{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:56:44Z","timestamp":1721131004939},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Nutr"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s12263-013-0355-5","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T13:58:00Z","timestamp":1375711080000},"page":"581-587","source":"Crossref","is-referenced-by-count":8,"title":["PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case\u2013control study in a population with relatively low folate intake"],"prefix":"10.1007","volume":"8","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"issue":"14","key":"355_CR1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1096\/fasebj.7.14.7901104","volume":"7","author":"RH Allen","year":"1993","unstructured":"Allen RH, Stabler SP, Savage DG, Lindenbaum J (1993) Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J 7(14):1344\u20131353","journal-title":"FASEB J"},{"issue":"2","key":"355_CR2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263\u2013265. doi: 10.1093\/bioinformatics\/bth457","journal-title":"Bioinformatics"},{"issue":"3","key":"355_CR3","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1136\/fn.78.3.F234c","volume":"78","author":"K Boduroglu","year":"1998","unstructured":"Boduroglu K, Alikasifoglu M, Anar B, Tuncbilek E (1998) 677\u2013\u00a0>\u00a0CT mutation on the methylenetetrahydrofolate reductase gene is not a risk factor for neural tube defects in Turkey. Arch Dis Child Fetal Neonatal Ed 78(3):F235","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"9","key":"355_CR4","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","volume":"151","author":"LD Botto","year":"2000","unstructured":"Botto LD, Yang Q (2000) 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151(9):862\u2013877","journal-title":"Am J Epidemiol"},{"issue":"10","key":"355_CR5","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1289\/ehp.9166","volume":"114","author":"AL Boyles","year":"2006","unstructured":"Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC (2006) Neural tube defects and folate pathway genes: family-based association tests of gene\u2013gene and gene-environment interactions. Environ Health Perspect 114(10):1547\u20131552","journal-title":"Environ Health Perspect"},{"issue":"40","key":"355_CR6","doi-asserted-by":"crossref","first-page":"10757","DOI":"10.1021\/bi8013467","volume":"47","author":"WG Carter","year":"2008","unstructured":"Carter WG, Aswad DW (2008) Formation, localization, and repair of l-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes. Biochemistry 47(40):10757\u201310764. doi: 10.1021\/bi8013467","journal-title":"Biochemistry"},{"issue":"26","key":"355_CR7","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","volume":"327","author":"AE Czeizel","year":"1992","unstructured":"Czeizel AE, Dudas I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327(26):1832\u20131835. doi: 10.1056\/NEJM199212243272602","journal-title":"N Engl J Med"},{"issue":"2","key":"355_CR8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/abbi.1997.0303","volume":"346","author":"CL David","year":"1997","unstructured":"David CL, Szumlanski CL, DeVry CG, Park-Hah JO, Clarke S, Weinshilboum RM, Aswad DW (1997) Human erythrocyte protein l-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability. Arch Biochem Biophys 346(2):277\u2013286. doi: 10.1006\/abbi.1997.0303","journal-title":"Arch Biochem Biophys"},{"issue":"Suppl 1","key":"355_CR9","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1002\/tera.90005","volume":"66","author":"MJ Davidoff","year":"2002","unstructured":"Davidoff MJ, Petrini J, Damus K, Russell RB, Mattison D (2002) Neural tube defect-specific infant mortality in the United States. Teratology 66(Suppl 1):S17\u2013S22. doi: 10.1002\/tera.90005","journal-title":"Teratology"},{"issue":"2","key":"355_CR10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa067103","volume":"357","author":"P Wals De","year":"2007","unstructured":"De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, Fernandez B, Lee NS, Niyonsenga T (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357(2):135\u2013142. doi: 10.1056\/NEJMoa067103","journal-title":"N Engl J Med"},{"issue":"5","key":"355_CR11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s100380050161","volume":"44","author":"CG DeVry","year":"1999","unstructured":"DeVry CG, Clarke S (1999) Polymorphic forms of the protein l-isoaspartate (d-aspartate) O-methyltransferase involved in the repair of age-damaged proteins. J Hum Genet 44(5):275\u2013288. doi: 10.1007\/s100380050161","journal-title":"J Hum Genet"},{"issue":"31","key":"355_CR12","doi-asserted-by":"crossref","first-page":"27856","DOI":"10.1074\/jbc.M203911200","volume":"277","author":"C Farrar","year":"2002","unstructured":"Farrar C, Clarke S (2002) Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of l-isoaspartyl (d-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem 277(31):27856\u201327863. doi: 10.1074\/jbc.M203911200","journal-title":"J Biol Chem"},{"issue":"6","key":"355_CR13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/bdra.20545","volume":"85","author":"M Felkner","year":"2009","unstructured":"Felkner M, Suarez L, Canfield MA, Brender JD, Sun Q (2009) Maternal serum homocysteine and risk for neural tube defects in a Texas-Mexico border population. Birth Defects Res A Clin Mol Teratol 85(6):574\u2013581. doi: 10.1002\/bdra.20545","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"Suppl 3","key":"355_CR14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1528-1157.44.s3.5.x","volume":"44","author":"RH Finnell","year":"2003","unstructured":"Finnell RH, Gould A, Spiegelstein O (2003) Pathobiology and genetics of neural tube defects. Epilepsia 44(Suppl 3):14\u201323","journal-title":"Epilepsia"},{"issue":"6","key":"355_CR15","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/jn\/132.6.1357","volume":"132","author":"H Ghandour","year":"2002","unstructured":"Ghandour H, Lin BF, Choi SW, Mason JB, Selhub J (2002) Folate status and age affect the accumulation of l-isoaspartyl residues in rat liver proteins. J Nutr 132(6):1357\u20131360","journal-title":"J Nutr"},{"issue":"10","key":"355_CR16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/bdra.20397","volume":"79","author":"X Gu","year":"2007","unstructured":"Gu X, Lin L, Zheng X, Zhang T, Song X, Wang J, Li X, Li P, Chen G, Wu J, Wu L, Liu J (2007) High prevalence of NTDs in Shanxi Province: a combined epidemiological approach. Birth Defects Res A Clin Mol Teratol 79(10):702\u2013707. doi: 10.1002\/bdra.20397","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"355_CR17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bdra.20333","volume":"79","author":"MJ Harris","year":"2007","unstructured":"Harris MJ, Juriloff DM (2007) Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. Birth Defects Res A Clin Mol Teratol 79(3):187\u2013210. doi: 10.1002\/bdra.20333","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"7","key":"355_CR18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM197602122940704","volume":"294","author":"LB Holmes","year":"1976","unstructured":"Holmes LB, Driscoll SG, Atkins L (1976) Etiologic heterogeneity of neural-tube defects. N Engl J Med 294(7):365\u2013369. doi: 10.1056\/NEJM197602122940704","journal-title":"N Engl J Med"},{"issue":"2","key":"355_CR19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0378-1119(99)00443-6","volume":"240","author":"KJ Huebscher","year":"1999","unstructured":"Huebscher KJ, Lee J, Rovelli G, Ludin B, Matus A, Stauffer D, Furst P (1999) Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis. Gene 240(2):333\u2013341","journal-title":"Gene"},{"issue":"6","key":"355_CR20","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jhep.2007.01.026","volume":"46","author":"KK Kharbanda","year":"2007","unstructured":"Kharbanda KK, Mailliard ME, Baldwin CR, Sorrell MF, Tuma DJ (2007) Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-l-isoaspartyl methyltransferase activity. J Hepatol 46(6):1119\u20131125. doi: 10.1016\/j.jhep.2007.01.026","journal-title":"J Hepatol"},{"issue":"4","key":"355_CR21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bbrc.2009.02.082","volume":"381","author":"KK Kharbanda","year":"2009","unstructured":"Kharbanda KK, Vigneswara V, McVicker BL, Newlaczyl AU, Bailey K, Tuma D, Ray DE, Carter WG (2009) Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Biochem Biophys Res Commun 381(4):523\u2013527. doi: 10.1016\/j.bbrc.2009.02.082","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"355_CR22","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1073\/pnas.94.12.6132","volume":"94","author":"E Kim","year":"1997","unstructured":"Kim E, Lowenson JD, MacLaren DC, Clarke S, Young SG (1997) Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Proc Natl Acad Sci USA 94(12):6132\u20136137","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"355_CR23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2008.03.109","volume":"371","author":"S Kosugi","year":"2008","unstructured":"Kosugi S, Furuchi T, Katane M, Sekine M, Shirasawa T, Homma H (2008) Suppression of protein l-isoaspartyl (d-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells. Biochem Biophys Res Commun 371(1):22\u201327. doi: 10.1016\/j.bbrc.2008.03.109","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"355_CR24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1034\/j.1399-0004.2003.00161.x","volume":"64","author":"CL Relton","year":"2003","unstructured":"Relton CL, Wilding CS, Jonas PA, Lynch SA, Tawn EJ, Burn J (2003) Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype. Clin Genet 64(5):424\u2013428","journal-title":"Clin Genet"},{"issue":"26","key":"355_CR25","doi-asserted-by":"crossref","first-page":"15227","DOI":"10.1073\/pnas.93.26.15227","volume":"93","author":"TH Rosenquist","year":"1996","unstructured":"Rosenquist TH, Ratashak SA, Selhub J (1996) Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc Natl Acad Sci USA 93(26):15227\u201315232","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"355_CR26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/protein\/gzp056","volume":"22","author":"K Rutherford","year":"2009","unstructured":"Rutherford K, Daggett V (2009) The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface. Protein Eng Des Sel. 22(12):713\u2013721. doi: 10.1093\/protein\/gzp056","journal-title":"Protein Eng Des Sel."},{"issue":"2","key":"355_CR27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/tera.1420490210","volume":"49","author":"GM Shaw","year":"1994","unstructured":"Shaw GM, Jensvold NG, Wasserman CR, Lammer EJ (1994) Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births, 1983-1987. Teratology 49(2):143\u2013149. doi: 10.1002\/tera.1420490210","journal-title":"Teratology"},{"issue":"6","key":"355_CR28","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1023\/B:NERE.0000023597.37698.13","volume":"29","author":"O Spiegelstein","year":"2004","unstructured":"Spiegelstein O, Cabrera RM, Bozinov D, Wlodarczyk B, Finnell RH (2004) Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos. Neurochem Res 29(6):1105\u20131112","journal-title":"Neurochem Res"},{"issue":"8801","key":"355_CR29","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/0140-6736(92)90725-I","volume":"339","author":"RP Steegers-Theunissen","year":"1992","unstructured":"Steegers-Theunissen RP, Boers GH, Blom HJ, Trijbels FJ, Eskes TK (1992) Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 339(8801):1122\u20131123","journal-title":"Lancet"},{"issue":"12","key":"355_CR30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0026-0495(94)90004-3","volume":"43","author":"RP Steegers-Theunissen","year":"1994","unstructured":"Steegers-Theunissen RP, Boers GH, Trijbels FJ, Finkelstein JD, Blom HJ, Thomas CM, Borm GF, Wouters MG, Eskes TK (1994) Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 43(12):1475\u20131480","journal-title":"Metabolism"},{"issue":"2","key":"355_CR31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1079\/PNS2006495","volume":"65","author":"IJ Linden van der","year":"2006","unstructured":"van der Linden IJ, Afman LA, Heil SG, Blom HJ (2006) Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc 65(2):204\u2013215","journal-title":"Proc Nutr Soc"},{"issue":"4","key":"355_CR32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/153537020122600402","volume":"226","author":"NM Put van der","year":"2001","unstructured":"van der Put NM, van Straaten HW, Trijbels FJ, Blom HJ (2001) Folate, homocysteine and neural tube defects: an overview. Exp Biol Med (Maywood) 226(4):243\u2013270","journal-title":"Exp Biol Med (Maywood)"},{"issue":"5","key":"355_CR33","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3945\/ajcn.2009.28858","volume":"91","author":"L Wang","year":"2010","unstructured":"Wang L, Wang F, Guan J, Le J, Wu L, Zou J, Zhao H, Pei L, Zheng X, Zhang T (2010) Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am J Clin Nutr 91(5):1359\u20131367. doi: 10.3945\/ajcn.2009.28858","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"355_CR34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0895-3988(08)60005-7","volume":"21","author":"BY Zhang","year":"2008","unstructured":"Zhang BY, Zhang T, Lin LM, Wang F, Xin RL, Gu X, He YN, Yu DM, Li PZ, Zhang QS, Zhao J, Qin YF, Yang XF, Chen G, Liu JF, Song XM, Zheng XY (2008a) Correlation between birth defects and dietary nutrition status in a high incidence area of China. Biomed Environ Sci 21(1):37\u201344. doi: 10.1016\/S0895-3988(08)60005-7","journal-title":"Biomed Environ Sci"},{"issue":"2","key":"355_CR35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.expneurol.2008.04.044","volume":"212","author":"HY Zhang","year":"2008","unstructured":"Zhang HY, Luo GA, Liang QL, Wang Y, Yang HH, Wang YM, Zheng XY, Song XM, Chen G, Zhang T, Wu JX (2008b) Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism. Exp Neurol 212(2):515\u2013521. doi: 10.1016\/j.expneurol.2008.04.044","journal-title":"Exp Neurol"},{"issue":"5","key":"355_CR36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1017\/S1368980008002735","volume":"12","author":"T Zhang","year":"2009","unstructured":"Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L, Chen G, Wu J, Zheng X (2009) Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 12(5):680\u2013686. doi: 10.1017\/S1368980008002735","journal-title":"Public Health Nutr"},{"issue":"2","key":"355_CR37","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.gene.2012.05.035","volume":"505","author":"H Zhao","year":"2012","unstructured":"Zhao H, Wang F, Wang J, Xie H, Guo J, Liu C, Wang L, Lu X, Bao Y, Wang G, Zhong R, Niu B, Zhang T (2012) Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area. Gene 505(2):340\u2013344. doi: 10.1016\/j.gene.2012.05.035","journal-title":"Gene"},{"issue":"3","key":"355_CR38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S1096-7192(03)00008-8","volume":"78","author":"H Zhu","year":"2003","unstructured":"Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, Suarez L, Canfield M, Finnell RH (2003) Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab 78(3):216\u2013221","journal-title":"Mol Genet Metab"},{"issue":"1","key":"355_CR39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ymgme.2005.09.008","volume":"87","author":"H Zhu","year":"2006","unstructured":"Zhu H, Yang W, Lu W, Zhang J, Shaw GM, Lammer EJ, Finnell RH (2006) A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Mol Genet Metab 87(1):66\u201370. doi: 10.1016\/j.ymgme.2005.09.008","journal-title":"Mol Genet Metab"}],"container-title":["Genes &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12263-013-0355-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12263-013-0355-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12263-013-0355-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T11:07:42Z","timestamp":1563620862000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12263-013-0355-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["355"],"URL":"https:\/\/doi.org\/10.1007\/s12263-013-0355-5","relation":{},"ISSN":["1555-8932","1865-3499"],"issn-type":[{"value":"1555-8932","type":"print"},{"value":"1865-3499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,6]]}}}