{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:47Z","timestamp":1790775467155,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s12264-013-1360-9","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T05:21:52Z","timestamp":1373347312000},"page":"493-500","source":"Crossref","is-referenced-by-count":30,"title":["Peripheral nerve axons contain machinery for co-translational secretion of axonally-generated proteins"],"prefix":"10.1007","volume":"29","author":[{"given":"Tanuja","family":"Merianda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Twiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"1360_CR1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tcb.2009.02.007","volume":"19","author":"JL Twiss","year":"2009","unstructured":"Twiss JL, Fainzilber M. Ribosomes in axons\u2014scrounging from the neighbors? Trends Cell Biol 2009, 19: 236\u2013243.","journal-title":"Trends Cell Biol"},{"key":"1360_CR2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/neu.2006.23.295","volume":"23","author":"JL Twiss","year":"2006","unstructured":"Twiss JL, van Minnen J. New insights into neuronal regeneration: the role of axonal protein synthesis in pathfinding and axonal extension. J Neurotrauma 2006, 23:295\u2013308.","journal-title":"J Neurotrauma"},{"key":"1360_CR3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.semcdb.2009.04.014","volume":"20","author":"RB Perry","year":"2009","unstructured":"Perry RB, Fainzilber M. Nuclear transport factors in neuronal function. Semin Cell Dev Biol 2009, 20:600\u2013606.","journal-title":"Semin Cell Dev Biol"},{"key":"1360_CR4","doi-asserted-by":"crossref","first-page":"e1961","DOI":"10.1371\/journal.pone.0001961","volume":"3","author":"L Imenez-Diaz","year":"2008","unstructured":"Imenez-Diaz L, Geranton SM, Passmore GM, Leith JL, Fisher AS, Berliocchi L, et al. Local translation in primary afferent fibers regulates nociception. PLoS One 2008, 3:e1961.","journal-title":"PLoS One"},{"key":"1360_CR5","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1523\/JNEUROSCI.3947-10.2010","volume":"30","author":"OK Melemedjian","year":"2010","unstructured":"Melemedjian OK, Asiedu MN, Tillu DV, Peebles KA, Yan J, Ertz N, et al. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci 2010, 30:15113\u201315123.","journal-title":"J Neurosci"},{"key":"1360_CR6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chom.2012.10.021","volume":"13","author":"OO Koyuncu","year":"2013","unstructured":"Koyuncu OO, Perlman DH, Enquist LW. Efficient retrograde transport of pseudorabies virus within neurons requires local protein synthesis in axons. Cell Host Microbe 2013, 13:54\u201366.","journal-title":"Cell Host Microbe"},{"key":"1360_CR7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.200703209","volume":"178","author":"DE Willis","year":"2007","unstructured":"Willis DE, van Niekerk EA, Sasaki Y, Mesngon M, Merianda TT, Williams GG, et al. Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. J Cell Biol 2007, 178:965\u2013980.","journal-title":"J Cell Biol"},{"key":"1360_CR8","doi-asserted-by":"crossref","first-page":"15464","DOI":"10.1523\/JNEUROSCI.1800-10.2010","volume":"30","author":"KH Zivraj","year":"2010","unstructured":"Zivraj KH, Tung YC, Piper M, Gumy L, Fawcett JW, Yeo GS, et al. Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs. J Neurosci 2010, 30:15464\u201315478.","journal-title":"J Neurosci"},{"key":"1360_CR9","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1523\/JNEUROSCI.6130-08.2009","volume":"29","author":"AM Taylor","year":"2009","unstructured":"Taylor AM, Berchtold NC, Perreau VM, Tu CH, Li Jeon N, Cotman CW. Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci 2009, 29:4697\u20134707.","journal-title":"J Neurosci"},{"key":"1360_CR10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0006-8993(70)90120-4","volume":"24","author":"J Zelena","year":"1970","unstructured":"Zelena J. Ribosome-like particles in myelinated axons of the rat. Brain Res 1970, 24:359\u2013363.","journal-title":"Brain Res"},{"key":"1360_CR11","first-page":"91","volume":"20","author":"J Zelena","year":"1972","unstructured":"Zelena J. Ribosomes in the axoplasm of myelinated nerve fibres. Folia Morphol (Praha) 1972, 20:91\u201393.","journal-title":"Folia Morphol (Praha)"},{"key":"1360_CR12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/1097-4695(200007)44:1<72::AID-NEU7>3.0.CO;2-#","volume":"44","author":"GE Spencer","year":"2000","unstructured":"Spencer GE, Syed NI, van Kesteren E, Lukowiak K, Geraerts WP, van Minnen J. Synthesis and functional integration of a neurotransmitter receptor in isolated invertebrate axons. J Neurobiol 2000, 44:72\u201381.","journal-title":"J Neurobiol"},{"key":"1360_CR13","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1523\/JNEUROSCI.21-23-09291.2001","volume":"21","author":"JQ Zheng","year":"2001","unstructured":"Zheng JQ, Kelly TK, Chang B, Ryazantsev S, Rajasekaran AK, Martin KC, et al. A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. J Neurosci 2001, 21:9291\u20139303.","journal-title":"J Neurosci"},{"key":"1360_CR14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mcn.2008.09.008","volume":"40","author":"TT Merianda","year":"2009","unstructured":"Merianda TT, Lin AC, Lam JS, Vuppalanchi D, Willis DE, Karin N, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci 2009, 40:128\u2013142.","journal-title":"Mol Cell Neurosci"},{"issue":"22","key":"1360_CR15","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1038\/emboj.2011.347","volume":"30","author":"CJ Donnelly","year":"2011","unstructured":"Donnelly CJ, Willis DE, Xu M, Tep C, Jiang C, Yoo S, et al. Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity. EMBO J 2011, 30(22):4665\u20134677.","journal-title":"EMBO J"},{"key":"1360_CR16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1523\/JNEUROSCI.3073-04.2005","volume":"25","author":"P Verma","year":"2005","unstructured":"Verma P, Chierzi S, Codd AM, Campbell DS, Meyer RL, Holt CE, et al. Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J Neurosci 2005, 25:331\u2013342.","journal-title":"J Neurosci"},{"key":"1360_CR17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2012.05.033","volume":"75","author":"R Ben-Tov Perry","year":"2012","unstructured":"Ben-Tov Perry R, Doron-Mandel E, Iavnilovitch E, Rishal I, Dagan SY, Tsoory M, et al. Subcellular knockout of importin beta1 perturbs axonal retrograde signaling. Neuron 2012, 75:294\u2013305.","journal-title":"Neuron"},{"key":"1360_CR18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/emboj.2011.494","volume":"31","author":"K Ben-Yaakov","year":"2012","unstructured":"Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, et al. Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J 2012, 31:1350\u20131363.","journal-title":"EMBO J"},{"key":"1360_CR19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1006\/nbdi.2000.0293","volume":"7","author":"JL Twiss","year":"2000","unstructured":"Twiss JL, Smith DS, Chang B, Shooter EM. Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration. Neurobiol Dis 2000, 7:416\u2013428.","journal-title":"Neurobiol Dis"},{"issue":"Pt1","key":"1360_CR20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1242\/jcs.107268","volume":"126","author":"TT Merianda","year":"2013","unstructured":"Merianda TT, Vuppalanchi D, Yoo S, Blesch A, Twiss JL. Axonal transport of neural membrane protein 35 mrna increases axon growth. J Cell Sci 2013, 126(Pt 1):90\u2013102.","journal-title":"J Cell Sci"},{"key":"1360_CR21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tibs.2010.02.006","volume":"35","author":"J Kraut-Cohen","year":"2010","unstructured":"Kraut-Cohen J, Gerst JE. Addressing mRNAs to the ER: cis sequences act up! Trends Biochem Sci 2010, 35: 459\u2013469.","journal-title":"Trends Biochem Sci"},{"key":"1360_CR22","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1146\/annurev.biochem.70.1.755","volume":"70","author":"RJ Keenan","year":"2001","unstructured":"Keenan RJ, Freymann DM, Stroud RM, Walter P. The signal recognition particle. Annu Rev Biochem 2001, 70:755\u2013775.","journal-title":"Annu Rev Biochem"},{"key":"1360_CR23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1078\/S0171-9335(04)70025-4","volume":"79","author":"J Fu","year":"2000","unstructured":"Fu J, Pirozzi G, Sanjay A, Levy R, Chen Y, De Lemos-Chiarandini C, et al. Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains. Eur J Cell Biol 2000, 79:219\u2013228.","journal-title":"Eur J Cell Biol"},{"key":"1360_CR24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1146\/annurev.cellbio.15.1.799","volume":"15","author":"AE Johnson","year":"1999","unstructured":"Johnson AE, van Waes MA. The translocon: a dynamic gateway at the ER membrane. Annu Rev Cell Dev Biol 1999, 15:799\u2013842.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1360_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0962-8924(01)01926-2","volume":"11","author":"S Johnson","year":"2001","unstructured":"Johnson S, Michalak M, Opas M, Eggleton P. The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol 2001, 11:122\u2013129.","journal-title":"Trends Cell Biol"},{"key":"1360_CR26","first-page":"407","volume":"63","author":"CC Wang","year":"1998","unstructured":"Wang CC. Isomerase and chaperone activities of protein disulfide isomerase are both required for its function as a foldase. Biochemistry (Mosc) 1998, 63:407\u2013412.","journal-title":"Biochemistry (Mosc)"},{"key":"1360_CR27","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1091\/mbc.E03-04-0194","volume":"14","author":"M Cabrera","year":"2003","unstructured":"Cabrera M, Muniz M, Hidalgo J, Vega L, Martin ME, Velasco A. The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus. Mol Biol Cell 2003, 14:4114\u20134125.","journal-title":"Mol Biol Cell"},{"key":"1360_CR28","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1038\/emboj.2011.347","volume":"30","author":"CJ Donnelly","year":"2011","unstructured":"Donnelly CJ, Willis DE, Xu M, Tep C, Jiang C, Yoo S, et al. Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity. EMBO J 2011, 30:4665\u20134677.","journal-title":"EMBO J"},{"key":"1360_CR29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0092-8674(02)00813-9","volume":"110","author":"PA Brittis","year":"2002","unstructured":"Brittis PA, Lu Q, Flanagan JG. Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 2002, 110:223\u2013235.","journal-title":"Cell"},{"key":"1360_CR30","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/gt.2011.217","volume":"19","author":"BA Walker","year":"2012","unstructured":"Walker BA, Hengst U, Kim HJ, Jeon NL, Schmidt EF, Heintz N, et al. Reprogramming axonal behavior by axon-specific viral transduction. Gene Ther 2012, 19:947\u2013955.","journal-title":"Gene Ther"},{"key":"1360_CR31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/NEN.0b013e31819ac71b","volume":"68","author":"CC Toth","year":"2009","unstructured":"Toth CC, Willis D, Twiss JL, Walsh S, Martinez JA, Liu WQ, et al. Locally synthesized calcitonin gene-related peptide has a critical role in peripheral nerve regeneration. J Neuropathol Exp Neurol 2009, 68:326\u2013337.","journal-title":"J Neuropathol Exp Neurol"},{"key":"1360_CR32","doi-asserted-by":"crossref","first-page":"18025","DOI":"10.1074\/jbc.M109.061333","volume":"285","author":"D Vuppalanchi","year":"2010","unstructured":"Vuppalanchi D, Coleman J, Yoo S, Merianda TT, Yadhati AG, Hossain J, et al. Conserved 3\u2019-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons. J Biol Chem 2010, 285:18025\u201318038.","journal-title":"J Biol Chem"},{"key":"1360_CR33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mcn.2012.04.001","volume":"50","author":"D Vuppalanchi","year":"2012","unstructured":"Vuppalanchi D, Merianda TT, Donnelly C, Pacheco A, Williams G, Yoo S, et al. Lysophosphatidic acid differentially regulates axonal mRNA translation through 5\u2019UTR elements. Mol Cell Neurosci 2012, 50:136\u2013146.","journal-title":"Mol Cell Neurosci"},{"key":"1360_CR34","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1523\/JNEUROSCI.1722-12.2013","volume":"33","author":"CJ Donnelly","year":"2013","unstructured":"Donnelly CJ, Park M, Spillane M, Yoo S, Pacheco A, Gomes C, et al. Axonally synthesized beta-actin and GAP-43 proteins support distinct modes of axonal growth. J Neurosci 2013, 33:3311\u20133322.","journal-title":"J Neurosci"},{"key":"1360_CR35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-61779-005-8_21","volume":"714","author":"DE Willis","year":"2011","unstructured":"Willis DE, Twiss JL. Profiling axonal mRNA transport. Methods Mol Biol 2011, 714:335\u2013352.","journal-title":"Methods Mol Biol"},{"key":"1360_CR36","doi-asserted-by":"crossref","first-page":"14481","DOI":"10.1523\/JNEUROSCI.2950-11.2011","volume":"31","author":"DE Willis","year":"2011","unstructured":"Willis DE, Xu M, Donnelly CJ, Tep C, Kendall M, Erenstheyn M, et al. Axonal Localization of transgene mRNA in mature PNS and CNS neurons. J Neurosci 2011, 31:14481\u201314487.","journal-title":"J Neurosci"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-013-1360-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12264-013-1360-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-013-1360-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T17:50:44Z","timestamp":1563385844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12264-013-1360-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["1360"],"URL":"https:\/\/doi.org\/10.1007\/s12264-013-1360-9","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}