{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:33:50Z","timestamp":1789403630539,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81301834"],"award-info":[{"award-number":["81301834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12253-019-00647-8","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T14:31:45Z","timestamp":1554474705000},"page":"1007-1013","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-2843","authenticated-orcid":false,"given":"Yan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"647_CR1","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.7314\/APJCP.2013.14.10.5567","volume":"14","author":"SV Krishna Rao","year":"2013","unstructured":"Krishna Rao SV, Mejia G, Roberts-Thomson K, Logan R (2013) Epidemiology of oral cancer in Asia in the past decade--an update (2000-2012). Asian Pac J Cancer Prev 14:5567\u20135577","journal-title":"Asian Pac J Cancer Prev"},{"key":"647_CR2","unstructured":"de Morais EF, Mafra RP, Gonzaga AK,de Souza DL, Pinto LP, da Silveira \u00c9J (2016) Prognostic Factors of Oral Squamous Cell Carcinoma in Young Patients: A Systematic Review. J Oral Maxillofac Surg, pii: S0278\u20132391(16): 31286\u201331281"},{"issue":"1","key":"647_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bjoms.2007.08.006","volume":"46","author":"P Kessler","year":"2008","unstructured":"Kessler P, Grabenbauer G, Leher A, Bloch-Birkholz A, Vairaktaris E, Neukam FW (2008) Neoadjuvant and adjuvant therapy in patients with oral squamous cell carcinoma Long-term survival in a prospective, non-randomized study. Br J Oral Maxillofac Surg 46(1):1\u20135","journal-title":"Br J Oral Maxillofac Surg"},{"key":"647_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2982","volume":"11","author":"CR Leemans","year":"2011","unstructured":"Leemans CR, Braakhuis BJ, Brakenhoff RH (2011) The molecular biology of head and neck cancer. Nat Rev Cancer 11:9\u201322","journal-title":"Nat Rev Cancer"},{"issue":"21","key":"647_CR5","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.7150\/jca.28588","volume":"9","author":"S Huang","year":"2018","unstructured":"Huang S, Tan X, Huang Z, Chen Z, Lin P, Fu SW (2018) microRNA biomarkers in colorectal cancer liver metastasis. J Cancer 9(21):3867\u20133873","journal-title":"J Cancer"},{"issue":"12","key":"647_CR6","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1080\/15384047.2018.1491505","volume":"19","author":"J Shen","year":"2018","unstructured":"Shen J, Zhou W, Bi N, Song YM, Zhang FQ, Zhan QM, Wang LH (2018) MicroRNA-886-3P functions as a tumor suppressor in small cell lung cancer. Cancer Biol Ther 19(12):1185\u20131192","journal-title":"Cancer Biol Ther"},{"key":"647_CR7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fncel.2016.00235","volume":"10","author":"C Shang","year":"2016","unstructured":"Shang C, Guo Y, Hong Y, Xue YX (2016) Long non-coding RNA TUSC7, a target of miR-23b, plays tumor-suppressing roles in human gliomas. Front Cell Neurosci 10:235","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"647_CR8","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41419-018-1091-y","volume":"9","author":"P Kong","year":"2018","unstructured":"Kong P, Chen L, Yu M, Tao J, Liu J, Wang Y, Pan H, Zhou W, Wang S (2018) miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer. Cell Death Dis 9(11):1059","journal-title":"Cell Death Dis"},{"issue":"3","key":"647_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s12253-017-0263-x","volume":"24","author":"D Zhao","year":"2018","unstructured":"Zhao D, Zhang Y, Song L (2018) MiR-16-1 targeted silences far upstream element binding protein 1 to advance the Chemosensitivity to Adriamycin in gastric Cancer. Pathol Oncol Res 24(3):483\u2013488","journal-title":"Pathol Oncol Res"},{"issue":"4","key":"647_CR10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00280-018-3522-y","volume":"81","author":"C Shang","year":"2018","unstructured":"Shang C, Tang W, Pan C, Hu XH, Hong Y (2018) Long non-coding RNA TUSC7 inhibits temozolomide resistance by targeting miR-10a in glioblastoma. Cancer Chemother Pharmacol 81(4):671\u2013678","journal-title":"Cancer Chemother Pharmacol"},{"issue":"2","key":"647_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/cgt.2016.79","volume":"24","author":"M Sharifi","year":"2017","unstructured":"Sharifi M, Moridnia A (2017) Apoptosis-inducing and antiproliferative effect by inhibition of miR-182-5p through the regulation of CASP9 expression in human breast cancer. Cancer Gene Ther 24(2):75\u201382","journal-title":"Cancer Gene Ther"},{"issue":"3","key":"647_CR12","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170136","volume":"37","author":"Y Li","year":"2017","unstructured":"Li Y, Chen S, Shan Z, Bi L, Yu S, Li Y, Xu S (2017) miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A. Biosci Rep 37(3):pii: BSR20170136","journal-title":"Biosci Rep"},{"issue":"1","key":"647_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055502","volume":"8","author":"H Hirata","year":"2013","unstructured":"Hirata H, Ueno K, Shahryari V, Deng G, Tanaka Y, Tabatabai ZL, Hinoda Y, Dahiya R (2013) MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PLoS One 8(1):e55502","journal-title":"PLoS One"},{"key":"647_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3389\/fonc.2018.00446","volume":"8","author":"R Suzuki","year":"2018","unstructured":"Suzuki R, Amatya VJ, Kushitani K, Kai Y, Kambara T, Takeshima Y (2018) miR-182 and miR-183 promote cell proliferation and invasion by targeting FOXO1 in mesothelioma. Front Oncol 8:446","journal-title":"Front Oncol"},{"issue":"6","key":"647_CR15","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.5114\/aoms.2016.60091","volume":"13","author":"MR Golbakhsh","year":"2017","unstructured":"Golbakhsh MR, Boddouhi B, Hatami N, Goudarzi PK, Shakeri M, Yahaghi E, Taheriazam A (2017) Down-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma. Arch Med Sci 13(6):1352\u20131356","journal-title":"Arch Med Sci"},{"key":"647_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1476-4598-13-109","volume":"13","author":"X Xu","year":"2014","unstructured":"Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, Liang Z, Wang X, Lin Y, Mao Y, Chen H, Luo J, Liu B, Zheng X, Xie L (2014) Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT\/FOXO3a signaling pathway. Mol Cancer 13:109","journal-title":"Mol Cancer"},{"issue":"9","key":"647_CR17","first-page":"15441","volume":"8","author":"Y Guo","year":"2015","unstructured":"Guo Y, Ren MS, Shang C, Zhu L, Zhong M (2015) MTSS1 gene regulated by miR-96 inhibits cell proliferation and metastasis in tongue squamous cellular carcinoma Tca8113 cell line. Int J Clin Exp Med 8(9):15441\u201315449","journal-title":"Int J Clin Exp Med"},{"key":"647_CR18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-1-61779-207-6_8","volume":"769","author":"J Marshall","year":"2011","unstructured":"Marshall J (2011) Transwell(\u00ae) invasion assays. Methods Mol Biol 769:97\u2013110","journal-title":"Methods Mol Biol"},{"key":"647_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/1471-2407-12-227","volume":"12","author":"J Wang","year":"2012","unstructured":"Wang J, Li J, Shen J, Wang C, Yang L, Zhang X (2012) MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer 12:227","journal-title":"BMC Cancer"},{"issue":"3","key":"647_CR20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1080\/15384047.2017.1281497","volume":"18","author":"Q Lv","year":"2017","unstructured":"Lv Q, Hu JX, Li YJ, Xie N, Song DD, Zhao W, Yan YF, Li BS, Wang PY, Xie SY (2017) MiR-320a effectively suppresses lung adenocarcinoma cell proliferation and metastasis by regulating STAT3 signals. Cancer Biol Ther 18(3):142\u2013151","journal-title":"Cancer Biol Ther"},{"issue":"4","key":"647_CR21","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00280-017-3418-2","volume":"80","author":"A Rajabpour","year":"2017","unstructured":"Rajabpour A, Afgar A, Mahmoodzadeh H, Radfar JE, Rajaei F, Teimoori-Toolabi L (2017) MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells. Cancer Chemother Pharmacol 80(4):765\u2013775","journal-title":"Cancer Chemother Pharmacol"},{"key":"647_CR22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fncel.2017.00329","volume":"11","author":"J Wang","year":"2017","unstructured":"Wang J, Chen T, Shan G (2017) miR-148b regulates proliferation and differentiation of neural stem cells via Wnt\/\u03b2-catenin signaling in rat ischemic stroke model. Front Cell Neurosci 11:329","journal-title":"Front Cell Neurosci"},{"issue":"15","key":"647_CR23","doi-asserted-by":"publisher","first-page":"24949","DOI":"10.18632\/oncotarget.15327","volume":"8","author":"Z Xi","year":"2017","unstructured":"Xi Z, Wang P, Xue Y, Shang C, Liu X, Ma J, Li Z, Li Z, Bao M, Liu Y (2017) Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating quaking gene isoform 6. Oncotarget. 8(15):24949\u201324963","journal-title":"Oncotarget."},{"issue":"8","key":"647_CR24","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/pros.22626","volume":"73","author":"K Tsuchiyama","year":"2013","unstructured":"Tsuchiyama K, Ito H, Taga M, Naganuma S, Oshinoya Y, Nagano K, Yokoyama O, Itoh H (2013) Expression of microRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer. Prostate. 73(8):827\u2013834","journal-title":"Prostate."},{"issue":"14","key":"647_CR25","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1158\/0008-5472.CAN-15-3073","volume":"76","author":"J Xue","year":"2016","unstructured":"Xue J, Zhou A, Wu Y, Morris SA, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger AB, Huang S (2016) miR-182-5p induced by STAT3 activation promotes glioma tumorigenesis. Cancer Res 76(14):4293\u20134304","journal-title":"Cancer Res"},{"issue":"10","key":"647_CR26","doi-asserted-by":"publisher","first-page":"16473","DOI":"10.18632\/oncotarget.14869","volume":"8","author":"AE Zeleniak","year":"2017","unstructured":"Zeleniak AE, Huang W, Brinkman MK, Fishel ML, Hill R (2017) Loss of MTSS1 results in increased metastatic potential in pancreatic cancer. Oncotarget. 8(10):16473\u201316487","journal-title":"Oncotarget."},{"issue":"2","key":"647_CR27","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3892\/etm.2016.3382","volume":"12","author":"DJ Ling","year":"2016","unstructured":"Ling DJ, Chen ZS, Liao QD, Feng JX, Zhang XY, Yin TY (2016) Differential effects of MTSS1 on invasion and proliferation in subtypes of non-small cell lung cancer cells. Exp Ther Med 12(2):1225\u20131231","journal-title":"Exp Ther Med"},{"issue":"10","key":"647_CR28","first-page":"1974","volume":"7","author":"W Shi","year":"2015","unstructured":"Shi W, Hasimu G, Wang Y, Li N, Chen M, Zhang H (2015) MTSS1 is an independent prognostic biomarker for survival in intrahepatic cholangiocarcinoma patients. Am J Transl Res 7(10):1974\u20131983","journal-title":"Am J Transl Res"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-019-00647-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-019-00647-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-019-00647-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T13:18:25Z","timestamp":1590067105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-019-00647-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["647"],"URL":"https:\/\/doi.org\/10.1007\/s12253-019-00647-8","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,4]]},"assertion":[{"value":"14 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study has been carried out with the approval of the Ethics Committees of School of Stomatology. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}