{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:19:16Z","timestamp":1791091156432,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Nutr"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s12263-013-0382-2","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T17:31:02Z","timestamp":1392658262000},"source":"Crossref","is-referenced-by-count":25,"title":["Nutritional contributions to dementia prevention: main issues on antioxidant micronutrients"],"prefix":"10.1007","volume":"9","author":[{"given":"Maria Cristina","family":"Polidori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Joachim","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"382_CR1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000094973","volume":"22","author":"HKM Ag\u00fcero-Torres","year":"2006","unstructured":"Ag\u00fcero-Torres HKM, von Strauss E (2006) Rethinking dementia diagnoses in a population-based study: what is Alzheimer\u2019s disease and what is vascular dementia? A study from the Kungsholmen Project. Dement Geriatr Cogn Disord 22:244\u2013249","journal-title":"Dement Geriatr Cogn Disord"},{"key":"382_CR2","doi-asserted-by":"crossref","first-page":"17589","DOI":"10.1073\/pnas.0608757103","volume":"103","author":"BN Ames","year":"2006","unstructured":"Ames BN (2006a) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103:17589\u201317594","journal-title":"Proc Natl Acad Sci USA"},{"key":"382_CR3","doi-asserted-by":"crossref","first-page":"17589","DOI":"10.1073\/pnas.0608757103","volume":"103","author":"BN Ames","year":"2006","unstructured":"Ames BN (2006b) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103:17589\u201317594","journal-title":"Proc Natl Acad Sci USA"},{"key":"382_CR4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1079\/BJN20051574","volume":"94","author":"T Anlasik","year":"2005","unstructured":"Anlasik T, Sies H, Griffiths HR, Stahl W, Polidori MC (2005) Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. Br J Nutr 94:639\u2013642","journal-title":"Br J Nutr"},{"key":"382_CR5","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1212\/01.wnl.0000278116.37320.52","volume":"69","author":"P Barberger-Gateau","year":"2007","unstructured":"Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alperovitch A (2007) Dietary patterns and risk of dementia. Neurology 69:1921\u20131930","journal-title":"Neurology"},{"key":"382_CR03","doi-asserted-by":"crossref","unstructured":"Bayer-Carter JL, Green PS, Montine TJ, VanFossen B, Baker LD, Watson GS, Bonner LM, Callaghan M, Leverenz JB, Walter BK, Tsai E, Plymate SR, Postupna N, Wilkinson CW, Zhang J, Lampe J, Kahn SE, Craft S (2011) Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol 68(6):743\u2013752","DOI":"10.1001\/archneurol.2011.125"},{"key":"382_CR6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00394-012-0380-y","volume":"51","author":"H Boeing","year":"2012","unstructured":"Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, M\u00fcller MJ, Oberrittler H, Schulze M, Stehle P, Watzl B (2012) Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51:637\u2013663","journal-title":"Eur J Nutr"},{"key":"382_CR7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exger.2009.11.007","volume":"45","author":"GJ Brewer","year":"2010","unstructured":"Brewer GJ (2010) Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol 45:173\u2013179","journal-title":"Exp Gerontol"},{"key":"382_CR8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/BF02982159","volume":"12","author":"SC Burgener","year":"2008","unstructured":"Burgener SC, Buettner L, Coen Buckwalter K, Beattie E, Bossen AL, Fick DM, Fitzsimmons S, Kolanowski A, Richeson NE, Rose K, Schreiner A, Pringle Specht JK, Testad I, Yu F, McKenzie S (2008) Evidence supporting nutritional interventions for persons in early stage Alzheimer\u2019s disease. J Nutr Health Aging 12:18\u201321","journal-title":"J Nutr Health Aging"},{"issue":"9","key":"382_CR9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.amjmed.2006.03.045","volume":"119","author":"Q Dai","year":"2006","unstructured":"Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB (2006) Fruit and vegetable juices and Alzheimer\u2019s disease: the Kame Project. Am J Med 119(9):751\u2013759","journal-title":"Am J Med"},{"key":"382_CR10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0197-4580(00)00111-1","volume":"21","author":"JC Torre de la","year":"2000","unstructured":"de la Torre JC (2000) Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer\u2019s pathogenesis. Neurobiol Aging 21:331\u2013342","journal-title":"Neurobiol Aging"},{"key":"382_CR11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1533317513494457","volume":"28","author":"JC Torre de la","year":"2013","unstructured":"de la Torre JC (2013) Vascular risk factors: a ticking time bomb to Alzheimer\u2019s disease. Am J Alzheimers Dis Other Dement 28:551\u2013559","journal-title":"Am J Alzheimers Dis Other Dement"},{"key":"382_CR05","doi-asserted-by":"crossref","unstructured":"de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99(6):779\u2013785","DOI":"10.1161\/01.CIR.99.6.779"},{"key":"382_CR12","doi-asserted-by":"crossref","first-page":"S633","DOI":"10.3233\/JAD-2010-100507","volume":"20","author":"M Dumont","year":"2010","unstructured":"Dumont M, Lin MT, Beal MF (2010) Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer\u2019s disease. J Alzheimers Dis 20:S633\u2013S643","journal-title":"J Alzheimers Dis"},{"key":"382_CR13","volume-title":"European nutrition and health report 2009","year":"2009","unstructured":"Elmadfa I (ed) (2009) European nutrition and health report 2009. Karger, Basel"},{"key":"382_CR14","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1001\/jama.287.24.3223","volume":"287","author":"MJ Engelhart","year":"2002","unstructured":"Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hoffman A, Witteman JC, Breteler MM (2002) Dietary intake of antioxidants and risk of Alzheimer\u2019s disease. JAMA 287:3223\u20133229","journal-title":"JAMA"},{"key":"382_CR15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-2012-120349","volume":"31","author":"L Feng-Jiao","year":"2012","unstructured":"Feng-Jiao L, Shen L, Ji HF (2012) Dietary intakes of vitamin E, vitamin C and \u03b2-carotene and risk of Alzheimer\u2019s disease: a meta-analysis. J Alzheimer\u2019s Dis 31:253\u2013258","journal-title":"J Alzheimer\u2019s Dis"},{"key":"382_CR02","doi-asserted-by":"crossref","unstructured":"Friedland RP (2003) Fish consumption and the risk of Alzheimer disease: is it time to make dietary recommendations? Arch Neurol 60(7):923\u2013924","DOI":"10.1001\/archneur.60.7.923"},{"key":"382_CR16","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ajcn\/77.4.975","volume":"77","author":"F Grodstein","year":"2003","unstructured":"Grodstein F, Chen J, Willett WC (2003) High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr 77:975\u2013984","journal-title":"Am J Clin Nutr"},{"key":"382_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2003.10.009","volume":"36","author":"K Hensley","year":"2004","unstructured":"Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, Mou S, Pye QN, Stoddard MF, Wallis G, Williamson KS, West M, Wechter WJ, Floyd RA (2004) New perspectives on vitamin E: gamma-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med 36:1\u201315","journal-title":"Free Radic Biol Med"},{"key":"382_CR18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/JGP.0b013e3181c65250","volume":"18","author":"TF Hughes","year":"2010","unstructured":"Hughes TF, Andel R, Small BJ et al (2010) Midlife fruit and vegetable consumption and risk of dementia in later life in Swedish twins. Am J Geriatr Psychiatry 18:413\u2013420","journal-title":"Am J Geriatr Psychiatry"},{"key":"382_CR19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3233\/JAD-2012-121585","volume":"33","author":"TM Hughes","year":"2013","unstructured":"Hughes TM, Rosano C, Evand RW, Kuller LH (2013) Brain cholesterol metabolism, oxysterols, and dementia. J Alzheimer\u2019s Dis 33:891\u2013911","journal-title":"J Alzheimer\u2019s Dis"},{"key":"382_CR20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/biof.195","volume":"38","author":"JB Joshi","year":"2012","unstructured":"Joshi JB, Pratic\u00f3 D (2012) Vitamin E in aging, dementia, and Alzheimer\u2019s disease. BioFactors 38:90\u201397","journal-title":"BioFactors"},{"key":"382_CR04","doi-asserted-by":"crossref","unstructured":"Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, van Staveren WA (2004) Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 292(12):1433\u20131439","DOI":"10.1001\/jama.292.12.1433"},{"key":"382_CR21","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1161\/01.CIR.103.13.1823","volume":"103","author":"P Kris-Etherton","year":"2001","unstructured":"Kris-Etherton P, Eckel RH, Howard BV, Jeor S, Bazzarre TL (2001) Lyon Diet Heart Study: benefits of a Mediterranean-Style, National Cholesterol education program\/American Heart Association Step I dietary pattern on cardiovascular disease. Circulation 103:1823\u20131825","journal-title":"Circulation"},{"issue":"4","key":"382_CR22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.exger.2010.01.001","volume":"45","author":"DK Lahiri","year":"2010","unstructured":"Lahiri DK, Maloney B (2010) The \u201cLEARn\u201d (latent early-life associated regulation) model integrates environmental risk factors and the developmental basis of Alzheimer\u2019s disease, and proposes remedial steps. Exp Gerontol 45(4):291\u2013296","journal-title":"Exp Gerontol"},{"issue":"6","key":"382_CR23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10522-008-9162-6","volume":"9","author":"DK Lahiri","year":"2008","unstructured":"Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B (2008) Early-life events may trigger biochemical pathways for Alzheimer\u2019s disease: the \u201cLEARn\u201d model. Biogerontology 9(6):375\u2013379","journal-title":"Biogerontology"},{"key":"382_CR24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.maturitas.2012.10.019","volume":"74","author":"I Lambrinoudaki","year":"2013","unstructured":"Lambrinoudaki I, Ceasu I, Depypere H, Erel T, Rees M, Schenck-Gustafsson K, Simoncini T, Tremollieres F, van der Schouw YT, P\u00e9rez-L\u00f3pez FR (2013) EMAS position statement: diet and health in midlife and beyond. Maturitas 74:99\u2013104","journal-title":"Maturitas"},{"key":"382_CR25","unstructured":"Larrieu S, Latenneur L, Helmer C, Dartigues JF, Barberger-Gateau P (2004) Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. J Nutr Health Aging 8(3):150\u2013154"},{"key":"382_CR26","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1056\/NEJMp1311405","volume":"369","author":"EB Larson","year":"2013","unstructured":"Larson EB, Yaffe K, Langa KM (2013) New insights into the dementia epidemic. N Engl J Med 369:2275\u20132277","journal-title":"N Engl J Med"},{"key":"382_CR27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jns.2012.09.010","volume":"323","author":"J Leszek","year":"2012","unstructured":"Leszek J, Sochocka M, Gasiorowski K (2012) Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer\u2019s disease. J Neurol Sci 323:25\u201332","journal-title":"J Neurol Sci"},{"key":"382_CR28","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12035-012-8307-4","volume":"46","author":"K Leuner","year":"2012","unstructured":"Leuner K, M\u00fcller WE, Reichert AS (2012) From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer\u2019s disease. Mol Neurobiol 46:186\u2013193","journal-title":"Mol Neurobiol"},{"key":"382_CR29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/archneur.60.2.203","volume":"60","author":"JA Luchsinger","year":"2003","unstructured":"Luchsinger JA, Wang MX, Shea S, Mayeux R (2003) Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 60:203\u2013208","journal-title":"Arch Neurol"},{"key":"382_CR30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1474-4422(10)70119-8","volume":"9","author":"F Mangialasche","year":"2010","unstructured":"Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M (2010) Alzheimer\u2019s disease: clinical trials and drug development. Lancet Neurol 9:702\u2013716","journal-title":"Lancet Neurol"},{"key":"382_CR06","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Gonz\u00e1lez MA, de la Fuente-Arrillaga C, Nunez-Cordoba JM, Basterra-Gortari FJ, Beunza JJ, Vazquez Z, Benito S, Tortosa A, Bes-Rastrollo M (2008) Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ 336(7657):1348\u20131351","DOI":"10.1136\/bmj.39561.501007.BE"},{"key":"382_CR31","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1212\/WNL.54.6.1265","volume":"54","author":"KH Masaki","year":"2000","unstructured":"Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR (2000) Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 54:1265\u20131272","journal-title":"Neurology"},{"key":"382_CR32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbadis.2011.10.006","volume":"1822","author":"P Mecocci","year":"2012","unstructured":"Mecocci P, Polidori MC (2012) Antioxidant clinical trials in mild cognitive impairment and Alzheimer\u2019s disease. Biochim Biophys Acta 1822:631\u2013638","journal-title":"Biochim Biophys Acta"},{"key":"382_CR33","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1001\/jama.287.24.3230","volume":"287","author":"MC Morris","year":"2002","unstructured":"Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Wilson RS, Scherr PA (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287:3230\u20133237","journal-title":"JAMA"},{"key":"382_CR34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ajcn.81.2.508","volume":"81","author":"MC Morris","year":"2005","unstructured":"Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA (2005a) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 81:508\u2013514","journal-title":"Am J Clin Nutr"},{"key":"382_CR35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ajcn.81.2.508","volume":"81","author":"MC Morris","year":"2005","unstructured":"Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA (2005b) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 81:508\u2013514","journal-title":"Am J Clin Nutr"},{"key":"382_CR36","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1212\/01.wnl.0000240224.38978.d8","volume":"67","author":"MC Morris","year":"2006","unstructured":"Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS (2006) Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 67:1370\u20131376","journal-title":"Neurology"},{"key":"382_CR37","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa050151","volume":"52","author":"RC Petersen","year":"2005","unstructured":"Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 52:2379\u20132388","journal-title":"N Engl J Med"},{"key":"382_CR38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/biof.1000","volume":"38","author":"MC Polidori","year":"2012","unstructured":"Polidori MC (2012a) Biofactors and cognitive function. BioFactors 38:77\u2013171","journal-title":"BioFactors"},{"key":"382_CR039","doi-asserted-by":"crossref","unstructured":"Polidori MC (2012b) Demenz. Z Gerontol Geriatr Eur J Geriatr 45:4\u201354","DOI":"10.1007\/s00391-011-0273-3"},{"key":"382_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2011-111034","volume":"28","author":"MC Polidori","year":"2012","unstructured":"Polidori MC, Pientka L (2012) Bridging the pathophysiology of Alzheimer\u2019s disease with vascular pathology: the feed-back, the feed\u2013forward and oxidative stress. J Alzheimer\u2019s Dis 28:1\u20139","journal-title":"J Alzheimer\u2019s Dis"},{"key":"382_CR41","doi-asserted-by":"crossref","unstructured":"Polidori MC, Nelles G (2013) Antioxidant clinical trials in mild cognitive impairment and Alzheimer\u2019s disease\u2014challenges and perspectives. Curr Pharmachol Des 20 (Epub ahead of print)","DOI":"10.2174\/13816128113196660706"},{"key":"382_CR42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3233\/JAD-2009-1114","volume":"17","author":"MC Polidori","year":"2009","unstructured":"Polidori MC, Pratic\u00f3 D, Mangialasche F, Mariani E, Aust O, Anlasik T, Mang N, Pientka L, Stahl W, Sies H, Mecocci P, Nelles G (2009a) High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis 17:921\u2013927","journal-title":"J Alzheimers Dis"},{"key":"382_CR43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-2891-8-10","volume":"8","author":"MC Polidori","year":"2009","unstructured":"Polidori MC, Carrillo JC, Verde PE, Stahl W, Sies H, Siegrist J (2009b) Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels. Nutr J 8:10\u201311","journal-title":"Nutr J"},{"key":"382_CR44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-2012-120871","volume":"32","author":"MC Polidori","year":"2012","unstructured":"Polidori MC, Pientka L, Mecocci P (2012) A review of the major vascular risk factors related to Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 32:521\u2013530","journal-title":"J Alzheimer\u2019s Dis"},{"key":"382_CR45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1079\/PHN2002456","volume":"6","author":"J Pomerleau","year":"2003","unstructured":"Pomerleau J, McKee M, Lobstein T, Knai C (2003) The burden of disease attributable to nutrition in Europe. Public Health Nutr 6:453\u2013461","journal-title":"Public Health Nutr"},{"key":"382_CR46","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/archneur.59.6.972","volume":"59","author":"D Pratic\u00f3","year":"2002","unstructured":"Pratic\u00f3 D, Clark CM, Liun F, Rokach J, Lee VY, Trojanowski JQ (2002) Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer\u2019s disease. Arch Neurol 59:972\u2013976","journal-title":"Arch Neurol"},{"key":"382_CR47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","volume":"9","author":"M Prince","year":"2013","unstructured":"Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement 9:63\u201375","journal-title":"Alzheimers Dement"},{"key":"382_CR48","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0197-4580(03)00031-9","volume":"24","author":"P Rinaldi","year":"2003","unstructured":"Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli P, Cherubini A, Catani M, Cecchetti R, Senin U, Mecocci P (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer\u2019s disease. Neurobiol Aging 24:915\u2013919","journal-title":"Neurobiol Aging"},{"key":"382_CR49","doi-asserted-by":"crossref","first-page":"c3885","DOI":"10.1136\/bmj.c3885","volume":"341","author":"K Ritchie","year":"2010","unstructured":"Ritchie K, Carriere I, Ritchie CW et al (2010) Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors. BMJ 341:c3885","journal-title":"BMJ"},{"key":"382_CR01","doi-asserted-by":"crossref","unstructured":"Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer\u2019s Disease Cooperative Study. N Engl J Med 336(17):1216\u20131222","DOI":"10.1056\/NEJM199704243361704"},{"key":"382_CR50","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ana.20854","volume":"59","author":"N Scarmeas","year":"2006","unstructured":"Scarmeas N, Stern YY, Tang MX et al (2006) Mediterranean diet and risk for Alzheimer\u2019s disease. Ann Neurol 59:912\u2013921","journal-title":"Ann Neurol"},{"key":"382_CR51","first-page":"216","volume":"66","author":"N Scarmeas","year":"2009","unstructured":"Scarmeas N, Stern Y, Meyeaux R et al (2009a) Mediterranean diet and mild cognitive impairment. Arch Neurol 66:216\u2013225","journal-title":"Arch Neurol"},{"key":"382_CR52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/jama.2009.1144","volume":"302","author":"N Scarmeas","year":"2009","unstructured":"Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y (2009b) Physical activity, diet, and risk of Alzhemer\u2019s disease. JAMA 302:627\u2013637","journal-title":"JAMA"},{"key":"382_CR53","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1212\/WNL.0b013e3182553be6","volume":"78","author":"EMC Schrijvers","year":"2012","unstructured":"Schrijvers EMC, Verhaaren BFJ, Koudstaal PJ, Hofman A, Ikram MA, Breteler MMB (2012) Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology 78:1456\u20131463","journal-title":"Neurology"},{"key":"382_CR54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-642760-8.50005-3","volume-title":"Oxidative stress","author":"H Sies","year":"1985","unstructured":"Sies H (1985) Oxidative stress: introductory remarks. In: Sies H (ed) Oxidative stress. Academic Press, Orlando, pp 1\u201315"},{"key":"382_CR55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1432-1033.1993.tb18025.x","volume":"215","author":"H Sies","year":"1993","unstructured":"Sies H (1993) Strategies of antioxidant defense. Eur J Biochem 215:213\u2013219","journal-title":"Eur J Biochem"},{"key":"382_CR56","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neurobiolaging.2004.09.021","volume":"26","author":"MA Smith","year":"2005","unstructured":"Smith MA, Nunomura A, Lee H, Zhu X, Moreira PI, Avila J, Perry G (2005) Chronological primacy of oxidative stress in Alzheimer\u2019s disease. Neurobiol Aging 26:579\u2013580","journal-title":"Neurobiol Aging"},{"key":"382_CR57","doi-asserted-by":"crossref","first-page":"A1344","DOI":"10.1136\/bmj.a1344","volume":"337","author":"F Sofi","year":"2008","unstructured":"Sofi F, Cesari F, Abbate R, Gensini GF, Casini A (2008) Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337:A1344","journal-title":"BMJ"},{"key":"382_CR58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0140-6736(03)12521-4","volume":"361","author":"AH Vagnucci","year":"2003","unstructured":"Vagnucci AH, Li WW (2003) Alzheimer\u2019s disease and angiogenesis. Lancet 361:605\u2013608","journal-title":"Lancet"},{"key":"382_CR59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2011-111020","volume":"26","author":"PJ Whitehouse","year":"2011","unstructured":"Whitehouse PJ, George DR (2011) Uncertain progress on the fuzzy boundaries of Alzheimer\u2019s disease: reading between the guidelines. J Alzheimers Dis 26:1\u20135","journal-title":"J Alzheimers Dis"},{"key":"382_CR60","doi-asserted-by":"crossref","unstructured":"Willett WC, Sacks F, Thricopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61(6 Suppl):1402S\u20131406S","DOI":"10.1093\/ajcn\/61.6.1402S"},{"key":"382_CR62","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1212\/01.WNL.0000134666.64593.BA","volume":"63","author":"K Yaffe","year":"2004","unstructured":"Yaffe K, Clemons TE, McBee WL, Lindblad AS (2004) Impact of antioxidants, zinc and copper on cognition in the elderly: a randomized, controlled trial. Neurology 63:1705\u20131707","journal-title":"Neurology"},{"key":"382_CR63","doi-asserted-by":"crossref","unstructured":"Yan MH, Wang X, Zhu X (2013) Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med 62:90\u2013101","DOI":"10.1016\/j.freeradbiomed.2012.11.014"},{"key":"382_CR64","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archneur.61.1.82","volume":"61","author":"PP Zandi","year":"2004","unstructured":"Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT, Norton MC, Welsh-Bohmer KA, Breitner JC (2004) Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61:82\u201388","journal-title":"Arch Neurol"},{"key":"382_CR65","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1474-4422(04)00707-0","volume":"3","author":"X Zhu","year":"2004","unstructured":"Zhu X, Raina AK, Perry G, Smith MA (2004) Alzheimer\u2019s disease: the two-hit hypothesis. Lancet Neurol 3:219\u2013226","journal-title":"Lancet Neurol"}],"container-title":["Genes &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12263-013-0382-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12263-013-0382-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12263-013-0382-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:10:23Z","timestamp":1565201423000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12263-013-0382-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["382"],"URL":"https:\/\/doi.org\/10.1007\/s12263-013-0382-2","relation":{},"ISSN":["1555-8932","1865-3499"],"issn-type":[{"value":"1555-8932","type":"print"},{"value":"1865-3499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,18]]},"article-number":"382"}}