{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:26:37Z","timestamp":1760243197200,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"New National Excellence Program of The Ministry of Human Capacities","award":["\u00daNKP-17-4-III-SE-51"],"award-info":[{"award-number":["\u00daNKP-17-4-III-SE-51"]}]},{"name":"New National Excellence Program of The Ministry of Human Capacities","award":["\u00daNKP-17-4-I-SE-56"],"award-info":[{"award-number":["\u00daNKP-17-4-I-SE-56"]}]},{"DOI":"10.13039\/501100011019","name":"National Research, Development and Innovation Office","doi-asserted-by":"crossref","award":["NVKP_16-1-2016-0004"],"award-info":[{"award-number":["NVKP_16-1-2016-0004"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s12253-020-00800-8","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T02:02:25Z","timestamp":1587348145000},"page":"2209-2223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Promoter Hypomethylation and Increased Expression of the Long Non-coding RNA LINC00152 Support Colorectal Carcinogenesis"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-5667","authenticated-orcid":false,"given":"Orsolya","family":"Galamb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-1534","authenticated-orcid":false,"given":"Alexandra","family":"Kalm\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-4794","authenticated-orcid":false,"given":"Anna","family":"Sebesty\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-4560","authenticated-orcid":false,"given":"Titanilla","family":"Dank\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-0401","authenticated-orcid":false,"given":"Csilla","family":"Kriston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-3177","authenticated-orcid":false,"given":"Istv\u00e1n","family":"F\u0171ri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-8748","authenticated-orcid":false,"given":"P\u00e9ter","family":"Holl\u00f3si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-9898","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Csabai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-8459","authenticated-orcid":false,"given":"Barnab\u00e1s","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-065X","authenticated-orcid":false,"given":"Tibor","family":"Kren\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-6768","authenticated-orcid":false,"given":"Barbara Kinga","family":"Bart\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-9568","authenticated-orcid":false,"given":"Zs\u00f3fia Brigitta","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-5637","authenticated-orcid":false,"given":"S\u00e1ra","family":"Zsigrai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-5061","authenticated-orcid":false,"given":"G\u00e1bor","family":"Barna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-6640","authenticated-orcid":false,"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2192-554X","authenticated-orcid":false,"given":"P\u00e9ter","family":"Igaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-1273","authenticated-orcid":false,"given":"B\u00e9la","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"issue":"5","key":"800_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359\u2013E386. \nhttps:\/\/doi.org\/10.1002\/ijc.29210","journal-title":"Int J Cancer"},{"key":"800_CR2","doi-asserted-by":"publisher","first-page":"509348","DOI":"10.1155\/2012\/509348","volume":"2012","author":"M Pancione","year":"2012","unstructured":"Pancione M, Remo A, Colantuoni V (2012) Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. Patholog Res Int 2012:509348. \nhttps:\/\/doi.org\/10.1155\/2012\/509348","journal-title":"Patholog Res Int"},{"key":"800_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1741-7007-11-59","volume":"11","author":"AE Kornienko","year":"2013","unstructured":"Kornienko AE, Guenzl PM, Barlow DP, Pauler FM (2013) Gene regulation by the act of long non-coding RNA transcription. BMC Biol 11:59. \nhttps:\/\/doi.org\/10.1186\/1741-7007-11-59","journal-title":"BMC Biol"},{"issue":"6","key":"800_CR4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.4161\/rna.20481","volume":"9","author":"T Gutschner","year":"2012","unstructured":"Gutschner T, Diederichs S (2012) The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol 9(6):703\u2013719. \nhttps:\/\/doi.org\/10.4161\/rna.20481","journal-title":"RNA Biol"},{"issue":"9","key":"800_CR5","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1136\/gutjnl-2014-308392","volume":"65","author":"Y Ma","year":"2016","unstructured":"Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, Wang H, Wang H, Qin H (2016) Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt\/beta-catenin signalling pathway via suppression of activator protein 2alpha. Gut 65(9):1494\u20131504. \nhttps:\/\/doi.org\/10.1136\/gutjnl-2014-308392","journal-title":"Gut"},{"key":"800_CR6","doi-asserted-by":"publisher","first-page":"6088","DOI":"10.1038\/srep06088","volume":"4","author":"T Xia","year":"2014","unstructured":"Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y, Guo J (2014) Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep 4:6088. \nhttps:\/\/doi.org\/10.1038\/srep06088","journal-title":"Sci Rep"},{"issue":"23","key":"800_CR7","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.3748\/wjg.v19.i23.3658","volume":"19","author":"WJ Cao","year":"2013","unstructured":"Cao WJ, Wu HL, He BS, Zhang YS, Zhang ZY (2013) Analysis of long non-coding RNA expression profiles in gastric cancer. World J Gastroenterol 19(23):3658\u20133664. \nhttps:\/\/doi.org\/10.3748\/wjg.v19.i23.3658","journal-title":"World J Gastroenterol"},{"issue":"9","key":"800_CR8","doi-asserted-by":"publisher","first-page":"9773","DOI":"10.18632\/oncotarget.6949","volume":"7","author":"WM Chen","year":"2016","unstructured":"Chen WM, Huang MD, Sun DP, Kong R, Xu TP, Xia R, Zhang EB, Shu YQ (2016) Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer. Oncotarget 7(9):9773\u20139787. \nhttps:\/\/doi.org\/10.18632\/oncotarget.6949","journal-title":"Oncotarget"},{"issue":"40","key":"800_CR9","doi-asserted-by":"publisher","first-page":"42813","DOI":"10.18632\/oncotarget.5970","volume":"6","author":"J Ji","year":"2015","unstructured":"Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G, Sun B (2015) LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway. Oncotarget 6(40):42813\u201342824. \nhttps:\/\/doi.org\/10.18632\/oncotarget.5970","journal-title":"Oncotarget"},{"issue":"6","key":"800_CR10","doi-asserted-by":"publisher","first-page":"5441","DOI":"10.1007\/s13277-014-1709-3","volume":"35","author":"Q Pang","year":"2014","unstructured":"Pang Q, Ge J, Shao Y, Sun W, Song H, Xia T, Xiao B, Guo J (2014) Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance. Tumour Biol 35(6):5441\u20135447. \nhttps:\/\/doi.org\/10.1007\/s13277-014-1709-3","journal-title":"Tumour Biol"},{"issue":"19","key":"800_CR11","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1080\/15384101.2015.1078034","volume":"14","author":"J Zhao","year":"2015","unstructured":"Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y, Huang G (2015) Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer. Cell Cycle 14(19):3112\u20133123. \nhttps:\/\/doi.org\/10.1080\/15384101.2015.1078034","journal-title":"Cell Cycle"},{"issue":"3","key":"800_CR12","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s13277-014-2807-y","volume":"36","author":"Q Li","year":"2015","unstructured":"Li Q, Shao Y, Zhang X, Zheng T, Miao M, Qin L, Wang B, Ye G, Xiao B, Guo J (2015) Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer. Tumour Biol 36(3):2007\u20132012. \nhttps:\/\/doi.org\/10.1007\/s13277-014-2807-y","journal-title":"Tumour Biol"},{"issue":"2","key":"800_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1159\/000430387","volume":"37","author":"J Li","year":"2015","unstructured":"Li J, Wang X, Tang J, Jiang R, Zhang W, Ji J, Sun B (2015) HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma. Cell Physiol Biochem 37(2):687\u2013696. \nhttps:\/\/doi.org\/10.1159\/000430387","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"800_CR14","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1002\/hep.25870","volume":"56","author":"O Neumann","year":"2012","unstructured":"Neumann O, Kesselmeier M, Geffers R, Pellegrino R, Radlwimmer B, Hoffmann K, Ehemann V, Schemmer P, Schirmacher P, Lorenzo Bermejo J, Longerich T (2012) Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology 56(5):1817\u20131827. \nhttps:\/\/doi.org\/10.1002\/hep.25870","journal-title":"Hepatology"},{"key":"800_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13046-015-0250-6","volume":"34","author":"J Zhou","year":"2015","unstructured":"Zhou J, Zhi X, Wang L, Wang W, Li Z, Tang J, Wang J, Zhang Q, Xu Z (2015) Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway. J Exp Clin Cancer Res 34:135. \nhttps:\/\/doi.org\/10.1186\/s13046-015-0250-6","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"800_CR16","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41389-017-0008-4","volume":"6","author":"Z Bian","year":"2017","unstructured":"Bian Z, Zhang J, Li M, Feng Y, Yao S, Song M, Qi X, Fei B, Yin Y, Hua D, Huang Z (2017) Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p. Oncogenesis 6(11):395. \nhttps:\/\/doi.org\/10.1038\/s41389-017-0008-4","journal-title":"Oncogenesis"},{"issue":"12","key":"800_CR17","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/mt.2016.180","volume":"24","author":"B Yue","year":"2016","unstructured":"Yue B, Cai D, Liu C, Fang C, Yan D (2016) Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer. Mol Ther 24(12):2064\u20132077. \nhttps:\/\/doi.org\/10.1038\/mt.2016.180","journal-title":"Mol Ther"},{"issue":"9","key":"800_CR18","doi-asserted-by":"publisher","first-page":"7175","DOI":"10.1007\/s13277-015-3448-5","volume":"36","author":"JJ Qiu","year":"2015","unstructured":"Qiu JJ, Yan JB (2015) Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer. Tumour Biol 36(9):7175\u20137183. \nhttps:\/\/doi.org\/10.1007\/s13277-015-3448-5","journal-title":"Tumour Biol"},{"issue":"1","key":"800_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2008\/586721","volume":"25","author":"O Galamb","year":"2008","unstructured":"Galamb O, Gyorffy B, Sipos F, Spisak S, Nemeth AM, Miheller P, Tulassay Z, Dinya E, Molnar B (2008) Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature. Dis Markers 25(1):1\u201316","journal-title":"Dis Markers"},{"issue":"10","key":"800_CR20","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1158\/1055-9965.EPI-08-0231","volume":"17","author":"O Galamb","year":"2008","unstructured":"Galamb O, Sipos F, Solymosi N, Spisak S, Krenacs T, Toth K, Tulassay Z, Molnar B (2008) Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. Cancer Epidemiol Biomarkers Prev 17(10):2835\u20132845. \nhttps:\/\/doi.org\/10.1158\/1055-9965.EPI-08-0231","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11","key":"800_CR21","doi-asserted-by":"publisher","first-page":"e48547","DOI":"10.1371\/journal.pone.0048547","volume":"7","author":"O Galamb","year":"2012","unstructured":"Galamb O, Wichmann B, Sipos F, Spisak S, Krenacs T, Toth K, Leiszter K, Kalmar A, Tulassay Z, Molnar B (2012) Dysplasia-carcinoma transition specific transcripts in colonic biopsy samples. PLoS One 7(11):e48547. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0048547","journal-title":"PLoS One"},{"issue":"1","key":"800_CR22","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1186\/s12885-019-6180-5","volume":"19","author":"A Kalmar","year":"2019","unstructured":"Kalmar A, Nagy ZB, Galamb O, Csabai I, Bodor A, Wichmann B, Valcz G, Bartak BK, Tulassay Z, Igaz P, Molnar B (2019) Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition. BMC Cancer 19(1):1059. \nhttps:\/\/doi.org\/10.1186\/s12885-019-6180-5","journal-title":"BMC Cancer"},{"issue":"8","key":"800_CR23","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1080\/15592294.2016.1190894","volume":"11","author":"O Galamb","year":"2016","unstructured":"Galamb O, Kalmar A, Peterfia B, Csabai I, Bodor A, Ribli D, Krenacs T, Patai AV, Wichmann B, Bartak BK, Toth K, Valcz G, Spisak S, Tulassay Z, Molnar B (2016) Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. Epigenetics 11(8):588\u2013602. \nhttps:\/\/doi.org\/10.1080\/15592294.2016.1190894","journal-title":"Epigenetics"},{"issue":"2","key":"800_CR24","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1053\/j.gastro.2014.04.039","volume":"147","author":"Y Luo","year":"2014","unstructured":"Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM (2014) Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology 147(2):418-429 e418. \nhttps:\/\/doi.org\/10.1053\/j.gastro.2014.04.039","journal-title":"Gastroenterology"},{"issue":"7407","key":"800_CR25","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature11252","volume":"487","author":"Cancer Genome Atlas N","year":"2012","unstructured":"Cancer Genome Atlas N (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330\u2013337. \nhttps:\/\/doi.org\/10.1038\/nature11252","journal-title":"Nature"},{"issue":"10","key":"800_CR26","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1002\/jcb.25606","volume":"117","author":"CM Anderson","year":"2016","unstructured":"Anderson CM, Zhang B, Miller M, Butko E, Wu X, Laver T, Kernag C, Kim J, Luo Y, Lamparski H, Park E, Su N, Ma XJ (2016) Fully Automated RNAscope In Situ Hybridization Assays for Formalin-Fixed Paraffin-Embedded Cells and Tissues. J Cell Biochem 117(10):2201\u20132208. \nhttps:\/\/doi.org\/10.1002\/jcb.25606","journal-title":"J Cell Biochem"},{"issue":"1","key":"800_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrd3010","volume":"9","author":"AL Jackson","year":"2010","unstructured":"Jackson AL, Linsley PS (2010) Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 9(1):57\u201367. \nhttps:\/\/doi.org\/10.1038\/nrd3010","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"800_CR28","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/cyto.990130802","volume":"13","author":"Z Darzynkiewicz","year":"1992","unstructured":"Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13(8):795\u2013808. \nhttps:\/\/doi.org\/10.1002\/cyto.990130802","journal-title":"Cytometry"},{"issue":"4","key":"800_CR29","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/sj.bjc.6605515","volume":"102","author":"O Galamb","year":"2010","unstructured":"Galamb O, Spis\u00e1k S, Sipos F, T\u00f3th K, Solymosi N, Wichmann B, Kren\u00e1cs T, Valcz G, Tulassay Z, Moln\u00e1r B (2010) Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. Br J Cancer 102(4):765\u2013773. \nhttps:\/\/doi.org\/10.1038\/sj.bjc.6605515","journal-title":"Br J Cancer"},{"issue":"10","key":"800_CR30","first-page":"4068","volume":"8","author":"Q Cai","year":"2016","unstructured":"Cai Q, Wang ZQ, Wang SH, Li C, Zhu ZG, Quan ZW, Zhang WJ (2016) Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K\/AKT pathway. Am J Transl Res 8(10):4068\u20134081","journal-title":"Am J Transl Res"},{"issue":"2","key":"800_CR31","first-page":"312","volume":"7","author":"Y Wang","year":"2017","unstructured":"Wang Y, Liu J, Bai H, Dang Y, Lv P, Wu S (2017) Long intergenic non-coding RNA 00152 promotes renal cell carcinoma progression by epigenetically suppressing P16 and negatively regulates miR-205. Am J Cancer Res 7(2):312\u2013322","journal-title":"Am J Cancer Res"},{"key":"800_CR32","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.biopha.2017.03.031","volume":"90","author":"X Deng","year":"2017","unstructured":"Deng X, Zhao XF, Liang XQ, Chen R, Pan YF, Liang J (2017) Linc00152 promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. Biomed Pharmacother 90:100\u2013108. \nhttps:\/\/doi.org\/10.1016\/j.biopha.2017.03.031","journal-title":"Biomed Pharmacother"},{"issue":"1\u20132","key":"800_CR33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000452529","volume":"40","author":"HB Hu","year":"2016","unstructured":"Hu HB, Jie HY, Zheng XX (2016) Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma. Cell Physiol Biochem 40(1\u20132):117\u2013125. \nhttps:\/\/doi.org\/10.1159\/000452529","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"800_CR34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/cam4.1027","volume":"6","author":"X Yu","year":"2017","unstructured":"Yu X, Lin Y, Sui W, Zou Y, Lv Z (2017) Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma. Cancer Med 6(3):673\u2013680. \nhttps:\/\/doi.org\/10.1002\/cam4.1027","journal-title":"Cancer Med"},{"issue":"2","key":"800_CR35","first-page":"285","volume":"6","author":"Y Wu","year":"2016","unstructured":"Wu Y, Tan C, Weng WW, Deng Y, Zhang QY, Yang XQ, Gan HL, Wang T, Zhang PP, Xu MD, Wang YQ, Wang CF (2016) Long non-coding RNA Linc00152 is a positive prognostic factor for and demonstrates malignant biological behavior in clear cell renal cell carcinoma. Am J Cancer Res 6(2):285\u2013299","journal-title":"Am J Cancer Res"},{"issue":"4","key":"800_CR36","doi-asserted-by":"publisher","first-page":"523","DOI":"10.7150\/jca.17510","volume":"8","author":"J Yu","year":"2017","unstructured":"Yu J, Liu Y, Guo C, Zhang S, Gong Z, Tang Y, Yang L, He Y, Lian Y, Li X, Deng H, Liao Q, Li X, Li Y, Li G, Zeng Z, Xiong W, Yang X (2017) Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma. J Cancer 8(4):523\u2013530. \nhttps:\/\/doi.org\/10.7150\/jca.17510","journal-title":"J Cancer"},{"issue":"10","key":"800_CR37","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1002\/ijc.25256","volume":"127","author":"T Matsuyama","year":"2010","unstructured":"Matsuyama T, Ishikawa T, Mogushi K, Yoshida T, Iida S, Uetake H, Mizushima H, Tanaka H, Sugihara K (2010) MUC12 mRNA expression is an independent marker of prognosis in stage II and stage III colorectal cancer. Int J Cancer 127(10):2292\u20132299. \nhttps:\/\/doi.org\/10.1002\/ijc.25256","journal-title":"Int J Cancer"},{"key":"800_CR38","doi-asserted-by":"publisher","unstructured":"Hong Y, Downey T, Eu KW, Koh PK, Cheah PY (2010) A \u201cmetastasis-prone\u201d signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis 27(2):83\u201390. \nhttps:\/\/doi.org\/10.1007\/s10585-010-9305-4","DOI":"10.1007\/s10585-010-9305-4"},{"issue":"12","key":"800_CR39","first-page":"5286","volume":"8","author":"YH Zhang","year":"2016","unstructured":"Zhang YH, Fu J, Zhang ZJ, Ge CC, Yi Y (2016) LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells. Am J Transl Res 8(12):5286\u20135297","journal-title":"Am J Transl Res"},{"issue":"13","key":"800_CR40","doi-asserted-by":"publisher","first-page":"22187","DOI":"10.18632\/oncotarget.14728","volume":"8","author":"J Luo","year":"2017","unstructured":"Luo J, Qu J, Wu DK, Lu ZL, Sun YS, Qu Q (2017) Long non-coding RNAs: a rising biotarget in colorectal cancer. Oncotarget 8(13):22187\u201322202. \nhttps:\/\/doi.org\/10.18632\/oncotarget.14728","journal-title":"Oncotarget"},{"issue":"2","key":"800_CR41","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3892\/ijo.2017.4218","volume":"52","author":"Y Nishizawa","year":"2018","unstructured":"Nishizawa Y, Konno M, Asai A, Koseki J, Kawamoto K, Miyoshi N, Takahashi H, Nishida N, Haraguchi N, Sakai D, Kudo T, Hata T, Matsuda C, Mizushima T, Satoh T, Doki Y, Mori M, Ishii H (2018) Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer. Int J Oncol 52(2):453\u2013460. \nhttps:\/\/doi.org\/10.3892\/ijo.2017.4218","journal-title":"Int J Oncol"},{"issue":"5","key":"800_CR42","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.ymthe.2018.02.024","volume":"26","author":"B Yue","year":"2018","unstructured":"Yue B, Liu C, Sun H, Liu M, Song C, Cui R, Qiu S, Zhong M (2018) A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt\/beta-Catenin Signaling Promotes Metastasis of Colon Cancer. Mol Ther 26(5):1287\u20131298. \nhttps:\/\/doi.org\/10.1016\/j.ymthe.2018.02.024","journal-title":"Mol Ther"},{"issue":"5","key":"800_CR43","doi-asserted-by":"publisher","first-page":"e1001453","DOI":"10.1371\/journal.pmed.1001453","volume":"10","author":"L Marisa","year":"2013","unstructured":"Marisa L, de Reynies A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Flejou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V (2013) Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med 10(5):e1001453. \nhttps:\/\/doi.org\/10.1371\/journal.pmed.1001453","journal-title":"PLoS Med"},{"issue":"7345","key":"800_CR44","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature09906","volume":"473","author":"J Ernst","year":"2011","unstructured":"Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE (2011) Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473(7345):43\u201349. \nhttps:\/\/doi.org\/10.1038\/nature09906","journal-title":"Nature"},{"issue":"22","key":"800_CR45","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1093\/hmg\/ddr356","volume":"20","author":"H Han","year":"2011","unstructured":"Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G (2011) DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet 20(22):4299\u20134310. \nhttps:\/\/doi.org\/10.1093\/hmg\/ddr356","journal-title":"Hum Mol Genet"},{"key":"800_CR46","doi-asserted-by":"publisher","unstructured":"Oster B, Linnet L, Christensen LL, Thorsen K, Ongen H, Dermitzakis ET, Sandoval J, Moran S, Esteller M, Hansen TF, Lamy P, Laurberg S, Orntoft TF, Andersen CL (2013) Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer. Int J Cancer 132(10):2303\u20132315. \nhttps:\/\/doi.org\/10.1002\/ijc.27921","DOI":"10.1002\/ijc.27921"},{"key":"800_CR47","doi-asserted-by":"publisher","first-page":"785731","DOI":"10.1155\/2013\/785731","volume":"2013","author":"A Marx","year":"2013","unstructured":"Marx A, Kahan T, Simon I (2013) Integrative analysis of methylome and transcriptome reveals the importance of unmethylated CpGs in non-CpG island gene activation. Biomed Res Int 2013:785731. \nhttps:\/\/doi.org\/10.1155\/2013\/785731","journal-title":"Biomed Res Int"},{"key":"800_CR48","doi-asserted-by":"publisher","unstructured":"Yu Y, Yang J, Li Q, Xu B, Lian Y, Miao L (2017) LINC00152: A pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif 50 (4). \nhttps:\/\/doi.org\/10.1111\/cpr.12349","DOI":"10.1111\/cpr.12349"},{"key":"800_CR49","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.biopha.2017.07.120","volume":"94","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Xiang C, Wang Y, Duan Y, Liu C, Jin Y, Zhang Y (2017) lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR\/PI3K\/AKT pathway. Biomed Pharmacother 94:644\u2013651. \nhttps:\/\/doi.org\/10.1016\/j.biopha.2017.07.120","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"800_CR50","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","volume":"151","author":"J Rosenbluh","year":"2012","unstructured":"Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC (2012) beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 151(7):1457\u20131473. \nhttps:\/\/doi.org\/10.1016\/j.cell.2012.11.026","journal-title":"Cell"},{"issue":"17","key":"800_CR51","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1038\/onc.2015.280","volume":"35","author":"B Madan","year":"2016","unstructured":"Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM (2016) Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene 35(17):2197\u20132207. \nhttps:\/\/doi.org\/10.1038\/onc.2015.280","journal-title":"Oncogene"},{"issue":"10","key":"800_CR52","doi-asserted-by":"publisher","first-page":"e1001168","DOI":"10.1371\/journal.pgen.1001168","volume":"6","author":"VG Beaudry","year":"2010","unstructured":"Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD (2010) Loss of the p53\/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet 6(10):e1001168. \nhttps:\/\/doi.org\/10.1371\/journal.pgen.1001168","journal-title":"PLoS Genet"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-020-00800-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-020-00800-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-020-00800-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:14:11Z","timestamp":1599142451000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-020-00800-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["800"],"URL":"https:\/\/doi.org\/10.1007\/s12253-020-00800-8","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"type":"print","value":"1219-4956"},{"type":"electronic","value":"1532-2807"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"18 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}