{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T21:57:39Z","timestamp":1768859859736,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12253-018-0444-2","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T04:24:54Z","timestamp":1528691094000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["IL-2 And IL-15 Induced NKG2D, CD158a and CD158b Expression on T, NKT- like and NK Cell Lymphocyte Subsets from Regional Lymph Nodes of Melanoma Patients"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-8215","authenticated-orcid":false,"given":"Ana","family":"Vuleti\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Jovani\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Juri\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorka","family":"Milovanovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sr\u0111an","family":"Nikoli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Spurni\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Konjevi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"444_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semcancer.2012.02.003","volume":"22","author":"V Umansky","year":"2012","unstructured":"Umansky V, Sevko A (2012) Melanoma-induced immunosuppression and its neutralization. Semin Cancer Biol 22:319\u2013326","journal-title":"Semin Cancer Biol"},{"key":"444_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/CMR.0b013e32834e1f33","volume":"22","author":"TE Grotz","year":"2012","unstructured":"Grotz TE, Mansfield AS, Jakub JW, Markovic SN (2012) Regional lymphatic immunity in melanoma. Melanoma Res 22:9\u201318","journal-title":"Melanoma Res"},{"key":"444_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/978-0-387-69219-7_17","volume":"135","author":"R Zheng","year":"2007","unstructured":"Zheng R, Kjaergaard J, Lee WT, Cohen PA, Shu S (2007) Significance of regional draining lymph nodes in the development of tumor immunity: implications for cancer immunotherapy. Cancer Treat Res 135:223\u2013237","journal-title":"Cancer Treat Res"},{"key":"444_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.imlet.2015.11.007","volume":"169","author":"SR Pulliam","year":"2016","unstructured":"Pulliam SR, Uzhachenko RV, Adunyah SE, Shanker A (2016) Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett 169:61\u201372","journal-title":"Immunol Lett"},{"key":"444_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/PPO.0b013e3181eacbc4","volume":"16","author":"NM Fewkes","year":"2010","unstructured":"Fewkes NM, Mackall CL (2010) Novel gamma-chain cytokines as candidate immune modulators in immune therapies for cancer. Cancer J 16:392\u2013398","journal-title":"Cancer J"},{"key":"444_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.1198687","volume":"331","author":"E Vivier","year":"2011","unstructured":"Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S (2011) Innate or adaptive immunity? The example of natural killer cells. Science 331:44\u201349","journal-title":"Science"},{"key":"444_CR7","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1007\/s00018-011-0797-0","volume":"68","author":"B Zafirova","year":"2011","unstructured":"Zafirova B, Wensveen FM, Gulin M, Poli\u0107 B (2011) Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci 68:3519\u20133529","journal-title":"Cell Mol Life Sci"},{"key":"444_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.it.2003.10.011","volume":"25","author":"MR Snyder","year":"2004","unstructured":"Snyder MR, Weyand CM, Goronzy JJ (2004) The double life of NK receptors: stimulation or co-stimulation? Trends Immunol 25:25\u201332","journal-title":"Trends Immunol"},{"key":"444_CR9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nri1306","volume":"4","author":"E Vivier","year":"2004","unstructured":"Vivier E, Anfossi N (2004) Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol 4:190\u2013198","journal-title":"Nat Rev Immunol"},{"key":"444_CR10","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.4049\/jimmunol.181.5.3268","volume":"181","author":"S Patterson","year":"2008","unstructured":"Patterson S, Chaidos A, Neville DC, Poggi A, Butters TD, Roberts IA, Karadimitris A (2008) Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors. J Immunol 181:3268\u20133276","journal-title":"J Immunol"},{"key":"444_CR11","first-page":"226","volume-title":"Manual of Clin Lab immunology","author":"A Jackson","year":"1986","unstructured":"Jackson A, Warner N (1986) Preparation, staining and analysis by flow cytometry of peripheral blood leukocytes. In: Rose N, Friedman H, Fahey J (eds) Manual of Clin Lab immunology, 3rd edn. American Society for Microbiology, Washington, pp 226\u2013235","edition":"3"},{"key":"444_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/CMR.0000000000000126","volume":"25","author":"AM Vuleti\u0107","year":"2015","unstructured":"Vuleti\u0107 AM, Jovani\u0107 IP, Juri\u0161i\u0107 VB, Milovanovi\u0107 ZM, Nikoli\u0107 SS, Tani\u0107 NT, Konjevi\u0107 GM (2015) In-vitro activation of natural killer cells from regional lymph nodes of melanoma patients with interleukin-2 and interleukin-15. Melanoma Res 25:22\u201334","journal-title":"Melanoma Res"},{"key":"444_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nri1919","volume":"6","author":"AJ Cochran","year":"2006","unstructured":"Cochran AJ, Huang RR, Lee J, Itakura E, Leong SP, Essner R (2006) Tumour-induced immune modulation of sentinel lymph nodes. Nat Rev Immunol 6:659\u2013670","journal-title":"Nat Rev Immunol"},{"key":"444_CR14","first-page":"3585","volume":"50","author":"Z Farzad","year":"1990","unstructured":"Farzad Z, Cochran AJ, McBrideWH GJD, Wong V, Morton L (1990) Lymphocyte subset alterations in nodes regional to human melanoma. Cancer Res 50:3585\u201335888","journal-title":"Cancer Res"},{"key":"444_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s12253-015-9938-3","volume":"21","author":"A Vuleti\u0107","year":"2015","unstructured":"Vuleti\u0107 A, Jovani\u0107 I, Juri\u0161i\u0107 V, Milovanovi\u0107 Z, Nikoli\u0107 S, Spurni\u0107 I, Konjevi\u0107 G (2015) Decreased interferon \u03b3 production in CD3+ and CD3- CD56+ lymphocyte subsets in metastatic regional lymph nodes of melanoma patients. Pathol Oncol Res 21:1109\u20131114","journal-title":"Pathol Oncol Res"},{"key":"444_CR16","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1200\/JCO.2001.19.16.3622","volume":"19","author":"CM Balch","year":"2001","unstructured":"Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, Cascinelli N, Urist M, McMasters KM, Ross MI, Kirkwood JM, Atkins MB, Thompson JA, Coit DG, Byrd D, Desmond R, Zhang Y, Liu PY, Lyman GH, Morabito A (2001) Prognostic factors analysis of 17,600 melanoma patients: validation of the American joint committee on Cancer melanoma staging system. J Clin Oncol 19:3622\u20133634","journal-title":"J Clin Oncol"},{"key":"444_CR17","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.jss.2013.02.025","volume":"183","author":"A Vuleti\u0107","year":"2013","unstructured":"Vuleti\u0107 A, Juri\u0161i\u0107 V, Jovani\u0107 I, Milovanovi\u0107 Z, Nikoli\u0107 S, Konjevi\u0107 G (2013) Distribution of several activating and inhibitory receptors on CD3(\u2212)CD56(+) NK cells in regional lymph nodes of melanoma patients. J Surg Res 183:860\u2013868","journal-title":"J Surg Res"},{"key":"444_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00232-009-9191-3","volume":"230","author":"G Konjevi\u0107","year":"2009","unstructured":"Konjevi\u0107 G, Mirjaci\u0107 Martinovi\u0107 K, Vuleti\u0107 A, Jurisi\u0107 V, Spuzi\u0107 I (2009) Distribution of several activating and inhibitory receptors on CD3-CD16+ NK cells and their correlation with NK cell function in healthy individuals. J Membr Biol 230:113\u2013123","journal-title":"J Membr Biol"},{"key":"444_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6639","volume":"5","author":"TH Ali","year":"2014","unstructured":"Ali TH, Pisanti S, Ciaglia E, Mortarini R, Anichini A, Garofalo C, Tallerico R, Santinami M, Gulletta E, Ietto C, Galgani M, Matarese G, Bifulco M, Ferrone S, Colucci F, Moretta A, K\u00e4rre K, Carbone E (2014) Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients. Nat Commun 5:5639. \nhttps:\/\/doi.org\/10.1038\/ncomms6639","journal-title":"Nat Commun"},{"key":"444_CR20","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1073\/pnas.0611098104","volume":"104","author":"DB Keskin","year":"2007","unstructured":"Keskin DB, Allan DS, Rybalov B, Andzelm MM, Stern JN, Kopcow HD, Koopman LA, Strominger JL (2007) TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A 104:3378\u20133383","journal-title":"Proc Natl Acad Sci U S A"},{"key":"444_CR21","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/ijc.27755","volume":"132","author":"MF Fransen","year":"2013","unstructured":"Fransen MF, Arens R, Melief CJ (2013) Local targets for immune therapy to cancer: tumor draining lymph nodes and tumor microenvironment. Int J Cancer 132:1971\u20131976","journal-title":"Int J Cancer"},{"key":"444_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12026-015-8695-4","volume":"64","author":"G Konjevi\u0107","year":"2016","unstructured":"Konjevi\u0107 G, Vuleti\u0107 A, Mirja\u010di\u0107 Martinovi\u0107 K (2016) Natural killer cell receptors: alterations and therapeutic targeting in malignancies. Immunol Res 64:25\u201335","journal-title":"Immunol Res"},{"key":"444_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cyto.2008.01.003","volume":"42","author":"C Zhang","year":"2008","unstructured":"Zhang C, Zhang J, Niu J, Zhang J, Tian Z (2008) Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1\/2 phosphorylation. Cytokine 42:128\u2013136","journal-title":"Cytokine"},{"key":"444_CR24","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1016\/j.molimm.2008.06.016","volume":"45","author":"DH Verhoeven","year":"2008","unstructured":"Verhoeven DH, de Hooge AS, Mooiman EC, Santos SJ, ten Dam MM, Gelderblom H, Melief CJ, Hogendoorn PC, Egeler RM, van Tol MJ, Schilham MW, Lankester AC (2008) NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways. Mol Immunol 45:3917\u20133925","journal-title":"Mol Immunol"},{"key":"444_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151535","volume":"11","author":"I Hromadnikova","year":"2016","unstructured":"Hromadnikova I, Li S, Kotlabova K, Dickinson AM (2016) Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp 70 derived 14-Mer peptide (TKD) on the expression of NK cell Activatory and inhibitory receptors on peripheral blood T cells, B cells and NKT cells. PLoS One 11:e0151535","journal-title":"PLoS One"},{"key":"444_CR26","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.imbio.2010.09.012","volume":"216","author":"MP Correia","year":"2011","unstructured":"Correia MP, Costa AV, Uhrberg M, Cardoso EM, Arosa FA (2011) IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion. Immunobiology 216:604\u2013612","journal-title":"Immunobiology"},{"key":"444_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.exphem.2010.02.006","volume":"38","author":"V Decot","year":"2010","unstructured":"Decot V, Voillard L, Latger-Cannard V, Aissi-Roth\u00e9 L, Perrier P, Stoltz JF, Bensoussan D (2010) Natural-killer cell amplification for adoptive leukemia relapse immunotherapy: comparison of three cytokines, IL-2, IL-15, or IL-7 and impact on NKG2D, KIR2DL1, and KIR2DL2 expression. Exp Hematol 38:351\u2013362","journal-title":"Exp Hematol"},{"key":"444_CR28","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.4049\/jimmunol.178.8.4947","volume":"178","author":"C Romagnani","year":"2007","unstructured":"Romagnani C, Juelke K, Falco M, Morandi B, D'Agostino A, Costa R, Ratto G, Forte G, Carrega P, Lui G, Conte R, Strowig T, Moretta A, M\u00fcnz C, Thiel A, Moretta L, Ferlazzo G (2007) CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J Immunol 178:4947\u20134955","journal-title":"J Immunol"},{"key":"444_CR29","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.4049\/jimmunol.172.3.1455","volume":"172","author":"G Ferlazzo","year":"2004","unstructured":"Ferlazzo G, Thomas D, Lin SL, Goodman K, Morandi B, Muller WA, Moretta A, M\u00fcnz C (2004) The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172:1455\u20131462","journal-title":"J Immunol"},{"key":"444_CR30","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1182\/blood-2008-07-166389","volume":"113","author":"F Cichocki","year":"2009","unstructured":"Cichocki F, Hanson RJ, Lenvik T, Pitt M, McCullar V, Li H, Anderson SK, Miller JS (2009) The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter element. Blood 113:3245\u20133253","journal-title":"Blood"},{"key":"444_CR31","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1002\/eji.200939307","volume":"39","author":"K Juelke","year":"2009","unstructured":"Juelke K, Killig M, Thiel A, Dong J, Romagnani C (2009) Education of hyporesponsive NK cells by cytokines. Eur J Immunol 39:2548\u20132555","journal-title":"Eur J Immunol"},{"key":"444_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s12026-012-8285-7","volume":"52","author":"G Konjevic","year":"2012","unstructured":"Konjevic G, Jurisic V, Jovic V, Vuletic A, Mirjacic Martinovic K, Radenkovic S, Spu\u017ei\u0107 I (2012) Investigation of NK cell function and their modulation in different malignancies. Immunol Res 52:139\u2013156","journal-title":"Immunol Res"},{"key":"444_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10585-006-9043-9","volume":"24","author":"G Konjevi\u0107","year":"2007","unstructured":"Konjevi\u0107 G, Mirjaci\u0107 Martinovi\u0107 K, Vuleti\u0107 A, Jovi\u0107 V, Jurisi\u0107 V, Babovi\u0107 N, Spuzi\u0107 I (2007) Low expression of CD161 and NKG2D activating NK receptor is associated with impaired NK cell cytotoxicity in metastatic melanoma patients. Clin Exp Metastasis 24:1\u201311","journal-title":"Clin Exp Metastasis"},{"key":"444_CR34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/PL00005268","volume":"358","author":"MG Seidel","year":"1998","unstructured":"Seidel MG, Freissmuth M, Pehamberger H, Micksche M (1998) Stimulation of natural killer activity in peripheral blood lymphocytes of healthy donors and melanoma patients in vitro: synergism between interleukin (IL)-12 and IL-15 or IL-12 and IL-2. Naunyn Schmiedeberg's Arch Pharmacol 358:382\u2013389","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"444_CR35","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3389\/fimmu.2013.00408","volume":"4","author":"M Sabry","year":"2013","unstructured":"Sabry M, Lowdell MW (2013) Tumor-primed NK cells: waiting for the green light. Front Immunol 4:408","journal-title":"Front Immunol"},{"key":"444_CR36","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/CMR.0b013e32833e3286","volume":"20","author":"G Konjevi\u0107","year":"2010","unstructured":"Konjevi\u0107 G, Mirja\u010di\u0107 Martinovi\u0107 K, Vuleti\u0107 A, Babovi\u0107 N (2010) In-vitro IL-2 or IFN-\u03b1- induced NKG2D and CD161 NK cell receptor expression indicates novel aspects of NK cell activation in metastatic melanoma patients. Melanoma Res 20:459\u2013467","journal-title":"Melanoma Res"},{"key":"444_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1365-2567.2009.03123.x","volume":"128","author":"NJ Topham","year":"2009","unstructured":"Topham NJ, Hewitt EW (2009) Natural killer cell cytotoxicity: how do they pull the trigger? Immunology 128:7\u201315","journal-title":"Immunology"},{"key":"444_CR38","doi-asserted-by":"publisher","first-page":"ra21","DOI":"10.1126\/scisignal.2001608","volume":"4","author":"S Guia","year":"2011","unstructured":"Guia S, Jaeger BN, Piatek S, Mailfert S, Trombik T, Fenis A, Chevrier N, Walzer T, Kerdiles YM, Marguet D, Vivier E, Ugolini S (2011) Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal 4:ra21","journal-title":"Sci Signal"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-018-0444-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-018-0444-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-018-0444-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T18:21:04Z","timestamp":1585678864000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-018-0444-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["444"],"URL":"https:\/\/doi.org\/10.1007\/s12253-018-0444-2","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,11]]},"assertion":[{"value":"25 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}