{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:36:46Z","timestamp":1770453406118,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T00:00:00Z","timestamp":1517097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Science and Technology (DST) New Delhi, India","award":["IF120759"],"award-info":[{"award-number":["IF120759"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s12253-017-0380-6","type":"journal-article","created":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T23:00:16Z","timestamp":1517180416000},"page":"925-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Diagnostic Value of Circulating Free DNA Integrity and Global Methylation Status in Gall Bladder Carcinoma"],"prefix":"10.1007","volume":"25","author":[{"given":"Swati","family":"Kumari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuzhat","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azfar","family":"Neyaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohtashim","family":"Lohani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav Arun","family":"Sonkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,28]]},"reference":[{"issue":"2","key":"380_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1365-2559.2008.03192.x","volume":"55","author":"RD Goldin","year":"2009","unstructured":"Goldin RD, Roa JC (2009) Gallbladder cancer: a morphological and molecular update. Histopathology 55(2):218\u2013229","journal-title":"Histopathology"},{"issue":"2","key":"380_CR2","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.amjsurg.2007.11.011","volume":"196","author":"S Gourgiotis","year":"2008","unstructured":"Gourgiotis S, Kocher HM, Solaini L, Yarollahi A, Tsiambas E, Salemis NS (2008) Gallbladder cancer. Am J Surg 196(2):252\u2013264","journal-title":"Am J Surg"},{"issue":"6","key":"380_CR3","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s00534-007-1225-6","volume":"14","author":"G Bazoua","year":"2007","unstructured":"Bazoua G, Hamza N, Lazim T (2007) Do we need histology for a normal-looking gallbladder? J Hepato-Biliary-Pancreat Surg 14(6):564\u2013568","journal-title":"J Hepato-Biliary-Pancreat Surg"},{"issue":"3","key":"380_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1155\/2005\/218759","volume":"21","author":"G Goebel","year":"2005","unstructured":"Goebel G, Zitt M, Muller HM (2005) Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias. Dis Markers 21(3):105\u2013120","journal-title":"Dis Markers"},{"issue":"1","key":"380_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.juro.2008.08.118","volume":"181","author":"J Ellinger","year":"2009","unstructured":"Ellinger J, Wittkamp V, Albers P, Perabo FG, Mueller SC, von Ruecker A, Bastian PJ (2009) Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. J Urol 181(1):363\u2013371","journal-title":"J Urol"},{"key":"380_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1196\/annals.1448.027","volume":"1137","author":"YH Su","year":"2008","unstructured":"Su YH, Wang M, Brenner DE, Norton PA, Block TM (2008) Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann N Y Acad Sci 1137:197\u2013206","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"380_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12253-016-0087-0","volume":"23","author":"S Kumari","year":"2017","unstructured":"Kumari S, Tewari S, Husain N, Agarwal A, Pandey A, Singhal A, Lohani M (2017) Quantification of circulating free DNA as a diagnostic marker in gall bladder cancer. Pathol Oncol Res 23(1):91\u201397","journal-title":"Pathol Oncol Res"},{"issue":"26","key":"380_CR8","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1200\/JCO.2006.05.9493","volume":"24","author":"N Umetani","year":"2006","unstructured":"Umetani N, Giuliano AE, Hiramatsu SH, Amersi F, Nakagawa T, Martino S, Hoon DS (2006) Prediction of breast tumor progression by integrity of free circulating DNA in serum. J Clin Oncol 24(26):4270\u20134276","journal-title":"J Clin Oncol"},{"issue":"6","key":"380_CR9","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1373\/clinchem.2006.068577","volume":"52","author":"N Umetani","year":"2006","unstructured":"Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS (2006) Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem 52(6):1062\u20131069","journal-title":"Clin Chem"},{"issue":"6","key":"380_CR10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrc3066","volume":"11","author":"H Schwarzenbach","year":"2011","unstructured":"Schwarzenbach H, Hoon DS, Pantel K (2011) Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 11(6):426\u2013437","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"380_CR11","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1073\/pnas.83.11.3875","volume":"83","author":"HR Hwu","year":"1986","unstructured":"Hwu HR, Roberts JW, Davidson EH, Britten RJ (1986) Insertion and\/or deletion of many repeated DNA sequences in human and higher ape evolution. Proc Natl Acad Sci U S A 83(11):3875\u20133879","journal-title":"Proc Natl Acad Sci U S A"},{"key":"380_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0378-1119(00)00434-0","volume":"259","author":"Z Gu","year":"2000","unstructured":"Gu Z, Wang H, Nekrutenko A, Li WH (2000) Densities, length proportions, and other distributional features of repetitive sequences in the human genome estimated from 430 megabases of genomic sequence. Gene 259:81\u201388","journal-title":"Gene"},{"issue":"1","key":"380_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00006676-199807000-00012","volume":"17","author":"MB Giacona","year":"1998","unstructured":"Giacona MB, Ruben GC, Iczkowski KA, Roos TB, Porter DM, Sorenson GD (1998) Cell-free DNA in human blood plasma: length measurements in patients with pancreatic cancer and healthy controls. Pancreas 17(1):89\u201397","journal-title":"Pancreas"},{"issue":"5756","key":"380_CR14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/284555a0","volume":"284","author":"AH Wyllie","year":"1980","unstructured":"Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284(5756):555\u2013556","journal-title":"Nature"},{"issue":"2","key":"380_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4161\/cbt.4.2.1508","volume":"4","author":"Z Jin","year":"2005","unstructured":"Jin Z, El-Deiry WS (2005) Overview of cell death signaling pathways. Cancer Biol Ther 4(2):139\u2013163","journal-title":"Cancer Biol Ther"},{"issue":"4","key":"380_CR16","first-page":"1659","volume":"61","author":"S Jahr","year":"2001","unstructured":"Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R (2001) DNA fragments in the blood plasma of cancer patients: quantitation and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61(4):1659\u20131665","journal-title":"Cancer Res"},{"issue":"7","key":"380_CR17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nm0795-686","volume":"1","author":"A Merlo","year":"1995","unstructured":"Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D (1995) 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16\/CDKN2\/MTS1 in human cancers. Nat Med 1(7):686\u2013692","journal-title":"Nat Med"},{"issue":"12","key":"380_CR18","doi-asserted-by":"publisher","first-page":"6870","DOI":"10.1073\/pnas.95.12.6870","volume":"95","author":"JG Herman","year":"1998","unstructured":"Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95(12):6870\u20136875","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"380_CR19","first-page":"7641","volume":"63","author":"HM Muller","year":"2003","unstructured":"Muller HM, Widschwendter A, Fiegl H, Ivarsson L, Goebel G, Perkmann E, Marth C, Widschwendter M (2003) DNA methylation in serum of breast cancer patients: an independent prognostic marker. Cancer Res 63(22):7641\u20137645","journal-title":"Cancer Res"},{"issue":"36","key":"380_CR20","doi-asserted-by":"publisher","first-page":"9351","DOI":"10.1200\/JCO.2005.02.9876","volume":"23","author":"T Mori","year":"2005","unstructured":"Mori T, O\u2019Day SJ, Umetani N, Martinez RS, Kitago M, Koyanagi K, Kuo C, Takeshima TL, Milford R, Wang JH, Vu DV, Nguyen SL, Hoon D (2005) Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy. J Clin Oncol 23(36):9351\u20139358","journal-title":"J Clin Oncol"},{"key":"380_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.genet.30.1.441","volume":"30","author":"PW Laird","year":"1996","unstructured":"Laird PW, Jaenisch R (1996) The role of DNA methylation in cancer genetic and epigenetics. Annu Rev Genet 30:441\u2013464","journal-title":"Annu Rev Genet"},{"key":"380_CR22","doi-asserted-by":"publisher","first-page":"D489","DOI":"10.1093\/nar\/gkh132","volume":"32","author":"T Dagan","year":"2004","unstructured":"Dagan T, Sorek R, Sharon E, Ast G, Graur D (2004) Alu Gene: a database of Alu elements incorporated within protein-coding genes. Nucleic Acids Res 32:D489\u2013D492","journal-title":"Nucleic Acids Res"},{"key":"380_CR23","doi-asserted-by":"publisher","unstructured":"Parpart-Li S, Bartlett B, Popoli M, Adleff V, Tucker L, Steinberg R, Georgiadis A, Phallen J, Brahmer JR, Azad NA, Browner I, Laheru DA, Velculescu VE, Sausen M, Diaz LA (2016) The effect of preservative and temperature on the analysis of circulating tumor DNA. Clin Cancer Res. \n                    https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-1691","DOI":"10.1158\/1078-0432.CCR-16-1691"},{"issue":"8","key":"380_CR24","first-page":"1837","volume":"6","author":"WK Utomo","year":"2016","unstructured":"Utomo WK, Janmaat VT, Verhaar AP, Cros J, L\u00e9vy P, Ruszniewski P, den Berg MS, Jenster G, Bruno MJ, Braat H, Fuhler GM, Peppelenbosch MP (2016) DNA integrity as biomarker in pancreatic cyst fluid. Am J Cancer Res 6(8):1837\u20131841","journal-title":"Am J Cancer Res"},{"issue":"9","key":"380_CR25","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1245\/s10434-011-1638-y","volume":"18","author":"M Agostini","year":"2011","unstructured":"Agostini M, Pucciarelli S, Enzo MV, Del Bianco P, Briarava M, Bedin C, Maretto I, Friso ML, Lonardi S, Mescoli C, Toppan P, Urso E, Nitti D (2011) Circulating cell-free DNA: a promising marker of pathologic tumor response in rectal cancer patients receiving preoperative chemoradiotherapy. Ann Surg Oncol 18(9):2461\u20132468","journal-title":"Ann Surg Oncol"},{"key":"380_CR26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1749-6632.2000.tb06608.x","volume":"906","author":"M Stroun","year":"2000","unstructured":"Stroun M, Maurice P, Vasioukhin V, Lyautey J, Lederrey C, Lefort F, Rossier A, Chen XQ, Anker P (2000) The origin and mechanism of circulating DNA. Ann N Y Acad Sci 906:161\u2013168","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"380_CR27","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1200\/JCO.2012.45.2011","volume":"32","author":"LA Diaz Jr","year":"2014","unstructured":"Diaz LA Jr, Bardelli A (2014) Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol 32(6):579\u2013586","journal-title":"J Clin Oncol"},{"key":"380_CR28","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1196\/annals.1368.031","volume":"1075","author":"AA Kamat","year":"2006","unstructured":"Kamat AA, Sood AK, Dang D, Gershenson DM, Simpson JL, Bischoff FZ (2006) Quantification of total plasma cell-free DNA in ovarian cancer using real-time PCR. Ann N Y Acad Sci 1075:230\u2013234","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"380_CR29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1515\/CCLM.2006.003","volume":"44","author":"TW Chiu","year":"2006","unstructured":"Chiu TW, Young R, Chan LY, Burd A, Lo DY (2006) Plasma cell-free DNA as an indicator of severity of injury in burn patients. Clin Chem Lab Med 44(1):13\u201317","journal-title":"Clin Chem Lab Med"},{"issue":"7","key":"380_CR30","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1097\/01.CCM.0000074719.40109.95","volume":"31","author":"S Zeerleder","year":"2003","unstructured":"Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C, van Nieuwenhuijze AE, van Mierlo GJ, Eerenberg AJ, L\u00e4mmle B, Hack CE (2003) Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med 31(7):1947\u20131951","journal-title":"Crit Care Med"},{"key":"380_CR31","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1196\/annals.1368.043","volume":"1075","author":"S Holdenrieder","year":"2006","unstructured":"Holdenrieder S, Eichhorn P, Beuers U, Samtleben W, Schoenermarck U, Zachoval R, Nagel D, Stieber P (2006) Nucleosomal DNA fragments in autoimmune diseases. Ann N Y Acad Sci 1075:318\u2013327","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"380_CR32","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1111\/cas.13068","volume":"107","author":"T Ohira","year":"2016","unstructured":"Ohira T, Sakai K, Matsubayashi J, Kajiwara N, Kakihana M, Hagiwara M, Hibi M, Yoshida K, Maeda J, Ohtani K, Nagao T, Nishio K, Ikeda N (2016) Tumor volume determines the feasibility of cell-free DNA sequencing for mutation detection in non-small cell lung cancer. Cancer Sci 107(11):1660\u20131666","journal-title":"Cancer Sci"},{"issue":"2-3","key":"380_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3233\/CBM-2012-0263","volume":"11","author":"M Agostini","year":"2012","unstructured":"Agostini M, Enzo MV, Bedin C, Belardinelli V, Goldin E, Del Bianco P, Maschietto E, D'Angelo E, Izzi L, Saccani A, Zavagno G, Nitti D (2012) Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients. Cancer Biomark 11(2-3):89\u201398","journal-title":"Cancer Biomark"},{"key":"380_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21767\/2472-1158.100040","volume":"3","author":"T Vos de","year":"2017","unstructured":"de Vos T, Molnar B (2017) Screening for colorectal cancer based on the promoter methylation status of the septin 9 gene in plasma cell free DNA. J Clin Epigenet 3:1. \n                    https:\/\/doi.org\/10.21767\/2472-1158.100040","journal-title":"J Clin Epigenet"},{"issue":"3","key":"380_CR35","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12253-010-9338-7","volume":"17","author":"K T\u00f3th","year":"2011","unstructured":"T\u00f3th K, Galamb O, Spis\u00e1k S, Wichmann B, Sipos F, Valcz G, Leiszter K, Moln\u00e1r B, Tulassay Z (2011) The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer. Pathol Oncol Res 17(3):503\u2013509","journal-title":"Pathol Oncol Res"},{"issue":"7404","key":"380_CR36","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nature11156","volume":"486","author":"S Misale","year":"2012","unstructured":"Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A (2012) Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486(7404):532\u2013536","journal-title":"Nature"},{"issue":"7404","key":"380_CR37","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nature11219","volume":"486","author":"LA Diaz","year":"2012","unstructured":"Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486(7404):537\u2013540","journal-title":"Nature"},{"key":"380_CR38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13148-016-0282-6","volume":"8","author":"Q Tang","year":"2016","unstructured":"Tang Q, Cheng J, Cao X, Surowy H, Burwinkel B (2016) Blood-based DNA methylation as biomarker for breast cancer: a systematic review. Clin Epigenetics 8:115","journal-title":"Clin Epigenetics"},{"issue":"1","key":"380_CR39","first-page":"71","volume":"59","author":"IH Wong","year":"1999","unstructured":"Wong IH, Lo YM, Zhang J, Liew CT, Ng MH, Wong N, Lai PB, Lau WY, Hjelm NM, Johnson PJ (1999) Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res 59(1):71\u201373","journal-title":"Cancer Res"},{"issue":"8","key":"380_CR40","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/sj.bjc.6690495","volume":"80","author":"JM Silva","year":"1999","unstructured":"Silva JM, Dominguez G, Villanueva MJ, Gonzalez R, Garcia JM, Corbacho C, Provencio M, Espana P, Bonilla F (1999) Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer 80(8):1262\u20131264","journal-title":"Br J Cancer"},{"issue":"21","key":"380_CR41","first-page":"5941","volume":"60","author":"C Goessl","year":"2000","unstructured":"Goessl C, Krause H, Muller M, Heicappell R, Schrader M, Sachsinger J, Miller K (2000) Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids. Cancer Res 60(21):5941\u20135945","journal-title":"Cancer Res"},{"issue":"35","key":"380_CR42","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.1038\/sj.onc.1205651","volume":"21","author":"M Ehrlich","year":"2002","unstructured":"Ehrlich M (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21(35):5400\u20135413","journal-title":"Oncogene"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-017-0380-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-017-0380-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-017-0380-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T05:34:28Z","timestamp":1567748068000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-017-0380-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,28]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["380"],"URL":"https:\/\/doi.org\/10.1007\/s12253-017-0380-6","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,28]]},"assertion":[{"value":"1 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}