{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:36:20Z","timestamp":1790537780279,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosci. Bull."],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12264-019-00405-5","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T12:22:56Z","timestamp":1560946976000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model of Cerebral Ischemia"],"prefix":"10.1007","volume":"35","author":[{"given":"Lili","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aowei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"405_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000093098","volume":"22","author":"S Meairs","year":"2006","unstructured":"Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron JC, et al. Stroke research priorities for the next decade\u2013A representative view of the European scientific community. Cerebrovasc Dis 2006, 22: 75\u201382.","journal-title":"Cerebrovasc Dis"},{"key":"405_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrn1106","volume":"4","author":"EH Lo","year":"2003","unstructured":"Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke: Neurological diseases. Nat Rev Neurosci 2003, 4: 399\u2013414.","journal-title":"Nat Rev Neurosci"},{"key":"405_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.brainres.2004.04.038","volume":"1016","author":"K Chu","year":"2004","unstructured":"Chu K, Kim M, Park K-I, Jeong S-W, Park H-K, Jung K-H, et al. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res 2004, 1016: 145\u2013153.","journal-title":"Brain Res"},{"key":"405_CR4","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1460-9568.2007.05702.x","volume":"26","author":"V Darsalia","year":"2007","unstructured":"Darsalia V, Kallur T, Kokaia Z. Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum: Transplantation of neural stem cells from human fetal brain. Eur J Neurosci 2007, 26: 605\u2013614.","journal-title":"Eur J Neurosci"},{"key":"405_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.stem.2009.05.008","volume":"4","author":"FD Miller","year":"2009","unstructured":"Miller FD, Gauthier-Fisher A. Home at last: neural stem cell niches defined. Cell Stem Cell 2009, 4: 507\u2013510.","journal-title":"Cell Stem Cell"},{"key":"405_CR6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","volume":"8","author":"A Arvidsson","year":"2002","unstructured":"Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002, 8: 963\u2013970.","journal-title":"Nat Med"},{"key":"405_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.nbd.2012.08.020","volume":"49","author":"SS Kang","year":"2013","unstructured":"Kang SS, Keasey MP, Arnold SA, Reid R, Geralds J, Hagg T. Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice. Neurobiol Dis 2013, 49: 68\u201378.","journal-title":"Neurobiol Dis"},{"key":"405_CR8","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/stem.46","volume":"27","author":"B Jenny","year":"2009","unstructured":"Jenny B, Kanemitsu M, Tsupykov O, Potter G, Salmon P, Zgraggen E, et al. Fibroblast growth factor-2 overexpression in transplanted neural progenitors promotes perivascular cluster formation with a neurogenic potential. Stem Cells 2009, 27: 1309\u20131317.","journal-title":"Stem Cells"},{"key":"405_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1227\/01.NEU.0000166682.50272.BC","volume":"57","author":"W Zhu","year":"2005","unstructured":"Zhu W, Mao Y, Zhao Y, Zhou L-F, Wang Y, Zhu J-H, et al. Transplantation of vascular endothelial growth factor-transfected neural stem cells into the rat brain provides neuroprotection after transient focal cerebral ischemia. Neurosurgery 2005, 57: 325\u2013333.","journal-title":"Neurosurgery"},{"key":"405_CR10","doi-asserted-by":"publisher","first-page":"12089","DOI":"10.1523\/JNEUROSCI.3047-06.2006","volume":"26","author":"S Bauer","year":"2006","unstructured":"Bauer S, Patterson PH. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci 2006, 26: 12089\u201312099.","journal-title":"J Neurosci"},{"key":"405_CR11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.cytogfr.2015.07.001","volume":"26","author":"NA Nicola","year":"2015","unstructured":"Nicola NA, Babon JJ. Leukemia inhibitory factor (LIF). Cytokine Growth Factor Rev 2015, 26: 533\u2013544.","journal-title":"Cytokine Growth Factor Rev"},{"key":"405_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1046\/j.1460-9568.2000.00922.x","volume":"12","author":"S Sugiura","year":"2000","unstructured":"Sugiura S, Lahav R, Han J, Kou S-Y, Banner LR, De Pablo F, et al. Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro: LIF in neural injury. Eur J Neurosci 2000, 12: 457\u2013466.","journal-title":"Eur J Neurosci"},{"key":"405_CR13","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1111\/ejn.12675","volume":"40","author":"DD Rowe","year":"2014","unstructured":"Rowe DD, Collier LA, Seifert HA, Chapman CB, Leonardo CC, Willing AE, et al. Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia. Eur J Neurosci 2014, 40: 3111\u20133119.","journal-title":"Eur J Neurosci"},{"key":"405_CR14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0165-3806(93)90132-T","volume":"76","author":"T Yoshida","year":"1993","unstructured":"Yoshida T, Satoh M, Nakagaito Y, Kuno H, Takeuchi M. Cytokines affecting survival and differentiation of an astrocyte progenitor cell line. Brain Res Dev Brain Res 1993, 76: 147\u2013150.","journal-title":"Brain Res Dev Brain Res"},{"key":"405_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/exnr.1997.6536","volume":"147","author":"LR Banner","year":"1997","unstructured":"Banner LR, Moayeri NN, Patterson PH. Leukemia inhibitory factor is expressed in astrocytes following cortical brain injury. Exp Neurol 1997, 147: 1\u20139.","journal-title":"Exp Neurol"},{"key":"405_CR16","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.1073\/pnas.91.15.7109","volume":"91","author":"LR Banner","year":"1994","unstructured":"Banner LR, Patterson PH. Major changes in the expression of the mRNAs for cholinergic differentiation factor\/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia. Proc Natl Acad Sci U S A 1994, 91: 7109\u20137113.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"405_CR17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0896-6273(94)90163-5","volume":"12","author":"R Curtis","year":"1994","unstructured":"Curtis R, Scherer SS, Somogyi R, Adryan KM, Ip NY, Zhu Y, et al. Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve. Neuron 1994, 12: 191\u2013204.","journal-title":"Neuron"},{"key":"405_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/gene.2011.9","volume":"12","author":"SM Metcalfe","year":"2011","unstructured":"Metcalfe SM. LIF in the regulation of T-cell fate and as a potential therapeutic. Genes Immun 2011, 12: 157\u2013168.","journal-title":"Genes Immun"},{"key":"405_CR19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/labinvest.3700216","volume":"85","author":"MA Weber","year":"2005","unstructured":"Weber MA, Schnyder-Candrian S, Schnyder B, Quesniaux V, Poli V, Stewart CL, et al. Endogenous leukemia inhibitory factor attenuates endotoxin response. Lab Invest 2005, 85: 276\u2013284.","journal-title":"Lab Invest"},{"key":"405_CR20","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/mt.2012.12","volume":"20","author":"Y Yan","year":"2012","unstructured":"Yan Y, Ding X, Li K, Ciric B, Wu S, Xu H, et al. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Mol Ther 2012, 20: 1338\u20131348.","journal-title":"Mol Ther"},{"key":"405_CR21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/jcbfm.1992.86","volume":"12","author":"H Chen","year":"1992","unstructured":"Chen H, Chopp M, Zhang ZG, Garcia JH. The effect of hypothermia on transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992, 12: 621\u2013628.","journal-title":"J Cereb Blood Flow Metab"},{"key":"405_CR22","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001, 32: 1005\u20131011.","journal-title":"Stroke"},{"key":"405_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/jnr.21857","volume":"87","author":"AA Hall","year":"2009","unstructured":"Hall AA, Guyer AG, Leonardo CC, Ajmo CT, Collier LA, Willing AE, et al. Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death. J Neurosci Res 2009, 87: 333\u2013341.","journal-title":"J Neurosci Res"},{"key":"405_CR24","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s12264-018-0294-7","volume":"34","author":"Z Dong","year":"2018","unstructured":"Dong Z, Pan K, Pan J, Peng Q, Wang YJ. The Possibility and molecular mechanisms of cell pyroptosis after cerebral ischemia. Neurosci Bull 2018, 34: 1131\u20131136.","journal-title":"Neurosci Bull"},{"key":"405_CR25","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.09.008","volume":"22","author":"MB Jensen","year":"2013","unstructured":"Jensen MB, Yan H, Krishnaney-Davison R, Al Sawaf A, Zhang S-C. Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model. J Stroke Cerebrovasc Dis 2013, 22: 304\u2013308.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"405_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1742-4658.2008.06766.x","volume":"276","author":"D Amantea","year":"2009","unstructured":"Amantea D, Nappi G, Bernardi G, Bagetta G, Corasaniti MT. Post-ischemic brain damage: pathophysiology and role of inflammatory mediators: neuroinflammatory mediators in brain ischemia. FEBS J 2009, 276: 13\u201326.","journal-title":"FEBS J"},{"key":"405_CR27","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1189\/jlb.1109766","volume":"87","author":"R Jin","year":"2010","unstructured":"Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leuko Biol 2010, 87: 779\u2013789.","journal-title":"J Leuko Biol"},{"key":"405_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.mcn.2004.07.004","volume":"27","author":"M Pitman","year":"2004","unstructured":"Pitman M, Emery B, Binder M, Wang S, Butzkueven H, Kilpatrick TJ. LIF receptor signaling modulates neural stem cell renewal. Mol Cell Neurosci 2004, 27: 255\u2013266.","journal-title":"Mol Cell Neurosci"},{"key":"405_CR29","doi-asserted-by":"publisher","first-page":"7642","DOI":"10.1523\/JNEUROSCI.21-19-07642.2001","volume":"21","author":"T Shimazaki","year":"2001","unstructured":"Shimazaki T, Shingo T, Weiss S. The ciliary neurotrophic factor\/leukemia inhibitory factor\/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J Neurosci 2001,21:7642\u20137653.","journal-title":"J Neurosci"},{"key":"405_CR30","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.expneurol.2004.04.012","volume":"188","author":"BJ Kerr","year":"2004","unstructured":"Kerr BJ, Patterson PH. Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. Exp Neurol 2004, 188: 391\u2013407.","journal-title":"Exp Neurol"},{"key":"405_CR31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s12264-016-0091-0","volume":"33","author":"LJ Zhou","year":"2017","unstructured":"Zhou LJ, Liu XG. Glial Activation, A common mechanism underlying spinal synaptic plasticity? Neurosci Bull 2017, 33: 121\u2013123.","journal-title":"Neurosci Bull"},{"key":"405_CR32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1460-9568.1996.tb01213.x","volume":"8","author":"LJ Richards","year":"1996","unstructured":"Richards LJ, Kilpatrick TJ, Dutton R, Tan S-S, Gearing DP, Bartlett PF, et al. Leukaemia inhibitory factor or related factors promote the differentiation of neuronal and astrocytic precursors within the developing murine spinal cord. Eur J Neurosci 1996, 8: 291\u2013299.","journal-title":"Eur J Neurosci"},{"key":"405_CR33","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1523\/JNEUROSCI.3803-11.2012","volume":"32","author":"BE Deverman","year":"2012","unstructured":"Deverman BE, Patterson PH. Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination. J Neurosci 2012, 32: 2100\u20132109.","journal-title":"J Neurosci"},{"key":"405_CR34","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s12035-015-9587-2","volume":"54","author":"SM Davis","year":"2017","unstructured":"Davis SM, Collier LA, Leonardo CC, Seifert HA, Ajmo CT, Pennypacker KR. Leukemia inhibitory factor protects neurons from ischemic damage via upregulation of superoxide dismutase 3. Mol Neurobiol 2017, 54: 608\u2013622.","journal-title":"Mol Neurobiol"},{"key":"405_CR35","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/jcbfm.2009.219","volume":"30","author":"K Jin","year":"2010","unstructured":"Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, et al. Transplantation of human neural precursor cells in matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab 2010, 30: 534\u2013544.","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Neuroscience Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-019-00405-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12264-019-00405-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12264-019-00405-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T23:28:51Z","timestamp":1592436531000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12264-019-00405-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["405"],"URL":"https:\/\/doi.org\/10.1007\/s12264-019-00405-5","relation":{},"ISSN":["1673-7067","1995-8218"],"issn-type":[{"value":"1673-7067","type":"print"},{"value":"1995-8218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"7 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors claim that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}