{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:14:31Z","timestamp":1779210871685,"version":"3.51.4"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathol. Oncol. Res."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s12253-020-00819-x","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T06:02:30Z","timestamp":1590559350000},"page":"2281-2289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Aberrant Telomere Length in Circulating Cell-Free DNA as Possible Blood Biomarker with High Diagnostic Performance in Endometrial Cancer"],"prefix":"10.1007","volume":"26","author":[{"given":"Marco","family":"Benati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Montagnana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Danese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Mazzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Paviati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5840-699X","authenticated-orcid":false,"given":"Simone","family":"Garzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jvan","family":"Casarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Giudici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricciarda","family":"Raffaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ghezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"819_CR1","doi-asserted-by":"publisher","unstructured":"Colombo N, Creutzberg C, Amant F, Bosse T, Gonz\u00e1lez-Mart\u00edn A, Ledermann J, Marth C, Nout R, Querleu D, Mirza MR, Sessa C, ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group (2016) ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Int J Gynecol Cancer 26:2\u201330. https:\/\/doi.org\/10.1097\/IGC.0000000000000609","DOI":"10.1097\/IGC.0000000000000609"},{"key":"819_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/onc.2012.76","volume":"32","author":"A Yeramian","year":"2013","unstructured":"Yeramian A, Moreno-Bueno G, Dolcet X, Catasus L, Abal M, Colas E, Reventos J, Palacios J, Prat J, Matias-Guiu X (2013) Endometrial carcinoma: molecular alterations involved in tumor development and progression. Oncogene 32:403\u2013413. https:\/\/doi.org\/10.1038\/onc.2012.76","journal-title":"Oncogene"},{"key":"819_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/jcla.20340","volume":"23","author":"M Montagnana","year":"2009","unstructured":"Montagnana M, Lippi G, Ruzzenente O, Bresciani V, Danese E, Scevarolli S, Salvagno GL, Giudici S, Franchi M, Guidi GC (2009) The utility of serum human epididymis protein 4 (HE4) in patients with a pelvic mass. J Clin Lab Anal 23:331\u2013335. https:\/\/doi.org\/10.1002\/jcla.20340","journal-title":"J Clin Lab Anal"},{"key":"819_CR4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/IGC.0000000000000913","volume":"27","author":"M Montagnana","year":"2017","unstructured":"Montagnana M, Benati M, Danese E, Giudici S, Perfranceschi M, Ruzzenenete O, Salvagno GL, Bassi A, Gelati M, Paviati E, Guidi GC, Franchi M, Lippi G (2017) Aberrant MicroRNA expression in patients with endometrial cancer. Int J Gynecol Cancer 27:459\u2013466. https:\/\/doi.org\/10.1097\/IGC.0000000000000913","journal-title":"Int J Gynecol Cancer"},{"key":"819_CR5","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.7754\/Clin.Lab.2017.170421","volume":"63","author":"M Benati","year":"2017","unstructured":"Benati M, Montagnana M, Danese E, Paviati E, Giudici S, Franchi M, Lippi G (2017) Evaluation of mir-203 expression levels and DNA promoter methylation status in serum of patients with endometrial cancer. Clin Lab 63:1675\u20131681. https:\/\/doi.org\/10.7754\/Clin.Lab.2017.170421","journal-title":"Clin Lab"},{"key":"819_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22223","volume":"32","author":"M Benati","year":"2018","unstructured":"Benati M, Montagnana M, Danese E, Paviati E, Giudici S, Ruzzenente O, Franchi M, Lippi G (2018) The clinical significance of DJ-1 and HE4 in patients with endometrial cancer. J Clin Lab Anal 32:e22223. https:\/\/doi.org\/10.1002\/jcla.22223","journal-title":"J Clin Lab Anal"},{"key":"819_CR7","doi-asserted-by":"crossref","unstructured":"Casarin J, Bogani G, Serati M, Pinelli C, Lagan\u00e0 AS, Garzon S, Raspagliesi F, Ghezzi F (2019) Presence of glandular cells at the preoperative cervical cytology and local recurrence in endometrial cancer. Int J Gynecol Pathol.\u00a0 https:\/\/doi.org\/10.1097\/PGP.0000000000000642","DOI":"10.1097\/PGP.0000000000000642"},{"key":"819_CR8","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/350569a0","volume":"350","author":"EH Blackburn","year":"1991","unstructured":"Blackburn EH (1991) Structure and function of telomeres. Nature 350:569\u2013573. https:\/\/doi.org\/10.1038\/350569a0","journal-title":"Nature"},{"key":"819_CR9","doi-asserted-by":"publisher","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","volume":"85","author":"RK Moyzis","year":"1988","unstructured":"Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD, Meyne J, Ratliff RL, Wu JR (1988) A highly conserved repetitive DNA sequence, (TTAGGG) n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 85:6622\u20136626. https:\/\/doi.org\/10.1073\/pnas.85.18.6622","journal-title":"Proc Natl Acad Sci U S A"},{"key":"819_CR10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","volume":"26","author":"B McClintock","year":"1941","unstructured":"McClintock B (1941) The stability of broken ends of chromosomes in Zea Mays. Genetics 26:234\u2013282","journal-title":"Genetics"},{"key":"819_CR11","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrg1656","volume":"6","author":"MA Blasco","year":"2005","unstructured":"Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6:611\u2013622. https:\/\/doi.org\/10.1038\/nrg1656","journal-title":"Nat Rev Genet"},{"key":"819_CR12","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/sj.neo.7900267","volume":"4","author":"AW Lo","year":"2002","unstructured":"Lo AW, Sabatier L, Fouladi B, Pottier G, Ricoul M, Mumane JP (2002) DNA amplification by breakage\/fusion\/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia 4:531\u2013538. https:\/\/doi.org\/10.1038\/sj.neo.7900267","journal-title":"Neoplasia"},{"key":"819_CR13","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1126\/science.297.5581.565","volume":"297","author":"RS Maser","year":"2002","unstructured":"Maser RS (2002) Connecting chromosomes, crisis, and cancer. Science 297:565\u2013569. https:\/\/doi.org\/10.1126\/science.297.5581.565","journal-title":"Science"},{"key":"819_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nrc3537","volume":"13","author":"SF Bunting","year":"2013","unstructured":"Bunting SF, Nussenzweig A (2013) End-joining, translocations and cancer. Nat Rev Cancer 13:443\u2013454. https:\/\/doi.org\/10.1038\/nrc3537","journal-title":"Nat Rev Cancer"},{"key":"819_CR15","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1073\/pnas.91.8.2900","volume":"91","author":"CM Counter","year":"1994","unstructured":"Counter CM, Hirte HW, Bacchetti S, Harley CB (1994) Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A 91:2900\u20132904. https:\/\/doi.org\/10.1073\/pnas.91.8.2900","journal-title":"Proc Natl Acad Sci U S A"},{"key":"819_CR16","doi-asserted-by":"publisher","unstructured":"Hastie ND, Dempster M, Dunlop MG,\u00a0Thompson AM, Green DK, Allshire\u00a0RC\u00a0(1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866\u2013868. https:\/\/doi.org\/10.1038\/346866a0","DOI":"10.1038\/346866a0"},{"key":"819_CR17","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.leukres.2003.11.020","volume":"28","author":"Z Sieglov\u00e1","year":"2004","unstructured":"Sieglov\u00e1 Z, \u017dilovcov\u00e1 S, \u010cerm\u00e1k J, \u0158\u0131\u0301hov\u00e1 H, B\u0159ezinov\u00e1 D, Dvo\u0159\u00e1kov\u00e1 R, Markov\u00e1 M, Maaloufov\u00e1 J, Sajdov\u00e1 J, B\u0159ezinov\u00e1 J, Zemanov\u00e1 Z, Michalov\u00e1 K (2004) Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis? Leuk Res 28:1013\u20131021. https:\/\/doi.org\/10.1016\/j.leukres.2003.11.020","journal-title":"Leuk Res"},{"key":"819_CR18","doi-asserted-by":"publisher","unstructured":"McGrath M, Wong JY, Michaud D,\u00a0Hunter DJ, De Vivo\u00a0I (2007) Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomark Prev 16:815\u2013819. https:\/\/doi.org\/10.1158\/1055-9965.EPI-06-0961","DOI":"10.1158\/1055-9965.EPI-06-0961"},{"key":"819_CR19","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.juro.2007.05.112","volume":"178","author":"L Shao","year":"2007","unstructured":"Shao L, Wood CG, Zhang D, Tannir NM, Matin S, Dinney CP, Wu X (2007) Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer. J Urol 178:1492\u20131496. https:\/\/doi.org\/10.1016\/j.juro.2007.05.112","journal-title":"J Urol"},{"key":"819_CR20","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/jnci\/djg011","volume":"95","author":"X Wu","year":"2003","unstructured":"Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR (2003) Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95:1211\u20131218. https:\/\/doi.org\/10.1093\/jnci\/djg011","journal-title":"J Natl Cancer Inst"},{"key":"819_CR21","doi-asserted-by":"publisher","unstructured":"Jang JS, Choi YY, Lee WK, Choi JE, Cha SI, Kim YJ, Kim CH, Kam S, Jung TH, Park JY\u00a0(2008) Telomere length and the risk of lung cancer. Cancer Sci 99:1385\u20131389. https:\/\/doi.org\/10.1111\/j.1349-7006.2008.00831.x","DOI":"10.1111\/j.1349-7006.2008.00831.x"},{"key":"819_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/jama.2010.897","volume":"304","author":"P Willeit","year":"2010","unstructured":"Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandst\u00e4tter A, Kronenberg F, Kiechl S (2010) Telomere length and risk of incident cancer and cancer mortality. JAMA 304:69\u201375. https:\/\/doi.org\/10.1001\/jama.2010.897","journal-title":"JAMA"},{"key":"819_CR23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1093\/jnci\/djt016","volume":"105","author":"M Weischer","year":"2013","unstructured":"Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybj\u00e6rg-Hansen A, Bojesen SE (2013) Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 105:459\u2013468. https:\/\/doi.org\/10.1093\/jnci\/djt016","journal-title":"J Natl Cancer Inst"},{"key":"819_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnci\/djv074","volume":"107","author":"L Rode","year":"2015","unstructured":"Rode L, Nordestgaard BG, Bojesen SE (2015) Peripheral blood leukocyte telomere length and mortality among 64 637 individuals from the general population. J Natl Cancer Inst 107:1\u20138. https:\/\/doi.org\/10.1093\/jnci\/djv074","journal-title":"J Natl Cancer Inst"},{"key":"819_CR25","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/j.1478-3231.2012.02801.x","volume":"32","author":"S Wan","year":"2012","unstructured":"Wan S, Hann HW, Myers RE, Fu X, Hann RS, Kim SH, Tang H, Xing J, Yang H (2012) Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis: a nested case-control analysis. Liver Int 32:1233\u20131241. https:\/\/doi.org\/10.1111\/j.1478-3231.2012.02801.x","journal-title":"Liver Int"},{"key":"819_CR26","doi-asserted-by":"publisher","first-page":"29795","DOI":"10.18632\/oncotarget.5083","volume":"6","author":"X Wu","year":"2015","unstructured":"Wu X, Tanaka H (2015) Aberrant reduction of telomere repetitive sequences in plasma cell-free DNA for early breast cancer detection. Oncotarget 6:29795\u201329807. https:\/\/doi.org\/10.18632\/oncotarget.5083","journal-title":"Oncotarget"},{"key":"819_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/carcin\/bgx021","volume":"38","author":"S Wan","year":"2017","unstructured":"Wan S, Hann HW, Ye Z, Hann RS, Lai Y, Wang C, Li L, Myers RE, Li B, Xing J, Yang H (2017) Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients. Carcinogenesis 38:439\u2013446. https:\/\/doi.org\/10.1093\/carcin\/bgx021","journal-title":"Carcinogenesis"},{"key":"819_CR28","doi-asserted-by":"publisher","unstructured":"Franchi M, Garzon S, Zorzato PC, Lagan\u00e0 AS, Casarin J, Locantore L, Raffaelli R, Ghezzi F (2019) PET-CT scan in the preoperative workup of early stage intermediate- and high-risk endometrial cancer. Minim Invasive Ther Allied Technol. https:\/\/doi.org\/10.1080\/13645706.2019.1624576","DOI":"10.1080\/13645706.2019.1624576"},{"key":"819_CR29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ijgo.2009.02.010","volume":"105","author":"W Creasman","year":"2009","unstructured":"Creasman W (2009) Revised FIGO staging for carcinoma of the endometrium. Int J Gynecol Obstet 105:109\u2013109. https:\/\/doi.org\/10.1016\/j.ijgo.2009.02.010","journal-title":"Int J Gynecol Obstet"},{"key":"819_CR30","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","volume":"30","author":"RM Cawthon","year":"2002","unstructured":"Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30:e47\u2013e51","journal-title":"Nucleic Acids Res"},{"key":"819_CR31","doi-asserted-by":"publisher","first-page":"268","DOI":"10.21037\/atm.2017.06.20","volume":"5","author":"M Montagnana","year":"2017","unstructured":"Montagnana M, Lippi G (2017) Cancer diagnostics: current concepts and future perspectives. Ann Transl Med 5:268\u2013271. https:\/\/doi.org\/10.21037\/atm.2017.06.20","journal-title":"Ann Transl Med"},{"key":"819_CR32","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.2174\/1381612819666131206110317","volume":"20","author":"D Cerne","year":"2014","unstructured":"Cerne D, Bajalo JL (2014) Cell-free nucleic acids as a non-invasive route for investigating atherosclerosis. Curr Pharm Des 20:5004\u20135009. https:\/\/doi.org\/10.2174\/1381612819666131206110317","journal-title":"Curr Pharm Des"},{"key":"819_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","volume":"14","author":"G Siravegna","year":"2017","unstructured":"Siravegna G, Marsoni S, Siena S, Bardelli A (2017) Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol 14:531\u2013548. https:\/\/doi.org\/10.1038\/nrclinonc.2017.14","journal-title":"Nat Rev Clin Oncol"},{"key":"819_CR34","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.febslet.2007.01.051","volume":"581","author":"V Swarup","year":"2007","unstructured":"Swarup V, Rajeswari MR (2007) Circulating (cell-free) nucleic acids - a promising, non-invasive tool for early detection of several human diseases. FEBS Lett 581:795\u2013799. https:\/\/doi.org\/10.1016\/j.febslet.2007.01.051","journal-title":"FEBS Lett"},{"key":"819_CR35","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1055\/s-0034-1387923","volume":"40","author":"E Danese","year":"2014","unstructured":"Danese E, Montagnana M, Fava C, Guidi G (2014) Circulating nucleic acids and hemostasis: biological basis behind their relationship and technical issues in assessment. Semin Thromb Hemost 40:766\u2013773 https:\/\/doi.org\/10.1055\/s-0034-1387923","journal-title":"Semin Thromb Hemost"},{"key":"819_CR36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1196\/annals.1318.005","volume":"1022","author":"H Schwarzenbach","year":"2004","unstructured":"Schwarzenbach H, M\u00fcller V, Stahmann N, Pantel K (2004) Detection and characterization of circulating microsatellite-DNA in blood of patients with breast cancer. Ann N Y Acad Sci 1022:25\u201332. https:\/\/doi.org\/10.1196\/annals.1318.005","journal-title":"Ann N Y Acad Sci"},{"key":"819_CR37","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.1158\/1078-0432.CCR-12-0142","volume":"18","author":"H Schwarzenbach","year":"2012","unstructured":"Schwarzenbach H, Eichelser C, Kropidlowski J, Janni W, Rack B, Pantel K (2012) Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression. Clin Cancer Res 18:5719\u20135730. https:\/\/doi.org\/10.1158\/1078-0432.CCR-12-0142","journal-title":"Clin Cancer Res"},{"key":"819_CR38","doi-asserted-by":"publisher","unstructured":"Phallen J, Sausen M, Adleff V,\u00a0Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz Jr LA, Jones S, Angiuoli S, \u00d8rntoft T, Nielsen HJ, Andersen CL, Velculescu\u00a0VE (2017) Direct detection of early-stage cancers using circulating tumor DNA. Sci Transl med 9:eaan2415. https:\/\/doi.org\/10.1126\/scitranslmed.aan2415","DOI":"10.1126\/scitranslmed.aan2415"},{"key":"819_CR39","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-1-4939-7778-9_13","volume":"1768","author":"AJ Medford","year":"2018","unstructured":"Medford AJ, Gillani RN, Park BH (2018) Detection of cancer DNA in early stage and metastatic breast cancer patients. Methods Mol Biol 1768:209\u2013227. https:\/\/doi.org\/10.1007\/978-1-4939-7778-9_13","journal-title":"Methods Mol Biol"},{"key":"819_CR40","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrc3066","volume":"11","author":"H Schwarzenbach","year":"2011","unstructured":"Schwarzenbach H, Hoon DS, Pantel K (2011) Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 11:426\u2013437. https:\/\/doi.org\/10.1038\/nrc3066","journal-title":"Nat Rev Cancer"},{"key":"819_CR41","first-page":"1659","volume":"61","author":"S Jahr","year":"2001","unstructured":"Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R (2001) DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61:1659\u20131665","journal-title":"Cancer Res"},{"key":"819_CR42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1373\/clinchem.2014.222679","volume":"61","author":"E Heitzer","year":"2015","unstructured":"Heitzer E, Ulz P, Geigl JB (2015) Circulating tumor DNA as a liquid biopsy for cancer. Clin Chem 61:112\u2013123. https:\/\/doi.org\/10.1373\/clinchem.2014.222679","journal-title":"Clin Chem"},{"key":"819_CR43","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/bs.acc.2016.11.005","volume":"80","author":"S Perakis","year":"2017","unstructured":"Perakis S, Auer M, Belic J, Heitzer E (2017) Advances in circulating tumor DNA analysis. Adv Clin Chem 80:73\u2013153. https:\/\/doi.org\/10.1016\/bs.acc.2016.11.005","journal-title":"Adv Clin Chem"},{"key":"819_CR44","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/ijc.30759","volume":"141","author":"P Ulz","year":"2017","unstructured":"Ulz P, Heitzer E, Geigl JB, Speicher MR (2017) Patient monitoring through liquid biopsies using circulating tumor DNA. Int J Cancer 141:887\u2013896. https:\/\/doi.org\/10.1002\/ijc.30759","journal-title":"Int J Cancer"},{"key":"819_CR45","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1586\/14737159.2013.845088","volume":"13","author":"DM Marzese","year":"2013","unstructured":"Marzese DM, Hirose H, Hoon DS (2013) Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients. Expert Rev Mol Diagn 13:827\u2013844. https:\/\/doi.org\/10.1586\/14737159.2013.845088","journal-title":"Expert Rev Mol Diagn"},{"key":"819_CR46","doi-asserted-by":"publisher","unstructured":"Chan KC, Jiang P, Zheng YW,\u00a0Liao GJ, Sun H, Wong J, Siu SS, Chan WC, Chan SL, Chan AT, Lai PB, Chiu RW, Lo YM\u00a0(2013) Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and Tumoral heterogeneity by massively parallel sequencing. Clin Chem 59:211\u2013224. https:\/\/doi.org\/10.1373\/clinchem.2012.196014","DOI":"10.1373\/clinchem.2012.196014"},{"key":"819_CR47","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nature12113","volume":"497","author":"The Cancer Genome Atlas Research Network","year":"2013","unstructured":"The Cancer Genome Atlas Research Network (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497:67\u201373 https:\/\/doi.org\/10.1038\/nature12113","journal-title":"Nature"},{"key":"819_CR48","doi-asserted-by":"publisher","unstructured":"MacKay HJ, Levine DA, Bae-Jump VL, Bell DW, McAlpine JN, Santin A, Fleming GF, Mutch DG, Nephew KP, Wentzensen N, Goodfellow PJ, Dorigo O, Nijman HW, Broaddus R, Kohn EC\u00a0(2017) Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials. Oncotarget 8:84579\u201384594 https:\/\/doi.org\/10.18632\/oncotarget.19961","DOI":"10.18632\/oncotarget.19961"},{"key":"819_CR49","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1093\/ije\/dyu191","volume":"44","author":"CM Martin-Ruiz","year":"2015","unstructured":"Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T (2015) Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol 44:1673\u20131683. https:\/\/doi.org\/10.1093\/ije\/dyu191","journal-title":"Int J Epidemiol"},{"key":"819_CR50","doi-asserted-by":"publisher","unstructured":"Cicchillitti L, Corrado G, De Angeli M,\u00a0Mancini E, Baiocco E, Patrizi L, Zampa A, Merola R, Martayan A, Conti L, Piaggio G, Vizza E\u00a0(2017) Circulating cell-free DNA content as blood based biomarker in endometrial cancer. Oncotarget 8:115230\u2013115243. https:\/\/doi.org\/10.18632\/oncotarget.23247","DOI":"10.18632\/oncotarget.23247"},{"key":"819_CR51","doi-asserted-by":"publisher","unstructured":"Vizza E, Corrado G, De Angeli M,\u00a0Carosi M, Mancini E, Baiocco E, Chiofalo B, Patrizi L, Zampa A, Piaggio G, Cicchillitti L\u00a0(2018) Serum DNA integrity index as a potential molecular biomarker in endometrial cancer. J Exp Clin Cancer Res 37:16\u201324. https:\/\/doi.org\/10.1186\/s13046-018-0688-4","DOI":"10.1186\/s13046-018-0688-4"},{"key":"819_CR52","doi-asserted-by":"publisher","unstructured":"Harley CB (1991) Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256:271\u2013282. https:\/\/doi.org\/10.1016\/0921-8734(91)90018-7","DOI":"10.1016\/0921-8734(91)90018-7"},{"key":"819_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2174\/1874609808666150122153151","volume":"7","author":"S Rizvi","year":"2014","unstructured":"Rizvi S, Raza ST, Mahdi F (2014) Telomere length variations in aging and age-related diseases. Curr Aging Sci 7:161\u2013167 https:\/\/doi.org\/10.2174\/1874609808666150122153151","journal-title":"Curr Aging Sci"},{"key":"819_CR54","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1023\/A:1022922726418","volume":"8","author":"RG Goya","year":"2003","unstructured":"Goya RG, C\u00f3nsole GM, Spinelli OM, Carino MH, Riccillo F, Corrons FJ (2003) Glucocorticoid-induced apoptosis in lymphoid organs is associated with a delayed increase in circulating deoxyribonucleic acid. Apoptosis 8:171\u2013177. https:\/\/doi.org\/10.1023\/A:1022922726418","journal-title":"Apoptosis"},{"key":"819_CR55","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000486586","volume":"20","author":"LM P\u00e9rez","year":"2017","unstructured":"P\u00e9rez LM, Amaral MA, Mundstock E, Barb\u00e9-Tuana FM, Guma FTCR, Jones MH, Machado DC, Sarria EE, Marques e Marques M, Preto LT, Epifanio M, Meinem Garbin JG, Mattiello R (2017) Effects of diet on telomere length: systematic review and meta-analysis. Public Health Genomics 20:286\u2013292. https:\/\/doi.org\/10.1159\/000486586","journal-title":"Public Health Genomics"},{"key":"819_CR56","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1196\/annals.1448.016","volume":"1137","author":"AV Cherepanova","year":"2008","unstructured":"Cherepanova AV, Tamkovich SN, Bryzgunova OE, Vlassov VV, Laktionov PP (2008) Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors. Ann N Y Acad Sci 1137:218\u2013221. https:\/\/doi.org\/10.1196\/annals.1448.016","journal-title":"Ann N Y Acad Sci"},{"key":"819_CR57","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.envres.2017.06.038","volume":"158","author":"Y Astuti","year":"2017","unstructured":"Astuti Y, Wardhana A, Watkins J, Wulaningsih W (2017) Cigarette smoking and telomere length: a systematic review of 84 studies and meta-analysis. Environ Res 158:480\u2013489. https:\/\/doi.org\/10.1016\/j.envres.2017.06.038","journal-title":"Environ Res"},{"key":"819_CR58","doi-asserted-by":"publisher","unstructured":"Haghiac M, Vora NL, Basu S, Johnson KL, Presley L, Bianchi DW, de Mouzon SH (2012) Increased death of adipose cells, a path to release cell free DNA into systemic circulation of obese women. Obesity (Silver Spring) Md 20:2213\u20132219. https:\/\/doi.org\/10.1038\/oby.2012.138","DOI":"10.1038\/oby.2012.138"},{"key":"819_CR59","doi-asserted-by":"publisher","unstructured":"Needham BL, Adler N, Gregorich S, Rehkopf D, Lin J, Blackburn EH, Epel ES (2013) socioeconomic status, health behavior, and leukocyte telomere length in the National Health and nutrition examination survey, 1999\u20132002. Soc Sci Med 85:1\u20138. https:\/\/doi.org\/10.1016\/j.socscimed.2013.02.023","DOI":"10.1016\/j.socscimed.2013.02.023"},{"key":"819_CR60","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.yexcr.2012.09.005","volume":"319","author":"W Lu","year":"2013","unstructured":"Lu W, Zhang Y, Liu D, Songyang Z, Wan M (2013) Telomeres-structure, function, and regulation. Exp Cell Res 319:133\u2013141 https:\/\/doi.org\/10.1016\/j.yexcr.2012.09.005","journal-title":"Exp Cell Res"},{"key":"819_CR61","doi-asserted-by":"publisher","first-page":"g4227","DOI":"10.1136\/bmj.g4227","volume":"349","author":"PC Haycock","year":"2014","unstructured":"Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P (2014) Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 349:g4227. https:\/\/doi.org\/10.1136\/bmj.g4227","journal-title":"BMJ"},{"key":"819_CR62","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3389\/fendo.2018.00309","volume":"9","author":"S Pavanello","year":"2018","unstructured":"Pavanello S, Angelici L, Hoxha M, Cantone L, Campisi M, Tirelli AS, Vigna L, Pesatori AC, Bollati V (2018) Sterol 27-hydroxylase polymorphism significantly associates with shorter telomere, higher cardiovascular and Type-2 diabetes risk in obese subjects. Front Endocrinol 9:309. https:\/\/doi.org\/10.3389\/fendo.2018.00309","journal-title":"Front Endocrinol"},{"key":"819_CR63","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.schres.2018.07.015","volume":"202","author":"P Russo","year":"2018","unstructured":"Russo P, Prinzi G, Proietti S, Lamonaca P, Frustaci A, Boccia S, Amore R, Lorenzi M, onder G, Marzetti E, Valdiglesias V, Guadagni F, Valente MG, Cascio GL, Fraietta S, Ducci G, Bonassi S (2018) Shorter telomere length in schizophrenia: evidence from a real-world population and meta-analysis of most recent literature. Schizophr Res 202:37\u201345. https:\/\/doi.org\/10.1016\/j.schres.2018.07.015","journal-title":"Schizophr Res"},{"key":"819_CR64","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/mp.2014.89","volume":"20","author":"BL Needham","year":"2015","unstructured":"Needham BL, Mezuk B, Bareis N, Lin J, Blackburn EH, Epel ES (2015) Depression, anxiety and telomere length in young adults: evidence from the National Health and nutrition examination survey. Mol Psychiatry 20:520\u2013528. https:\/\/doi.org\/10.1038\/mp.2014.89","journal-title":"Mol Psychiatry"},{"key":"819_CR65","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/j.neurobiolaging.2009.12.006","volume":"32","author":"K Yaffe","year":"2011","unstructured":"Yaffe K, Lindquist K, Kluse M, Cawthon R, Harris T, Hsueh WC, Simonsick EM, Kuller L, Li R, Ayonayon HN, Rubin SM, Cummings SR (2011) Telomere length and cognitive function in community-dwelling elders: findings from the health ABC study. Neurobiol Aging 32:2055\u20132060. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.12.006","journal-title":"Neurobiol Aging"},{"key":"819_CR66","doi-asserted-by":"publisher","unstructured":"Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL (2015) Telomere length variation: a potential new telomere biomarker for lung cancer risk. Lung Cancer 88:297\u2013303. https:\/\/doi.org\/10.1016\/j.lungcan.2015.03.011","DOI":"10.1016\/j.lungcan.2015.03.011"},{"key":"819_CR67","doi-asserted-by":"publisher","unstructured":"Latifovic L, Peacock SD, Massey TE, King WD (2016) The influence of alcohol consumption, cigarette smoking, and physical activity on leukocyte telomere length. Cancer Epidemiol Biomarkers Prev 25:374\u2013380. https:\/\/doi.org\/10.1158\/1055-9965.EPI-14-1364","DOI":"10.1158\/1055-9965.EPI-14-1364"},{"key":"819_CR68","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/MCO.0b013e32834121b1","volume":"14","author":"MA Shammas","year":"2011","unstructured":"Shammas MA (2011) Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care 14:28\u201334. https:\/\/doi.org\/10.1097\/MCO.0b013e32834121b1","journal-title":"Curr Opin Clin Nutr Metab Care"}],"container-title":["Pathology & Oncology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-020-00819-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12253-020-00819-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12253-020-00819-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T02:06:52Z","timestamp":1666663612000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12253-020-00819-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["819"],"URL":"https:\/\/doi.org\/10.1007\/s12253-020-00819-x","relation":{},"ISSN":["1219-4956","1532-2807"],"issn-type":[{"value":"1219-4956","type":"print"},{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"assertion":[{"value":"25 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no proprietary, financial, professional or other personal interest of any nature in any product, service or company. The authors alone are responsible for the content and writing of the paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}