{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:22:12Z","timestamp":1790256132706,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s12253-014-9755-0","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T13:15:02Z","timestamp":1394630102000},"page":"741-746","source":"Crossref","is-referenced-by-count":22,"title":["Confocal Microscopy of Epithelial and Langerhans Cells of the Cornea in Patients Using Travoprost Drops Containing Two Different Preservatives"],"prefix":"10.1007","volume":"20","author":[{"given":"L\u00e1szl\u00f3","family":"Marsovszky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s D.","family":"Resch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Visontai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"9755_CR1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ajo.2008.10.019","volume":"147","author":"G Martone","year":"2009","unstructured":"Martone G, Frezzotti P, Tosi GM, Traversi C, Mittica V, Malandrini A, Pichierri P, Balestrazzi A, Motolese PA, Motolese I, Motolese E (2009) An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol 147:725\u2013735","journal-title":"Am J Ophthalmol"},{"key":"9755_CR2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/jop.2008.0140","volume":"25","author":"SP Epstein","year":"2009","unstructured":"Epstein SP, Chen D, Asbell PA (2009) Evaluation of biomarkers of inflammation in response to benzalkonium chloride on corneal and conjunctival epithelial cells. J Ocul Pharmacol and Ther 25:415\u2013424","journal-title":"J Ocul Pharmacol and Ther"},{"key":"9755_CR3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/01.ico.0000116526.57227.82","volume":"23","author":"RJ Noecker","year":"2004","unstructured":"Noecker RJ, Herrygers LA, Anwaruddin R (2004) Corneal and conjunctival changes caused by commonly used glaucoma medications. Cornea 23:490\u2013496","journal-title":"Cornea"},{"key":"9755_CR4","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s12325-012-0057-1","volume":"29","author":"JT Whitson","year":"2012","unstructured":"Whitson JT, Petroll WM (2012) Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and\/or antihypertensive agents. Adv Ther 29:874\u2013888","journal-title":"Adv Ther"},{"key":"9755_CR5","first-page":"291","volume":"3","author":"MB Horsley","year":"2009","unstructured":"Horsley MB, Kahook MY (2009) Effects of prostaglandin analog therapy on the ocular surface of glaucoma patients. Clin Ophthalmol 3:291\u2013295","journal-title":"Clin Ophthalmol"},{"key":"9755_CR6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/jop.2006.22.267","volume":"22","author":"A Labb\u00e9","year":"2006","unstructured":"Labb\u00e9 A, Pauly A, Liang H, Brignole-Baudouin F, Martin C, Warnet JM, Baudouin C (2006) Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study. J Ocul Pharmacol 22:267\u2013278","journal-title":"J Ocul Pharmacol"},{"key":"9755_CR7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/IJG.0b013e3181666557","volume":"17","author":"F Aptel","year":"2008","unstructured":"Aptel F, Cucherat M, Denis P (2008) Efficacy and tolerability of prostaglandin analogs: a meta-analysis of randomized controlled clinical trials. J Glaucoma 17:667\u2013673","journal-title":"J Glaucoma"},{"key":"9755_CR8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1189\/jlb.1102544","volume":"74","author":"P Hamrah","year":"2003","unstructured":"Hamrah P, Huq SO, Liu Y, Zhang Q, Dana MR (2003) Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leuk Biol 74:172\u2013178","journal-title":"J Leuk Biol"},{"key":"9755_CR9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1006\/exer.1999.0728","volume":"69","author":"LD Hazlett","year":"1999","unstructured":"Hazlett LD, McClellan SM, Hume EB, Dajcs JJ, O\u2019Callaghan RJ (1999) Willcox, M.D. Extended wear contact lens wear usage induces Langerhans cell migration into cornea. Exp Eye Res 69:575\u2013577","journal-title":"Exp Eye Res"},{"key":"9755_CR10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/ICO.0b013e31802e3b55","volume":"26","author":"A Zhivov","year":"2007","unstructured":"Zhivov A, Stave J, Vollmar B, Guthoff R (2007) In vivo confocal microscopic evaluation of Langerhans cell density and distribution in the corneal epithelium of healthy volunteers and contact lens wearers. Cornea 26:47\u201354","journal-title":"Cornea"},{"key":"9755_CR11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/1753425912461677","volume":"19","author":"L Marsovszky","year":"2013","unstructured":"Marsovszky L, Resch MD, N\u00e9meth J, Toldi G, Medgyesi E, Kov\u00e1cs L, Balog A (2013) In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis. Innate Immun 19:348\u2013354","journal-title":"Innate Immun"},{"key":"9755_CR12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/eye.2010.228","volume":"25","author":"H Pult","year":"2011","unstructured":"Pult H, Purslow C, Murphy PJ (2011) The relationship between clinical signs and dry eye symptoms. Eye 25:502\u2013510","journal-title":"Eye"},{"key":"9755_CR13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s00417-004-1075-8","volume":"243","author":"A Zhivov","year":"2005","unstructured":"Zhivov A, Stave J, Vollmar B, Guthoff R (2005) In vivo confocal microscopic evaluation of Langerhans cells density and distribution in the normal corneal epithelium. Graefe\u2019s Arch Clin Exp Ophthalmol 243:1056\u20131061","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"9755_CR14","doi-asserted-by":"crossref","unstructured":"Marsovszky L, N\u00e9meth J, Resch MD, Toldi G, Leg\u00e1ny N, Kov\u00e1cs L, Balog A (2013) Corneal Langerhans cell and dry eye examinations in ankylosing spondylitis. Innate Immun Aug 19","DOI":"10.1111\/j.1755-3768.2013.1636.x"},{"key":"9755_CR15","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/01.ico.0000230499.07273.c5","volume":"25","author":"KH Baratz","year":"2006","unstructured":"Baratz KH, Nau CB, Winter EJ, McLaren JW, Hodge DO, Herman DC, Bourne WM (2006) Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the Ocular Hypertension Treatment Study. Cornea 25:1046\u20131052","journal-title":"Cornea"},{"key":"9755_CR16","first-page":"1806","volume":"17","author":"DA Ammar","year":"2011","unstructured":"Ammar DA, Kahook MY (2011) Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells. Mol Vision 17:1806\u20131813","journal-title":"Mol Vision"},{"key":"9755_CR17","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1167\/iovs.05-0776","volume":"46","author":"JM Guenoun","year":"2005","unstructured":"Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F (2005) In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjuctiva-derived epithelial cells. Inv Ophth Vis Sci 46:4594\u20134599","journal-title":"Inv Ophth Vis Sci"},{"key":"9755_CR18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1167\/iovs.10-5995","volume":"52","author":"E Villani","year":"2011","unstructured":"Villani E, Beretta S, De Capitani M, Galimberti D, Viola F, Ratiglia R (2011) In vivo confocal microscopy of meibomian glands in Sj\u00f6gren\u2019s syndrome. Invest Ophthalmol Vis Sci 52:933\u2013939","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9755_CR19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/bjo.86.4.418","volume":"86","author":"PJ Pisella","year":"2002","unstructured":"Pisella PJ, Pouliquen P, Baudouin C (2002) Prevalence of ocular symptoms and signs with preserved and preservative-free glaucoma medications. Br J Ophthalmol 86:418\u2013423","journal-title":"Br J Ophthalmol"},{"key":"9755_CR20","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3109\/02713683.2010.489181","volume":"35","author":"A Zhivov","year":"2010","unstructured":"Zhivov A, Kraak R, Bergter H, Kundf G, Beck R, Guthoff RF (2010) Influence of benzalkonium chloride on Langerhans cells in corneal epithelium and development of dry eye in healthy volunteers. Curr Eye Res 35:762\u2013769","journal-title":"Curr Eye Res"},{"key":"9755_CR21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0008-8749(81)90481-0","volume":"64","author":"I Gery","year":"1981","unstructured":"Gery I, Davies P, Derr J, Krett N, Barranger JA (1981) Relationship between production and release of lymphocyte-activating factor (interleukin-1) by murine macrophages: 1. Effects of various agents. Cell Immunol 64:293\u2013303","journal-title":"Cell Immunol"},{"key":"9755_CR22","first-page":"83","volume":"2","author":"JY Niederkorn","year":"1989","unstructured":"Niederkorn JY, Peeler JS, Mellon J (1989) Phagocytosis of particulate antigens by corneal epithelial cells stimulate interleukin-1 secretion and migration of Langerhans cells into the central cornea. Reg Immunol 2:83\u201390","journal-title":"Reg Immunol"},{"key":"9755_CR23","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.4049\/jimmunol.162.7.4235","volume":"162","author":"I Dekaris","year":"1999","unstructured":"Dekaris I, Zhu SN, Dana MR (1999) TNF-alpha regulates corneal Langerhans cell migration. J Immunol 162:4235\u20134239","journal-title":"J Immunol"},{"key":"9755_CR24","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1167\/iovs.10-6741","volume":"52","author":"T Hattori","year":"2011","unstructured":"Hattori T, Chauhan SK, Lee H, Ueno H, Dana MR (2011) Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea. Invest Ophthalmol Vis Sci 52:4598\u20134604","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9755_CR25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1542-0124(12)70030-7","volume":"4","author":"A Zhivov","year":"2006","unstructured":"Zhivov A, Stachs O, Kraak R, Stave J, Guthoff RF (2006) In vivo confocal microscopy of the ocular surface. Ocul Surf 4:81\u201393","journal-title":"Ocul Surf"},{"key":"9755_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000335984","volume":"48","author":"H Liang","year":"2012","unstructured":"Liang H, Brignole-Baudouin F, Riancho L, Baudouin C (2012) Reduced in vivo ocular surface toxicity with polyquad-preserved travoprost versus benzalkonium-preserved travoprost or latanoprost ophthalmic solutions. Ophthalmic Res 48:89\u2013101","journal-title":"Ophthalmic Res"},{"key":"9755_CR27","first-page":"1189","volume":"18","author":"T Paimela","year":"2012","unstructured":"Paimela T, Ryh\u00e4nen T, Kauppinen A, Marttila L, Salminen A, Kaarniranta K (2012) The preservative polyquaternium-1 increases cytoxicity and NFkappaB linked inflammation in human corneal epithelial cells. Mol Vis 18:1189\u20131196","journal-title":"Mol Vis"},{"key":"9755_CR28","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2147\/OPTH.S22874","volume":"5","author":"S Ranno","year":"2011","unstructured":"Ranno S, Fogagnolo P, Rossetti L, Orzalesi N, Nucci P (2011) Changes in corneal parameters at confocal microscopy in treated glaucoma patients. Clin Ophthalmol 5:1037\u20131042","journal-title":"Clin Ophthalmol"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-014-9755-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-014-9755-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-014-9755-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T04:19:14Z","timestamp":1689049154000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-014-9755-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["9755"],"URL":"https:\/\/doi.org\/10.1007\/s12253-014-9755-0","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}