756. doi: 10.2353\/jmoldx.2010.090237","journal-title":"J Mol Diagn"},{"issue":"7","key":"9732_CR7","first-page":"651","volume":"4","author":"X Song","year":"2011","unstructured":"Song X, Andrew Allen R, Terence Dunn S, Fung KM, Farmer P, Gandhi S, Ranjan T, Demopoulos A, Symons M, Schulder M, Li JY (2011) Glioblastoma with PNET-like components has a higher frequency of isocitrate dehydrogenase 1 (IDH1) mutation and likely a better prognosis than primary glioblastoma. Int J Clin Exp Pathol 4(7):651\u2013660","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"9732_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5414\/NPP28073","volume":"28","author":"S Park","year":"2009","unstructured":"Park S, Suh YL, Nam DH, Kim ST (2009) Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types. Clin Neuropathol 28(2):73\u201382","journal-title":"Clin Neuropathol"},{"issue":"1","key":"9732_CR9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0303-8467(87)80075-6","volume":"89","author":"D Troost","year":"1987","unstructured":"Troost D, Kuiper H, Valk J, Fleury P (1987) Gliomatosis cerebri, report of a clinically diagnosed and histologically confirmed case. Clin Neurol Neurosurg 89(1):43\u201347","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"9732_CR10","first-page":"183","volume":"25","author":"M Piccirilli LA","year":"2006","unstructured":"LA Piccirilli M, Salvati M (2006) Gliomatosis cerebri treatment in 11 elderly patients. J Exp Clin Cancer Res 25(2):183\u2013187","journal-title":"J Exp Clin Cancer Res"},{"issue":"8","key":"9732_CR11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s007010050176","volume":"140","author":"DG Kim","year":"1998","unstructured":"Kim DG, Yang HJ, Park IA, Chi JG, Jung HW, Han DH, Choi KS, Cho BK (1998) Gliomatosis cerebri: clinical features, treatment, and prognosis. Acta Neurochirurgica 140(8):755\u2013762. doi: 10.1007\/s007010050176","journal-title":"Acta Neurochirurgica"},{"key":"9732_CR12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2407-10-424","volume":"10","author":"DS Kong","year":"2010","unstructured":"Kong DS, Kim ST, Lee JI, Suh YL, Lim do H, Kim WS, Kwon KH, Park K, Kim JH, Nam DH (2010) Impact of adjuvant chemotherapy for gliomatosis cerebri. BMC Cancer 10:424. doi: 10.1186\/1471-2407-10-424","journal-title":"BMC Cancer"},{"issue":"1","key":"9732_CR13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1440-1789.2011.01216.x","volume":"32","author":"D Narasimhaiah","year":"2012","unstructured":"Narasimhaiah D, Miquel C, Verhamme E, Desclee P, Cosnard G, Godfraind C (2012) IDH1 mutation, a genetic alteration associated with adult gliomatosis cerebri. Neuropathology 32(1):30\u201337. doi: 10.1111\/j.1440-1789.2011.01216.x","journal-title":"Neuropathology"},{"issue":"4","key":"9732_CR14","first-page":"135","volume":"4","author":"J Artigas","year":"1985","unstructured":"Artigas J, Cervos-Navarro J, Iglesias JR, Ebhardt G (1985) Gliomatosis cerebri: clinical and histological findings. Clin Neuropathol 4(4):135\u2013148","journal-title":"Clin Neuropathol"},{"issue":"5","key":"9732_CR15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0090-3019(81)90171-3","volume":"15","author":"JJ Corbett","year":"1981","unstructured":"Corbett JJ, Newman NM (1981) Symptomatic leptomeningeal metastases preceding other manifestations of occult primary brain tumors. Surg Neurol 15(5):362\u2013367","journal-title":"Surg Neurol"},{"key":"9732_CR16","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0028-3886.28122","volume":"54","author":"MAM Karaca","year":"2006","unstructured":"Karaca MAM, Hicsonmez A, Guney Y, Kurtman C (2006) Cases of glioblastoma multiforme metastasizing to spinal cord. Neurol India 54:428\u2013430","journal-title":"Neurol India"},{"issue":"5","key":"9732_CR17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3171\/2012.7.SPINE12212","volume":"17","author":"CD Lawton","year":"2012","unstructured":"Lawton CD, Nagasawa DT, Yang I, Fessler RG, Smith ZA (2012) Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease. J Neurosurg Spine 17(5):438\u2013448. doi: 10.3171\/2012.7.SPINE12212","journal-title":"J Neurosurg Spine"},{"issue":"6","key":"9732_CR18","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/0046-8177(92)90329-2","volume":"23","author":"MG Balko","year":"1992","unstructured":"Balko MG, Blisard KS, Samaha FJ (1992) Oligodendroglial gliomatosis cerebri. Hum Pathol 23(6):706\u2013707","journal-title":"Hum Pathol"},{"issue":"1","key":"9732_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1750-3639.2009.00352.x","volume":"20","author":"D Capper","year":"2010","unstructured":"Capper D, Weissert S, Balss J, Habel A, Meyer J, Jager D, Ackermann U, Tessmer C, Korshunov A, Zentgraf H, Hartmann C, von Deimling A (2010) Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 20(1):245\u2013254. doi: 10.1111\/j.1750-3639.2009.00352.x","journal-title":"Brain Pathol"},{"issue":"2","key":"9732_CR20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00401-010-0701-2","volume":"120","author":"M Seiz","year":"2010","unstructured":"Seiz M, Tuettenberg J, Meyer J, Essig M, Schmieder K, Mawrin C, von Deimling A, Hartmann C (2010) Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes. Acta Neuropathol 120(2):261\u2013267. doi: 10.1007\/s00401-010-0701-2","journal-title":"Acta Neuropathol"},{"issue":"2","key":"9732_CR21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11060-011-0587-4","volume":"105","author":"V Desestret","year":"2011","unstructured":"Desestret V, Ciccarino P, Ducray F, Criniere E, Boisselier B, Labussiere M, Polivka M, Idbaih A, Kaloshi G, von Deimling A, Hoang-Xuan K, Delattre JY, Mokhtari K, Sanson M (2011) Prognostic stratification of gliomatosis cerebri by IDH1 R132H and INA expression. J Neurooncol 105(2):219\u2013224. doi: 10.1007\/s11060-011-0587-4","journal-title":"J Neurooncol"},{"issue":"3","key":"9732_CR22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1750-3639.2011.00532.x","volume":"22","author":"MJ Kwon","year":"2012","unstructured":"Kwon MJ, Kim ST, Kong DS, Lee D, Park S, Kang SY, Song JY, Nam DH, Kato Y, Choi YL, Suh YL (2012) Mutated IDH1 is a favorable prognostic factor for type 2 gliomatosis cerebri. Brain Pathol 22(3):307\u2013317. doi: 10.1111\/j.1750-3639.2011.00532.x","journal-title":"Brain Pathol"},{"issue":"2","key":"9732_CR23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11060-004-2061-z","volume":"72","author":"C Mawrin","year":"2005","unstructured":"Mawrin C, Kirches E, Schneider-Stock R, Boltze C, Vorwerk CK, von Mawrin A, von Deimling A, Stoltenburg-Didinge G, Bornemann A, Romeike B, Sellhaus B, Dietzmann K (2005) Alterations of cell cycle regulators in gliomatosis cerebri. J Neurooncol 72(2):115\u2013122. doi: 10.1007\/s11060-004-2061-z","journal-title":"J Neurooncol"},{"key":"9732_CR24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1756-9966-30-76","volume":"30","author":"W Liu","year":"2011","unstructured":"Liu W, Lv G, Li Y, Li L, Wang B (2011) Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas. J Exp Clin Cancer Res 30:76. doi: 10.1186\/1756-9966-30-76","journal-title":"J Exp Clin Cancer Res"},{"issue":"23","key":"9732_CR25","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.0500989102","volume":"102","author":"S Giovanni Di","year":"2005","unstructured":"Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI (2005) Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A 102(23):8333\u20138338. doi: 10.1073\/pnas.0500989102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9732_CR26","doi-asserted-by":"crossref","first-page":"838916","DOI":"10.1100\/2012\/838916","volume":"2012","author":"FM Kouri","year":"2012","unstructured":"Kouri FM, Jensen SA, Stegh AH (2012) The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond. Sci World J 2012:838916. doi: 10.1100\/2012\/838916","journal-title":"Sci World J"},{"issue":"1","key":"9732_CR27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/hupa.2003.1","volume":"34","author":"C Mawrin","year":"2003","unstructured":"Mawrin C, Lins H, Kirches E, Schildhaus HU, Scherlach C, Kanakis D, Dietzmann K (2003) Distribution of p53 alterations in a case of gliomatosis cerebri. Hum Pathol 34(1):102\u2013106. doi: 10.1053\/hupa.2003.1","journal-title":"Hum Pathol"},{"key":"9732_CR28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","volume":"116","author":"PTGM Wan","year":"2004","unstructured":"Wan PTGM, Roe SM, Lee S, NiculescuDuvaz D, Good VM, Jones CM, Marshall CJ, Springer CJBD, Marais R (2004) Cancer genome project. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116:855\u2013867. doi: 10.1016\/S0092-8674(04)00215-6","journal-title":"Cell"},{"issue":"2","key":"9732_CR29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5414\/NP300492","volume":"31","author":"D Capper","year":"2012","unstructured":"Capper D, Berghoff AS, von Deimling A, Preusser M (2012) Clinical neuropathology practice news 2-2012: BRAF V600E testing. Clin Neuropathol 31(2):64\u201366","journal-title":"Clin Neuropathol"},{"issue":"3","key":"9732_CR30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00401-011-0802-6","volume":"121","author":"G Schindler","year":"2011","unstructured":"Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A (2011) Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121(3):397\u2013405. doi: 10.1007\/s00401-011-0802-6","journal-title":"Acta Neuropathol"},{"issue":"5","key":"9732_CR31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/PAS.0b013e31827f9c5e","volume":"37","author":"BK Kleinschmidt-DeMasters","year":"2013","unstructured":"Kleinschmidt-DeMasters BK, Aisner DL, Birks DK, Foreman NK (2013) Epithelioid GBMs show a high percentage of BRAF V600E mutation. Am J Surg Pathol 37(5):685\u2013698. doi: 10.1097\/PAS.0b013e31827f9c5e","journal-title":"Am J Surg Pathol"},{"issue":"22","key":"9732_CR32","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.1117255109","volume":"109","author":"E Huillard","year":"2012","unstructured":"Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH (2012) Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A 109(22):8710\u20138715. doi: 10.1073\/pnas.1117255109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"9732_CR33","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1158\/1078-0432.CCR-11-1456","volume":"17","author":"TP Nicolaides","year":"2011","unstructured":"Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD (2011) Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res 17(24):7595\u20137604. doi: 10.1158\/1078-0432.CCR-11-1456","journal-title":"Clin Cancer Res"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-013-9732-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-013-9732-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-013-9732-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T06:39:26Z","timestamp":1559457566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-013-9732-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["9732"],"URL":"https:\/\/doi.org\/10.1007\/s12253-013-9732-z","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}