{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:05:23Z","timestamp":1782255923152,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s12253-015-9990-z","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T22:28:21Z","timestamp":1444775301000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Claudin-1 as a Biomarker of Cervical Cytology and Histology"],"prefix":"10.1007","volume":"22","author":[{"given":"M\u00e1rta","family":"Benczik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Galamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"Koiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"J\u00e1ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Sz\u00e9kely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Szekercz\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Schaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Sobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Jeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"9990_CR1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(11)61351-2","volume":"378","author":"MH Forouzanfar","year":"2011","unstructured":"Forouzanfar MH, Foreman KJ, Delossantos AM, et al. (2011) Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 378:1461\u20131484. doi: 10.1016\/S0140-6736(11)61351-2","journal-title":"Lancet"},{"key":"9990_CR2","unstructured":"Iarc (2003) Colposcopy and treatment of cervical intraepithelial neoplasia: A beginners' manual. 1\u2013132."},{"key":"9990_CR3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","volume":"197","author":"TC Wright","year":"2007","unstructured":"Wright TC, Massad LS, Dunton CJ, et al. (2007) 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol 197:346\u2013355. doi: 10.1016\/j.ajog.2007.07.047","journal-title":"Am J Obstet Gynecol"},{"key":"9990_CR4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/(SICI)1097-0215(19970410)71:2<159::AID-IJC6>3.0.CO;2-#","volume":"71","author":"L Gustafsson","year":"1997","unstructured":"Gustafsson L, Pont\u00e9n J, Bergstr\u00f6m R, Adami HO (1997) International incidence rates of invasive cervical cancer before cytological screening. Int J Cancer 71:159\u2013165","journal-title":"Int J Cancer"},{"key":"9990_CR5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","volume":"189","author":"JM Walboomers","year":"1999","unstructured":"Walboomers JM, Jacobs MV, Manos MM, et al. (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12\u201319. doi: 10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","journal-title":"J Pathol"},{"key":"9990_CR6","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ijc.21955","volume":"119","author":"J Cuzick","year":"2006","unstructured":"Cuzick J, Clavel C, Petry K-U, et al. (2006) Overview of the European and north American studies on HPV testing in primary cervical cancer screening. Int J Cancer 119:1095\u20131101. doi: 10.1002\/ijc.21955","journal-title":"Int J Cancer"},{"key":"9990_CR7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1470-2045(09)70360-2","volume":"11","author":"G Ronco","year":"2010","unstructured":"Ronco G, Giorgi-Rossi P, Carozzi F, et al. (2010) Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial. Lancet Oncol 11:249\u2013257. doi: 10.1016\/S1470-2045(09)70360-2","journal-title":"Lancet Oncol"},{"key":"9990_CR8","doi-asserted-by":"crossref","first-page":"c1804","DOI":"10.1136\/bmj.c1804","volume":"340","author":"A Anttila","year":"2010","unstructured":"Anttila A, Kotaniemi-Talonen L, Leinonen M, et al. (2010) Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme. BMJ 340:c1804","journal-title":"BMJ"},{"key":"9990_CR9","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/516784","volume":"195","author":"M Plummer","year":"2007","unstructured":"Plummer M, Schiffman M, Castle PE, et al. (2007) A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion. J Infect Dis 195:1582\u20131589. doi: 10.1086\/516784","journal-title":"J Infect Dis"},{"key":"9990_CR10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/jnci\/djn044","volume":"100","author":"AC Rodr\u00edguez","year":"2008","unstructured":"Rodr\u00edguez AC, Schiffman M, Herrero R, et al. (2008) Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. J Natl Cancer Inst 100:513\u2013517. doi: 10.1093\/jnci\/djn044","journal-title":"J Natl Cancer Inst"},{"key":"9990_CR11","doi-asserted-by":"crossref","unstructured":"Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. CA Cancer J Clin 62:147\u2013172. doi: 10.3322\/caac.21139","DOI":"10.3322\/caac.21139"},{"key":"9990_CR12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/jnci\/djn444","volume":"101","author":"P Naucler","year":"2009","unstructured":"Naucler P, Ryd W, T\u00f6rnberg S, et al. (2009) Efficacy of HPV DNA testing with cytology triage and\/or repeat HPV DNA testing in primary cervical cancer screening. J Natl Cancer Inst 101:88\u201399. doi: 10.1093\/jnci\/djn444","journal-title":"J Natl Cancer Inst"},{"key":"9990_CR13","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/bjc.2011.581","volume":"106","author":"DC Rijkaart","year":"2012","unstructured":"Rijkaart DC, Berkhof J, van Kemenade FJ, et al. (2012) HPV DNA testing in population-based cervical screening (VUSA-screen study): results and implications. Br J Cancer 106:975\u2013981. doi: 10.1038\/bjc.2011.581","journal-title":"Br J Cancer"},{"key":"9990_CR14","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S1470-2045(11)70188-7","volume":"12","author":"PE Castle","year":"2011","unstructured":"Castle PE, Stoler MH, Wright TC, et al. (2011) Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25\u00a0years and older: a subanalysis of the ATHENA study. Lancet Oncol 12:880\u2013890. doi: 10.1016\/S1470-2045(11)70188-7","journal-title":"Lancet Oncol"},{"key":"9990_CR15","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ijc.25890","volume":"129","author":"RM Overmeer","year":"2011","unstructured":"Overmeer RM, Louwers JA, Meijer CJLM, et al. (2011) Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women. Int J Cancer 129:2218\u20132225. doi: 10.1002\/ijc.25890","journal-title":"Int J Cancer"},{"key":"9990_CR16","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1158\/1055-9965.EPI-10-0818","volume":"20","author":"CE Depuydt","year":"2011","unstructured":"Depuydt CE, Makar AP, Ruymbeke MJ, et al. (2011) BD-ProExC as adjunct molecular marker for improved detection of CIN2+ after HPV primary screening. Cancer Epidemiol Biomark Prev 20:628\u2013637. doi: 10.1158\/1055-9965.EPI-10-0818","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"9990_CR17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jviromet.2012.05.022","volume":"184","author":"DA Patel","year":"2012","unstructured":"Patel DA, Rozek LS, Colacino JA, et al. (2012) Patterns of cellular and HPV 16 methylation as biomarkers for cervical neoplasia. J Virol Methods 184:84\u201392. doi: 10.1016\/j.jviromet.2012.05.022","journal-title":"J Virol Methods"},{"key":"9990_CR18","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1158\/1055-9965.EPI-14-0347","volume":"23","author":"LMA Strooper De","year":"2014","unstructured":"De Strooper LMA, Hesselink AT, Berkhof J, et al. (2014) Combined CADM1\/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women. Cancer Epidemiol Biomark Prev 23:1933\u20131937. doi: 10.1158\/1055-9965.EPI-14-0347","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"9990_CR19","first-page":"8","volume":"25","author":"M Bibbo","year":"2003","unstructured":"Bibbo M, DeCecco J, Kovatich AJ (2003) P16INK4A as an adjunct test in liquid-based cytology. Anal Quant Cytol Histol 25:8\u201311","journal-title":"Anal Quant Cytol Histol"},{"key":"9990_CR20","author":"\u00c1 Galamb","year":"2015","unstructured":"Galamb \u00c1, Benczik M, Zinner B, et al. (2015) Dysregulation of microRNA expression in human cervical preneoplastic and neoplastic lesions. Pathol Oncol Res. doi: 10.1007\/s12253-014-9871-x","journal-title":"Pathol Oncol Res"},{"key":"9990_CR21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ctrv.2008.10.005","volume":"35","author":"I Tsoumpou","year":"2009","unstructured":"Tsoumpou I, Arbyn M, Kyrgiou M, et al. (2009) p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev 35:210\u2013220. doi: 10.1016\/j.ctrv.2008.10.005","journal-title":"Cancer Treat Rev"},{"key":"9990_CR22","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/PAS.0b013e3181e8b2c4","volume":"34","author":"MT Galgano","year":"2010","unstructured":"Galgano MT, Castle PE, Atkins KA, et al. (2010) Using biomarkers as objective standards in the diagnosis of cervical biopsies. Am J Surg Pathol 34:1077\u20131087. doi: 10.1097\/PAS.0b013e3181e8b2c4","journal-title":"Am J Surg Pathol"},{"key":"9990_CR23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1309\/AJCP3CD9YKYFJDQL","volume":"134","author":"KJ Denton","year":"2010","unstructured":"Denton KJ, Bergeron C, Klement P, et al. (2010) The sensitivity and specificity of p16(INK4a) cytology vs HPV testing for detecting high-grade cervical disease in the triage of ASC-US and LSIL pap cytology results. Am J Clin Pathol 134:12\u201321. doi: 10.1309\/AJCP3CD9YKYFJDQL","journal-title":"Am J Clin Pathol"},{"key":"9990_CR24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.anndiagpath.2012.03.006","volume":"16","author":"L-J Bogaert Van","year":"2012","unstructured":"Van Bogaert L-J (2012) P16INK4a immunocytochemistry\/immunohistochemistry: need for scoring uniformization to be clinically useful in gynecological pathology. Ann Diagn Pathol 16:422\u2013426. doi: 10.1016\/j.anndiagpath.2012.03.006","journal-title":"Ann Diagn Pathol"},{"key":"9990_CR25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/gb-2009-10-8-235","volume":"10","author":"M Lal-Nag","year":"2009","unstructured":"Lal-Nag M, Morin PJ (2009) The claudins. Genome Biol 10:235. doi: 10.1186\/gb-2009-10-8-235","journal-title":"Genome Biol"},{"key":"9990_CR26","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1038\/onc.2008.344","volume":"27","author":"S Tsukita","year":"2008","unstructured":"Tsukita S, Yamazaki Y, Katsuno T, Tamura A (2008) Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27:6930\u20136938. doi: 10.1038\/onc.2008.344","journal-title":"Oncogene"},{"key":"9990_CR27","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1158\/0008-5472.CAN-05-2782","volume":"65","author":"PJ Morin","year":"2005","unstructured":"Morin PJ (2005) Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res 65:9603\u20139606. doi: 10.1158\/0008-5472.CAN-05-2782","journal-title":"Cancer Res"},{"key":"9990_CR28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ygyno.2006.04.005","volume":"103","author":"G Sobel","year":"2006","unstructured":"Sobel G, N\u00e9meth J, Kiss A, et al. (2006) Claudin 1 differentiates endometrioid and serous papillary endometrial adenocarcinoma. Gynecol Oncol 103:591\u2013598. doi: 10.1016\/j.ygyno.2006.04.005","journal-title":"Gynecol Oncol"},{"key":"9990_CR29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.humpath.2004.12.001","volume":"36","author":"G Sobel","year":"2005","unstructured":"Sobel G, P\u00e1ska C, Szab\u00f3 I, et al. (2005) Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma. Hum Pathol 36:162\u2013169. doi: 10.1016\/j.humpath.2004.12.001","journal-title":"Hum Pathol"},{"key":"9990_CR30","first-page":"1607","volume":"24","author":"I Szab\u00f3","year":"2009","unstructured":"Szab\u00f3 I, Kiss A, Schaff Z, Sobel G (2009) Claudins as diagnostic and prognostic markers in gynecological cancer. Histol Histopathol 24:1607\u20131615","journal-title":"Histol Histopathol"},{"key":"9990_CR31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ygyno.2004.11.058","volume":"97","author":"J-W Lee","year":"2005","unstructured":"Lee J-W, Lee S-J, Seo J, et al. (2005) Increased expressions of claudin-1 and claudin-7 during the progression of cervical neoplasia. Gynecol Oncol 97:53\u201359. doi: 10.1016\/j.ygyno.2004.11.058","journal-title":"Gynecol Oncol"},{"key":"9990_CR32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1155\/2007\/678793","volume":"23","author":"N Wentzensen","year":"2007","unstructured":"Wentzensen N, von Knebel DM (2007) Biomarkers in cervical cancer screening. Dis Markers 23:315\u2013330","journal-title":"Dis Markers"},{"key":"9990_CR33","doi-asserted-by":"crossref","first-page":"519619","DOI":"10.1155\/2013\/519619","volume":"2013","author":"ML Tornesello","year":"2013","unstructured":"Tornesello ML, Buonaguro L, Giorgi-Rossi P, Buonaguro FM (2013) Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer. Biomed Res Int 2013:519619. doi: 10.1155\/2013\/519619","journal-title":"Biomed Res Int"},{"key":"9990_CR34","doi-asserted-by":"crossref","unstructured":"V\u00e1zquez-Ort\u00edz G, Ciudad CJ, Pi\u00f1a P, et al. Gene identification by cDNA arrays in HPV-positive cervical cancer. Arch Med Res 36:448\u2013458. doi: 10.1016\/j.arcmed.2005.04.016","DOI":"10.1016\/j.arcmed.2005.04.016"},{"key":"9990_CR35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/cyt.12121","volume":"26","author":"D Vrdoljak-Mozeti\u010d","year":"2015","unstructured":"Vrdoljak-Mozeti\u010d D, Kra\u0161evi\u0107 M, Ver\u0161a Ostoji\u0107 D, et al. (2015) HPV16 genotype, p16\/Ki-67 dual staining and koilocytic morphology as potential predictors of the clinical outcome for cervical low-grade squamous intraepithelial lesions. Cytopathology 26:10\u201318. doi: 10.1111\/cyt.12121","journal-title":"Cytopathology"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-015-9990-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-015-9990-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-015-9990-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T06:39:34Z","timestamp":1559457574000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-015-9990-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["9990"],"URL":"https:\/\/doi.org\/10.1007\/s12253-015-9990-z","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}