{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:51:01Z","timestamp":1785682261978,"version":"3.56.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12253-019-00662-9","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T07:03:22Z","timestamp":1556694202000},"page":"1073-1078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-8927","authenticated-orcid":false,"given":"Sami","family":"Shousha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Anscombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taneisha","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"662_CR1","doi-asserted-by":"publisher","first-page":"18148","DOI":"10.3390\/ijms140918148","volume":"14","author":"MJ Kwon","year":"2013","unstructured":"Kwon MJ (2013) Emerging roles of claudins in human cancer. Int J Mol Sci 14:18148\u201318181","journal-title":"Int J Mol Sci"},{"key":"662_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00424-016-1918-2","volume":"469","author":"M Bleich","year":"2017","unstructured":"Bleich M, Gunzel D (2017) Physiology, pathophysiology and clinical impact of claudins. Pflugers Arch 469:1\u20132","journal-title":"Pflugers Arch"},{"key":"662_CR3","doi-asserted-by":"publisher","unstructured":"Tobaries S, Siegel PM (2016, 15 August) The role of claudins in cancer metastasis. Oncogene. \nhttps:\/\/doi.org\/10.1036\/onc.216.289","DOI":"10.1036\/onc.216.289"},{"key":"662_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00424-016-1877-7","volume":"469","author":"M Osanai","year":"2017","unstructured":"Osanai M, Takasawa A, Murata M, Sawada N (2017) Claudins in cancer. Pflugers Arch 469:55\u201367","journal-title":"Pflugers Arch"},{"key":"662_CR5","doi-asserted-by":"publisher","first-page":"R296","DOI":"10.1186\/bcr983","volume":"7","author":"A-M Tokes","year":"2005","unstructured":"Tokes A-M, Kulka J, Paku S, Szik A, Paska C, Novak PK et al (2005) Claudin-1. -3 and \u22124 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 7:R296\u2013R305. \nhttps:\/\/doi.org\/10.1186\/bcr983","journal-title":"Breast Cancer Res"},{"key":"662_CR6","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1038\/sj.onc.1206199","volume":"22","author":"SL Kominsky","year":"2003","unstructured":"Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S (2003) Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal cartcinoma of the breast. Oncogene 22:2021\u20132033","journal-title":"Oncogene"},{"key":"662_CR7","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00428-009-0770-6","volume":"454","author":"AA Blanchard","year":"2009","unstructured":"Blanchard AA, Skliris GP, Watson P, Murphy LC, Penner C, Tomes L et al (2009) Claudin 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype. Virchows Arch 454:647\u2013656","journal-title":"Virchows Arch"},{"key":"662_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12253-008-9089-x","volume":"15","author":"J Kulka","year":"2009","unstructured":"Kulka J, Szasz AM, Nemeth Z, Madaras L, Schaff Z, Molnar IA et al (2009) Expression of tight junction protein claudin-4 in basal-like breast carcinoma. Pathol Oncol Res 15:59\u201364","journal-title":"Pathol Oncol Res"},{"key":"662_CR9","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1002\/ijc.24159","volume":"124","author":"F Lanigan","year":"2009","unstructured":"Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, Jirstrom K, Landberg G, Martin F, Duffy MJ, Gallagher WM (2009) Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer 124:2088\u20132097","journal-title":"Int J Cancer"},{"key":"662_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/956897","volume":"2010","author":"Yvonne Myal","year":"2010","unstructured":"Myal Y, Leygue E, Blanchard AA (2010 Article ID 956897) Claudin 1 in breast tumorigenesis: Revelation of a possible novel \u201cclaudin high\u201d subset of breast cancers. J Biomed Bioteh. \nhttps:\/\/doi.org\/10.1155\/2010\/956897","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"662_CR11","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.breast.2012.03.001","volume":"21","author":"R Gerhard","year":"2012","unstructured":"Gerhard R, Ricardo S, Albergaria A, Gomes M, Silva AR, Logullo AF, Cameselle-Teijeiro JF, Paredes J, Schmitt F (2012) Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas. Breast 21:354\u2013360","journal-title":"Breast"},{"key":"662_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/1471-2407-13-268","volume":"13","author":"AA Blanchard","year":"2013","unstructured":"Blanchard AA, Ma X, Dueck KJ, Penner C, Cooper SC, Mulhall D, Murphy LC, Leygue E, Myal Y (2013) Cladin 1 expression in basal-like breast cancer is related to patient age. BMC Cancer 13:268","journal-title":"BMC Cancer"},{"key":"662_CR13","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/modpathol.2012.187","volume":"26","author":"S Lu","year":"2013","unstructured":"Lu S, Singh K, Mangray S, Tavares R, Noble L, Resnick M et al (2013) Claudin expression in high grade invasive ductal carcinoma of the breast: correlation with the molecular type. Modern Pathol 26:485\u2013495","journal-title":"Modern Pathol"},{"issue":"6","key":"662_CR14","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/his.12490","volume":"65","author":"Marise R Heerma van Voss","year":"2014","unstructured":"Van Voss MRH, van Diest PJ, Smolders YHCM, Bart J, van der Wal E, van der Groep. Distinct claudin expression characterizes BRCA1=related breast cancer. Histopathology 2014;65:814\u2013827","journal-title":"Histopathology"},{"key":"662_CR15","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3390\/jcm4121952","volume":"4","author":"B Zhou","year":"2015","unstructured":"Zhou B, Moodie A, Blanchard AA, Leygue E, Myal Y (2015) Claudin 1 in breast cancer: new insights. J Clin Med 4:1960\u20131976","journal-title":"J Clin Med"},{"key":"662_CR16","doi-asserted-by":"publisher","first-page":"e0168669","DOI":"10.1371\/journal.pone.0168669","volume":"12","author":"K Dias","year":"2017","unstructured":"Dias K, Dvorkin-Gheva A, Hallett RM, Wu Y, Hassell J, Pond GR, Levine M, Whelan T, Bane AL (2017) Claudin-low breast cancer, clinical & pathological characteristics. PLoS One 12:e0168669. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0168669","journal-title":"PLoS One"},{"issue":"11","key":"662_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112765","volume":"9","author":"F Ma","year":"2014","unstructured":"Ma F, Ding X, Fan Y, Ying J, Zheng S, Lu N, Xu B (2014) A CLDN1-negative phenotype predicts poor prognosis in triple negative breast cancer. PLoS One 9(11):e112765","journal-title":"PLoS One"},{"key":"662_CR18","first-page":"139","volume":"20","author":"S Morohashi","year":"2007","unstructured":"Morohashi S, Kusumi T, Sato F, Odagiri h CH, Yoshihara S et al (2007) Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med 20:139\u2013143","journal-title":"Int J Mol Med"},{"key":"662_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.anndiagpath.2014.10.003","volume":"19","author":"MA Abd-Elazeem","year":"2015","unstructured":"Abd-Elazeem MA, Abd-Elazeem MA (2015) Claudin 4 expression in triple negative breast cancer: correlation with androgen receptors and Ki-67 expression. Ann Diag Pathol 19:37\u201342","journal-title":"Ann Diag Pathol"},{"key":"662_CR20","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.humpath.2004.09.015","volume":"35","author":"Y Soini","year":"2004","unstructured":"Soini Y (2004) Claudin 2, 3, 4 and 5 in Paget\u2019s disease and breast carcinoma. Hum Pathol 35:1531\u20131536","journal-title":"Hum Pathol"},{"issue":"6","key":"662_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067496","volume":"8","author":"X Lin","year":"2013","unstructured":"Lin X, Shang X, Manorek G, Howell SB (2013) Regulation of the epithelial-mesenchymal transition by claudin-3 and claudi-4. PLoS One 8(6):e67496","journal-title":"PLoS One"},{"issue":"8","key":"662_CR22","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1586\/14737159.2015.1057125","volume":"15","author":"P Gromov","year":"2015","unstructured":"Gromov P, Espinoza JA, Gromova I (2015) Molecular and diagnostic features of apocrine breast lesions. Expert Rev Mol Diagn 15(8):1011\u20131022","journal-title":"Expert Rev Mol Diagn"},{"key":"662_CR23","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.humpath.2015.05.017","volume":"45","author":"S Vranic","year":"2015","unstructured":"Vranic S, Merchio C, Castellano I, Botta C, Scalzo MS, Bender RP et al (2015) Immunohistochemical and molecular profiling of histologically defined apocrine carcinoma of the breast. Hum Pathol 45:1350\u20131359","journal-title":"Hum Pathol"},{"key":"662_CR24","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1097\/PAS.0000000000000671","volume":"40","author":"AM Mills","year":"2016","unstructured":"Mills AM, Gottlieb CE, Wendroth SM, Brenin CM, Atkins KA (2016) Pure apocrine carcinomas represent a clinicopathologically distinct androgen receptor-positive subset of triple-negative breast cancers. Am J Surg Pathol 40:1109\u20131116","journal-title":"Am J Surg Pathol"},{"key":"662_CR25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/jcp.10076","volume":"191","author":"T Hoevel","year":"2002","unstructured":"Hoevel T, Macer R, Mundigl O, Swisshelm K, Kubbies M (2002) Expression and targeting of the tight junction protein CLDN1 in CLDN1- negative human breast tumour cells. J Cell Physiol 191:60\u201368","journal-title":"J Cell Physiol"},{"key":"662_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12253-016-0115-0","volume":"23","author":"J Moldvay","year":"2017","unstructured":"Moldvay J, Fabian K, Jacket M, Nemeth Z, Bogos K, Furak J et al (2017) Claudin-1 protein expression is a good prognostic factor in non-small cell lung cacer, but only in squamous cell carcinoma cases. Pathol Oncol Res 23:151\u2013156","journal-title":"Pathol Oncol Res"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-019-00662-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-019-00662-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-019-00662-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T13:22:39Z","timestamp":1590067359000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-019-00662-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["662"],"URL":"https:\/\/doi.org\/10.1007\/s12253-019-00662-9","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]},"assertion":[{"value":"22 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Ethical approval was granted by Imperial College Healthcare NHS Trust Tissue Bank on 02\/07\/2014 Project number R14056 and on 02\/08\/2015 Project number R15039.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"None declared.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}