{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:22:02Z","timestamp":1781954522375,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12264-017-0128-z","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T04:28:21Z","timestamp":1491884901000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice"],"prefix":"10.1007","volume":"34","author":[{"given":"Peng-Bo","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Si","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Qiang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"128_CR1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","volume":"354","author":"IF Charo","year":"2006","unstructured":"Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006, 354: 610\u2013621.","journal-title":"N Engl J Med"},{"key":"128_CR2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0166-2236(99)01453-8","volume":"22","author":"VC Asensio","year":"1999","unstructured":"Asensio VC, Campbell IL. Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci 1999, 22: 504\u2013512.","journal-title":"Trends Neurosci"},{"key":"128_CR3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.nurt.2007.07.004","volume":"4","author":"C Savarin-Vuaillat","year":"2007","unstructured":"Savarin-Vuaillat C, Ransohoff RM. Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce? Neurotherapeutics 2007, 4: 590\u2013601.","journal-title":"Neurotherapeutics"},{"key":"128_CR4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","volume":"126","author":"YJ Gao","year":"2010","unstructured":"Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther 2010, 126: 56\u201368.","journal-title":"Pharmacol Ther"},{"key":"128_CR5","doi-asserted-by":"crossref","first-page":"20151","DOI":"10.1073\/pnas.0709250104","volume":"104","author":"FA White","year":"2007","unstructured":"White FA, Jung H, Miller RJ. Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci U S A 2007, 104: 20151\u201320158.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"128_CR6","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1517\/14656566.2010.484420","volume":"11","author":"T Patel","year":"2010","unstructured":"Patel T, Yosipovitch G. Therapy of pruritus. Expert Opin Pharmacother 2010, 11: 1673\u20131682.","journal-title":"Expert Opin Pharmacother"},{"key":"128_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pupt.2015.09.001","volume":"35","author":"RR Ji","year":"2015","unstructured":"Ji RR. Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms? Pulm Pharmacol Ther 2015, 35: 81\u201386.","journal-title":"Pulm Pharmacol Ther"},{"key":"128_CR8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12264-012-1219-5","volume":"28","author":"T Liu","year":"2012","unstructured":"Liu T, Gao YJ, Ji RR. Emerging role of Toll-like receptors in the control of pain and itch. Neurosci Bull 2012, 28: 131\u2013144.","journal-title":"Neurosci Bull"},{"key":"128_CR9","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.pain.2011.09.020","volume":"152","author":"CA Christianson","year":"2011","unstructured":"Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, et al. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain 2011, 152: 2881\u20132891.","journal-title":"Pain"},{"key":"128_CR10","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.0501634102","volume":"102","author":"FY Tanga","year":"2005","unstructured":"Tanga FY, Nutile-McMenemy N, DeLeo JA. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 2005, 102: 5856\u20135861.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"128_CR11","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jpain.2014.04.001","volume":"15","author":"Y Li","year":"2014","unstructured":"Li Y, Zhang H, Zhang H, Kosturakis AK, Jawad AB, Dougherty PM. Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy. J Pain 2014, 15: 712\u2013725.","journal-title":"J Pain"},{"key":"128_CR12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/j.pain.0000000000000439","volume":"157","author":"T Liu","year":"2016","unstructured":"Liu T, Han Q, Chen G, Huang Y, Zhao LX, Berta T, et al. Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice. Pain 2016, 157: 806\u2013817.","journal-title":"Pain"},{"key":"128_CR13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0074-7742(07)82010-1","volume":"82","author":"RM Ransohoff","year":"2007","unstructured":"Ransohoff RM, Liu L, Cardona AE. Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol 2007, 82: 187\u2013204.","journal-title":"Int Rev Neurobiol"},{"key":"128_CR14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cytogfr.2014.11.009","volume":"26","author":"K Raemdonck Van","year":"2015","unstructured":"Van Raemdonck K, Van den Steen PE, Liekens S, Van Damme J, Struyf S. CXCR3 ligands in disease and therapy. Cytokine Growth Factor Rev 2015, 26: 311\u2013327.","journal-title":"Cytokine Growth Factor Rev"},{"key":"128_CR15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1749-6632.2009.04813.x","volume":"1173","author":"S Lacotte","year":"2009","unstructured":"Lacotte S, Brun S, Muller S, Dumortier H. CXCR3, inflammation, and autoimmune diseases. Ann N Y Acad Sci 2009, 1173: 310\u2013317.","journal-title":"Ann N Y Acad Sci"},{"key":"128_CR16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1523\/JNEUROSCI.2262-16.2016","volume":"37","author":"BC Jiang","year":"2017","unstructured":"Jiang BC, He LN, Wu XB, Shi H, Zhang WW, Zhang ZJ, et al. Promoted interaction of C\/EBPalpha with demethylated Cxcr3 gene promoter contributes to neuropathic pain in mice. J Neurosci 2017, 37: 685\u2013700.","journal-title":"J Neurosci"},{"key":"128_CR17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2013.04.011","volume":"32","author":"K Schmitz","year":"2013","unstructured":"Schmitz K, Pickert G, Wijnvoord N, Haussler A, Tegeder I. Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia. Brain Behav Immun 2013, 32: 186\u2013200.","journal-title":"Brain Behav Immun"},{"key":"128_CR18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.expneurol.2014.09.019","volume":"263","author":"XH Guan","year":"2015","unstructured":"Guan XH, Fu QC, Shi D, Bu HL, Song ZP, Xiong BR, et al. Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats. Exp Neurol 2015, 263: 39\u201349.","journal-title":"Exp Neurol"},{"key":"128_CR19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1097\/j.pain.0000000000000208","volume":"156","author":"L Qu","year":"2015","unstructured":"Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain 2015, 156: 1737\u20131746.","journal-title":"Pain"},{"key":"128_CR20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1073\/pnas.89.4.1398","volume":"89","author":"AH Enk","year":"1992","unstructured":"Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci U S A 1992, 89: 1398\u20131402.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"128_CR21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1046\/j.1523-1747.1999.00730.x","volume":"113","author":"J Flier","year":"1999","unstructured":"Flier J, Boorsma DM, Bruynzeel DP, Van Beek PJ, Stoof TJ, Scheper RJ, et al. The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions. J Invest Dermatol 1999, 113: 574\u2013578.","journal-title":"J Invest Dermatol"},{"key":"128_CR22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.alit.2016.07.007","volume":"66","author":"M Tsuda","year":"2017","unstructured":"Tsuda M. Spinal dorsal horn astrocytes: New players in chronic itch. Allergol Int 2017, 66: 31\u201335.","journal-title":"Allergol Int"},{"key":"128_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0076-z","author":"FM Zhou","year":"2016","unstructured":"Zhou FM, Cheng RX, Wang S, Huang Y, Gao YJ, Zhou Y, et al. Antioxidants attenuate acute and chronic itch: peripheral and central mechanisms of oxidative stress in pruritus. Neurosci Bull 2016. doi: 10.1007\/s12264-016-0076-z .","journal-title":"Neurosci Bull"},{"key":"128_CR24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","volume":"139","author":"SG Shimada","year":"2008","unstructured":"Shimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse. Pain 2008, 139: 681\u2013687.","journal-title":"Pain"},{"key":"128_CR25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","volume":"20","author":"WJ Dixon","year":"1980","unstructured":"Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980, 20: 441\u2013462.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"128_CR26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","volume":"32","author":"K Hargreaves","year":"1988","unstructured":"Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32: 77\u201388.","journal-title":"Pain"},{"key":"128_CR27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI81950","volume":"126","author":"BC Jiang","year":"2016","unstructured":"Jiang BC, Cao DL, Zhang X, Zhang ZJ, He LN, Li CH, et al. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest 2016, 126: 745\u2013761.","journal-title":"J Clin Invest"},{"key":"128_CR28","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","volume":"154","author":"ZJ Zhang","year":"2013","unstructured":"Zhang ZJ, Cao DL, Zhang X, Ji RR, Gao YJ. Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain 2013, 154: 2185\u20132197.","journal-title":"Pain"},{"key":"128_CR29","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1523\/JNEUROSCI.5290-05.2006","volume":"26","author":"ZY Zhuang","year":"2006","unstructured":"Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, et al. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 2006, 26: 3551\u20133560.","journal-title":"J Neurosci"},{"key":"128_CR30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jjp.88.285","volume":"88","author":"T Miyamoto","year":"2002","unstructured":"Miyamoto T, Nojima H, Shinkado T, Nakahashi T, Kuraishi Y. Itch-associated response induced by experimental dry skin in mice. Jpn J Pharmacol 2002, 88: 285\u2013292.","journal-title":"Jpn J Pharmacol"},{"key":"128_CR31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2006.07.019","volume":"546","author":"N Inagaki","year":"2006","unstructured":"Inagaki N, Shiraishi N, Igeta K, Itoh T, Chikumoto T, Nagao M, et al. Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone. Eur J Pharmacol 2006, 546: 189\u2013196.","journal-title":"Eur J Pharmacol"},{"key":"128_CR32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0536.2012.02083.x","volume":"67","author":"MT Vennegaard","year":"2012","unstructured":"Vennegaard MT, Bonefeld CM, Hagedorn PH, Bangsgaard N, Lovendorf MB, Odum N, et al. Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice. Contact Dermatitis 2012, 67: 298\u2013305.","journal-title":"Contact Dermatitis"},{"key":"128_CR33","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/jid.2012.52","volume":"132","author":"T Akiyama","year":"2012","unstructured":"Akiyama T, Carstens MI, Ikoma A, Cevikbas F, Steinhoff M, Carstens E. Mouse model of touch-evoked itch (alloknesis). J Invest Dermatol 2012, 132: 1886\u20131891.","journal-title":"J Invest Dermatol"},{"key":"128_CR34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.3912","volume":"21","author":"M Shiratori-Hayashi","year":"2015","unstructured":"Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, et al. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nat Med 2015, 21: 927\u2013931.","journal-title":"Nat Med"},{"key":"128_CR35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/sj.bjp.0705754","volume":"142","author":"JK Bell","year":"2004","unstructured":"Bell JK, McQueen DS, Rees JL. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. Br J Pharmacol 2004, 142: 374\u2013380.","journal-title":"Br J Pharmacol"},{"key":"128_CR36","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","volume":"139","author":"Q Liu","year":"2009","unstructured":"Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009, 139: 1353\u20131365.","journal-title":"Cell"},{"key":"128_CR37","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1523\/JNEUROSCI.0716-08.2008","volume":"28","author":"VB Reddy","year":"2008","unstructured":"Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci 2008, 28: 4331\u20134335.","journal-title":"J Neurosci"},{"key":"128_CR38","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuroscience.2013.07.035","volume":"250","author":"T Akiyama","year":"2013","unstructured":"Akiyama T, Carstens E. Neural processing of itch. Neuroscience 2013, 250: 697\u2013714.","journal-title":"Neuroscience"},{"key":"128_CR39","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1523\/JNEUROSCI.12-09-03665.1992","volume":"12","author":"TJ Coderre","year":"1992","unstructured":"Coderre TJ, Melzack R. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 1992, 12: 3665\u20133670.","journal-title":"J Neurosci"},{"key":"128_CR40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0304-3959(95)00121-2","volume":"64","author":"S Puig","year":"1996","unstructured":"Puig S, Sorkin LS. Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain 1996, 64: 345\u2013355.","journal-title":"Pain"},{"key":"128_CR41","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pain.2010.11.014","volume":"152","author":"L Zhang","year":"2011","unstructured":"Zhang L, Berta T, Xu ZZ, Liu T, Park JY, Ji RR. TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. Pain 2011, 152: 419\u2013427.","journal-title":"Pain"},{"key":"128_CR42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000446011","volume":"50","author":"E Carstens","year":"2016","unstructured":"Carstens E, Akiyama T. Central mechanisms of itch. Curr Probl Dermatol 2016, 50: 11\u201317.","journal-title":"Curr Probl Dermatol"},{"key":"128_CR43","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","volume":"10","author":"A Latremoliere","year":"2009","unstructured":"Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 2009, 10: 895\u2013926.","journal-title":"J Pain"},{"key":"128_CR44","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nurt.2010.05.016","volume":"7","author":"YJ Gao","year":"2010","unstructured":"Gao YJ, Ji RR. Targeting astrocyte signaling for chronic pain. Neurotherapeutics 2010, 7: 482\u2013493.","journal-title":"Neurotherapeutics"},{"issue":"Suppl 1","key":"128_CR45","first-page":"S10","volume":"154","author":"RR Ji","year":"2013","unstructured":"Ji RR, Berta T, Nedergaard M. Glia and pain: is chronic pain a gliopathy? Pain 2013, 154 Suppl 1: S10\u2013S28.","journal-title":"Pain"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12264-017-0128-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-017-0128-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-017-0128-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T22:10:10Z","timestamp":1569017410000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12264-017-0128-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["128"],"URL":"https:\/\/doi.org\/10.1007\/s12264-017-0128-z","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]}}}