{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:24Z","timestamp":1790959344572,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s12253-017-0359-3","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T22:00:46Z","timestamp":1510610446000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Roles of Fibroblast Activation Protein and Hepatocyte Growth Factor Expressions in Angiogenesis and Metastasis of Gastric Cancer"],"prefix":"10.1007","volume":"25","author":[{"given":"Li-Ming","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Zhao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"359_CR1","first-page":"3441","volume":"30","author":"A Shirahata","year":"2010","unstructured":"Shirahata A, Sakata M, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K (2010) MACC 1 as a marker for peritoneal-disseminated gastric carcinoma. Anticancer Res 30:3441\u20133444","journal-title":"Anticancer Res"},{"key":"359_CR2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1159\/000321703","volume":"78","author":"BG Jang","year":"2011","unstructured":"Jang BG, Kim WH (2011) Molecular pathology of gastric carcinoma. Pathobiology 78:302\u2013310","journal-title":"Pathobiology"},{"key":"359_CR3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.15403\/jgld.2014.1121.251.rv2","volume":"25","author":"K Izuishi","year":"2016","unstructured":"Izuishi K, Mori H (2016) Recent strategies for treating stage iv gastric cancer: roles of palliative gastrectomy, chemotherapy, and radiotherapy. J Gastrointestin Liver Dis 25:87\u201394","journal-title":"J Gastrointestin Liver Dis"},{"key":"359_CR4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1470-2045(10)70070-X","volume":"11","author":"I Songun","year":"2010","unstructured":"Songun I, Putter H, Kranenbarg EM, Sasako M, van de Velde CJ (2010) Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol 11:439\u2013449","journal-title":"Lancet Oncol"},{"key":"359_CR5","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/01.sla.0000152019.14741.97","volume":"241","author":"D Marrelli","year":"2005","unstructured":"Marrelli D, De Stefano A, de Manzoni G, Morgagni P, Di Leo A, Roviello F (2005) Prediction of recurrence after radical surgery for gastric cancer: a scoring system obtained from a prospective multicenter study. Ann Surg 241:247\u2013255","journal-title":"Ann Surg"},{"key":"359_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1245\/s10434-006-9063-3","volume":"14","author":"D Marrelli","year":"2007","unstructured":"Marrelli D, Pedrazzani C, Neri A, Corso G, DeStefano A, Pinto E, Roviello F (2007) Complications after extended (D2) and superextended (D3) lymphadenectomy for gastric cancer: analysis of potential risk factors. Ann Surg Oncol 14:25\u201333","journal-title":"Ann Surg Oncol"},{"key":"359_CR7","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.yexmp.2013.10.008","volume":"95","author":"RF Wang","year":"2013","unstructured":"Wang RF, Zhang LH, Shan LH, Sun WG, Chai CC, Wu HM, Ibla JC, Wang LF, Liu JR (2013) Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol 95:350\u2013356","journal-title":"Exp Mol Pathol"},{"key":"359_CR8","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S1470-2045(14)70273-6","volume":"15","author":"F Lordick","year":"2014","unstructured":"Lordick F (2014) Targeting the HGF\/MET pathway in gastric cancer. Lancet Oncol 15:914\u2013916","journal-title":"Lancet Oncol"},{"key":"359_CR9","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1200\/JCO.2011.36.7706","volume":"29","author":"F Graziano","year":"2011","unstructured":"Graziano F, Galluccio N, Lorenzini P, Ruzzo A, Canestrari E, D'Emidio S, Catalano V, Sisti V, Ligorio C, Andreoni F, Rulli E, Di Oto E, Fiorentini G, Zingaretti C, De Nictolis M, Cappuzzo F, Magnani M (2011) Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. J Clin Oncol 29:4789\u20134795","journal-title":"J Clin Oncol"},{"key":"359_CR10","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/modpathol.2010.142","volume":"23","author":"O Abbas","year":"2010","unstructured":"Abbas O, Richards JE, Mahalingam M (2010) Fibroblast-activation protein: a single marker that confidently differentiates morpheaform\/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma. Mod Pathol 23:1535\u20131543","journal-title":"Mod Pathol"},{"key":"359_CR11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00403-014-1456-8","volume":"306","author":"J Khoury El","year":"2014","unstructured":"El Khoury J, Kurban M, Kibbi AG, Abbas O (2014) Fibroblast-activation protein: valuable marker of cutaneous epithelial malignancy. Arch Dermatol Res 306:359\u2013365","journal-title":"Arch Dermatol Res"},{"key":"359_CR12","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.humpath.2013.06.016","volume":"44","author":"J Tchou","year":"2013","unstructured":"Tchou J, Zhang PJ, Bi Y, Satija C, Marjumdar R, Stephen TL, Lo A, Chen H, Mies C, June CH, Conejo-Garcia J, Pure E (2013) Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Hum Pathol 44:2549\u20132557","journal-title":"Hum Pathol"},{"key":"359_CR13","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1111\/j.1349-7006.2010.01695.x","volume":"101","author":"Y Wen","year":"2010","unstructured":"Wen Y, Wang CT, Ma TT, Li ZY, Zhou LN, Mu B, Leng F, Shi HS, Li YO, Wei YQ (2010) Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model. Cancer Sci 101:2325\u20132332","journal-title":"Cancer Sci"},{"key":"359_CR14","first-page":"1028","volume":"15","author":"T Yanovitch","year":"2009","unstructured":"Yanovitch T, Li YJ, Metlapally R, Abbott D, Viet KN, Young TL (2009) Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. Mol Vis 15:1028\u20131035","journal-title":"Mol Vis"},{"key":"359_CR15","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1634\/stemcells.2007-0388","volume":"25","author":"L Cai","year":"2007","unstructured":"Cai L, Johnstone BH, Cook TG, Liang Z, Traktuev D, Cornetta K, Ingram DA, Rosen ED, March KL (2007) Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells 25:3234\u20133243","journal-title":"Stem Cells"},{"key":"359_CR16","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1161\/01.ATV.0000190701.92007.6d","volume":"25","author":"H Nakagami","year":"2005","unstructured":"Nakagami H, Maeda K, Morishita R, Iguchi S, Nishikawa T, Takami Y, Kikuchi Y, Saito Y, Tamai K, Ogihara T, Kaneda Y (2005) Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol 25:2542\u20132547","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"359_CR17","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1111\/cas.12301","volume":"104","author":"L Zhao","year":"2013","unstructured":"Zhao L, Yasumoto K, Kawashima A, Nakagawa T, Takeuchi S, Yamada T, Matsumoto K, Yonekura K, Yoshie O, Yano S (2013) Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer. Cancer Sci 104:1640\u20131646","journal-title":"Cancer Sci"},{"key":"359_CR18","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1093\/annonc\/mdq716","volume":"22","author":"W Wang","year":"2011","unstructured":"Wang W, Xu DZ, Li YF, Guan YX, Sun XW, Chen YB, Kesari R, Huang CY, Li W, Zhan YQ, Zhou ZW (2011) Tumor-ratio-metastasis staging system as an alternative to the 7th edition UICC TNM system in gastric cancer after D2 resection--results of a single-institution study of 1343 Chinese patients. Ann Oncol 22:2049\u20132056","journal-title":"Ann Oncol"},{"key":"359_CR19","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1128\/CMR.00011-10","volume":"23","author":"LE Wroblewski","year":"2010","unstructured":"Wroblewski LE, Peek RM Jr, Wilson KT (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23:713\u2013739","journal-title":"Clin Microbiol Rev"},{"key":"359_CR20","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1021\/jm801052f","volume":"52","author":"PC Lo","year":"2009","unstructured":"Lo PC, Chen J, Stefflova K, Warren MS, Navab R, Bandarchi B, Mullins S, Tsao M, Cheng JD, Zheng G (2009) Photodynamic molecular beacon triggered by fibroblast activation protein on cancer-associated fibroblasts for diagnosis and treatment of epithelial cancers. J Med Chem 52:358\u2013368","journal-title":"J Med Chem"},{"key":"359_CR21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.4251\/wjgo.v7.i11.317","volume":"7","author":"M Inokuchi","year":"2015","unstructured":"Inokuchi M, Otsuki S, Fujimori Y, Sato Y, Nakagawa M, Kojima K (2015) Clinical significance of MET in gastric cancer. World J Gastrointest Oncol 7:317\u2013327","journal-title":"World J Gastrointest Oncol"},{"key":"359_CR22","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00345-009-0471-4","volume":"28","author":"A Erbersdobler","year":"2010","unstructured":"Erbersdobler A, Isbarn H, Dix K, Steiner I, Schlomm T, Mirlacher M, Sauter G, Haese A (2010) Prognostic value of microvessel density in prostate cancer: a tissue microarray study. World J Urol 28:687\u2013692","journal-title":"World J Urol"},{"key":"359_CR23","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.3748\/wjg.v9.i7.1604","volume":"9","author":"JR Du","year":"2003","unstructured":"Du JR, Jiang Y, Zhang YM, Fu H (2003) Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas. World J Gastroenterol 9:1604\u20131606","journal-title":"World J Gastroenterol"},{"key":"359_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116683","volume":"10","author":"F Liu","year":"2015","unstructured":"Liu F, Qi L, Liu B, Liu J, Zhang H, Che D, Cao J, Shen J, Geng J, Bi Y, Ye L, Pan B, Yu Y (2015) Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis. PLoS One 10:e0116683","journal-title":"PLoS One"},{"key":"359_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.5483\/BMBRep.2013.46.5.172","volume":"46","author":"F Cai","year":"2013","unstructured":"Cai F, Li Z, Wang C, Xian S, Xu G, Peng F, Wei Y, Lu Y (2013) Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. BMB Rep 46:252\u2013257","journal-title":"BMB Rep"},{"key":"359_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/1475-2867-13-121","volume":"13","author":"T Guo","year":"2013","unstructured":"Guo T, Yang J, Yao J, Zhang Y, Da M, Duan Y (2013) Expression of MACC1 and c-Met in human gastric cancer and its clinical significance. Cancer Cell Int 13:121","journal-title":"Cancer Cell Int"},{"key":"359_CR27","first-page":"3423","volume":"11","author":"E Noguchi","year":"2015","unstructured":"Noguchi E, Saito N, Kobayashi M, Kameoka S (2015) Clinical significance of hepatocyte growth factor\/c-Met expression in the assessment of gastric cancer progression. Mol Med Rep 11:3423\u20133431","journal-title":"Mol Med Rep"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-017-0359-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-017-0359-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-017-0359-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T19:43:21Z","timestamp":1603309401000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-017-0359-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1007\/s12253-017-0359-3","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]},"assertion":[{"value":"24 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}