{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:33:01Z","timestamp":1791419581209,"version":"4.3.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s12264-011-1015-7","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T10:34:36Z","timestamp":1312454076000},"page":"221-232","source":"Crossref","is-referenced-by-count":87,"title":["Biochemical and behavioral characterization of the double transgenic mouse model (APPswe\/PS1dE9) of Alzheimer\u2019s disease","\u963f\u5c14\u8328\u6d77\u9ed8\u75c5APPswe\/PS1dE9 \u53cc\u8f6c\u57fa\u56e0\u5c0f\u9f20\u7684\u75c5\u7406\u751f\u5316\u548c\u884c\u4e3a\u5b66\u7814\u7a76"],"prefix":"10.1007","volume":"27","author":[{"given":"Huaqi","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Wodzinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Premyslova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,5]]},"reference":[{"key":"1015_CR1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"D.J. Selkoe","year":"2001","unstructured":"Selkoe DJ. Alzheimer\u2019s disease: genes, proteins, and therapy. Physiol Rev 2001, 81: 741\u2013766.","journal-title":"Physiol Rev"},{"key":"1015_CR2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.pharmtox.43.100901.140248","volume":"43","author":"D.J. Selkoe","year":"2003","unstructured":"Selkoe DJ, Schenk D. Alzheimer\u2019s disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 2003, 43: 545\u2013584.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"2","key":"1015_CR3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","volume":"13","author":"J.L. Jankowsky","year":"2004","unstructured":"Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 2004, 13(2): 159\u2013170.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"1015_CR4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","volume":"19","author":"D.R. Borchelt","year":"1997","unstructured":"Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997, 19(4): 939\u2013945.","journal-title":"Neuron"},{"key":"1015_CR5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-2094-4-12","volume":"4","author":"J. Mojsilovic-Petrovic","year":"2007","unstructured":"Mojsilovic-Petrovic J, Callaghan D, Cui H, Dean C, Stanimirovic DB, Zhang W. Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1\/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation 2007, 4: 12.","journal-title":"J Neuroinflammation"},{"issue":"1\u20132","key":"1015_CR6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2004.02.081","volume":"1012","author":"G.W. Arendash","year":"2004","unstructured":"Arendash GW, Lewis J, Leighty RE, McGowan E, Cracchiolo JR, Hutton M, et al. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer\u2019s disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Res 2004, 1012(1\u20132): 29\u201341.","journal-title":"Brain Res"},{"issue":"1","key":"1015_CR7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2003.11.004","volume":"153","author":"R.E. Leighty","year":"2004","unstructured":"Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, et al. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer\u2019s transgenic mouse lines differing in Abeta deposition. Behav Brain Res 2004, 153(1): 107\u2013121.","journal-title":"Behav Brain Res"},{"issue":"17","key":"1015_CR8","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1523\/JNEUROSCI.5103-08.2009","volume":"29","author":"H. Xiong","year":"2009","unstructured":"Xiong H, Callaghan D, Jones A, Bai J, Rasquinha I, Smith C, et al. ABCG2 is up-regulated in Alzheimer\u2019s brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for A\u03b21\u201340 peptides. J Neurosci 2009, 29(17): 5463\u20135475.","journal-title":"J Neurosci"},{"issue":"3","key":"1015_CR9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2007.10.005","volume":"29","author":"H. Xiong","year":"2008","unstructured":"Xiong H, Callaghan D, Jones A, Walker DG, Lue LF, Beach TG, et al. Cholesterol retention in Alzheimer\u2019s brain is responsible for high \u03b2- and \u03b3-secretase activities and Abeta production. Neurobiol Dis 2008, 29(3): 422\u2013437.","journal-title":"Neurobiol Dis"},{"issue":"34","key":"1015_CR10","doi-asserted-by":"crossref","first-page":"24431","DOI":"10.1074\/jbc.274.34.24431","volume":"274","author":"H. Komano","year":"1999","unstructured":"Komano H, Rockwell N, Wang GT, Krafft GA, Fuller RS. Purification and characterization of the yeast glycosylphosphatidylinositolanchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). J Biol Chem 1999, 274(34): 24431\u201324437.","journal-title":"J Biol Chem"},{"issue":"1","key":"1015_CR11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2008.02.016","volume":"192","author":"D.J. Selkoe","year":"2008","unstructured":"Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 2008, 192(1): 106\u2013113.","journal-title":"Behav Brain Res"},{"issue":"3","key":"1015_CR12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S. Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003, 39(3): 409\u2013421.","journal-title":"Neuron"},{"key":"1015_CR13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nbd.2008.12.007","volume":"34","author":"V. Vukic","year":"2009","unstructured":"Vukic V, Callaghan D, Walker D, Lue LF, Liu QY, Couraud PO, et al. Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer\u2019s brain is mediated by the JNK-AP1 signaling pathway. Neurobiol Dis 2009, 34: 95\u2013106.","journal-title":"Neurobiol Dis"},{"key":"1015_CR14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0197-4580(01)00306-2","volume":"22","author":"D.G. Walker","year":"2001","unstructured":"Walker DG, Lue LF, Beach TG. Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol Aging 2001, 22: 957\u2013966.","journal-title":"Neurobiol Aging"},{"key":"1015_CR15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1189\/jlb.0705377","volume":"79","author":"D.G. Walker","year":"2006","unstructured":"Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE. Gene expression changes by amyloid beta peptide-stimulated human post mortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 2006, 79: 589\u2013610.","journal-title":"J Leukoc Biol"},{"key":"1015_CR16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","volume":"57","author":"V.B. Zlokovic","year":"2008","unstructured":"Zlokovic VB. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57: 178\u2013201.","journal-title":"Neuron"},{"issue":"1","key":"1015_CR17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1515\/REVNEURO.2010.21.1.29","volume":"21","author":"S. Shen","year":"2010","unstructured":"Shen S, Zhang W. ABC transporters and drug efflux at the bloodbrain barrier. Reviews in Neurosci 2010, 21(1): 29\u201353.","journal-title":"Reviews in Neurosci"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-011-1015-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12264-011-1015-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-011-1015-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T15:31:48Z","timestamp":1560439908000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12264-011-1015-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["1015"],"URL":"https:\/\/doi.org\/10.1007\/s12264-011-1015-7","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}